hexamidine diisethionate

ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI)

CAS: 659-40-5 C24 H38 N4 O10 S2 MW: 606.71686000

Identification

Namehexamidine diisethionate
CAS Number659-40-5
EINECS211-533-5
FDA UNII023XA5Z50L
Molecular FormulaC24 H38 N4 O10 S2
Molecular Weight606.71686000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 548.60 °C. @ 760.00 mm Hg (est)
Flash Point 546.00 °F. TCC ( 285.60 °C. ) (est)
logP (o/w) 3.003 (est)
Soluble in water, 9.136 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantifoaming agents

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for hexamidine diisethionate usage levels up tonot for fragrance use.
Recommendation for hexamidine diisethionate flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

4-[6-(4- carbamimidoylphenoxy)hexoxy]benzenecarboximidamide;2-hydroxyethanesulfonic acid desmedine desomedine esomedina ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(1,6-hexanediylbis(oxy))bis(benzenecarboximidamide) (2:1) (9CI) ethanesulfonic acid, 2-hydroxy-, compd. with 4,4'-(hexamethylenedioxy)dibenzamidine (2:1) (8CI) hexamidin 2-hydroxyethansulfonat hexamidine isethionate hexomedine 2- hydroxyethanesulphonic acid, compound with 4,4'-(hexane-1,6-diylbis(oxy))bis(benzenecarboxamidine) (2:1) ophtamedine PubMed: Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis. PubMed: A double-blind randomized controlled comparison of APDDR-0901, a novel cosmeceutical formulation, and 0.1% adapalene gel in the treatment of mild-to-moderate acne vulgaris. PubMed: Microsporidial keratoconjunctivitis in the tropics: a case series. PubMed: Final report on the safety assessment of Hexamidine and Hexamidine Diisethionate. PubMed: A keratitis rat model for evaluation of anti-Acanthamoeba polyphaga agents. PubMed: Plasmid-mediated resistance to antimicrobial agents among listeriae. PubMed: Successful treatment of Acanthamoeba keratitis by hexamidine. PubMed: Hexamidine isethionate: a sensitizer in topical pharmaceutical products and cosmetics. PubMed: Ring-shaped positive allergic patch test reactions to allergens in liquid vehicles. PubMed: Quantitative determination of hexamidine isethionate in pharmaceutical preparations by high-performance liquid chromatography.