isopropyl paraben
benzoic acid, 4-hydroxy-, 1-methylethyl ester (9CI)
Identification
| Name | isopropyl paraben |
| CAS Number | 4191-73-5 |
| EINECS | 224-069-3 |
| FDA UNII | A6EOX47QK0 |
| Molecular Formula | C10 H12 O3 |
| Molecular Weight | 180.20324000 |
| MDL Number | MFCD00016468 |
| Nikkaji Number | J1.260B |
| Beilstein | 2641564 |
| XlogP3 | 2.80 (est) |
Regulatory
| DG SANTE Food Contact Materials | 4-hydroxybenzoic acid isopropyl ester |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 286.00 to 287.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.001000 mmHg @ 25.00 °C. (est) |
| Flash Point | 249.00 °F. TCC ( 120.40 °C. ) (est) |
| logP (o/w) | 2.745 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | preservatives |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | subcutaneous-mouse LD50 1900 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antimicrobial agents |
| Recommendation for isopropyl paraben usage levels up to | not for fragrance use. |
| Recommendation for isopropyl paraben flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzoic acid, 4-hydroxy-, 1-methylethyl ester (9CI)
benzoic acid, 4-hydroxy-, isopropyl ester
benzoic acid, p-hydroxy-, isopropyl ester
4-
hydroxybenzoic acid isopropyl ester
p-
hydroxybenzoic acid isopropyl ester
para-
hydroxybenzoic acid isopropyl ester
4-
hydroxybenzoic acid, 1-methylethyl ester
methylethyl 4-hydroxybenzoate
1-
methylethyl 4-hydroxybenzoate
propan-2-yl 4-hydroxybenzoate
iso
propyl 4-hydroxybenzoate
iso
propyl p-hydroxybenzoate
iso
propyl para-hydroxybenzoate
iso
propyl-p-hydroxy benzoate
iso
propylhydroxybenzoate
iso
propylparaben
PubMed:
Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes.
PubMed:
Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA).
PubMed:
A multiclass method for the analysis of endocrine disrupting chemicals in human urine samples. Sample treatment by dispersive liquid-liquid microextraction.
PubMed:
Drug-excipient compatibility studies in binary mixtures of avobenzone.
PubMed:
The role of vehicle interactions on permeation of an active through model membranes and human skin.
PubMed:
The influence of volatile solvents on transport across model membranes and human skin.
PubMed:
Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells.
PubMed:
Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding.
PubMed:
Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455).
PubMed:
[Effect of topical application of aminoguanidine cream on skin tissue of rats with diabetes].
PubMed:
Estrogen receptor α is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens.
PubMed:
Preparation of monoliths from single crosslinking monomers for reversed-phase capillary chromatography of small molecules.
PubMed:
Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods.
PubMed:
Molecularly imprinted polymer for the extraction of parabens from environmental solid samples prior to their determination by high performance liquid chromatography-ultraviolet detection.
PubMed:
Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model.
PubMed:
In vitro and in vivo evaluation of efficacy of citrate/methylene blue/parabens/IPA solution as a skin disinfectant.
PubMed:
An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model.
PubMed:
Probabilistic ecological hazard assessment of parabens using Daphnia magna and Pimephales promelas.
PubMed:
Single-drop microextraction followed by in-syringe derivatization and GC-MS detection for the determination of parabens in water and cosmetic products.
PubMed:
Determination of parabens in environmental solid samples by ultrasonic-assisted extraction and liquid chromatography with triple quadrupole mass spectrometry.
PubMed:
Associations between baseline allergens and polysensitization.
PubMed:
Association of nicotinamide with parabens: effect on solubility, partition and transdermal permeation.
PubMed:
20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies.
PubMed:
[Determination of six p-hydroxybenzoic acid esters in laver (nori) by HPLC].
PubMed:
[Competitive binding of some alkyl p-hydroxybenzoates to human estrogen receptor alpha and beta].
PubMed:
A simplified and rapid high-performance liquid chromatographic assay for ketoprofen in isopropyl myristate.
PubMed:
Mechanism of p-hydroxybenzoate ester-induced mitochondrial dysfunction and cytotoxicity in isolated rat hepatocytes.
PubMed:
[13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate in F344 rats].
PubMed:
High-performance liquid chromatographic determination of six p-hydroxybenzoic acid esters in cosmetics using Sep-Pak florisil cartridges for sample pre-treatment.
PubMed:
Drug migration into soft gelatin capsule shells and its effect on in-vitro availability.
PubMed:
An in-vitro investigation of drug availability from lipophilic solutions.
PubMed:
Treatment of psoriasis of the scalp with betamethasone 17, 21-dipropionate plus salicylic acid lotion ('Diprosalic').