sodium ortho-phenylphenate
sodium 2-biphenylate
Identification
| Name | sodium ortho-phenylphenate |
| IUPAC | sodium 2-phenylphenolate |
| CAS Number | 132-27-4 |
| EINECS | 205-055-6 |
| FDA UNII | KFV9K7N7UI |
| Molecular Formula | C12 H9 Na O |
| Molecular Weight | 192.19269928 |
| MDL Number | MFCD00002209 |
| Nikkaji Number | J2.946G |
Regulatory
| JECFA Food Additive | Sodium o-Phenylphenol |
| GSFA Codex | Sodium ortho-phenylphenol (232) |
| FDA Mainterm (IAUFC) | 132-27-4 ; SODIUM O-PHENYLPHENATE |
Physical Properties
| Appearance | white powder (est) |
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 282.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.002020 mmHg @ 25.00 °C. (est) |
| Flash Point | 285.00 °F. TCC ( 140.30 °C. ) (est) |
| logP (o/w) | 2.939 (est) |
| Soluble in | water, 1000000 mg/L @ 25 °C (exp) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antimicrobial agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-cat LD50 500 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nGASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH\nBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)']
Safety in Use
| Category | antimicrobial preservatives |
| Recommendation for sodium ortho-phenylphenate usage levels up to | not for fragrance use. |
| Recommendation for sodium ortho-phenylphenate flavor usage levels up to | not for flavor use. |
Potential Uses
Natural Occurrence
Synonyms
(1,1'-
biphenyl)-2-ol sodium salt (1:1)
(1,1'-
biphenyl)-2-ol, sodium salt
[1,1'-
biphenyl]-2-ol, sodium salt
[1,1'-
biphenyl]-2-ol, sodium salt (1:1)
2-
biphenylol sodium salt
2-
biphenylol, sodium salt
2-
hydroxybiphenyl sodium salt
2-
hydroxydiphenyl sodium
o-
phenyl phenol sodium salt
ortho-
phenyl phenol sodium salt
o-
phenylphenate sodium
o-
phenylphenate, sodium
o-
phenylphenol sodium
2-
phenylphenol sodium salt
o-
phenylphenol sodium salt
ortho-
phenylphenol sodium salt
o-
phenylphenol, sodium
phenylphenol, sodium salt
2-
phenylphenol, sodium salt
o-
phenylphenol, sodium salt
sodium (1,1'-biphenyl)-2-olate
sodium [1,1'-biphenyl]-2-olate
sodium 2-biphenylate
sodium 2-biphenylolate
sodium 2-hydroxydiphenyl
sodium 2-phenyl phenolate
sodium 2-phenylphenate
sodium 2-phenylphenolate
sodium o-phenol phenate
sodium o-phenolphenate
sodium o-phenyl phenate
sodium o-phenylphenate
sodium o-phenylphenol
sodium o-phenylphenolate
sodium o-phenylphenyolate
sodium ortho-phenol phenate
sodium ortho-phenolphenate
sodium ortho-phenyl phenate
sodium-2-biphenylate
sodium-o-phenylphenate
sodium-o-phenylphenol
sodium, (2-biphenylyloxy)-
PubMed:
Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats.
PubMed:
Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats.
PubMed:
Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium.
PubMed:
Initiating activity of quinones in the two-stage transformation of BALB/3T3 cells.
PubMed:
Genotoxic effects of the o-phenylphenol metabolites phenylhydroquinone and phenylbenzoquinone in V79 cells.
PubMed:
Enhancing potential of 6 different carcinogens on multi-organ tumorigenesis after initial treatment with N-methyl-N-nitrosourea in rats.
PubMed:
Sex differences in o-phenylphenol and sodium o-phenylphenate rat urinary bladder carcinogenesis: urinary metabolites and electrolytes under conditions of aciduria and alkalinuria.
PubMed:
Metabolism of phenylhydroquinone by prostaglandin (H) synthase: possible implications in o-phenylphenol carcinogenesis.
PubMed:
Effects of 2-phenyl-1,4-benzoquinone and 2,5-dihydroxybiphenyl on two-stage mouse skin carcinogenesis.
PubMed:
Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.
PubMed:
Species differences in sodium o-phenylphenate induction of urinary bladder lesions.
PubMed:
Proliferative response of renal pelvic epithelium in rats to oral administration of ortho-phenylphenol, sodium ortho-phenylphenate and diphenyl.
PubMed:
Correlation between the DNA damage in urinary bladder epithelium and the urinary 2-phenyl-1,4-benzoquinone levels from F344 rats fed sodium o-phenylphenate in the diet.
PubMed:
Co-carcinogenic effects of NaHCO3 on o-phenylphenol-induced rat bladder carcinogenesis.
PubMed:
Sodium o-phenylphenate (OPP-Na) promotes skin carcinogenesis in CD-1 female mice initiated with 7,12-dimethylbenz[a]anthracene.
PubMed:
In situ freezing of the urinary bladder: a trigger of rapid development of sodium o-phenylphenate-induced urinary bladder tumors in the rat.
PubMed:
DNA damage in urinary bladder epithelium of male F344 rats treated with 2-phenyl-1,4-benzoquinone, one of the non-conjugated urinary metabolites of sodium o-phenylphenate.
PubMed:
Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder.
PubMed:
Enhancing effect of thiabendazole on urinary bladder carcinogenesis induced by sodium o-phenylphenate in F344 rats.
PubMed:
Short-term screening of promoters of bladder carcinogenesis in N-butyl-N-(4-hydroxybutyl)nitrosamine-initiated, unilaterally ureter-ligated rats.
PubMed:
Subchronic toxicity study of sodium o-phenylphenate in mice.
PubMed:
Pathological analysis of the carcinogenicity of sodium o-phenylphenate and o-phenylphenol.
PubMed:
Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice.
PubMed:
Changes in enzyme activities in the urine and tissues of rats fed sodium o-phenylphenate.
PubMed:
Altered levels of cyclic nucleotides in F344 rats fed sodium o-phenylphenate.
PubMed:
Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed:
Promoting effect of sodium o-phenylphenate and o-phenylphenol on two-stage urinary bladder carcinogenesis in rats.
PubMed:
The metabolic profile of sodium o-phenylphenate after subchronic oral administration to rats.
PubMed:
Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate.
PubMed:
A practical approach to evaluation of the germicidal efficiency of a general purpose military disinfectant.
PubMed:
Factors affecting the activity of phenolic disinfectants.