sodium ortho-phenylphenate

sodium 2-biphenylate

CAS: 132-27-4 C12 H9 Na O MW: 192.19269928

Identification

Namesodium ortho-phenylphenate
IUPACsodium 2-phenylphenolate
CAS Number132-27-4
EINECS205-055-6
FDA UNIIKFV9K7N7UI
Molecular FormulaC12 H9 Na O
Molecular Weight192.19269928
MDL NumberMFCD00002209
Nikkaji NumberJ2.946G

Regulatory

JECFA Food AdditiveSodium o-Phenylphenol
GSFA CodexSodium ortho-phenylphenol (232)
FDA Mainterm (IAUFC)132-27-4 ; SODIUM O-PHENYLPHENATE

Physical Properties

Appearance white powder (est)
Assay 97.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 282.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.002020 mmHg @ 25.00 °C. (est)
Flash Point 285.00 °F. TCC ( 140.30 °C. ) (est)
logP (o/w) 2.939 (est)
Soluble in water, 1000000 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-cat LD50 500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nGASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH\nBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)']

Safety in Use

Categoryantimicrobial preservatives
Recommendation for sodium ortho-phenylphenate usage levels up tonot for fragrance use.
Recommendation for sodium ortho-phenylphenate flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

(1,1'- biphenyl)-2-ol sodium salt (1:1) (1,1'- biphenyl)-2-ol, sodium salt [1,1'- biphenyl]-2-ol, sodium salt [1,1'- biphenyl]-2-ol, sodium salt (1:1) 2- biphenylol sodium salt 2- biphenylol, sodium salt 2- hydroxybiphenyl sodium salt 2- hydroxydiphenyl sodium o- phenyl phenol sodium salt ortho- phenyl phenol sodium salt o- phenylphenate sodium o- phenylphenate, sodium o- phenylphenol sodium 2- phenylphenol sodium salt o- phenylphenol sodium salt ortho- phenylphenol sodium salt o- phenylphenol, sodium phenylphenol, sodium salt 2- phenylphenol, sodium salt o- phenylphenol, sodium salt sodium (1,1'-biphenyl)-2-olate sodium [1,1'-biphenyl]-2-olate sodium 2-biphenylate sodium 2-biphenylolate sodium 2-hydroxydiphenyl sodium 2-phenyl phenolate sodium 2-phenylphenate sodium 2-phenylphenolate sodium o-phenol phenate sodium o-phenolphenate sodium o-phenyl phenate sodium o-phenylphenate sodium o-phenylphenol sodium o-phenylphenolate sodium o-phenylphenyolate sodium ortho-phenol phenate sodium ortho-phenolphenate sodium ortho-phenyl phenate sodium-2-biphenylate sodium-o-phenylphenate sodium-o-phenylphenol sodium, (2-biphenylyloxy)- PubMed: Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats. PubMed: Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats. PubMed: Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium. PubMed: Initiating activity of quinones in the two-stage transformation of BALB/3T3 cells. PubMed: Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells. PubMed: Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats. PubMed: Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: urinary metabolites and electrolytes under conditions of aciduria and alkalinuria. PubMed: Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis. PubMed: Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis. PubMed: Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats. PubMed: Species differences in sodium o-phenylphenate induction of urinary bladder lesions. PubMed: Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl. PubMed: Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet. PubMed: Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis. PubMed: Sodium o-phenylphenate (OPP-Na) promotes skin carcinogenesis in CD-1 female mice initiated with 7,12-dimethylbenz[a]anthracene. PubMed: In situ freezing of the urinary bladder: a trigger of rapid development of sodium o-phenylphenate-induced urinary bladder tumors in the rat. PubMed: DNA damage in urinary bladder epithelium of male F344 rats treated with 2-phenyl-1,4-benzoquinone, one of the non-conjugated urinary metabolites of sodium o-phenylphenate. PubMed: Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder. PubMed: Enhancing effect of thiabendazole on urinary bladder carcinogenesis induced by sodium o-phenylphenate in F344 rats. PubMed: Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats. PubMed: Subchronic toxicity study of sodium o-phenylphenate in mice. PubMed: Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol. PubMed: Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice. PubMed: Changes in enzyme activities in the urine and tissues of rats fed sodium o-phenylphenate. PubMed: Altered levels of cyclic nucleotides in F344 rats fed sodium o-phenylphenate. PubMed: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis. PubMed: Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats. PubMed: The metabolic profile of sodium o-phenylphenate after subchronic oral administration to rats. PubMed: Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate. PubMed: A practical approach to evaluation of the germicidal efficiency of a general purpose military disinfectant. PubMed: Factors affecting the activity of phenolic disinfectants.