bromhexine hydrochloride
2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride (1:1)
Identification
| Name | bromhexine hydrochloride |
| IUPAC | 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride |
| CAS Number | 611-75-6 |
| EINECS | 210-280-8 |
| FDA UNII | YC2ZOM3Z8V |
| Molecular Formula | C14 H21 Br2 Cl N2 |
| Molecular Weight | 412.59537000 |
| MDL Number | MFCD00056626 |
| Beilstein | 4848376 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 441.50 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point | 429.00 °F. TCC ( 220.80 °C. ) (est) |
| logP (o/w) | 5.081 (est) |
| Soluble in | water, 5.346 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 2210 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 > 14000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for bromhexine hydrochloride usage levels up to | not for fragrance use. |
| Recommendation for bromhexine hydrochloride flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2-
amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine monohydrochloride
2-
amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride
[(2-
amino-3,5-dibromophenyl)methyl]cyclohexylmethylamine, chloride
2-
amino-N-cyclohexyl-3,5-dibromo-N-methylbenzylamine hydrochloride
benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, hydrochloride (1:1)
benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, monohydrochloride
benzylamine, 2-amino-N-cyclohexyl-3,5-dibromo-N-methyl-, hydrochloride
bisolvon
bromhexine chloride
bromhexine HCl
bromhexinehydrochloride
bromohexine HCl
bromohexine hydrochloride
N-
cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium chloride
2,4-
dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
2,4-
dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride (1:1)
3,5-
dibromo-Na-cyclohexyl-Na-methyltoluene-a,2-diamine Hydrochloride
PubMed:
Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples.
PubMed:
Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation.
PubMed:
On the formation of bromhexine impurity E and its chromatographic behaviour.
PubMed:
Solubility and solution stability studies of different amino acid prodrugs of bromhexine.
PubMed:
Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin.
PubMed:
[Treatment of acute exacerbation of the obstructive pulmonary disease with hospitalization at an intensive care unit].
PubMed:
Cyclodextrins: Efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems.
PubMed:
Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration.
PubMed:
Simultaneous determination of salbutamol sulphate and bromhexine hydrochloride in tablets by reverse phase liquid chromatography.
PubMed:
Recent developments in the treatment of alcoholic chronic pancreatitis.
PubMed:
Bioequivalence study of bromhexine by liquid chromatography-electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets.
PubMed:
Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent.
PubMed:
Design and evaluation of deformable talc agglomerates prepared by crystallo-co-agglomeration technique for generating heterogeneous matrix.
PubMed:
Simultaneous determination of salbutamol sulphate, bromhexine hydrochloride and etofylline in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods.
PubMed:
Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs.
PubMed:
Effect of bromhexine hydrochloride therapy for alcoholic chronic pancreatitis.
PubMed:
A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis.
PubMed:
Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography.
PubMed:
Mediastinal pancreatic pseudocyst caused by obstruction of the pancreatic duct was eliminated by bromhexine hydrochloride.
PubMed:
Treatment of gingival overgrowth induced by manidipine administration. A case report.
PubMed:
Solubilization of bromhexine hydrochloride in aqueous lecithin dispersions. Physicochemical characterization of interactions between drug and carrier.
PubMed:
Sjögren syndrome associated with multiple myeloma of the IgA κ-type.
PubMed:
Bromhexine hydrochloride eliminates protein plugs and relieves attacks of pancreatitis.
PubMed:
Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography.
PubMed:
Improvement of some pharmaceutical properties of drugs by cyclodextrin complexation. 3. Bromhexine hydrochloride.
PubMed:
[Experimental studies on the influence of selected preparations on secretion of tear fluid. II: Light and transmission electron microscopy].
PubMed:
[Experimental studies on the influence of selected preparations on secretion of tear fluid. I. Schirmer test I and lysozyme test].
PubMed:
Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry.
PubMed:
Bromhexine plus oxytetracycline: the effect of combined administration upon the rheological properties of mucus from the mini-pig.
PubMed:
Predisposition to uterine microbial contamination in the guinea-pig following administration of mucolytic drugs and steroid hormones.
PubMed:
[Experimental investigations on the influence of bromhexine hydrochloride on the excretion of lacrimal fluid].
PubMed:
The effect of bromhexine hydrochloride on the viscoelastic properties of mucus from the mini-pig.
PubMed:
[Simultaneous determination of three components in compound clorprenaline tablet by using the derivative-complementary tristimulus method].
PubMed:
Lack of detectable DNA alkylation for bromhexine in man.
PubMed:
The effects of bromhexine hydrochloride and S-carboxymethyl-L-cysteine on guinea-pig uterine microflora.
PubMed:
The negative effects of mucolytics in otitis media with effusion.
PubMed:
Gas-liquid chromatographic and ion-pair high-performance liquid chromatographic determination of pseudoephedrine hydrochloride and bromhexine hydrochloride in pharmaceuticals.
PubMed:
[Application of second derivative spectrometry to the determination of bromhexine hydrochloride and spectrophotometry to the determination of dyphylline in compound preparations].
PubMed:
Bromhexine in the treatment of otitis media with effusion.
PubMed:
Spectrophotometric determination of bromhexine hydrochloride in pharmaceutical preparations.
PubMed:
[Pharmacological effects of brovanexine hydrochloride (BR-222) on the respiratory tract system, particularly on the respiratory tract fluid, mucociliary transport and cough].
PubMed:
Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo.
PubMed:
Bioavailability of bromhexine tablets and preliminary pharmacokinetics in humans.
PubMed:
[Incompatibility of cefotiam dihydrochloride in parenteral preparation by high-performance liquid chromatography].
PubMed:
Bromhexine for otitis media with effusion.
PubMed:
Pharmacokinetics of bromhexine in the dog.
PubMed:
Bromhexine hydrochloride in chronic secretory otitis media--a clinical trial.