lanosterol
cholesta-8,24-dien-3-ol, 4,4,14-trimethyl-, (3b,5a)-
Identification
| Name | lanosterol |
| CAS Number | 79-63-0 |
| EINECS | 201-214-9 |
| FDA UNII | 1J05Z83K3M |
| Molecular Formula | C30 H50 O |
| Molecular Weight | 426.72770000 |
| MDL Number | MFCD00021108 |
| Beilstein | 2226449 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 140.00 to 141.00 °C. @ 760.00 mm Hg |
| Boiling Point | 498.00 to 499.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 430.00 °F. TCC ( 221.10 °C. ) (est) |
| logP (o/w) | 10.521 (est) |
| Soluble in | water, 4.105e-006 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antistatic agents |
Organoleptic Properties
| Odor Strength | none |
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for lanosterol usage levels up to | not for fragrance use. |
| Recommendation for lanosterol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
botalan base 138
cholesta-8,24-dien-3-ol, 4,4,14-trimethyl-, (3b,5a)-
(3S,5R,10S,13R,14R,17R)-17-(1,5-
dimethylhex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-ol
lanosta-8,24-dien-3-b-ol
lanosta-8,24-dien-3-beta-ol
(3.beta.)-
lanosta-8,24-dien-3-ol
lanosta-8,24-dien-3-ol, (3b)-
lanosta-8,24-dien-3b-ol (8CI)
lanosterin
PubMed:
Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats.
PubMed:
Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole.
PubMed:
Amides derived from heteroaromatic amines and selected steryl hemiesters.
PubMed:
Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury.
PubMed:
Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7.
PubMed:
Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus.
PubMed:
Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice.
PubMed:
A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction.
PubMed:
Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.
PubMed:
Effects of cationic hydroxyethyl cellulose on dyslipidemia in hamsters.
PubMed:
Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin.
PubMed:
Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture.
PubMed:
Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.
PubMed:
An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus à domestica.
PubMed:
Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice.
PubMed:
Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.
PubMed:
Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6.
PubMed:
Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters.
PubMed:
Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.
PubMed:
Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea.
PubMed:
Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside.
PubMed:
Inhibition of angiogenesis by the antifungal drug itraconazole.
PubMed:
Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.
PubMed:
Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase.
PubMed:
Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles.
PubMed:
Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells.
PubMed:
Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata.
PubMed:
Elution behavior of unsaponifiable lipids with various capillary electrochromatographic stationary phases.
PubMed:
Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya.
PubMed:
Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life.
PubMed:
Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent.
PubMed:
Ergosterol depletion and 4-methyl sterols accumulation in the yeast Saccharomyces cerevisiae treated with an antifungal, 6-amino-2-n-pentylthiobenzothiazole.
PubMed:
Influence of vitamin E administration on platelet functions in hormonal contraceptive users.
PubMed:
Further investigations of mutagenic cholesterol preparations.