isobutyl paraben
4-hydroxybenzoic acid, 2-methylpropyl ester
Identification
| Name | isobutyl paraben |
| CAS Number | 4247-02-3 |
| EINECS | 224-208-8 |
| FDA UNII | 0QQJ25X58G |
| Molecular Formula | C11 H14 O3 |
| Molecular Weight | 194.23018000 |
| MDL Number | MFCD00020167 |
| Nikkaji Number | J909A |
| Beilstein | 2642305 |
| XlogP3 | 3.40 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 76.00 °C. @ 760.00 mm Hg |
| Boiling Point | 302.00 to 303.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point | 258.00 °F. TCC ( 125.40 °C. ) (est) |
| logP (o/w) | 3.255 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | preservatives |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | subcutaneous-mouse LD50 2600 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | preservatives |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 4-hydroxy-, 2-methylpropyl ester (9CI)
benzoic acid, p-hydroxy-, isobutyl ester
iso
butyl 4-hydroxybenzoate
iso
butyl p-hydroxybenzoate
iso
butyl para-hydroxybenzoate
iso
butyl parahydroxybenzoate
iso
butyl-p-hydroxybenzoate
iso
butylparaben
cosept IB
4-
hydroxybenzoic acid 2-methylpropyl ester
4-
hydroxybenzoic acid isobutyl ester
p-
hydroxybenzoic acid isobutyl ester
4-
hydroxybenzoic acid isobutylester
4-
hydroxybenzoic acid, 2-methylpropyl ester
2-
methylpropyl 4-hydroxybenzoate
PubMed:
Additional effects of bisphenol A and paraben on the induction of calbindin-D(9K) and progesterone receptor via an estrogen receptor pathway in rat pituitary GH3 cells.
PubMed:
Calbindin-D9k as a sensitive molecular biomarker for evaluating the synergistic impact of estrogenic chemicals on GH3 rat pituitary cells.
PubMed:
Large volume sample stacking with EOF and sweeping in CE for determination of common preservatives in cosmetic products by chemometric experimental design.
PubMed:
Measurement of paraben concentrations in human breast tissue at serial locations across the breast from axilla to sternum.
PubMed:
Synergistic effects of octylphenol and isobutyl paraben on the expression of calbindin-Dâk in GH3 rat pituitary cells.
PubMed:
Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells.
PubMed:
Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding.
PubMed:
Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455).
PubMed:
Maternal exposure to isobutyl-paraben impairs social recognition in adult female rats.
PubMed:
In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay.
PubMed:
Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.
PubMed:
Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats.
PubMed:
An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model.
PubMed:
Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats.
PubMed:
Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products.
PubMed:
Removal of estrogenic activity of iso-butylparaben and n-butylparaben by laccase in the presence of 1-hydroxybenzotriazole.
PubMed:
Parabens in male infertility-is there a mitochondrial connection?
PubMed:
Construction of simplified models to simulate estrogenic disruptions by esters of 4-hydroxy benzoic acid (parabens).
PubMed:
A review of the endocrine activity of parabens and implications for potential risks to human health.
PubMed:
Uterotrophic effects of benzophenone derivatives and a p-hydroxybenzoate used in ultraviolet screens.
PubMed:
Oestrogenic activity of benzylparaben.
PubMed:
Oestrogenic activity of isobutylparaben in vitro and in vivo.
PubMed:
ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR.