hydrochlorothiazide

2H-1,2,4-benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide

CAS: 58-93-5 C7 H8 Cl N3 O4 S2 MW: 297.74056000

Identification

Namehydrochlorothiazide
CAS Number58-93-5
EINECS200-403-3
FDA UNII0J48LPH2TH
Molecular FormulaC7 H8 Cl N3 O4 S2
Molecular Weight297.74056000
MDL NumberMFCD00051765
Nikkaji NumberJ1.920H
Beilstein0625101
XlogP3-0.10 (est)

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 274.00 °C. @ 760.00 mm Hg
Boiling Point 576.96 °C. @ 760.00 mm Hg (est)
Flash Point 577.00 °F. TCC ( 302.70 °C. ) (est)
logP (o/w) -0.070
Soluble in water, 722 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintravenous-dog LD50 250 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 1470 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for hydrochlorothiazide usage levels up tonot for fragrance use.
Recommendation for hydrochlorothiazide flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

accuretic acuilix acuretic aldactazide aldazida aldectazide 50/50 aldoril apo-hydro apresazide apresoline-esidrix aquarills aquarius aquazide H aquazide-H avalide 2H-1,2,4- benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide bremil briazide CAM-AP-ES caplaril carozide catiazida 6- chlor-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamid-1,1-dioxid chlorizide 6- chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lamda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 6- chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lamda6-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 6- chloro-1,1-dioxo-2H,3H,4H-benzo[e]1,2,4-thiadiazine-7-sulfonamide 6- chloro-1,1-dioxo-3,4-dihydro-2H-1lamda6,2,4-benzothiadiazine-7-sulfonamide 6- chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6- chloro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide 6- chloro-3,4-dihydro-7-sulfamoyl-2H-1,2, 4-benzothiadiazine 1,1-dioxide 6- chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 6- chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine-1,1-dioxide 6- chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 6- chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide 6- chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide 6- chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide chlorosulphadil chlorosulthiadil chlorsulfonamidodihydrobenzothiadiazine dioxide chlorzide chlothia cidrex clorana neo codema neo- codema concor plus condiuren diaqua dichlorosal dichlothiazide dichlotiazid dichlotride diclot ride diclotride didral dihydran 3,4- dihydro-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide 3,4- dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide 3,4- dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide dihydrochlorothiazid 3,4- dihydrochlorothiazide dihydrochlorurite dihydroxychlorothiazidum direma disalunil disothiazid diu-melusin diurogen dixidrasi drenol dyazide esidrex esidrix esimil esoidrina neo flumen neo- flumen fluvin hidril hidro-niagrin hidrochlortiazid hidroronol hidrosaluretil hidrotiazida hyclosid hydra-zide hydrap-ES hydril hydro par hydro-aquil hydro-chlor hydro-D hydro-reserp hydro-ride hydro-saluric hydro-T hydrochloro thiazide hydrochlorothiazid hydrochlorthiazide hydrochlorthiazidum hydrocot hydrodiuretic hydrodiuril hydrosaluric hydrothide hydrozide hypothaizide hypothiazid hytrid hyzaar idrotiazide inderide indroclor ivaugan jen-diril lopressor HCT lotensin HCT manuril maschitt maxzide mazide 25 mg medozide megadiuril microzide mictrin mikorten neo- minzil modurcen moduretic monopril-HCT natrinax nefrix nefrol newtolide normozide novodiurex oretic pantemon panurin prinzide quinaretic raunova plus ro-hydrazide saldiuril sectrazide selozide ser-a-gen ser-ap-es servithiazid spironazide tandiur thiaretic thiuretic thlaretic timolide unazid unipres uniretic urodiazin urozide vaseretic vasoretic vetid rex vetidrex viskazide zestoretic ziac zide PubMed: Diuretic Exposure in Premature Infants from 1997 to 2011. 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