polysorbate 65
tween 65
Identification
| Name | polysorbate 65 |
| CAS Number | 9005-71-4 |
| FDA UNII | 14BGY2Y3MJ |
| Molecular Formula | C100 H194 O28 |
| Molecular Weight | 1844.62378000 |
| MDL Number | MFCD00165348 |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | EU SANCO |
| JECFA Food Additive | Polyoxyethylene (20) Sorbitan Tristearate |
| GSFA Codex | Polyoxyethylene (20) sorbitan tristearate (436) |
| DG SANTE Food Additives | polysorbate 65 |
| DG SANTE Food Contact Materials | polysorbate 65 |
| FDA Mainterm (SATF) | 9005-71-4 ; POLYSORBATE 65 |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | surfactants |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emulsifiers, surfactants |
| Recommendation for polysorbate 65 usage levels up to | not for fragrance use. |
| Recommendation for polysorbate 65 flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
glycosperse TS-20 KFG
hetsorb TS-20
liposorb TS-20
lonzest STS-20
nikkol TS-30V
poe-20 sorbitan tristearate
polyethyleneglycol sorbitan tristearate
polyoxyethylene (20) sorbitan tristearate
rheodol TW-S320V
tween 65
PubMed:
Characterization of a Riboflavin Non-aqueous Nanosuspension Prepared by Bead Milling for Cutaneous Application.
PubMed:
A new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriers.
PubMed:
Identification of phases of various oil, surfactant/ co-surfactants and water system by ternary phase diagram.
PubMed:
Is the adjuvanted influenza vaccine more effective than the trivalent inactivated vaccine in the elderly population? Results of a case-control study.
PubMed:
[The effect of Tween-80 on the differentiation of Trichophyton mentagrophytes and Trichophyton rubrum strains with FT-IR spectroscopy].
PubMed:
Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects.
PubMed:
Pharmacokinetics and Pharmacodynamics of two Vitamin K1 Formulations in Rats.
PubMed:
Nanocarrier-based approaches for treatment and detection of Alzheimer's disease.
PubMed:
Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy.
PubMed:
Nonionic surfactant-based vesicular system for transdermal drug delivery.
PubMed:
Microstructure characterization of a food-grade U-type microemulsion system by differential scanning calorimetry and electrical conductivity techniques.
PubMed:
Safety of MF59-adjuvanted influenza vaccination in the elderly: results of a comparative study of MF59-adjuvanted vaccine versus nonadjuvanted influenza vaccine in northern Italy.
PubMed:
Long-term and cross-reactive immunogenicity of inactivated trivalent influenza vaccine in the elderly: MF59-adjuvanted vaccine versus unadjuvanted vaccine.
PubMed:
Comparison of micronuclei frequency in bone marrow cells of three rat lines.
PubMed:
A novel method to produce solid lipid nanoparticles using n-butanol as an additional co-surfactant according to the o/w microemulsion quenching technique.
PubMed:
MF59-adjuvanted and virosomal influenza vaccines for preventing influenza hospitalization in older people: comparative effectiveness using the Valencia health care information system.
PubMed:
Development of micellar reactive oxygen species assay for photosafety evaluation of poorly water-soluble chemicals.
PubMed:
AS03-adjuvanted versus non-adjuvanted inactivated trivalent influenza vaccine against seasonal influenza in elderly people: a phase 3 randomised trial.
PubMed:
Gastrodin production from p-2-hydroxybenzyl alcohol through biotransformation by cultured cells of Aspergillus foetidus and Penicillium cyclopium.
PubMed:
Influenza A/H1N1 MF59 adjuvanted vaccine in pregnant women and adverse perinatal outcomes: multicentre study.
PubMed:
Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats.
PubMed:
Accelerated polymer biodegradation of risperidone poly(D, L-lactide-co-glycolide) microspheres.
PubMed:
Films of starch and poly(butylene adipate co-terephthalate) added of soybean oil (SO) and Tween 80.
PubMed:
Effectiveness of adjuvanted influenza vaccination in elderly subjects in northern Italy.
PubMed:
Adsorption of lipid liquid crystalline nanoparticles: effects of particle composition, internal structure, and phase behavior.
PubMed:
Comparison of the adverse events associated with MF59-adjuvanted and non-adjuvanted H1N1 vaccines in healthy young male Korean soldiers.
PubMed:
MF59 formulated with CpG ODN as a potent adjuvant of recombinant HSP65-MUC1 for inducing anti-MUC1+ tumor immunity in mice.
PubMed:
Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59 (®) adjuvant: results from a dose-finding clinical trial in older adults.
PubMed:
Vaccines for cytomegalovirus.
PubMed:
Characterization of ergocalciferol loaded solid lipid nanoparticles.
PubMed:
Preparation and evaluation of niosomes containing autoclaved Leishmania major: a preliminary study.
PubMed:
MF59 adjuvanted seasonal and pandemic influenza vaccines.
PubMed:
Role of non-ionic surfactants and plant oils on the solubilization of organochlorine pesticides by oil-in-water microemulsions.
PubMed:
Effect of F-File on removal of the smear layer: a scanning electron microscope study.
PubMed:
Immunogenicity and safety of the influenza A/H1N1 2009 inactivated split-virus vaccine in young and older adults: MF59-adjuvanted vaccine versus nonadjuvanted vaccine.
PubMed:
Pharmacoeconomic evaluation of the MF59--adjuvanted influenza vaccine in the elderly population in Italy.
PubMed:
Immunogenicity and safety of AS03-adjuvanted H1N1 pandemic vaccines in children and adolescents.
PubMed:
A phase III, randomized, open-label study to assess the tolerability and immunogenicity of an H5N1 influenza vaccine administered to healthy adults with a 1-, 2-, 3-, or 6-week interval between first and second doses.
PubMed:
Assessment of bioburden on human and animal tissues: Part 1--results of method development and validation studies.
PubMed:
Preparation of niosomes as an ocular delivery system for naltrexone hydrochloride: physicochemical characterization.
PubMed:
[Effect of surfactant on the evaporation of p-chloronitrobenzene and naphthalene in the turbulent process].
PubMed:
Eliminating inhibition of enzymatic hydrolysis by lignosulfonate in unwashed sulfite-pretreated aspen using metal salts.
PubMed:
Chitosan hydrogel with terbinafine--an evaluation of drug release.
PubMed:
Identification of variables and value optimization for optimum lipase production by Bacillus pumilus RK31 using statistical methodology.
PubMed:
Evaluation of non-inferiority of intradermal versus adjuvanted seasonal influenza vaccine using two serological techniques: a randomised comparative study.
PubMed:
The sealing ability of resilon and gutta-parcha following different smear layer removal methods: an ex vivo study.
PubMed:
Growth inhibiting activity of volatile oil from Cistus creticus L. against Borrelia burgdorferi s.s. in vitro.
PubMed:
Fast and sensitive determination of Polysorbate 80 in solutions containing proteins.
PubMed:
Gold nanoparticle extraction followed by capillary electrophoresis to determine the total, free, and protein-bound aminothiols in plasma.
PubMed:
Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems.
PubMed:
New approach to hydrophobic cyanine-type photosensitizer delivery using polymeric oil-cored nanocarriers: hemolytic activity, in vitro cytotoxicity and localization in cancer cells.
PubMed:
Remediation of polluted soil by a two-stage treatment system: desorption of phenanthrene in soil and electrochemical treatment to recover the extraction agent.
PubMed:
MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database.
PubMed:
Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy.
PubMed:
A quantitative kinetic study of polysorbate autoxidation: the role of unsaturated fatty acid ester substituents.
PubMed:
Mobilizing agents enhance fungal degradation of polycyclic aromatic hydrocarbons and affect diversity of indigenous bacteria in soil.
PubMed:
Monitoring the effects of component structure and source on formulation stability and adjuvant activity of oil-in-water emulsions.
PubMed:
[Preparation of docetaxel liposomes and their pharmacokinetics in rabbits].
PubMed:
The influence of cosurfactants and oils on the formation of pharmaceutical microemulsions based on PEG-8 caprylic/capric glycerides.
PubMed:
Increased bioavailability of a transdermal application of a nano-sized emulsion preparation.
PubMed:
Quantitative nuclear magnetic resonance spectroscopic determination of the oxyethylene group content of polysorbates.
PubMed:
Influence of surfactant supplementation and maceration on the feeding value of rice straw in growing-finishing diets for Holstein steers.
PubMed:
Vaccines for seasonal and pandemic influenza.
PubMed:
Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system.
PubMed:
Stability of thermostable alkaline protease from Bacillus licheniformis RP1 in commercial solid laundry detergent formulations.
PubMed:
New pharmaceutical microemulsion system for encapsulation and delivery of diospyrin, a plant-derived bioactive quinonoid compound.
PubMed:
Pharmacodynamics of piroxicam from self-emulsifying lipospheres formulated with homolipids extracted from Capra hircus.
PubMed:
Immobilization of hydrocarbon-oxidizing bacteria in poly(vinyl alcohol) cryogels hydrophobized using a biosurfactant.
PubMed:
In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus.
PubMed:
Designing and testing of an effective oil-in-water microemulsion drug delivery system for in vivo application.
PubMed:
Anaerobic biodegradability of Tween surfactants used as a carbon source for the microbial reductive dechlorination of hexachlorobenzene.
PubMed:
Influence of the washing buffer composition on the sensitivity of an enzyme-linked immunosorbent assay using mycobacterial glycolipids as capture antigens.
PubMed:
An improvement of double emulsion technique for preparing bovine serum albumin-loaded PLGA microspheres.
PubMed:
Effects of two eye drop products on computer users with subjective ocular discomfort.
PubMed:
Effectiveness of the MF59-adjuvanted influenza vaccine in preventing emergency admissions for pneumonia in the elderly over 64 years of age.
PubMed:
Effects of D-004, a lipid extract from Cuban royal palm fruit, on inhibiting prostatic hypertrophy induced with testosterone or dihydrotestosterone in a rat model: A randomized, controlled study.
PubMed:
Characterization of Pseudoalteromonas distincta-like sea-water isolates and description of Pseudoalteromonas aliena sp. nov.
PubMed:
Evaluation of chemical pretreatment of contaminated soil for improved PAH bioremediation.
PubMed:
A novel method for the determination of synthetic colors in ice cream samples.
PubMed:
Optimization of DNA extraction and molecular detection of Cryptosporidium oocysts in natural mineral water sources.
PubMed:
Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol-polysorbate 80 mixture.
PubMed:
Effect of MTAD on flexural strength and modulus of elasticity of dentin.
PubMed:
[Drug delivery to the brain with nanoparticles].
PubMed:
The use of solid self-emulsifying systems in the delivery of diclofenac.
PubMed:
A novel method for the reduction of numbers of Listeria monocytogenes cells by freezing in combination with an essential oil in bacteriological media.
PubMed:
The effect of various surfactants on the release rate of propranolol hydrochloride from hydroxypropylmethylcellulose (HPMC)-Eudragit matrices.
PubMed:
Influence of some polysorbates on hydrocortisone release from hydrophilic gels considered as two-compartment models.
PubMed:
Characterization and physicochemical properties of a lipase from Pseudomonas mendocina 3121-1.
PubMed:
Remarkably enhanced inhibitory effects of three-component hybrid liposomes including sugar surfactants on the growth of lung carcinoma cells.
PubMed:
Influence of lipid fraction, emulsifier fraction, and mean particle diameter of oil-in-water emulsions on the release of 20 aroma compounds.
PubMed:
Effectiveness of spraying with tween 20 and lactic acid in decontaminating inoculated Escherichia coli O157:H7 and indigenous Escherichia coli biotype I on beef.
PubMed:
Increased immunogenicity of the MF59-adjuvanted influenza vaccine compared to a conventional subunit vaccine in elderly subjects.
PubMed:
Conversion of milled pine wood by manganese peroxidase from Phlebia radiata.
PubMed:
Development of hexachlorobenzene-dechlorinating mixed cultures using polysorbate surfactants as a carbon source.
PubMed:
Nanoparticulate systems for brain delivery of drugs.
PubMed:
Purification of recombinant and human apolipoprotein A-1 using surfactant micelles in aqueous two-phase systems: recycling of thermoseparating polymer and surfactant with temperature-induced phase separation.
PubMed:
Phospholipase digestion of bound cardiolipin reversibly inactivates bovine cytochrome bc1.
PubMed:
Virus passage through track-etch membranes modified by salinity and a nonionic surfactant.
PubMed:
Bacteriophage inactivation at the air-water-solid interface in dynamic batch systems.
PubMed:
In vitro comparison of NALC-NaOH, tween 80, and C18-carboxypropylbetaine for processing of specimens for recovery of mycobacteria.
PubMed:
Influence of surfactants on oral bioavailability of albendazole based on the formation of the sulphoxide metabolites in rats.
PubMed:
The adjuvant MF59 increases the immunogenicity and protective efficacy of subunit influenza vaccine in mice.
PubMed:
MF59 adjuvant enhances antibody responses of infant baboons immunized with Haemophilus influenzae type b and Neisseria meningitidis group C oligosaccharide-CRM197 conjugate vaccine.
PubMed:
Spermine modulation of specific [3H]-gabapentin binding to the detergent-solubilized porcine cerebral cortex alpha 2 delta calcium channel subunit.
PubMed:
Effect of carriers and hydrophilic agents on papaverine spheres bioavailability.
PubMed:
Factors affecting the release of papaverine from spheres.
PubMed:
Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis.
PubMed:
Inhibition of etoposide elimination in the isolated perfused rat liver by Cremophor EL and Tween 80.
PubMed:
[Development of a selective differential medium for the isolation of Corynebacterium urealyticum (group D-2)].
PubMed:
NTP Toxicology and Carcinogenesis Studies of Polysorbate 80 (CAS No. 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies).
PubMed:
Biochemical and physical properties of a solvent-detergent-treated fibrin glue.
PubMed:
Effects of intrathecal capsaicin on autonomic and behavioral heat loss responses in the rat.
PubMed:
Radioimmunoassay of apolipoprotein A-i. application of a non-ionic detergent (Tween-20) and solid-phase staphylococcus.
PubMed:
Cholinephosphotransferase in rat lung. The in vitro synthesis of dipalmitoylphosphatidylcholine from dipalmitoylglycerol.
PubMed:
Degradation of rubella virus envelope components.
PubMed:
Mitochondrial biogenesis during fungal spore germination. Purification, properties and biosynthesis of cytochrome c oxidase from Botryodiplodia theobromae.
PubMed:
In vitro cholesterol esterification in human serum.
PubMed:
Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surfactant solutions I: Sulfathiazole, prednisone, and chloramphenicol.
PubMed:
Effects of bis(2-ethylhexyl) phthalate on chromosomes of human leukocytes and human fetal lung cells.
PubMed:
Physiological effects of sucrose substitutes and artificial sweeteners on growth pattern and acid production of glucose-grown Streptococcus mutans strains in vitro.
PubMed:
Effect of polysorbate 80 on apparent partition coefficient of salicylic acid and its absorption from the rat intestine.
PubMed:
Effects of lipids on bioavailability of sulfisoxazole acetyl, dicumarol, and griseofulvin in rats.
PubMed:
Drug permeation through membranes V: interaction of diazepam with common excipients.
PubMed:
Effect of polysorbate 85 on human skin.
PubMed:
Comparison of lung cancer and amyloidosis in rabbits induced by chemical carcinogens.
PubMed:
Combined effect of various surfactants on gastric carcino-genesis in rats treated with N-methyl-N-nitro-N-nitrosoguanidine.
PubMed:
The effect of tween-65 and tween-80 on gastrointestinal motility in man.