triclosan

2,4,4'-trichloro-2'-hydroxydiphenylether

CAS: 3380-34-5 C12 H7 Cl3 O2 MW: 289.54219000

Identification

Nametriclosan
IUPAC5-chloro-2-(2,4-dichlorophenoxy)phenol
CAS Number3380-34-5
EINECS222-182-2
FDA UNII4NM5039Y5X
Molecular FormulaC12 H7 Cl3 O2
Molecular Weight289.54219000
MDL NumberMFCD00800992
Nikkaji NumberJ7.727E
Beilstein0605448

Regulatory

DG SANTE Food Contact Materials2,4,4'-trichloro-2'-hydroxydiphenylether

Physical Properties

Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 54.00 to 58.00 °C. @ 760.00 mm Hg
Boiling Point 344.00 to 345.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000032 mmHg @ 25.00 °C. (est)
Flash Point 324.00 °F. TCC ( 162.20 °C. ) (est)
logP (o/w) 4.760
Soluble in water, 10 mg/L @ 20 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesdeodorants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 3700 mg/kg
Dermal Toxicityskin-rabbit LD50 9300 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for triclosan usage levels up tonot for fragrance use.
Recommendation for triclosan flavor usage levels up tonot for flavor use.

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Glentham Life Sciences Ltd

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Jiangyin Healthway International Trade Co., Ltd

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We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

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Vigon International

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Manufacturer and supplier of high quality flavor and fragrance ingredients.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

5- chlor-2-(2,4-dichlorphenoxy)phenol 5- chloro-(2,4-dichlorophenoxy)phenol 5- chloro-2-(2,4-dichlorophenoxy)phenol cliniclean cloxifenol cloxifenolum 2-(2,4- dichlorophenoxy)-5-chlorophenol ether, 2'-hydroxy-2,4,4'-trichlorodiphenyl 2- hydroxy-2',4,4'-trichlorodiphenyl ether irgasan manusept microban B phenol, 5-chloro-2-(2,4-dichlorophenoxy)- sapoderm symguard CD 2,4,4'- trichloro-2'-hydroxy diphenyl ether 2,4,4'- trichloro-2'-hydroxydiphenyl ether 2,4,4'- trichloro-2'-hydroxydiphenylether PubMed: Determination of plaque viability following a single brushing with commercial toothpastes. PubMed: Comparison of the short-term antiplaque/antibacterial efficacy of two commercial dentifrices. PubMed: The technology behind Colgate Total Advanced Fresh. PubMed: A model for studying the effects of mouthrinses on de novo plaque formation. PubMed: Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products. PubMed: News, views, & reviews. Update on antibacterial soaps: the FDA takes a second look at triclosans. PubMed: Quantitative microbial risk assessment of antibacterial hand hygiene products on risk of shigellosis. PubMed: Development of a multi-preservative method based on solid-phase microextraction-gas chromatography-tandem mass spectrometry for cosmetic analysis. PubMed: Triclosan Induced Aminoglycoside-Tolerant Listeria monocytogenes Isolates can appear as Small-Colony Variants. PubMed: Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica). PubMed: Urinary concentrations of environmental phenols in pregnant women in a pilot study of the National Children's Study. PubMed: Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women. PubMed: Uptake and accumulation of antimicrobials, triclocarban and triclosan, by food crops in a hydroponic system. PubMed: Identification of plant metabolites of environmental contaminants by UPLC-QToF-MS: the in vitro metabolism of triclosan in horseradish. PubMed: FDA pushes makers of antimicrobial soap to prove safety and effectiveness. PubMed: Fate and uptake of pharmaceuticals in soil-plant systems. PubMed: Triclocarban, triclosan and its transformation product methyl triclosan in native earthworm species four years after a commercial-scale biosolids application. PubMed: Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. PubMed: Analysis of triclosan-selected Salmonella enterica mutants of eight serovars revealed increased aminoglycoside susceptibility and reduced growth rates. PubMed: Analytical performance of two miniaturised extraction methods for triclosan and methyltriclosan, in fish roe and surimi samples. PubMed: Transcriptomic analysis of triclosan-susceptible and -tolerant Escherichia coli O157:H19 in response to triclosan exposure. PubMed: Biocide and copper tolerance in enterococci from different sources. PubMed: Structure-activity relationships of 44 halogenated compounds for iodotyrosine deiodinase-inhibitory activity. PubMed: Comparative uptake and translocation of pharmaceutical and personal care products (PPCPs) by common vegetables. PubMed: Bioconcentration of triclosan and methyl-triclosan in marine mussels (Mytilus galloprovincialis) under laboratory conditions and in metropolitan waters of Gulf St Vincent, South Australia. PubMed: Oregano essential oil as an antimicrobial additive to detergent for hand washing and food contact surface cleaning. PubMed: Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. PubMed: Foliar sorption of emerging and priority contaminants under controlled conditions. PubMed: Small colony variants (SCVs) of Staphylococcus aureus--a bacterial survival strategy. PubMed: Antibacterial electrospun poly(lactic acid) (PLA) nanofibrous webs incorporating triclosan/cyclodextrin inclusion complexes. PubMed: Comparative analysis of the susceptibility to triclosan and three other biocides of avian Salmonella enterica isolates collected 1979 through 1994 and 2004 through 2010. PubMed: Combined treatments of enterocin AS-48 with biocides to improve the inactivation of methicillin-sensitive and methicillin-resistant Staphylococcus aureus planktonic and sessile cells. PubMed: Assessment of the susceptibility of lactic acid bacteria to biocides. PubMed: Comparison of degradation between indigenous and spiked bisphenol A and triclosan in a biosolids amended soil. PubMed: Triclosan blocks MMP-13 expression in hormone-stimulated osteoblasts. PubMed: Proteomic and phenotypic analysis of triclosan tolerant verocytotoxigenic Escherichia coli O157:H19. PubMed: Development of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli adapted to biocides. PubMed: Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012. PubMed: How dirty are the dirty dozen ingredients in cosmetics? PubMed: Effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeB in biocide resistance of Campylobacter jejuni and Campylobacter coli. PubMed: Triclosan exposure and allergic sensitization in Norwegian children. PubMed: Metabolization of the bacteriostatic agent triclosan in edible plants and its consequences for plant uptake assessment. PubMed: Slow O-demethylation of methyl triclosan to triclosan, which is rapidly glucuronidated and sulfonated in channel catfish liver and intestine. PubMed: Uptake of galaxolide, tonalide, and triclosan by carrot, barley, and meadow fescue plants. PubMed: Toxicity and bioaccumulation of biosolids-borne triclosan in food crops. PubMed: Triple bioaffinity mass spectrometry concept for thyroid transporter ligands. PubMed: Cytotoxicity and inhibitory effects of low-concentration triclosan on adipogenic differentiation of human mesenchymal stem cells. PubMed: Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. PubMed: Comparative proteomic analysis of Salmonella tolerance to the biocide active agent triclosan. PubMed: Efficacy of biocides used in the modern food industry to control salmonella enterica, and links between biocide tolerance and resistance to clinically relevant antimicrobial compounds. PubMed: Transfer of Salmonella Enteritidis to four types of surfaces after cleaning procedures and cross-contamination to tomatoes. PubMed: Involvement of efflux mechanisms in biocide resistance of Campylobacter jejuni and Campylobacter coli. PubMed: Nitrate causes a dose-dependent augmentation of nitric oxide status in healthy women. PubMed: An expert panel report of a proposed scientific model demonstrating the effectiveness of antibacterial handwash products. PubMed: Pharmaceutical and personal care products in groundwater, subsurface drainage, soil, and wheat grain, following a high single application of municipal biosolids to a field. PubMed: Miniaturized extraction methods of triclosan from aqueous and fish roe samples. Bioconcentration studies in zebrafish larvae (Danio rerio). PubMed: Uptake of organic emergent contaminants in spath and lettuce: an in vitro experiment. PubMed: Effect of enterocin AS-48 in combination with biocides on planktonic and sessile Listeria monocytogenes. PubMed: Review of risk from potential emerging contaminants in UK groundwater. PubMed: Field dissipation of 4-nonylphenol, 4-t-octylphenol, triclosan and bisphenol A following land application of biosolids. PubMed: Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain). PubMed: A meta-analysis of the published literature on the effectiveness of antimicrobial soaps. PubMed: Sensitivity analysis for the SimpleTreat model to simulate fate of chemicals in sewage treatment plants. PubMed: Determination of preservative and antimicrobial compounds in fish from Manila Bay, Philippines using ultra high performance liquid chromatography tandem mass spectrometry, and assessment of human dietary exposure. PubMed: 4-Nonylphenol, bisphenol-A and triclosan levels in human urine of children and students in China, and the effects of drinking these bottled materials on the levels. PubMed: Sublethal triclosan exposure decreases susceptibility to gentamicin and other aminoglycosides in Listeria monocytogenes. PubMed: Degradation of 4-nonylphenol, 4-t-octylphenol, bisphenol A and triclosan following biosolids addition to soil under laboratory conditions. PubMed: In vitro interaction between fluconazole and triclosan against clinical isolates of fluconazole-resistant Candida albicans determined by different methods. PubMed: Inappropriate use of D-values for determining biocidal activity of various antimicrobials. PubMed: Effect of active packaging incorporated with triclosan on bacteria adhesion. PubMed: Uptake of 17α-ethynylestradiol and triclosan in pinto bean, Phaseolus vulgaris. PubMed: Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. PubMed: Assessment of the antibacterial activity of a triclosan-containing cutting board. PubMed: Listeria monocytogenes and Salmonella enterica enteritidis biofilms susceptibility to different disinfectants and stress-response and virulence gene expression of surviving cells. PubMed: Effectiveness of triclosan in the management of radiation-induced oral mucositis: a randomized clinical trial. PubMed: Characterization of Salmonella enterica isolates from turkeys in commercial processing plants for resistance to antibiotics, disinfectants, and a growth promoter. PubMed: Salmonella enterica Enteritidis biofilm formation and viability on regular and triclosan-impregnated bench cover materials. PubMed: Comparative efficacy of seven hand sanitizers against murine norovirus, feline calicivirus, and GII.4 norovirus. PubMed: Selected personal care products and endocrine disruptors in biosolids: an Australia-wide survey. PubMed: A review of personal care products in the aquatic environment: environmental concentrations and toxicity. PubMed: Fully automated determination of parabens, triclosan and methyl triclosan in wastewater by microextraction by packed sorbents and gas chromatography-mass spectrometry. PubMed: Occurrence, efficacy, metabolism, and toxicity of triclosan. PubMed: Probabilistic risk evaluation for triclosan in surface water, sediments, and aquatic biota tissues. PubMed: Review of 'emerging' organic contaminants in biosolids and assessment of international research priorities for the agricultural use of biosolids. PubMed: In-sample acetylation-non-porous membrane-assisted liquid-liquid extraction for the determination of parabens and triclosan in water samples. PubMed: Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. PubMed: The synergistic activity of triclosan and ciprofloxacin on biofilms of Salmonella Typhimurium. PubMed: Electrochemical sensor for rapid detection of triclosan using a multiwall carbon nanotube film. PubMed: Organic contaminants in sewage sludge (biosolids) and their significance for agricultural recycling. PubMed: Impact of biosolids on the persistence and dissipation pathways of triclosan and triclocarban in an agricultural soil. PubMed: Assessment of human exposure to Bisphenol-A, Triclosan and Tetrabromobisphenol-A through indoor dust intake in Belgium. PubMed: Runoff of pharmaceuticals and personal care products following application of dewatered municipal biosolids to an agricultural field. PubMed: Adsorption and degradation of triclosan and triclocarban in soils and biosolids-amended soils. PubMed: Simultaneous determination of parabens, triclosan and triclocarban in water by liquid chromatography/electrospray ionisation tandem mass spectrometry. PubMed: Pharmaceutical and personal care products in tile drainage following surface spreading and injection of dewatered municipal biosolids to an agricultural field. PubMed: Association of triclosan to casein proteins through solvent-mediated high-pressure homogenization. PubMed: Development of triclosan and antibiotic resistance in Salmonella enterica serovar Typhimurium. PubMed: An ecological risk assessment for triclosan in the terrestrial environment. PubMed: Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1. PubMed: Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. PubMed: Determinations and residual characteristics of triclosan in household food detergents of Taiwan. PubMed: Pharmaceutical and personal care products in tile drainage following land application of municipal biosolids. PubMed: Polychlorinated dibenzo-p-dioxins and dibenzofurans pollution in China: sources, environmental levels and potential human health impacts. PubMed: Snail bioaccumulation of triclocarban, triclosan, and methyltriclosan in a North Texas, USA, stream affected by wastewater treatment plant runoff. PubMed: Runoff of pharmaceuticals and personal care products following application of biosolids to an agricultural field. PubMed: Simplified sample preparation method for triclosan and methyltriclosan determination in biota and foodstuff samples. PubMed: Antibiotic and disinfectant susceptibility profiles of vancomycin-resistant Enterococcus faecium (VRE) isolated from community wastewater in Texas. PubMed: Individual and mixture effects of selected pharmaceuticals and personal care products on the marine phytoplankton species Dunaliella tertiolecta. PubMed: Antimicrobial susceptibility of Listeria monocytogenes from food products. PubMed: Measurement of triclosan in water using a magnetic particle enzyme immunoassay. PubMed: Effect of triclosan on Salmonella typhimurium at different growth stages and in biofilms. PubMed: Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents. PubMed: Risk assessment of triclosan [Irgasan] in human breast milk. PubMed: Triclosan and antimicrobial resistance in bacteria: an overview. PubMed: Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase. PubMed: Evaluation of the antibacterial effect of a triclosan-containing floor used in the food industry. PubMed: Environmental oestrogens, cosmetics and breast cancer. PubMed: Inhibition of sulfotransferases by xenobiotics. PubMed: Assessment of benefits from use of antimicrobial hand products: reduction in risk from handling ground beef. PubMed: A unique water optional health care personnel handwash provides antimicrobial persistence and residual effects while decreasing the need for additional products. PubMed: Possible associations between Salmonella persistence in poultry houses and resistance to commonly used disinfectants and a putative role of mar. PubMed: Inhibition of fatty acid synthase prevents preadipocyte differentiation. PubMed: Determination of triclosan in foodstuffs. PubMed: Effect of triclosan or a phenolic farm disinfectant on the selection of antibiotic-resistant Salmonella enterica. PubMed: The effect of a toothpaste containing 2% zinc citrate/0.3% Triclosan on the glycolysis of plaque bacteria ex vivo after food intake. PubMed: The effect of a 2% zinc citrate, 0.3% Triclosan dentifrice on plaque acid production following consumption of a snackfood. PubMed: Plaque antibacterial levels following controlled food intake and use of a toothpaste containing 2% zinc citrate and 0.3% Triclosan. PubMed: Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages. PubMed: Antimicrobial food packaging in meat industry. PubMed: Effectiveness of some recent antimicrobial packaging concepts. PubMed: [Can disinfectants contribute to antibiotic resistance?]. PubMed: The comparative anticaries efficacy of a dentifrice containing 0.3% triclosan and 2.0% copolymer in a 0.243% sodium fluoride/silica base and a dentifrice containing 0.243% sodium fluoride/silica base: a two-year coronal caries clinical trial on adults in Israel. PubMed: Determination of phenolic disinfectant agents in commercial formulations by liquid chromatography. PubMed: A method of assessing the efficacy of hand sanitizers: use of real soil encountered in the food service industry. PubMed: Percutaneous penetration and dermal metabolism of triclosan (2,4, 4'-trichloro-2'-hydroxydiphenyl ether). PubMed: The influence of specific foods and oral hygiene on the microflora of fissures and smooth surfaces of molar teeth: A 5-day study. PubMed: The effectiveness of triclosan-incorporated plastic against bacteria on beef surfaces. PubMed: [Analysis of components in natural food additive "grapefruit seed extract" by HPLC and LC/MS]. PubMed: Dietary staining in vitro by mouthrinses as a comparative measure of antiseptic activity and predictor of staining in vivo. PubMed: Evaluation of the skin disinfecting activity and cumulative effect of chlorhexidine and triclosan handwash preparations on hands artificially contaminated with Serratia marcescens.