isobutyl paraben

4-hydroxybenzoic acid, 2-methylpropyl ester

CAS: 4247-02-3 C11 H14 O3 MW: 194.23018000

Identification

Nameisobutyl paraben
CAS Number4247-02-3
EINECS224-208-8
FDA UNII0QQJ25X58G
Molecular FormulaC11 H14 O3
Molecular Weight194.23018000
MDL NumberMFCD00020167
Nikkaji NumberJ909A
Beilstein2642305
XlogP33.40 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 76.00 °C. @ 760.00 mm Hg
Boiling Point 302.00 to 303.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 258.00 °F. TCC ( 125.40 °C. ) (est)
logP (o/w) 3.255 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal Toxicitysubcutaneous-mouse LD50 2600 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

benzoic acid, 4-hydroxy-, 2-methylpropyl ester (9CI) benzoic acid, p-hydroxy-, isobutyl ester iso butyl 4-hydroxybenzoate iso butyl p-hydroxybenzoate iso butyl para-hydroxybenzoate iso butyl parahydroxybenzoate iso butyl-p-hydroxybenzoate iso butylparaben cosept IB 4- hydroxybenzoic acid 2-methylpropyl ester 4- hydroxybenzoic acid isobutyl ester p- hydroxybenzoic acid isobutyl ester 4- hydroxybenzoic acid isobutylester 4- hydroxybenzoic acid, 2-methylpropyl ester 2- methylpropyl 4-hydroxybenzoate PubMed: Additional effects of bisphenol A and paraben on the induction of calbindin-D(9K) and progesterone receptor via an estrogen receptor pathway in rat pituitary GH3 cells. PubMed: Calbindin-D9k as a sensitive molecular biomarker for evaluating the synergistic impact of estrogenic chemicals on GH3 rat pituitary cells. PubMed: Large volume sample stacking with EOF and sweeping in CE for determination of common preservatives in cosmetic products by chemometric experimental design. PubMed: Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum. PubMed: Synergistic effects of octylphenol and isobutyl paraben on the expression of calbindin-D₉k in GH3 rat pituitary cells. PubMed: Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells. PubMed: Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding. PubMed: Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455). PubMed: Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats. PubMed: In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay. PubMed: Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model. PubMed: Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats. PubMed: An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. PubMed: Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats. PubMed: Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. PubMed: Removal of estrogenic activity of iso-butylparaben and n-butylparaben by laccase in the presence of 1-hydroxybenzotriazole. PubMed: Parabens in male infertility-is there a mitochondrial connection? PubMed: Construction of simplified models to simulate estrogenic disruptions by esters of 4-hydroxy benzoic acid (parabens). PubMed: A review of the endocrine activity of parabens and implications for potential risks to human health. PubMed: Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens. PubMed: Oestrogenic activity of benzylparaben. PubMed: Oestrogenic activity of isobutylparaben in vitro and in vivo. PubMed: ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.