chloroprene
2-chloro-1,3-butadiene
Identification
| Name | chloroprene |
| CAS Number | 126-99-8 |
| EINECS | 204-826-4 |
| FDA UNII | 42L93DWV3A |
| Molecular Formula | C4 H5 Cl |
| Molecular Weight | 88.53585000 |
| Nikkaji Number | J384K |
| Beilstein | 741875 |
Regulatory
| FDA Mainterm (IAUFC) | 126-99-8 ; CHLOROPRENE |
| FDA Regulation | FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | -130.00 °C. @ 760.00 mm Hg |
| Boiling Point | 59.40 °C. @ 760.00 mm Hg |
| Vapor Pressure | 216.000000 mmHg @ 25.00 °C. |
| Flash Point | 16.00 °F. TCC ( -8.80 °C. ) (est) |
| logP (o/w) | 2.209 (est) |
| Soluble in | water, 874.9 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-mouse LD50 146 mg/kg |
| Dermal Toxicity | subcutaneous-cat LDLo 100 mg/kg |
| Inhalation Toxicity | inhalation-cat LCLo 1290 mg/m3/8H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | indirect food additives: adhesives and components of coatings |
| Recommendation for chloroprene usage levels up to | not for fragrance use. |
| Recommendation for chloroprene flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
1,3-
butadiene, 2-chloro-
2-
chloro-1,3-butadiene
2-
chlorobuta-1,3-diene
chlorobutadiene
2-
chlorobutadiene
chloroprene, inhibited [UN1991] [Flammable liquid, Poison]
PubMed:
An investigation on chloroprene-compatibilized acrylonitrile butadiene rubber/high density polyethylene blends.
PubMed:
Using gene expression profiling to evaluate cellular responses in mouse lungs exposed to V2O5 and a group of other mouse lung tumorigens and non-tumorigens.
PubMed:
Synthesis of a flexible poly(chloroprene)/methyl red film dosimeter using an environment-benign shear compounding method.
PubMed:
Hazardous air pollutants and breast cancer risk in California teachers: a cohort study.
PubMed:
Investigation of diethylthiourea and ethyl isothiocyanate as potent skin allergens in chloroprene rubber.
PubMed:
A constrained maximum likelihood approach to evaluate the impact of dose metric on cancer risk assessment: application to β-chloroprene.
PubMed:
Excretion of mercapturic acids in human urine after occupational exposure to 2-chloroprene.
PubMed:
Cross-species transcriptomic analysis of mouse and rat lung exposed to chloroprene.
PubMed:
Will medical examination gloves protect rescuers from defibrillation voltages during hands-on defibrillation?
PubMed:
Kinetic modeling of β-chloroprene metabolism: Probabilistic in vitro-in vivo extrapolation of metabolism in the lung, liver and kidneys of mice, rats and humans.
PubMed:
A method for the simultaneous determination of mercapturic acids as biomarkers of exposure to 2-chloroprene and epichlorohydrin in human urine.
PubMed:
Chloroprene.
PubMed:
A fatal intoxication by chloroprene.
PubMed:
Surface dielectric relaxation: probing technique and its application to thermal activation dynamics of polymer surface.
PubMed:
[Determination of organotin compounds in water soluble paints and adhesives by GC-MS].
PubMed:
DNA interstrand cross-linking activity of (1-Chloroethenyl)oxirane, a metabolite of beta-chloroprene.
PubMed:
Degradation of chlorinated butenes and butadienes in granular iron columns.
PubMed:
Preparation of 2-silicon-substituted 1,3-dienes and their Diels-Alder/cross-coupling reactions.
PubMed:
A frailty model approach for regression analysis of multivariate current status data.
PubMed:
4.7 Biological modeling as a method for data evaluation and integration in toxicology.
PubMed:
Epidemiologic evidence for chloroprene carcinogenicity: review of study quality and its application to risk assessment.
PubMed:
Technical performance and reflection capacity of the anaesthetic conserving device--a bench study with isoflurane and sevoflurane.
PubMed:
Regression analysis of multivariate interval-censored failure time data with application to tumorigenicity experiments.
PubMed:
Contact dermatitis from a prosthesis.
PubMed:
Identification and degradation characterization of hexachlorobutadiene degrading strain Serratia marcescens HL1.
PubMed:
Efficient estimation for the proportional hazards model with bivariate current status data.
PubMed:
Swelling of four glove materials challenged by six metalworking fluids.
PubMed:
Proceedings of the International Symposium for the Evaluation of Butadiene and Chloroprene Health Risks, September 20-22, 2005, Charleston, South Carolina, USA.
PubMed:
Preparation of 2-trialkylsiloxy- substituted 1,3-dienes and their diels-alder/cross-coupling reactions.
PubMed:
Future directions in butadiene risk assessment and the role of cross-species internal dosimetry.
PubMed:
International Symposium on the Evaluation of Butadiene and Chloroprene Health Risks.
PubMed:
Permeation of a straight oil metalworking fluid through disposable nitrile, chloroprene, vinyl, and latex gloves.
PubMed:
PBPK models in risk assessment--A focus on chloroprene.
PubMed:
Chloroprene: overview of studies under consideration for the development of an IRIS assessment.
PubMed:
Toxicology of 1,3-butadiene, chloroprene, and isoprene.
PubMed:
Chemical process based reconstruction of exposures for an epidemiological study. III. Analysis of industrial hygiene samples.
PubMed:
Comparison of standardized mortality ratios (SMRs) obtained from use of reference populations based on a company-wide registry cohort to SMRs calculated against local and national rates.
PubMed:
Spatial and temporal trend evaluation of ambient concentrations of 1,3-butadiene and chloroprene in Texas.
PubMed:
Chemical process based reconstruction of exposures for an epidemiological study. I. Theoretical and methodological issues.
PubMed:
Mortality patterns among industrial workers exposed to chloroprene and other substances. II. Mortality in relation to exposure.
PubMed:
Mortality patterns among industrial workers exposed to chloroprene and other substances. I. General mortality patterns.
PubMed:
Chemical process-based reconstruction of exposures for an epidemiological study. Part II. Estimated exposures to chloroprene and vinyl chloride.
PubMed:
The metabolism and molecular toxicology of chloroprene.
PubMed:
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
PubMed:
Fabrication of a planar-form screen-printed solid electrolyte modified Ag/AgCl reference electrode for application in a potentiometric biosensor.
PubMed:
Analyses of (1-chloroethenyl)oxirane headspace and hemoglobin N-valine adducts in erythrocytes indicate selective detoxification of (1-chloroethenyl)oxirane enantiomers.
PubMed:
Reproductive and developmental toxicity of inhaled 2,3-dichloro-1,3-butadiene in rats.
PubMed:
Effect of texture of polishing particle on the surface roughness of a cobalt-chromium alloy using a centrifugal shooting type polishing machine.
PubMed:
Preparation of 2-BF3-substituted 1,3-dienes and their Diels-Alder/cross-coupling reactions.
PubMed:
Comparison of genetic damage in Brazilian footwear-workers exposed to solvent-based or water-based adhesive.
PubMed:
Evaluation of an artificial intelligence program for estimating occupational exposures.
PubMed:
Influence of shooting angle of polishing particle on surface roughness of a cobalt-chromium alloy using a centrifugal shooting type polishing machine.
PubMed:
HPLC analysis of alkyl thioureas in an orthopaedic brace and patch testing with pure ethylbutylthiourea.
PubMed:
A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics.
PubMed:
Chloroprene.
PubMed:
Kinetic modeling of beta-chloroprene metabolism: I. In vitro rates in liver and lung tissue fractions from mice, rats, hamsters, and humans.
PubMed:
Kinetic modeling of beta-chloroprene metabolism: II. The application of physiologically based modeling for cancer dose response analysis.
PubMed:
Chloroprene.
PubMed:
Detoxication pathways involving glutathione and epoxide hydrolase in the in vitro metabolism of chloroprene.
PubMed:
The permeability of surgical gloves to seven chemicals commonly used in hospitals.
PubMed:
Permeation of 70% isopropyl alcohol through surgical gloves: comparison of the standard methods ASTM F739 and EN 374.
PubMed:
NTP Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
PubMed:
Carcinogenicity and mechanistic insights on the behavior of epoxides and epoxide-forming chemicals.
PubMed:
Identification of adducts derived from reactions of (1-chloroethenyl)oxirane with nucleosides and calf thymus DNA.
PubMed:
[Chloroprene as possible industrial carcinogen].
PubMed:
Identification of mammary carcinogens in rodent bioassays.
PubMed:
Bayesian models for multivariate current status data with informative censoring.
PubMed:
In vitro metabolism of chloroprene: species differences, epoxide stereochemistry and a de-chlorination pathway.
PubMed:
MCPA permeation through protective gloves.
PubMed:
Chloroprene as a source of fine chemicals: palladium-catalyzed synthesis of terminal allenes.
PubMed:
In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of beta-chloroprene.
PubMed:
A cohort study of workers exposed to chloroprene in the department of Isère, France.
PubMed:
Cohort studies of chloroprene-exposed workers in Russia.
PubMed:
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
PubMed:
The metabolism of beta-chloroprene: preliminary in-vitro studies using liver microsomes.
PubMed:
Occupational exposure to butadiene, isoprene and chloroprene.
PubMed:
Manufacture and use of chloroprene monomer.
PubMed:
BD monomer and elastomer production processes.
PubMed:
Overview of the acute, subchronic, reproductive, developmental and genetic toxicology of beta-chloroprene.
PubMed:
A review of the epidemiology of 1,3-butadiene and chloroprene.
PubMed:
Comparative carcinogenicity of 1,3-butadiene, isoprene, and chloroprene in rats and mice.
PubMed:
1,3-Butadiene, isoprene and chloroprene: reviews by the IARC monographs programme, outstanding issues, and research priorities in epidemiology.
PubMed:
Evaluation of 1,3-butadiene, isoprene and chloroprene health risks.
PubMed:
[Work and health status of workers of shoe manufacturing industries].
PubMed:
Evaluation of the TOPKAT system for predicting the carcinogenicity of chemicals.
PubMed:
[Exposure to chloroprene as an occupational hazard (a cohort epidemiologic study)].
PubMed:
Dose-response analyses of experimental cancer data.
PubMed:
Chloroprene.
PubMed:
In situ monitoring of the ambient air around the chloroprene rubber industrial plant using the Tradescantia-stamen-hair mutation assay.
PubMed:
Multiple organ carcinogenicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344/N rats and B6C3F1 mice and comparison of dose-response with 1,3-butadiene in mice.
PubMed:
High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.
PubMed:
Cancer incidence and mortality in a cohort of chloroprene workers from Armenia.
PubMed:
Cancer mortality among Moscow shoe workers exposed to chloroprene (Russia).
PubMed:
[New aspects of carcinogenic hazards in shoe industry (a retrospective epidemiological study)].
PubMed:
Prediction of the carcinogenicity of a second group of organic chemicals undergoing carcinogenicity testing.
PubMed:
COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.
PubMed:
Toxicity of inhaled chloroprene (2-chloro-1,3-butadiene) in F344 rats and B6C3F(1) mice.
PubMed:
Protective effect of vitamin E on liver damage induced by 2-chloro-1, 3-butadiene.
PubMed:
Bacterial mutagenicity of 2-chloro-1,3-butadiene (chloroprene) caused by decomposition products.
PubMed:
A study on reference standard for cytotoxicity assay of biomaterials.
PubMed:
[Preliminaries to a study of epidemiology of occupational cancer among workers of shoe factories].
PubMed:
Electrochemical prevention of marine biofouling with a carbon-chloroprene sheet.
PubMed:
Effects of the workplace on fertility and related reproductive outcomes.
PubMed:
[Probability of carcinogenic danger of chloroprene in chemical industry (review of literature)].
PubMed:
[Industrial hygiene in current production of synthetic chloroprene rubber].
PubMed:
[Gas chromatographic detection of 2- chlorbutadiene- 1,3 and 2,3-dichlorbutadiene- 1,3 in skin wash-off].
PubMed:
Results of NTP-sponsored mouse cytogenetic studies on 1,3-butadiene, isoprene, and chloroprene.
PubMed:
[The synthesis of chloroprene under laboratory conditions].
PubMed:
Cytogenetic assays in genotoxic studies: somatic cell effects of benzene and germinal cell effects of dibromochloropropane.
PubMed:
[Lung tumors induction short-term test of chloroprene in mice].
PubMed:
Short-term test for the induction of lung tumor in mouse by chloroprene.
PubMed:
Epidemiologic study of cancer mortality among chloroprene workers.
PubMed:
A combined testing protocol for assessing genotoxicity in individual animals: application to environmental toxicology.
PubMed:
[Beta-galactosidase activity in the seminal fluid and gonadal tissue as a biochemical criterion of the gonadotoxic effect of chemical substances].
PubMed:
The cytogenetic evaluation of in vivo genotoxic and cytotoxic activity using rodent somatic cells.
PubMed:
Genotoxic effects of a sub-acute low-level inhalation exposure to a mixture of carcinogenic chemicals.
PubMed:
Chloroprene and isoprene: cytogenetic studies in mice.
PubMed:
Eosinophilia, respiratory symptoms and pulmonary infiltrates in rubber workers.
PubMed:
[Induction of a micronucleus by chloroprene inhalation].
PubMed:
[Effect of a live tularemia vaccine on chemical mutagenesis in white rats].
PubMed:
Occupational exposures associated with male reproductive dysfunction.
PubMed:
NTP Toxicology and Carcinogenesis Studies of 1,3-Butadiene (CAS No. 106-99-0) in B6C3F1 Mice (Inhalation Studies).
PubMed:
[Comparative characteristics of the changes in the microsomal enzyme system under the biological action of chromium and chloroprene].
PubMed:
[Experimental study of the local and skin-resorptive effects of chemicals used in the manufacture of chloroprene rubber from butadiene].
PubMed:
Experimental and naturally-occurring gastric foreign bodies in laboratory rabbits.
PubMed:
Reproductive hazards in the work place.
PubMed:
Percutaneous absorption and chemical carcinogenesis.
PubMed:
The epidemiology and etiology of lung cancer.
PubMed:
[Development of gas chromatographic technics to determine chloroprene in blood and milk].
PubMed:
[Defunctionalization of the exocrine pancreas by central or peripheral obstruction of the excretory ductal system (experimental study)].
PubMed:
[Functional value of the pancreatic microtransplant in rats after intraductal injection of chloroprene].
PubMed:
Mutagenicity of rubber vulcanization gases in Salmonella typhimurium.
PubMed:
[Biological action of polymeric materials used in the manufacture of shoes].
PubMed:
[Treatment results in pancreatic fistulae using a method of occluding the pancreatic duct].
PubMed:
Biochemical and hematological evaluation of chloroprene workers.
PubMed:
Threshold levels in toxicology: significance of inactivation mechanisms.
PubMed:
Detoxification of chloroprene (2-chloro-1,3-butadiene) with glutathione in the rat.
PubMed:
[Disinfection effect of Orthosan BF12 on the collection strains of microbes and on strains isolated from clinical material (author's transl)].
PubMed:
[Exogenous causes of infertility. A literature review].
PubMed:
[Male reproductive function studied under the action of chemical substances].
PubMed:
[Effect of chloroprene on body enzymatic systems and its hygienic significance].
PubMed:
Long-term testing of vinylidene chloride and chloroprene for carcinogenicity in rats.
PubMed:
Permeation of glove materials by physiologically harmful chemicals.
PubMed:
Acute inhalation toxicity of 2-chloro-1,3-butadiene (chloroprene): effects on liver and lung.
PubMed:
Risks to the offspring from parental occupational exposures.
PubMed:
[Toxic diffuse alopecia after chloroprene as a consequence of toxicomania (author's transl)].
PubMed:
Mutagenicity of chloroprene, 1-chloro-1,3-trans-butadiene, 1-4-dichlorobutene-2 and 1,4-dichloro-2,3-epoxybutane in Drosophila melanogaster.
PubMed:
Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells.
PubMed:
[In vitro malignant transformation of hamster lung cells by 2-chlorobutadiene].
PubMed:
Potential halogenated industrial carcinogenic and mutagenic chemicals. I. Halogenated unsaturated hydrocarbons.
PubMed:
Chloroprene and polychloroprene.
PubMed:
Toxicity of beta-chloroprene (2-chlorobutadiene-1,3): acute and subacute toxicity.
PubMed:
[Comparison of epidemiological and experimental data on the influence of industrial solvents on workers].
PubMed:
Inhalation studies to evaluate the teratogenic and embryotoxic potential of beta-chloroprene (2-chlorobutadiene-1,3).
PubMed:
Genetic activity of allyl chloride.
PubMed:
[Effect of alpha-tocopherol acetate on Krebs cycle enzymatic activity in the rat brain in chloroprene poisoning].
PubMed:
Mortality of workers exposed to chloroprene.
PubMed:
Chloroprene (2-chloro-1, 3-butadiene)--what is the evidence for its carcinogenicity?
PubMed:
Mutagenic and carcinogenic risks associated with halogenated olefins.
PubMed:
Toxicity of chloroprene, 1,3-dichlorobutene-2, and 1,4-dichlorobutene-2.
PubMed:
[Experimental study of chloroprene for carcinogenicity].
PubMed:
Aspects of the toxicology of chloroprene: immediate and long-term effects.
PubMed:
[Changes in the sex organs of rats with chronic chloroprene poisoning].
PubMed:
[Establishing the value of the MPEL of chloroprene in the air of a work area].
PubMed:
Cancer risks among workers exposed to chloroprene.
PubMed:
[Immunologic shifts in the body of albino rats under the effect of chloroprene].
PubMed:
[Pentose cycle enzymatic activity in the liver of rats with chronic chloroprene toxicosis and the role of vitamin E in this process].
PubMed:
[Reproductive function and sex maturation in rats of 3 generations born to mothers with chloroprene poisoning].
PubMed:
[Results of a study of the mutagenic activity of chloroprene on microorganisms].
PubMed:
Industrial mutagens and potential mutagens I. Halogenated aliphatic derivatives.
PubMed:
[Comparative characteristics of the embryotropic effect of chloroprene depending on the mode of action via different routes of intake into the body].
PubMed:
Background information on chloroprene.
PubMed:
[Ultrastructure of the adrenal cortex of albino rats in chronic chloroprene poisoning].
PubMed:
[Ultrastructure of blood capillaries of the ovaries of albino rats under conditions of chronic chloroprene poisoning].
PubMed:
[Hyaluronidase activity in the placenta in chloroprene poisoning].
PubMed:
[Comparative characteristics of individual and total amino acids in breast milk of parturients: workers and women living in the villages located at different distance from the synthetic chloroprene resin plant].
PubMed:
[Cytogenetic analysis of the peripheral blood of workers engaged in the manufacture of chloroprene].
PubMed:
[Experimental study of the effect of chloroprene on embryogenesis].
PubMed:
[Comparative evaluation of the sensitivity of the pregnant and nonpregnant organism to chloroprene in an experiment].
PubMed:
[Immunomorphology of chloroprene toxicosis].
PubMed:
[Role of chloroprene compounds in the process of neoplastic formations of the skin].
PubMed:
[Lung cancer morbidity among persons working with chloroprene].
PubMed:
[Occupational hair loss due to chloroprene].
PubMed:
[The histamine level and histaminase activity of the blood in workers with chronic chloroprene poisoning].
PubMed:
[Pathological changes in the teeth and oral mucosa in workers of the chloroprene rubber industry].
PubMed:
[The effect of microconcentrations of chloroprene in the atmosphere on the function of the adrenal glands of children].
PubMed:
[Estrual cycle and ovarian structure in white rats with chronic chloroprene intoxication].
PubMed:
[Data on neuro-humoral changes caused by chloroprene].
PubMed:
[Electroencephalographic investigations in chronic chloroprene poisoning].
PubMed:
[ON THE EFFECT OF LOW CONCENTRATIONS OF CHLOROPRENE OF PORPHYRIN METABOLISM IN CHILDREN].
PubMed:
[DATA FOR DETERMINING THE MAXIMUM PERMISSIBLE CONCENTRATION OF CHLOROPRENE IN THE AIR].
PubMed:
[ON THE CONTENT OF ACETYLCHOLINE AND CHOLINESTERASE ACTIVITY OF THE BLOOD OF WORKERS EMPLOYED IN THE PRODUCTION OF THE CHLOROPRENE RUBBER].
PubMed:
[Estrus cycle in white rats in chronic chloroprene poisoning].
PubMed:
[Regenerative function of white rat ovaries in chronic chloroprene poisoning].
PubMed:
Depilatory Action of the Intermediary Polymers of Chloroprene.
PubMed:
Depilatory action of the intermediary polymers of chloroprene.
PubMed:
Elasticity measurements on polychloroprenes.