camphane
1,7,7-trimethylbicyclo[2.2.1]heptane
Identification
| Name | camphane |
| IUPAC | 4,7,7-trimethylbicyclo[2.2.1]heptane |
| CAS Number | 464-15-3 |
| FDA UNII | Search |
| Molecular Formula | C10 H18 |
| Molecular Weight | 138.25346000 |
| Nikkaji Number | J11.345J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 157.00 to 159.00 °C. @ 760.00 mm Hg |
| Boiling Point | 160.00 to 162.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 4.931000 mmHg @ 25.00 °C. (est) |
| Flash Point | 90.00 °F. TCC ( 32.40 °C. ) (est) |
| logP (o/w) | 4.431 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Organoleptic Properties
| Odor Description | mild borneol |
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for camphane usage levels up to | not for fragrance use. |
| Recommendation for camphane flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
bornane
bornylane
1,7,7-
trimethyl bicyclo(2.2.1)heptane
1,7,7-
trimethylbicyclo[2.2.1]heptane
4,7,7-
trimethylbicyclo[2.2.1]heptane
PubMed:
Antibacterial Adhesion of Borneol-Based Polymer via Surface Chiral Stereochemistry.
PubMed:
Design of novel camphane-based derivatives with antimycobacterial activity.
PubMed:
Antimycobacterial activity of chiral aminoalcohols with camphane scaffold.
PubMed:
Synthesis and antimycobacterial activity of novel camphane-based agents.
PubMed:
Novel camphane-based anti-tuberculosis agents with nanomolar activity.
PubMed:
Oxygen activation by P450(cin): Protein and substrate mutagenesis.
PubMed:
GC-MS analysis of the essential oils of ripe fruits, roots and flowering aerial parts of Elaeoselinum asclepium subsp. meoides growing in Sicily.
PubMed:
Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.
PubMed:
Composition, enantiomeric distribution, and antibacterial activity of the essential oil of Achillea ligustica All. from Corsica.
PubMed:
Calocedimers A, B, C, and D from the bark of Calocedrus macrolepis var. formosana.
PubMed:
Cytochrome P450cam-monoterpene interactions.
PubMed:
Substrates modulate the rate-determining step for CO binding in cytochrome P450cam (CYP101). A high-pressure stopped-flow study.
PubMed:
Toxaphenes and chlorinated naphthalenes in adipose tissue of children.
PubMed:
Changes in secondary structure and salt links of cytochrome P-450cam induced by photoreduction: a Fourier transform infrared spectroscopic study.
PubMed:
Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase.
PubMed:
Step-scan time-resolved FTIR spectroscopy of cytochrome P-450cam carbon monoxide complex: a salt link involved in the ligand-rebinding process.
PubMed:
Mobility of norbornane-type substrates and water accessibility in cytochrome P-450cam.
PubMed:
Substrate mobility in thiocamphor-bound cytochrome P450cam: an explanation of the conflict between the observed product profile and the X-ray structure.
PubMed:
Crystal structures of cytochrome P-450CAM complexed with camphane, thiocamphor, and adamantane: factors controlling P-450 substrate hydroxylation.
PubMed:
Biosynthesis of monoterpenes: stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to camphane and isocamphane monoterpenes.
PubMed:
The roles of active site hydrogen bonding in cytochrome P-450cam as revealed by site-directed mutagenesis.
PubMed:
Metabolism of camphanediols.
PubMed:
The influence of some new nor-camphane derivatives on the coronary flow.
PubMed:
Metabolism of camphors and related compounds.
PubMed:
Camphane derivatives. VII. Syntheses and structure of 3-methyl-3a-beta, 7a-beta-beta-bornano[3,2-d]oxazolidin-2-one and its derivatives.
PubMed:
[SYNTHESES OF ANALGESICS. XXXV. CAMPHANE DERIVATIVES. (6). SYNTHESES OF CAMPHORIMIDE AND ITS DERIVATIVES].
PubMed:
[SYNTHESES OF ANALGESICS. XXXIV. CAMPHANE DERIVATIVES. (5). SYNTHESES OF 9- AND 10-HYDROXYCAMPHOR DERIVATIVES].
PubMed:
[SYNTHESES OF ANALGESICS. 33. CAMPHANE DERIVATIVES. (4). SYNTHESES OF N-(3-CAMPHORYL)-AND N-(2-HYDROXY-3-BORNANYL-AMINO ACID DERIVATES].
PubMed:
[SYNTHESES OF ANALGESICS. XXXII. CAMPHANE DERIVATIVES. (3). SYNTHESES OF 1-ALKYL-3-(3-CAMPHORYL)UREAS AND THIOUREAS].
PubMed:
[Modification of work and learning ability in rats and pigeons by 2-ethylamino-3-phenylnor-camphane].