isopropyl paraben

benzoic acid, 4-hydroxy-, 1-methylethyl ester (9CI)

CAS: 4191-73-5 C10 H12 O3 MW: 180.20324000

Identification

Nameisopropyl paraben
CAS Number4191-73-5
EINECS224-069-3
FDA UNIIA6EOX47QK0
Molecular FormulaC10 H12 O3
Molecular Weight180.20324000
MDL NumberMFCD00016468
Nikkaji NumberJ1.260B
Beilstein2641564
XlogP32.80 (est)

Regulatory

DG SANTE Food Contact Materials4-hydroxybenzoic acid isopropyl ester

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 286.00 to 287.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Flash Point 249.00 °F. TCC ( 120.40 °C. ) (est)
logP (o/w) 2.745 (est)
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal Toxicitysubcutaneous-mouse LD50 1900 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial agents
Recommendation for isopropyl paraben usage levels up tonot for fragrance use.
Recommendation for isopropyl paraben flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

benzoic acid, 4-hydroxy-, 1-methylethyl ester (9CI) benzoic acid, 4-hydroxy-, isopropyl ester benzoic acid, p-hydroxy-, isopropyl ester 4- hydroxybenzoic acid isopropyl ester p- hydroxybenzoic acid isopropyl ester para- hydroxybenzoic acid isopropyl ester 4- hydroxybenzoic acid, 1-methylethyl ester methylethyl 4-hydroxybenzoate 1- methylethyl 4-hydroxybenzoate propan-2-yl 4-hydroxybenzoate iso propyl 4-hydroxybenzoate iso propyl p-hydroxybenzoate iso propyl para-hydroxybenzoate iso propyl-p-hydroxy benzoate iso propylhydroxybenzoate iso propylparaben PubMed: Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes. PubMed: Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA). PubMed: A multiclass method for the analysis of endocrine disrupting chemicals in human urine samples. Sample treatment by dispersive liquid-liquid microextraction. PubMed: Drug-excipient compatibility studies in binary mixtures of avobenzone. PubMed: The role of vehicle interactions on permeation of an active through model membranes and human skin. PubMed: The influence of volatile solvents on transport across model membranes and human skin. PubMed: Synergistic effects of parabens on the induction of calbindin-D(9k) gene expression act via a progesterone receptor-mediated pathway in GH3 cells. PubMed: Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding. PubMed: Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455). PubMed: [Effect of topical application of aminoguanidine cream on skin tissue of rats with diabetes]. PubMed: Estrogen receptor α is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens. PubMed: Preparation of monoliths from single crosslinking monomers for reversed-phase capillary chromatography of small molecules. PubMed: Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods. PubMed: Molecularly imprinted polymer for the extraction of parabens from environmental solid samples prior to their determination by high performance liquid chromatography-ultraviolet detection. PubMed: Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model. PubMed: In vitro and in vivo evaluation of efficacy of citrate/methylene blue/parabens/IPA solution as a skin disinfectant. PubMed: An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. PubMed: Probabilistic ecological hazard assessment of parabens using Daphnia magna and Pimephales promelas. PubMed: Single-drop microextraction followed by in-syringe derivatization and GC-MS detection for the determination of parabens in water and cosmetic products. PubMed: Determination of parabens in environmental solid samples by ultrasonic-assisted extraction and liquid chromatography with triple quadrupole mass spectrometry. PubMed: Associations between baseline allergens and polysensitization. PubMed: Association of nicotinamide with parabens: effect on solubility, partition and transdermal permeation. PubMed: 20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies. PubMed: [Determination of six p-hydroxybenzoic acid esters in laver (nori) by HPLC]. PubMed: [Competitive binding of some alkyl p-hydroxybenzoates to human estrogen receptor alpha and beta]. PubMed: A simplified and rapid high-performance liquid chromatographic assay for ketoprofen in isopropyl myristate. PubMed: Mechanism of p-hydroxybenzoate ester-induced mitochondrial dysfunction and cytotoxicity in isolated rat hepatocytes. PubMed: [13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate in F344 rats]. PubMed: High-performance liquid chromatographic determination of six p-hydroxybenzoic acid esters in cosmetics using Sep-Pak florisil cartridges for sample pre-treatment. PubMed: Drug migration into soft gelatin capsule shells and its effect on in-vitro availability. PubMed: An in-vitro investigation of drug availability from lipophilic solutions. PubMed: Treatment of psoriasis of the scalp with betamethasone 17, 21-dipropionate plus salicylic acid lotion ('Diprosalic').