lanosterol

cholesta-8,24-dien-3-ol, 4,4,14-trimethyl-, (3b,5a)-

CAS: 79-63-0 C30 H50 O MW: 426.72770000

Identification

Namelanosterol
CAS Number79-63-0
EINECS201-214-9
FDA UNII1J05Z83K3M
Molecular FormulaC30 H50 O
Molecular Weight426.72770000
MDL NumberMFCD00021108
Beilstein2226449

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 140.00 to 141.00 °C. @ 760.00 mm Hg
Boiling Point 498.00 to 499.00 °C. @ 760.00 mm Hg (est)
Flash Point 430.00 °F. TCC ( 221.10 °C. ) (est)
logP (o/w) 10.521 (est)
Soluble in water, 4.105e-006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantistatic agents

Organoleptic Properties

Odor Strength none
Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for lanosterol usage levels up tonot for fragrance use.
Recommendation for lanosterol flavor usage levels up tonot for flavor use.

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Potential Uses

antistatic agents emollients

Natural Occurrence

capsicum annuum coffee bean corn plant irish moss thallus PMC melon bitter melon fruit mushroom hen of the woods mushroom PMC pepper bell pepper seed shea tree seed oil soybean seed tomato seed

Synonyms

botalan base 138 cholesta-8,24-dien-3-ol, 4,4,14-trimethyl-, (3b,5a)- (3S,5R,10S,13R,14R,17R)-17-(1,5- dimethylhex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-3-ol lanosta-8,24-dien-3-b-ol lanosta-8,24-dien-3-beta-ol (3.beta.)- lanosta-8,24-dien-3-ol lanosta-8,24-dien-3-ol, (3b)- lanosta-8,24-dien-3b-ol (8CI) lanosterin PubMed: Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. PubMed: Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole. PubMed: Amides derived from heteroaromatic amines and selected steryl hemiesters. PubMed: Hepatoprotective effects of eburicoic acid and dehydroeburicoic acid from Antrodia camphorata in a mouse model of acute hepatic injury. PubMed: Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7. PubMed: Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus. PubMed: Analgesic and anti-inflammatory bioactivities of eburicoic acid and dehydroeburicoic acid isolated from Antrodia camphorata on the inflammatory mediator expression in mice. PubMed: A novel approach to enhancing ganoderic acid production by Ganoderma lucidum using apoptosis induction. PubMed: Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes. PubMed: Effects of cationic hydroxyethyl cellulose on dyslipidemia in hamsters. PubMed: Inhibition of the JAK-STAT3 signaling pathway by ganoderic acid A enhances chemosensitivity of HepG2 cells to cisplatin. PubMed: Enhanced production of ganoderic acids and cytotoxicity of Ganoderma lucidum using solid-medium culture. PubMed: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. PubMed: An unusual plant triterpene synthase with predominant α-amyrin-producing activity identified by characterizing oxidosqualene cyclases from Malus × domestica. PubMed: Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice. PubMed: Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. PubMed: Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6. PubMed: Hypocholesterolemic effects of hydroxypropyl methylcellulose are mediated by altered gene expression in hepatic bile and cholesterol pathways of male hamsters. PubMed: Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus. PubMed: Cloning and characterization of the lanosterol 14alpha-demethylase gene from Antrodia cinnamomea. PubMed: Characterization of sterol lipids in Kluyveromyces lactis strain M-16 accumulating a high amount of steryl glucoside. PubMed: Inhibition of angiogenesis by the antifungal drug itraconazole. PubMed: Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. PubMed: Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase. PubMed: Comparison of lanosterol-14 alpha-demethylase (CYP51) of human and Candida albicans for inhibition by different antifungal azoles. PubMed: Modulation of cholesterol metabolism by the green tea polyphenol (-)-epigallocatechin gallate in cultured human liver (HepG2) cells. PubMed: Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata. PubMed: Elution behavior of unsaponifiable lipids with various capillary electrochromatographic stationary phases. PubMed: Steryl and stanyl esters of fatty acids by solvent-free esterification and transesterification in vacuo using lipases from Rhizomucor miehei, Candida antarctica, and Carica papaya. PubMed: Influence of breast- and formula-feeding on plasma cholesterol precursor sterols throughout the first year of life. PubMed: Inhibition of sterol 4-demethylation in Candida albicans by 6-amino-2-n-pentylthiobenzothiazole, a novel mechanism of action for an antifungal agent. PubMed: Ergosterol depletion and 4-methyl sterols accumulation in the yeast Saccharomyces cerevisiae treated with an antifungal, 6-amino-2-n-pentylthiobenzothiazole. PubMed: Influence of vitamin E administration on platelet functions in hormonal contraceptive users. PubMed: Further investigations of mutagenic cholesterol preparations.