hexahydrophthalic anhydride

cyclohexane-1,2-dicarboxylic anhydride

CAS: 85-42-7 C8 H10 O3 MW: 154.16530000

Identification

Namehexahydrophthalic anhydride
CAS Number85-42-7
EINECS201-622-7
FDA UNIISearch
Molecular FormulaC8 H10 O3
Molecular Weight154.16530000
MDL NumberMFCD00005926
Nikkaji NumberJ70.181E

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 32.00 °C. @ 760.00 mm Hg
Boiling Point 283.00 to 284.00 °C. @ 760.00 mm Hg (est), 158.00 °C. @ 17.00 mm Hg
Vapor Pressure 0.003000 mmHg @ 25.00 °C. (est)
Flash Point 291.00 °F. TCC ( 143.90 °C. ) (est)
logP (o/w) 0.762 (est)
Soluble in water, 1014 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for hexahydrophthalic anhydride usage levels up tonot for fragrance use.
Recommendation for hexahydrophthalic anhydride flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

araldite HT 907 cyclohexane-1,2-dicarboxylic anhydride 1,2- cyclohexanedicarboxylic acid anhydride 3a,4,5,6,7,7a- hexahydro-2-benzofuran-1,3-dione hexahydrophthalic acid anhydride lekutherm hardener H PubMed: Synthesis and properties of a bio-based epoxy resin with high epoxy value and low viscosity. PubMed: [Investigation of the intramolecular cyclization of the thiophene substituted cyclohexane skeleton gamma-oxocarboxylic acid and synthesis of some N-heteroaryl isoindole derivatives]. PubMed: Occupational contact urticaria caused by cyclic acid anhydrides. PubMed: Identification of covalent binding sites of phthalic anhydride in human hemoglobin. PubMed: Evaluation of an immunoaffinity extraction column for enrichment of adducts between human serum albumin and hexahydrophthalic anhydride in plasma. PubMed: Adducts between nucleophilic amino acids and hexahydrophthalic anhydride, a structure inducing both types I and IV allergy. PubMed: Correlations between air levels of hexahydrophthalic anhydride (HHPA) and HHPA-adducted albumin tryptic peptides in nasal lavage fluid from experimentally exposed volunteers. PubMed: Determination of airborne anhydrides using LC-MS monitoring negative ions of di-n-butylamine derivatives. PubMed: In vivo conjugation of nasal lavage proteins by hexahydrophthalic anhydride. PubMed: Determination of hexahydrophthalic anhydride adducts to human serum albumin. PubMed: Identifying airway sensitizers: cytokine mRNA profiles induced by various anhydrides. PubMed: Exposure-response relationships for hexahydrophthalic and methylhexahydrophthalic anhydrides with total plasma protein adducts as biomarkers. PubMed: Methods for the identification of chemical respiratory allergens in rodents: comparisons of cytokine profiling with induced changes in serum IgE. PubMed: Application of stored waveform ion modulation 2D-FTICR MS/MS to the analysis of complex mixtures. PubMed: Mass spectrometric characterization of human hemoglobin adducts formed in vitro by hexahydrophthalic anhydride. PubMed: Effect of respiratory protective devices on development of antibody and occupational asthma to an acid anhydride. PubMed: A cross-sectional survey of 32 workers exposed to hexahydrophthalic and methylhexahydrophthalic anhydrides. PubMed: Occupational contact urticaria caused by airborne methylhexahydrophthalic anhydride. PubMed: Serum albumins are the major site for in vivo formation of hapten-carrier protein adducts in plasma from humans and guinea-pigs exposed to type-1 allergy inducing hexahydrophthalic anhydride. PubMed: Total plasma protein adducts of allergenic hexahydrophthalic and methylhexahydrophthalic anhydrides as biomarkers of long-term exposure. PubMed: Quantification of protein adducts of hexahydrophthalic anhydride and methylhexahydrophthalic anhydride in human plasma. PubMed: Characterization in mice of the immunological properties of five allergenic acid anhydrides. PubMed: In-source decay of hyperbranched polyesteramides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. PubMed: Airborne allergic contact urticaria from methylhexahydrophthalic anhydride and hexahydrophthalic anhydride. PubMed: Efficacy of measures of hygiene in workers sensitised to acid anhydrides and the influence of selection bias on the results. PubMed: Binding of the potent allergen hexahydrophthalic anhydride in the mucosa of the upper respiratory and alimentary tract following single inhalation exposures in guinea pigs and rats. PubMed: Human hemoglobin adducts following exposure to hexahydrophthalic anhydride and methylhexahydrophthalic anhydride. PubMed: Quantification method of human hemoglobin adducts from hexahydrophthalic anhydride and methylhexahydrophthalic anhydride. PubMed: Relationship between IgG1 levels and airway responses in guinea pigs actively and passively sensitized to hexahydrophthalic anhydride. PubMed: The characteristics of specific IgG to phthalic anhydride (PA)-albumin conjugate. PubMed: Determination of hexahydrophthalic acid and methylhexahydrophthalic acid in plasma after derivatisation with pentafluorobenzyl bromide using gas chromatography and mass spectrometric detection. PubMed: Antibody specificity to the chemical structures of organic acid anhydrides studied by in-vitro and in-vivo methods. PubMed: Haemoglobin adducts and specific immunoglobulin G in humans as biomarkers of exposure to hexahydrophthalic anhydride. PubMed: Anaphylactic bronchoconstriction in immunized guinea pigs provoked by inhalation and intravenous administration of hexahydrophthalic anhydride and methyltetrahydrophthalic anhydride. PubMed: Direct measurement of hexahydrophthalic anhydride in workplace air with a transportable Fourier transform infrared spectrometer. PubMed: Study of employees with anhydride-induced respiratory disease after removal from exposure. PubMed: Risk factors for immunologically mediated disease in workers with respiratory symptoms when exposed to hexahydrophthalic anhydride. PubMed: Study of employees with anhydride-induced respiratory disease after removal from exposure. PubMed: Exposure-response relationships in the formation of specific antibodies to hexahydrophthalic anhydride in exposed workers. PubMed: Risk factors for immunologically mediated respiratory disease from hexahydrophthalic anhydride. PubMed: Nasal challenge shows pathogenetic relevance of specific IgE serum antibodies for nasal symptoms caused by hexahydrophthalic anhydride. PubMed: Generation of hexahydrophthalic anhydride atmospheres in a controlled human-use test chamber. PubMed: Detection and clinical relevance of a type I allergy with occupational exposure to hexahydrophthalic anhydride and methyltetrahydrophthalic anhydride. PubMed: Hemorrhagic rhinitis. An immunologic disease due to hexahydrophthalic anhydride. PubMed: Immunologic specificity of IgG against trimellityl-human serum albumin in serum samples of workers exposed to trimellitic anhydride. PubMed: Toxicokinetics and biological monitoring in experimental exposure of humans to gaseous hexahydrophthalic anhydride. PubMed: Occupational exposure to hexahydrophthalic anhydride: air analysis, percutaneous absorption, and biological monitoring. PubMed: Method for the biological monitoring of hexahydrophthalic anhydride by the determination of hexahydrophthalic acid in urine using gas chromatography and selected-ion monitoring. PubMed: Determination of 4-methyl-cis-hexahydrophthalic anhydride in human blood by gas chromatography with electron-capture detection. PubMed: Immunologic tests of specific antibodies to organic acid anhydrides. PubMed: Determination of hexahydrophthalic anhydride in air using gas chromatography. PubMed: Occupational asthma due to hexahydrophthalic anhydride: a case report. PubMed: Allergic contact dermatitis from non-diglycidyl-ether-of-bisphenol-A epoxy resins. PubMed: Hexahydrophthalic acid in urine as an index of exposure to hexahydrophthalic anhydride. PubMed: Occupational dermatoses from epoxy resin compounds. PubMed: Occupational asthma caused by himic anhydride. PubMed: Occupational contact dermatitis and contact urticaria caused by epoxy resins. PubMed: Detection of IgE-mediated respiratory sensitization in workers exposed to hexahydrophthalic anhydride.