polysorbate 65

tween 65

CAS: 9005-71-4 C100 H194 O28 MW: 1844.62378000

Identification

Namepolysorbate 65
CAS Number9005-71-4
FDA UNII14BGY2Y3MJ
Molecular FormulaC100 H194 O28
Molecular Weight1844.62378000
MDL NumberMFCD00165348

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesEU SANCO
JECFA Food AdditivePolyoxyethylene (20) Sorbitan Tristearate
GSFA CodexPolyoxyethylene (20) sorbitan tristearate (436)
DG SANTE Food Additivespolysorbate 65
DG SANTE Food Contact Materialspolysorbate 65
FDA Mainterm (SATF)9005-71-4 ; POLYSORBATE 65
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Food Chemicals Codex Listed No

Cosmetic Information

CosIngcosmetic data
Cosmetic Usessurfactants

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemulsifiers, surfactants
Recommendation for polysorbate 65 usage levels up tonot for fragrance use.
Recommendation for polysorbate 65 flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

emulsifying agents surfactants

Natural Occurrence

not found in nature

Synonyms

glycosperse TS-20 KFG hetsorb TS-20 liposorb TS-20 lonzest STS-20 nikkol TS-30V poe-20 sorbitan tristearate polyethyleneglycol sorbitan tristearate polyoxyethylene (20) sorbitan tristearate rheodol TW-S320V tween 65 PubMed: Characterization of a Riboflavin Non-aqueous Nanosuspension Prepared by Bead Milling for Cutaneous Application. PubMed: A new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriers. PubMed: Identification of phases of various oil, surfactant/ co-surfactants and water system by ternary phase diagram. PubMed: Is the adjuvanted influenza vaccine more effective than the trivalent inactivated vaccine in the elderly population? Results of a case-control study. PubMed: [The effect of Tween-80 on the differentiation of Trichophyton mentagrophytes and Trichophyton rubrum strains with FT-IR spectroscopy]. PubMed: Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects. PubMed: Pharmacokinetics and Pharmacodynamics of two Vitamin K1 Formulations in Rats. PubMed: Nanocarrier-based approaches for treatment and detection of Alzheimer's disease. PubMed: Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy. PubMed: Nonionic surfactant-based vesicular system for transdermal drug delivery. PubMed: Microstructure characterization of a food-grade U-type microemulsion system by differential scanning calorimetry and electrical conductivity techniques. PubMed: Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy. PubMed: Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine. PubMed: Comparison of micronuclei frequency in bone marrow cells of three rat lines. PubMed: A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique. PubMed: MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system. PubMed: Development of micellar reactive oxygen species assay for photosafety evaluation of poorly water-soluble chemicals. PubMed: AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial. PubMed: Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium. PubMed: Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study. PubMed: Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats. PubMed: Accelerated polymer biodegradation of risperidone poly(D, L-lactide-co-glycolide) microspheres. PubMed: Films of starch and poly(butylene adipate co-terephthalate) added of soybean oil (SO) and Tween 80. PubMed: Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy. PubMed: Adsorption of lipid liquid crystalline nanoparticles: effects of particle composition, internal structure, and phase behavior. PubMed: Comparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiers. PubMed: MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice. PubMed: Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 (®) adjuvant: results from a dose-finding clinical trial in older adults. PubMed: Vaccines for cytomegalovirus. PubMed: Characterization of ergocalciferol loaded solid lipid nanoparticles. PubMed: Preparation and evaluation of niosomes containing autoclaved Leishmania major: a preliminary study. PubMed: MF59 adjuvanted seasonal and pandemic influenza vaccines. PubMed: Role of non-ionic surfactants and plant oils on the solubilization of organochlorine pesticides by oil-in-water microemulsions. PubMed: Effect of F-File on removal of the smear layer: a scanning electron microscope study. PubMed: Immunogenicity and safety of the influenza A/H1N1 2009 inactivated split-virus vaccine in young and older adults: MF59-adjuvanted vaccine versus nonadjuvanted vaccine. PubMed: Pharmacoeconomic evaluation of the MF59--adjuvanted influenza vaccine in the elderly population in Italy. PubMed: Immunogenicity and safety of AS03-adjuvanted H1N1 pandemic vaccines in children and adolescents. PubMed: A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses. PubMed: Assessment of bioburden on human and animal tissues: Part 1--results of method development and validation studies. PubMed: Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization. PubMed: [Effect of surfactant on the evaporation of p-chloronitrobenzene and naphthalene in the turbulent process]. PubMed: Eliminating inhibition of enzymatic hydrolysis by lignosulfonate in unwashed sulfite-pretreated aspen using metal salts. PubMed: Chitosan hydrogel with terbinafine--an evaluation of drug release. PubMed: Identification of variables and value optimization for optimum lipase production by Bacillus pumilus RK31 using statistical methodology. PubMed: Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study. PubMed: The sealing ability of resilon and gutta-parcha following different smear layer removal methods: an ex vivo study. PubMed: Growth inhibiting activity of volatile oil from Cistus creticus L. against Borrelia burgdorferi s.s. in vitro. PubMed: Fast and sensitive determination of Polysorbate 80 in solutions containing proteins. PubMed: Gold nanoparticle extraction followed by capillary electrophoresis to determine the total, free, and protein-bound aminothiols in plasma. PubMed: Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems. PubMed: New approach to hydrophobic cyanine-type photosensitizer delivery using polymeric oil-cored nanocarriers: hemolytic activity, in vitro cytotoxicity and localization in cancer cells. PubMed: Remediation of polluted soil by a two-stage treatment system: desorption of phenanthrene in soil and electrochemical treatment to recover the extraction agent. PubMed: MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database. PubMed: Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy. PubMed: A quantitative kinetic study of polysorbate autoxidation: the role of unsaturated fatty acid ester substituents. PubMed: Mobilizing agents enhance fungal degradation of polycyclic aromatic hydrocarbons and affect diversity of indigenous bacteria in soil. PubMed: Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions. PubMed: [Preparation of docetaxel liposomes and their pharmacokinetics in rabbits]. PubMed: The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides. PubMed: Increased bioavailability of a transdermal application of a nano-sized emulsion preparation. PubMed: Quantitative nuclear magnetic resonance spectroscopic determination of the oxyethylene group content of polysorbates. PubMed: Influence of surfactant supplementation and maceration on the feeding value of rice straw in growing-finishing diets for Holstein steers. PubMed: Vaccines for seasonal and pandemic influenza. PubMed: Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system. PubMed: Stability of thermostable alkaline protease from Bacillus licheniformis RP1 in commercial solid laundry detergent formulations. PubMed: New pharmaceutical microemulsion system for encapsulation and delivery of diospyrin, a plant-derived bioactive quinonoid compound. PubMed: Pharmacodynamics of piroxicam from self-emulsifying lipospheres formulated with homolipids extracted from Capra hircus. PubMed: Immobilization of hydrocarbon-oxidizing bacteria in poly(vinyl alcohol) cryogels hydrophobized using a biosurfactant. PubMed: In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus. PubMed: Designing and testing of an effective oil-in-water microemulsion drug delivery system for in vivo application. PubMed: Anaerobic biodegradability of Tween surfactants used as a carbon source for the microbial reductive dechlorination of hexachlorobenzene. PubMed: Influence of the washing buffer composition on the sensitivity of an enzyme-linked immunosorbent assay using mycobacterial glycolipids as capture antigens. PubMed: An improvement of double emulsion technique for preparing bovine serum albumin-loaded PLGA microspheres. PubMed: Effects of two eye drop products on computer users with subjective ocular discomfort. PubMed: Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age. PubMed: Effects of D-004, a lipid extract from Cuban royal palm fruit, on inhibiting prostatic hypertrophy induced with testosterone or dihydrotestosterone in a rat model: A randomized, controlled study. PubMed: Characterization of Pseudoalteromonas distincta-like sea-water isolates and description of Pseudoalteromonas aliena sp. nov. PubMed: Evaluation of chemical pretreatment of contaminated soil for improved PAH bioremediation. PubMed: A novel method for the determination of synthetic colors in ice cream samples. PubMed: Optimization of DNA extraction and molecular detection of Cryptosporidium oocysts in natural mineral water sources. PubMed: Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol-polysorbate 80 mixture. PubMed: Effect of MTAD on flexural strength and modulus of elasticity of dentin. PubMed: [Drug delivery to the brain with nanoparticles]. PubMed: The use of solid self-emulsifying systems in the delivery of diclofenac. PubMed: A novel method for the reduction of numbers of Listeria monocytogenes cells by freezing in combination with an essential oil in bacteriological media. PubMed: The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethylcellulose (HPMC)-Eudragit matrices. PubMed: Influence of some polysorbates on hydrocortisone release from hydrophilic gels considered as two-compartment models. PubMed: Characterization and physicochemical properties of a lipase from Pseudomonas mendocina 3121-1. PubMed: Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells. PubMed: Influence of lipid fraction, emulsifier fraction, and mean particle diameter of oil-in-water emulsions on the release of 20 aroma compounds. PubMed: Effectiveness of spraying with tween 20 and lactic acid in decontaminating inoculated Escherichia coli O157:H7 and indigenous Escherichia coli biotype I on beef. PubMed: Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects. PubMed: Conversion of milled pine wood by manganese peroxidase from Phlebia radiata. PubMed: Development of hexachlorobenzene-dechlorinating mixed cultures using polysorbate surfactants as a carbon source. PubMed: Nanoparticulate systems for brain delivery of drugs. PubMed: Purification of recombinant and human apolipoprotein A-1 using surfactant micelles in aqueous two-phase systems: recycling of thermoseparating polymer and surfactant with temperature-induced phase separation. PubMed: Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1. PubMed: Virus passage through track-etch membranes modified by salinity and a nonionic surfactant. PubMed: Bacteriophage inactivation at the air-water-solid interface in dynamic batch systems. PubMed: In vitro comparison of NALC-NaOH, tween 80, and C18-carboxypropylbetaine for processing of specimens for recovery of mycobacteria. PubMed: Influence of surfactants on oral bioavailability of albendazole based on the formation of the sulphoxide metabolites in rats. PubMed: The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice. PubMed: MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine. PubMed: Spermine modulation of specific [3H]-gabapentin binding to the detergent-solubilized porcine cerebral cortex alpha 2 delta calcium channel subunit. PubMed: Effect of carriers and hydrophilic agents on papaverine spheres bioavailability. PubMed: Factors affecting the release of papaverine from spheres. PubMed: Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis. PubMed: Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80. PubMed: [Development of a selective differential medium for the isolation of Corynebacterium urealyticum (group D-2)]. PubMed: NTP Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies). PubMed: Biochemical and physical properties of a solvent-detergent-treated fibrin glue. PubMed: Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat. PubMed: Radioimmunoassay of apolipoprotein A-i. application of a non-ionic detergent (Tween-20) and solid-phase staphylococcus. PubMed: Cholinephosphotransferase in rat lung. The in vitro synthesis of dipalmitoylphosphatidylcholine from dipalmitoylglycerol. PubMed: Degradation of rubella virus envelope components. PubMed: Mitochondrial biogenesis during fungal spore germination. Purification, properties and biosynthesis of cytochrome c oxidase from Botryodiplodia theobromae. PubMed: In vitro cholesterol esterification in human serum. PubMed: Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surfactant solutions I: Sulfathiazole, prednisone, and chloramphenicol. PubMed: Effects of bis(2-ethylhexyl) phthalate on chromosomes of human leukocytes and human fetal lung cells. PubMed: Physiological effects of sucrose substitutes and artificial sweeteners on growth pattern and acid production of glucose-grown Streptococcus mutans strains in vitro. PubMed: Effect of polysorbate 80 on apparent partition coefficient of salicylic acid and its absorption from the rat intestine. PubMed: Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats. PubMed: Drug permeation through membranes V: interaction of diazepam with common excipients. PubMed: Effect of polysorbate 85 on human skin. PubMed: Comparison of lung cancer and amyloidosis in rabbits induced by chemical carcinogens. PubMed: Combined effect of various surfactants on gastric carcino-genesis in rats treated with N-methyl-N-nitro-N-nitrosoguanidine. PubMed: The effect of tween-65 and tween-80 on gastrointestinal motility in man.