gamma-mangostin
9H-xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-
Identification
| Name | gamma-mangostin |
| CAS Number | 31271-07-5 |
| FDA UNII | G7HS6P8ZEC |
| Molecular Formula | C23 H24 O6 |
| Molecular Weight | 396.43948000 |
| MDL Number | MFCD00951752 |
| Nikkaji Number | J19.951F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 648.00 to 649.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 440.00 °F. TCC ( 226.40 °C. ) (est) |
| logP (o/w) | 5.744 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for gamma-mangostin usage levels up to | not for fragrance use. |
| Recommendation for gamma-mangostin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
g-
mangosin
2,8-bis(3-
methyl-2-butenyl)-1,3,6,7-tetrahydroxy-9H-xanthen-9-one
1,3,6,7-
tetrahydroxy-2,5-bis(3-methyl-2-butenyl)-9H-xanthen-9-one
1,3,6,7-
tetrahydroxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one
1,3,6,7-
tetrahydroxy-2,8-bis(3-methylbut-2-enyl)-9H-xanthen-9-one
1,3,6,7-
tetrahydroxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
9H-
xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-buten-1-yl)-
9H-
xanthen-9-one, 1,3,6,7-tetrahydroxy-2,8-bis(3-methyl-2-butenyl)-
PubMed:
Prenylated xanthones from mangosteen as promising cholinesterase inhibitors and their molecular docking studies.
PubMed:
Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana.
PubMed:
Rapid identification of cholinesterase inhibitors from the seedcases of mangosteen using an enzyme affinity assay.
PubMed:
γ-Mangostin from Garcinia mangostana pericarps as a dual agonist that activates Both PPARα and PPARδ.
PubMed:
Altered mRNA expression related to the apoptotic effect of three xanthones on human melanoma SK-MEL-28 cell line.
PubMed:
Antitumour and free radical scavenging effects of γ-mangostin isolated from Garcinia mangostana pericarps against hepatocellular carcinoma cell.
PubMed:
Antileptospiral activity of xanthones from Garcinia mangostana and synergy of gamma-mangostin with penicillin G.
PubMed:
Pharmacokinetic properties of pure xanthones in comparison to a mangosteen fruit extract in rats.
PubMed:
Distribution of major xanthones in the pericarp, aril, and yellow gum of mangosteen (Garcinia mangostana linn.) fruit and their contribution to antioxidative activity.
PubMed:
Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.
PubMed:
Inhibition of human aldose reductase-like protein (AKR1B10) by α- and γ-mangostins, major components of pericarps of mangosteen.
PubMed:
New "hyphenated" CPC-HPLC-DAD-MS strategy for simultaneous isolation, analysis and identification of phytochemicals: application to xanthones from Garcinia mangostana.
PubMed:
Mangosteen xanthones mitigate ovalbumin-induced airway inflammation in a mouse model of asthma.
PubMed:
In vitro and in vivo anti-colon cancer effects of Garcinia mangostana xanthones extract.
PubMed:
Inflammation-related disorders in the tryptophan catabolite pathway in depression and somatization.
PubMed:
Investigation of biological activities of dichloromethane and ethyl acetate fractions of Platonia insignis Mart. seed.
PubMed:
Gamma-mangostin, a micronutrient of mangosteen fruit, induces apoptosis in human colon cancer cells.
PubMed:
Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies.
PubMed:
Xanthones in mangosteen juice are absorbed and partially conjugated by healthy adults.
PubMed:
Antifibrotic constituents from Garcinia mangostana.
PubMed:
Combined microwave-assisted extraction and high-speed counter-current chromatography for separation and purification of xanthones from Garcinia mangostana.
PubMed:
Cytotoxic effect of xanthones from pericarp of the tropical fruit mangosteen (Garcinia mangostana Linn.) on human melanoma cells.
PubMed:
γ-Mangostin increases serotonin 2A/2C, muscarinic, histamine and bradykinin receptor mRNA expression.
PubMed:
Apoptotic effects of γ-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells.
PubMed:
A new prenylated xanthone from Garcinia xipshuanbannaensis Y.H. Li.
PubMed:
Preparative separation of major xanthones from mangosteen pericarp using high-performance centrifugal partition chromatography.
PubMed:
Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media.
PubMed:
New medicinal properties of mangostins: analgesic activity and pharmacological characterization of active ingredients from the fruit hull of Garcinia mangostana L.
PubMed:
Panaxanthone isolated from pericarp of Garcinia mangostana L. suppresses tumor growth and metastasis of a mouse model of mammary cancer.
PubMed:
Bioaccessibility, biotransformation, and transport of alpha-mangostin from Garcinia mangostana (Mangosteen) using simulated digestion and Caco-2 human intestinal cells.
PubMed:
Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes.
PubMed:
Anti-cancer effects of xanthones from pericarps of mangosteen.
PubMed:
Effects of compounds from Garcinia mangostana on inflammatory mediators in RAW264.7 macrophage cells.
PubMed:
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity.
PubMed:
Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.
PubMed:
Inhibitory effect of xanthones isolated from the pericarp of Garcinia mangostana L. on rat basophilic leukemia RBL-2H3 cell degranulation.
PubMed:
Anti-inflammatory activity of mangostins from Garcinia mangostana.
PubMed:
Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen).
PubMed:
Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen).
PubMed:
Garcinone B reduces prostaglandin E2 release and NF-kappaB-mediated transcription in C6 rat glioma cells.
PubMed:
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells.
PubMed:
A geranylated biphenyl derivative from Garcinia malvgostana.
PubMed:
Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.
PubMed:
gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.
PubMed:
Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
PubMed:
Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones.
PubMed:
Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice.
PubMed:
[Novel types of receptor antagonists from the medicinal plant Garcinia mangostana].
PubMed:
Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
PubMed:
Histaminergic and serotonergic receptor blocking substances from the medicinal plant Garcinia mangostana.
PubMed:
Active constituents against HIV-1 protease from Garcinia mangostana.
PubMed:
Inhibition of wheat embryo calcium-dependent protein kinase and other kinases by mangostin and gamma-mangostin.