tocopheryl succinate
vitamin E succinate
Identification
| Name | tocopheryl succinate |
| IUPAC | 4-oxo-4-{[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl]oxy}butanoic acid |
| CAS Number | 17407-37-3 |
| EINECS | 241-433-7 |
| FDA UNII | Search |
| Molecular Formula | C33 H54 O5 |
| Molecular Weight | 530.78938000 |
| Nikkaji Number | J24.825H |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 625.84 °C. @ 760.00 mm Hg (est) |
| Flash Point | 369.00 °F. TCC ( 187.00 °C. ) (est) |
| logP (o/w) | 10.159 (est) |
| Soluble in | water, 6.35e-008 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antioxidants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants |
| Recommendation for tocopheryl succinate usage levels up to | not for fragrance use. |
| Recommendation for tocopheryl succinate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))-
butanedioic acid, mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl] ester
6-
chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, hydrogen succinate
(3,4-
dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) hydrogen succinate
succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester
succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester
4-oxo-4-{[2,5,7,8-
tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-yl]oxy}butanoic acid
2,5,7,8-
tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl hydrogen succinate
tocopherol acid succinate
tocopherol hemisuccinate
tocopherol succinate
tocopheryl acid succinate
tocopheryl hydrogen succinate
vitamin E acid succinate
vitamin E hemisuccinate
vitamin E succinate
PubMed:
Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan.
PubMed:
RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway.
PubMed:
Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development.
PubMed:
Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells.
PubMed:
Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells.
PubMed:
Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux.
PubMed:
Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
PubMed:
Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells.
PubMed:
Targeting of cancer energy metabolism.
PubMed:
Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside?
PubMed:
Alpha-Tocopheryl succinate: toxicity and lack of anti-tumour activity in immuno-competent mice.
PubMed:
Stabilization of cranberry anthocyanins in nutraceutical capsules.
PubMed:
alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner.
PubMed:
Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate.
PubMed:
Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats.
PubMed:
RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest.
PubMed:
Inhibitory effects of RRR-alpha-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice.
PubMed:
Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice.
PubMed:
Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione.
PubMed:
Metabolism of tritiated D-alpha-tocopherol and D-alpha-tocopheryl succinate in intraruminally dosed sheep.
PubMed:
The protective but nonsynergistic effect of dietary beta-carotene and vitamin E on skin tumorigenesis in Skh mice.
PubMed:
Lipid peroxidation in rat tissue slices: effect of dietary vitamin E, corn oil-lard and menhaden oil.
PubMed:
Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates.