glyceryl caprylate
glycerol monooctanoate
Identification
| Name | glyceryl caprylate |
| CAS Number | 26402-26-6 |
| EINECS | 247-668-1 |
| FDA UNII | TM2TZD4G4A |
| Molecular Formula | C11 H22 O4 |
| Molecular Weight | 218.29314000 |
| MDL Number | MFCD00056652 |
| Nikkaji Number | J118.316H |
Regulatory
| DG SANTE Food Contact Materials | glycerol monooctanoate |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 339.95 °C. @ 760.00 mm Hg (est) |
| Flash Point | 254.00 °F. TCC ( 123.40 °C. ) (est) |
| logP (o/w) | 1.915 (est) |
| Soluble in | water, 1229 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning - emollient |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emollients, emulsifiers |
| Recommendation for glyceryl caprylate usage levels up to | not for fragrance use. |
| Recommendation for glyceryl caprylate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
capmul 708G
capmul MCM C8
capmul MCM C8 EP
capmul MCM-C8
caprylic acid monoglyceride
1-mono
caprylin
a-mono
caprylin
1-
capryloyl-rac-glycerol
2,3-
dihydroxypropyl octanoate
glycerol monooctanoate
glycerol, 1-monooctanoyl-
glyceryl monocaprylate
glyceryl octanoate
DL-
glyceryl-1-mono-octanoate
homotex PT
imwitor 308
moctanin
monocaprylin
octanoic acid 2,3-dihydroxypropyl ester
octanoic acid glycerol ester
octanoic acid monoester with 1,2,3-propanetriol
octanoic acid, 2,3-dihydroxypropyl ester
octanoic acid, monoester with 1,2,3-propanetriol
octanoic acid, monoester with glycerol
mono
octanoin
octanoin, mono-
1-
octanoyl-rac-glycerol
poem M 100
sefsol 318
sunsoft 700P
PubMed:
Glyceryl (mono)caprylate - a new contact allergen.
PubMed:
Tuning the viscoelasticity of nonionic wormlike micelles with β-cyclodextrin derivatives: a highly discriminative process.
PubMed:
Protein transduction domain-containing microemulsions as cutaneous delivery systems for an anticancer agent.
PubMed:
Silica-lipid hybrid (SLH) formulations enhance the oral bioavailability and efficacy of celecoxib: An in vivo evaluation.
PubMed:
Lamellar liquid crystalline phases for cutaneous delivery of Paclitaxel: impact of the monoglyceride.
PubMed:
Decylglucoside-based microemulsions for cutaneous localization of lycopene and ascorbic acid.
PubMed:
Self-nanoemulsifying drug delivery system of cefpodoxime proxetil containing tocopherol polyethylene glycol succinate.
PubMed:
Formulation and in vitro evaluation of self-emulsifying formulations of Cinnarizine.
PubMed:
Development of optimized self-nano-emulsifying drug delivery systems (SNEDDS) of carvedilol with enhanced bioavailability potential.
PubMed:
[Establishment and evaluation of a dynamic in vitro intestinal absorption model of lipid formulations].
PubMed:
Novel gastroretentive sustained-release tablet of tacrolimus based on self-microemulsifying mixture: in vitro evaluation and in vivo bioavailability test.
PubMed:
The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate.
PubMed:
In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis.
PubMed:
[Use of an in vitro lipolysis model to evaluate type I lipid formulations].
PubMed:
Inactivation of Escherichia coli O157:H7 and Salmonella spp. on alfalfa seeds by caprylic acid and monocaprylin.
PubMed:
Development and oral bioavailability assessment of a supersaturated self-microemulsifying drug delivery system (SMEDDS) of albendazole.
PubMed:
New alternatives to cosmetics preservation.
PubMed:
Preparation and bioavailability assessment of SMEDDS containing valsartan.
PubMed:
Synergistic effect of isopropyl myristate and glyceryl monocaprylate on the skin permeation of pentazocine.
PubMed:
Rheological investigation of self-emulsification process: effect of co-surfactant.
PubMed:
Effects of temperature on the rheological behavior of worm-like micelles in a mixed nonionic surfactant system.
PubMed:
Development of a self-emulsifying formulation that reduces the food effect for torcetrapib.
PubMed:
Inactivation of Listeria monocytogenes on frankfurters by monocaprylin alone or in combination with acetic acid.
PubMed:
Quality by design: characterization of self-nano-emulsified drug delivery systems (SNEDDs) using ultrasonic resonator technology.
PubMed:
Quality by design: understanding the formulation variables of a cyclosporine A self-nanoemulsified drug delivery systems by Box-Behnken design and desirability function.
PubMed:
Exploring the potential of N-methyl pyrrolidone as a cosurfactant in the microemulsion systems.
PubMed:
Impact of formulation excipients on human intestinal transit.
PubMed:
Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate.
PubMed:
Preparation and in vitro characterization of self-nanoemulsified drug delivery system (SNEDDS) of all-trans-retinol acetate.
PubMed:
Preparation, evaluation, and NMR characterization of vinpocetine microemulsion for transdermal delivery.
PubMed:
Evaluation of the in-vitro digestion profiles of long and medium chain glycerides and the phase behaviour of their lipolytic products.
PubMed:
Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements.
PubMed:
Evaluation of garlic oil as a contact dissolution agent for gallstones: comparison with monooctanoin.
PubMed:
A history of the dissolution of retained choledocholithiasis.
PubMed:
Site-specific immunosuppression using a new formulation of topical cyclosporine A with polyethylene glycol-8 glyceryl caprylate/caprate.
PubMed:
Medical management of common bile duct stones.
PubMed:
Problematic bile duct stones: polyvalent treatment.
PubMed:
Biochemical and structural characterization of triacylglycerol lipase from Penicillium cyclopium.
PubMed:
Moctanin.
PubMed:
In vitro study comparing the ability of mono-octanoin and mono-octanoin plus methyl tert-butyl ether to dissolve biliary stones.
PubMed:
A method to quantitatively compare in vivo the effects of gallstone solvents on intestinal mucosal function: a controlled study comparing mono-octanoin with methyl tert-butyl ether in the rat.
PubMed:
Dissolution rate of cholesterol and palmitic acid mixtures in cholelitholytic cosolvent systems.
PubMed:
Mono-octanoin and methyl tert-butyl ether mixture for bile duct stones.
PubMed:
Dissolution of gallstones.
PubMed:
Endoscopic diagnosis and treatment of Mirizzi's syndrome.
PubMed:
Non-surgical management of bile duct stones refractory to routine endoscopic measures.
PubMed:
Gallstone-dissolving agents.
PubMed:
Treatment of common bile duct stones using mono-octanoin.
PubMed:
[The combined treatment by chemical litholysis and lithotripsy of so-called difficult bile duct calculi].
PubMed:
A new technique for the rapid dissolution of retained ductal gallstones with monoctanoin in T-tube patients.
PubMed:
Enhanced rectal absorption of insulin in rabbits from hollow-type suppositories containing insulin and glyceryl-1-monooctanoate.
PubMed:
[Contact dissolution of gallstones].
PubMed:
[Monoctanoin for the dissolution of biliary calculi. Report of a case].
PubMed:
Contact dissolution of cholesterol gallstones with organic solvents.
PubMed:
Infusional therapy for post-surgical biliary stones.
PubMed:
In vitro comparison of different gall stone dissolution solvents.
PubMed:
Dissolution of bile duct stones by a hydrophilized glyceromonooctanoin-bile-acid-EDTA emulsion.
PubMed:
[A method of individual selection of cholelitholytic drugs for the treatment of cholelithiasis].
PubMed:
Dissolution of bile duct stones with monooctanoin: in vitro study.
PubMed:
Duration of absorption-enhancing effect of sodium octanoate, sodium hexanoate or glyceryl-1-monooctanoate on rectal absorption of gentamicin in rabbits.
PubMed:
[Pros and cons of chemical litholysis in bile duct calculi].
PubMed:
Management of retained common bile duct stones in patients with T-tube in situ: role of endoscopic sphincterotomy.
PubMed:
Biliary duct stones: percutaneous transhepatic removal.
PubMed:
Fatal intravenous injection of monooctanoin.
PubMed:
[Experimental studies on dissolution of cholesterol gallstones using MTBE].
PubMed:
Gallstones. Alternatives to surgery.
PubMed:
[Nonsurgical treatment of bile duct stones].
PubMed:
[Dissolution of residual biliary calculi in early postoperative periods].
PubMed:
Chemical dissolution of gallstones: in vitro studies.
PubMed:
Dissolution of bile duct stones.
PubMed:
Enhancing effect of glyceryl-1-monooctanoate on the rectal absorption of gentamicin from hollow-type suppositories in rabbits.
PubMed:
[A new therapeutic approach to retained biliary calculi. Results in 6 patients].
PubMed:
Biliary duct stones: update on 54 cases after percutaneous transhepatic removal.
PubMed:
Success of contact chemolysis in calcified cholesterol gallstones.
PubMed:
Alternatives to conventional surgical therapy for calculous biliary tract disease.
PubMed:
Gallbladder and bile duct stones: percutaneous therapy with primary MTBE dissolution and mechanical methods.
PubMed:
A primer on gallstones.
PubMed:
Monooctanoin-associated pulmonary edema.
PubMed:
Dissolution of cholesterol gallstones by perfusion: a solution for the matrix?
PubMed:
Can the newer interventional procedures replace cholecystectomy for cholecystolithiasis? The potential role of percutaneous cystic duct ablation.
PubMed:
Non-invasive treatment for retained common bile duct stones in patients with T tube in situ: saline washout after intravenous ceruletide.
PubMed:
Dissolving gallstones.
PubMed:
Effect of medium chain glycerides on enteral and rectal absorption of beta-lactam and aminoglycoside antibiotics.
PubMed:
Dissolution of calcified cholesterol stones and of brown and black pigment stones of the gallbladder.
PubMed:
Dissolution of cholesterol gallstones in vitro. Gallstone matrix content and diameter, not cholesterol content, predict gallstone dissolution in monooctanoin.
PubMed:
[New therapeutic methods--technics, application, efficacy and problems. Litholysis. c) Present status of direct litholytic agents].
PubMed:
Physicochemical investigations of dipolar aprotic solvents as potential cholelitholytic agents.
PubMed:
[Residual calculosis of the bile ducts. Current therapeutic guidelines].
PubMed:
Monooctanoin for gallstones.
PubMed:
[Use of monooctanoin to dissolve gallstones (experimental study)].
PubMed:
[Dissolution of biliary calculi with monooctanoin].
PubMed:
Dissolution of gallstones using cholecystostomy tube in the pig.
PubMed:
Monooctanoin infusion and stone removal through the transparenchymal tract: use in 17 patients.
PubMed:
Gallstone dissolution therapy. Current status and future prospects.
PubMed:
[Composition of gallbladder and bile duct calculi].
PubMed:
Methyl tert-butyl ether fails to dissolve retained radiolucent common bile duct stones.
PubMed:
Mechanism of dissolution of cholesterol-calcium bilirubinate compressed discs in monooctanoin.
PubMed:
Bile duct stones: percutaneous transhepatic removal.
PubMed:
Noncardiogenic pulmonary edema during intrabiliary infusion of mono-octanoin.
PubMed:
Chemical treatment of stones in the biliary tree.
PubMed:
Orphan approvals.
PubMed:
Orphan drugs.
PubMed:
Total parenteral feeding of rats with an acetoacetate monoglyceride and glucose mixture.
PubMed:
[Combination of monooctanoin and cicloxilic acid in treating secondary choledochal calculi. Preliminary data].
PubMed:
Intraductal mono-octanoin for the direct dissolution of bile duct stones: experience in 343 patients.
PubMed:
Dissolution of cholesterol gallstones: comparison of solvents.
PubMed:
In vitro dissolution of cholesterol gallstones. A study of factors influencing rate and a comparison of solvents.
PubMed:
Monooctanoin use for gallstone dissolution.
PubMed:
Identification of gallbladder mucin-bilirubin complex in human cholesterol gallstone matrix. Effects of reducing agents on in vitro dissolution of matrix and intact gallstones.
PubMed:
Ultrasonic fragmentation of gallstones in vitro.
PubMed:
[Local dissolving of residual and/or recurrent choledochal calculi. Criteria for selecting the patient].
PubMed:
[Monooctanoin dissolving of post-cholecystectomy residual biliary calculi].
PubMed:
[Combination lytic-endoscopic therapy of common bile duct retained stones. Irrigation procedures using a Seldinger catheter system].
PubMed:
Simplified solvent infusion and drainage in closed systems: double-lumen, single-catheter method.
PubMed:
[Solvent effects on cholesterol calculi: an in vitro study using octanoic acid, glycerol monooctanate, sodium cholate, heparin and ursodeoxycholic acid].
PubMed:
Cholelitholysis using methyl tertiary butyl ether.
PubMed:
Treatment of retained common bile duct stones with monooctanoin infusion.
PubMed:
Monooctanoin dissolution of gallstones via a cholecystostomy tube.
PubMed:
Monooctanoin perfusion for in vivo dissolution of biliary stones. A series of 11 patients.
PubMed:
Monooctanoin perfusion treatment of intrahepatic calculi.
PubMed:
Dissolution rate of cholesterol in monooctanoin.
PubMed:
The treatment of retained biliary stones with monooctanoin: report of 16 patients.
PubMed:
[Dissolution of recurrent stones in the choledochus by a modified irrigation treatment via an indwelling nasobiliary catheter].
PubMed:
Importance of viscosity in the dissolution rate of cholesterol in monooctanoin solutions.
PubMed:
[Current aspects of the dissolving of biliary calculi (review of the literature)].
PubMed:
Toxic effects of intrahepatic reflux of monooctanoin in a canine model.
PubMed:
Dissolution of biliary duct stones without papillotomy in a patient with Billroth II resection and Crohn's disease.
PubMed:
Percutaneous transhepatic removal of a common bile duct stone after mono-octanoin infusion.
PubMed:
Biochemical and morphological investigations of the toxicity of a Capmul preparation and a bile salt-EDTA solution in patients with bile duct stones.
PubMed:
Common bile duct calculi. 2. Nonsurgical therapy.
PubMed:
Duodenal ulcerations after monooctanoin therapy.
PubMed:
Investigations on the toxicity of bile salt solutions, Capmul 8210 and a bile salt-EDTA solution for common bile duct perfusion in dogs.
PubMed:
Chemical dissolution of common bile duct stones.
PubMed:
[Monooctanoin in the treatment of residual common bile duct calculi].
PubMed:
Monooctanoin dissolution of retained biliary stones in high risk patients.
PubMed:
Percutaneous transhepatic removal of common duct stones: report of ten patients.
PubMed:
Management of retained biliary tract stones, case report and overview.
PubMed:
A comparison of the toxicity of two agents that dissolve cholesterol stones.
PubMed:
Duodenal ulceration associated with monooctanoin infusion.
PubMed:
The action of alcohols and other non-ionic surface active substances on the sodium current of the squid giant axon.
PubMed:
Dissolution of bile duct stones.
PubMed:
Non-operative treatment of large common bile duct stones and hepatic abscess.
PubMed:
Management of calculi in the common duct.
PubMed:
Treatment of retained common bile duct stones: a prospective controlled study comparing monooctanoin and heparin.
PubMed:
[Treatment of retained choledocholithiasis with monooctanoin].
PubMed:
Cholelitholytic agents.
PubMed:
Biliary tract disorders. Postsurgical syndromes.
PubMed:
Necrotizing choledochomalacia after use of monooctanoin to dissolve bile-duct stones.
PubMed:
Endoscopically placed biliary drains and stents.
PubMed:
Selection of patients for dissolution of retained common duct stones with mono-octanoin.
PubMed:
Effect of mono-octanoin on canine gastric mucosa.
PubMed:
Systemic side effects from the intrabiliary infusion of monooctanoin for the dissolution of gallstones.
PubMed:
Gallstone dissolution using mono-octanoin infusion through an endoscopically placed nasobiliary catheter.
PubMed:
Gallstone dissolution in the biliary tract: in vitro investigations on inhibiting factors and special dissolution agents.
PubMed:
Unusual cholesterol solubility in water/glyceryl-1-monooctanoate solutions.
PubMed:
Dissolution of retained common bile duct stones using monooctanoin. A case report documented with cholangiography.
PubMed:
In vitro dissolution of gallstones: comparison of monooctanoin, sodium dehydrocholate, heparin, and saline.
PubMed:
Drug dissolution of gallstones.
PubMed:
Studies of chromophores in model membranes by polarized light-absorption spectroscopy. The orientation and binding of tetracaine and procaine.
PubMed:
Clinical experience with monooctanoin for dissolution of bile duct stones:" an uncontrolled multicenter trial.
PubMed:
Percutaneous transhepatic dissolution of common bile duct stones.
PubMed:
[In vitro dissolution of cholesterol gallstones with sodium cholate, heparin and monooctanoin (author's transl)].
PubMed:
The dissolution of gallstones.
PubMed:
Dissolution of retained duct stones by perfusion with monooctanoin via a Teflon catheter introduced endoscopically.
PubMed:
The effect of monooctanoin on retained common duct stones.
PubMed:
Infusion therapy of choledocholithiasis: technique for catheter placement.
PubMed:
Retained biliary tract stones. Nonsurgical treatment with capmul 8210, a new cholesterol gallstone dissolution agent.
PubMed:
Intra-ductal infusion of mono-octanoin for common duct stones.
PubMed:
Dissolution of bileduct stones.
PubMed:
Intraductal infusion of mono-octanoin: experience in 24 patients with retained common-duct stones.
PubMed:
Alternating treatment of common bile duct stones with a modified glyceryl-1-monooctanoate preparation and a bile acid-EDTA solution by nasobiliary tube.
PubMed:
[Treatment of retained common duct stones with intraductal infusion of monooctanoin (author's transl)].
PubMed:
[Resolution of cholesterol-gallstone with a modified Capmul 8210-emulsion and with an EDTA solution (author's transl)].
PubMed:
Treatment of choledocholithiasis using the transpapillary perfusion technique.
PubMed:
New methods in gastroenterology.
PubMed:
Dissolution of gallstones by perfusion with Capmul via a catheter introduced endoscopically into the bile duct.
PubMed:
Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application.
PubMed:
A new agent for gallstone dissolution: experimental and clinical evaluation.