chlorothiazide

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6-chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide

CAS: 58-94-6 C7 H6 Cl N3 O4 S2 MW: 295.72462000
All Ingredients Aromatic Ingredients CAS Numbers EINECS Numbers

Identification

Namechlorothiazide
CAS Number58-94-6
EINECS200-467-2
FDA UNII77W477J15H
Molecular FormulaC7 H6 Cl N3 O4 S2
Molecular Weight295.72462000
MDL NumberMFCD00058576
Nikkaji NumberJ2.807J
XlogP3-0.20 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 350.00 °C. @ 760.00 mm Hg
Boiling Point 608.77 °C. @ 760.00 mm Hg (est)
Flash Point 612.00 °F. TCC ( 322.00 °C. ) (est)
logP (o/w) -0.240
Soluble in water, 1854 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-dog LD50 1000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD', 'BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for chlorothiazide usage levels up tonot for fragrance use.
Recommendation for chlorothiazide flavor usage levels up tonot for flavor use.

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58-94-6 Chlorothiazide >98%
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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2H-1,2,4- benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide 4H-1,2,4- benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide 6- chloro-1,1-dioxo-4H-1lamda6,2,4-benzothiadiazine-7-sulfonamide 6- chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6- chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6- chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 6- chloro-7-sulfamyl-1,2,4-benzothiadiazine 1,1-dioxide chlorothiazid chlorothiazidum clotride diurilix diutrid minzil salisan saluretil warduzide yadalan yadulan PubMed: Diuretic Exposure in Premature Infants from 1997 to 2011. PubMed: Encapsulation of chlorothiazide in whey proteins: effects of wall-to-core ratio and cross-linking conditions on microcapsule properties and drug release. PubMed: Isolation of a 2:1 hydrochlorothiazide-formaldehyde adduct impurity in hydrochlorothiazide drug substance by preparative chromatography and characterization by electrospray ionization LC-MS. PubMed: Identification of chlorothiazide and hydrochlorothiazide UV-A photolytic decomposition products. PubMed: Determination of reserpine and chlorothiazide in commercial tablets by liquid chromatography with fluorescence and UV absorbance detectors in series. PubMed: Vasopressin and ethanol preference. II. Altered preference in two strains of diabetes insipidus rats and nephrogenic diabetes insipidus mice. PubMed: Influence of food and fluid volume on chlorothiazide bioavailability: comparison of plasma and urinary excretion methods. PubMed: Renin-like activity of the rat submaxillary gland: characterization and the effect of several drugs and stimuli.