vitamin A acetate

acetic acid, retinyl ester

CAS: 127-47-9 C22 H32 O2 MW: 328.49544000

Identification

Namevitamin A acetate
CAS Number127-47-9
EINECS204-844-2
FDA UNII3LE3D9D6OY
Molecular FormulaC22 H32 O2
Molecular Weight328.49544000
MDL NumberMFCD00019413
Nikkaji NumberJ34.628D
Beilstein1915439
XlogP36.30 (est)

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices184.1930
FDA Mainterm (SATF)127-47-9 ; VITAMIN A ACETATE
FDA RegulationFDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.0003555 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 4100 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient supplements
Recommendation for vitamin A acetate usage levels up tonot for fragrance use.
Recommendation for vitamin A acetate flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

View All Website (800) 238-0001 info@aicma.com

BOC Sciences

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Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

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Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Zanos Ltd.

Distributor of Speciality Chemicals and Natural Ingredients

Sourcing and supplying quality aroma chemicals and prestige natural ingredients for the flavour and fragrance industry.

View All Website +44 (0) 1565 755899 sales@zanos.co.uk

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

acetic acid, retinyl ester (2E,4E,6E,8E)-3,7- dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate (2E,4E,6E,8E)-3,7- dimethyl-9-(2,6,6-trimethylcyclohex-1-enyl)nona-2,4,6,8-tetr aenyl acetate [(2E,4E,6E,8E)-3,7- dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate all-trans- retinol acetate retinyl acetate all-trans- retinyl acetate all-trans- retinylacetate vitamin A acetate all-trans- vitamin A acetate PubMed: Determination of vitamins A and E in infant formula and adult/pediatric nutritional formula by HPLC with UV and fluorescence detection: First Action 2012.09. PubMed: Triple-fortified rice containing vitamin A reduced marginal vitamin A deficiency and increased vitamin A liver stores in school-aged Thai children. PubMed: Simultaneous determination of 13-cis and all-trans vitamin A palmitate (retinyl palmitate), vitamin A acetate (retinyl acetate), and total vitamin E (alpha-tocopherol and DL-alpha-tocopherol acetate) in infant formula and adult nutritionals by normal phase HPLC: first action 2012.10. PubMed: [Effects of vitamin A supplementation on nutritional status of iron in healthy adults]. PubMed: β-Carotene in Golden Rice is as good as β-carotene in oil at providing vitamin A to children. PubMed: Safety evaluation of vitamin A in growing dogs. PubMed: Cloning, expression and characterization of a lipase gene from the Candida antarctica ZJB09193 and its application in biosynthesis of vitamin A esters. PubMed: The effect of food preparation on the bioavailability of carotenoids from carrots using intrinsic labelling. PubMed: UVA photoirradiation of anhydroretinol--formation of singlet oxygen and superoxide. PubMed: Vitamin A equivalence of spirulina beta-carotene in Chinese adults as assessed by using a stable-isotope reference method. PubMed: beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements. PubMed: [Vitamin A equivalence of spinach beta-carotene in human body]. PubMed: Use of metabolic stimulators and inhibitors for enhanced production of beta-carotene and lycopene by Blakeslea trispora NRRL 2895 and 2896. PubMed: Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice. PubMed: Interactions of human serum albumin with retinoic acid, retinal and retinyl acetate. PubMed: Photodecomposition and phototoxicity of natural retinoids. PubMed: Spinach or carrots can supply significant amounts of vitamin A as assessed by feeding with intrinsically deuterated vegetables. PubMed: Photoreaction, phototoxicity, and photocarcinogenicity of retinoids. PubMed: Photodecomposition of retinyl palmitate in ethanol by UVA light-formation of photodecomposition products, reactive oxygen species, and lipid peroxides. PubMed: Use of the deuterated-retinol-dilution technique to monitor the vitamin A status of Nicaraguan schoolchildren 1 y after initiation of the Nicaraguan national program of sugar fortification with vitamin A. PubMed: Rapid determination by reversed-phase high-performance liquid chromatography of Vitamins A and E in infant formulas. PubMed: Mechanisms of TCDD-induced abnormalities and embryo lethality in white leghorn chickens. PubMed: Teratogenic effects of chronic ingestion of high levels of vitamin A in cats. PubMed: [Evaluation on intestinal and whole-body conversion of beta-carotene to vitamin A in Chinese adults using a stable isotope reference method]. PubMed: Simultaneous determination of vitamin A and beta-carotene in dietary supplements by liquid chromatography. PubMed: Determination of liposoluble vitamins in cooked meals, milk and milk products by liquid chromatography. PubMed: Alpha- and beta-carotene from a commercial puree are more bioavailable to humans than from boiled-mashed carrots, as determined using an extrinsic stable isotope reference method. PubMed: Bioavailability and antioxidant activity of some food supplements in men and women using the D-Roms test as a marker of oxidative stress. PubMed: A novel extrinsic reference method for assessing the vitamin A value of plant foods. PubMed: Influence of vitamin A status on the regulation of uridine (5'-)diphosphate-glucuronosyltransferase (UGT) 1A1 and UGT1A6 expression by L-triiodothyronine. PubMed: On-line supercritical fluid extraction/enzymatic hydrolysis of vitamin a esters: a new simplified approach for the determination of vitamins a and e in food. PubMed: A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk. PubMed: Bioavailability trials of beta-carotene from fresh and dehydrated drumstick leaves (Moringa oleifera) in a rat model. PubMed: Dietary vitamin A modulates the concentrations of RRR-alpha-tocopherol in plasma lipoproteins from calves fed milk replacer. PubMed: Estimation of the dietary vitamin A requirement of juvenile grass shrimp, Penaeus monodon. PubMed: Antimutagenic effects and possible mechanisms of action of vitamins and related compounds against genotoxic heterocyclic amines from cooked food. PubMed: Bioavailability of carotenoids in human subjects. PubMed: Effect of reduced body weight gain on the evaluation of chemopreventive agents in the methylnitrosourea-induced mammary cancer model. PubMed: Effect of vitamin A on the oxidative stability of broiler meat during storage: lack of interactions with vitamin E. PubMed: Binding of retinoids to beta-lactoglobulin isolated by bioselective adsorption. PubMed: Suppressive effects of retinoids, carotenoids and antioxidant vitamins on heterocyclic amine-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002). PubMed: Interactions in indices of vitamin A, zinc and copper status when these nutrients are fed to rats at adequate and increased levels. PubMed: Effect of retinyl acetate, ascorbic acid and tocopherol supplementation of the feed on egg vitamin A content in Japanese quail. PubMed: Pigment cholelithiasis induced by vitamin A and its prevention by butylated hydroxytoluene. PubMed: Strain variation in vitamin A (retinol) status of streptozotocin-induced diabetic rats. PubMed: Consumption of excess vitamin A, but not excess beta-carotene, causes accumulation of retinol that exceeds the binding capacity of cellular retinol-binding protein, type II in rat intestine. PubMed: The effect of excessive dietary vitamin A on performance and vitamin E status in swine fed diets varying in dietary vitamin E. PubMed: Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. PubMed: Glucuronidation of all-trans-retinoic acid in liposomal membranes. PubMed: The influence of dietary levels of vitamin A and fat on colon cancer. PubMed: Effects of dietary retinyl acetate on the promotion of hepatic enzyme-altered foci by polybrominated biphenyls in initiated rats. PubMed: Modification of retinyl acetate toxicity in rats by coadministration of menhaden oil. PubMed: Relationship of vitamin A and vitamin E intake to fasting plasma retinol, retinol-binding protein, retinyl esters, carotene, alpha-tocopherol, and cholesterol among elderly people and young adults: increased plasma retinyl esters among vitamin A-supplement users. PubMed: Retinyl acetate inhibits estrogen-induced mammary carcinogenesis in female ACI rats. PubMed: Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomach hyperplasia--complete inhibition by diethylmaleate in a 5-week feeding study. PubMed: Zinc-vitamin A interaction in pregnant and fetal rats: supplemental vitamin A does not prevent zinc-deficiency-induced teratogenesis. PubMed: Effect of moderate vitamin A supplementation and lack of dietary vitamin A on the development of mammary tumors in female rats treated with low carcinogenic dose levels of 7,12-dimethylbenz(a)anthracene. PubMed: Effects of vitamin A on cyclophosphamide mutagenicity in vitro (Ames test) and in vivo (mouse micronucleus test). PubMed: Fat and vitamin A stability in the presence of Ronoxan A and other antioxidants. PubMed: Localization of tritiated vitamin A in lymph nodes of the mouse: an autoradiographic study of vitamin A-storing cells. PubMed: Vitamin A - application technology. PubMed: Hypervitaminosis A combined with calcium deficiency in rats. PubMed: Studies on urinary arylsulphatase activity in vitamin A deficient rats. PubMed: Influence of excess vitamin E on vitamin A toxicity in rats. PubMed: Polarography of conjugated unsaturated lipids.