tocopheryl succinate

vitamin E succinate

CAS: 17407-37-3 C33 H54 O5 MW: 530.78938000

Identification

Nametocopheryl succinate
IUPAC4-oxo-4-{[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl]oxy}butanoic acid
CAS Number17407-37-3
EINECS241-433-7
FDA UNIISearch
Molecular FormulaC33 H54 O5
Molecular Weight530.78938000
Nikkaji NumberJ24.825H

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 625.84 °C. @ 760.00 mm Hg (est)
Flash Point 369.00 °F. TCC ( 187.00 °C. ) (est)
logP (o/w) 10.159 (est)
Soluble in water, 6.35e-008 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantioxidants

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants
Recommendation for tocopheryl succinate usage levels up tonot for fragrance use.
Recommendation for tocopheryl succinate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))- butanedioic acid, mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl] ester 6- chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, hydrogen succinate (3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) hydrogen succinate succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester 4-oxo-4-{[2,5,7,8- tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl]oxy}butanoic acid 2,5,7,8- tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl hydrogen succinate tocopherol acid succinate tocopherol hemisuccinate tocopherol succinate tocopheryl acid succinate tocopheryl hydrogen succinate vitamin E acid succinate vitamin E hemisuccinate vitamin E succinate PubMed: Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan. PubMed: RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway. PubMed: Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development. PubMed: Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells. PubMed: Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells. PubMed: Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux. PubMed: Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. PubMed: Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. PubMed: Targeting of cancer energy metabolism. PubMed: Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside? PubMed: Alpha-Tocopheryl succinate: toxicity and lack of anti-tumour activity in immuno-competent mice. PubMed: Stabilization of cranberry anthocyanins in nutraceutical capsules. PubMed: alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. PubMed: Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate. PubMed: Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats. PubMed: RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. PubMed: Inhibitory effects of RRR-alpha-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice. PubMed: Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice. PubMed: Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione. PubMed: Metabolism of tritiated D-alpha-tocopherol and D-alpha-tocopheryl succinate in intraruminally dosed sheep. PubMed: The protective but nonsynergistic effect of dietary beta-carotene and vitamin E on skin tumorigenesis in Skh mice. PubMed: Lipid peroxidation in rat tissue slices: effect of dietary vitamin E, corn oil-lard and menhaden oil. PubMed: Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates.