bromhexine hydrochloride

2,4-dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride (1:1)

CAS: 611-75-6 C14 H21 Br2 Cl N2 MW: 412.59537000

Identification

Namebromhexine hydrochloride
IUPAC2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride
CAS Number611-75-6
EINECS210-280-8
FDA UNIIYC2ZOM3Z8V
Molecular FormulaC14 H21 Br2 Cl N2
Molecular Weight412.59537000
MDL NumberMFCD00056626
Beilstein4848376

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 441.50 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000000 mmHg @ 25.00 °C. (est)
Flash Point 429.00 °F. TCC ( 220.80 °C. ) (est)
logP (o/w) 5.081 (est)
Soluble in water, 5.346 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 2210 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 > 14000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for bromhexine hydrochloride usage levels up tonot for fragrance use.
Recommendation for bromhexine hydrochloride flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2- amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine monohydrochloride 2- amino-3,5-dibromo-N-cyclohexyl-N-methylbenzylamine hydrochloride [(2- amino-3,5-dibromophenyl)methyl]cyclohexylmethylamine, chloride 2- amino-N-cyclohexyl-3,5-dibromo-N-methylbenzylamine hydrochloride benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, hydrochloride (1:1) benzenemethanamine, 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl-, monohydrochloride benzylamine, 2-amino-N-cyclohexyl-3,5-dibromo-N-methyl-, hydrochloride bisolvon bromhexine chloride bromhexine HCl bromhexinehydrochloride bromohexine HCl bromohexine hydrochloride N- cyclohexyl-N-methyl-(2-amino-3,5-dibromobenzyl)ammonium chloride 2,4- dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline;hydrochloride 2,4- dibromo-6-{[cyclohexyl(methyl)amino]methyl}aniline hydrochloride (1:1) 3,5- dibromo-Na-cyclohexyl-Na-methyltoluene-a,2-diamine Hydrochloride PubMed: Extractive determination of ephedrine hydrochloride and bromhexine hydrochloride in pure solutions, pharmaceutical dosage form and urine samples. PubMed: Investigation of internal structure of fine granules by microtomography using synchrotron X-ray radiation. PubMed: On the formation of bromhexine impurity E and its chromatographic behaviour. PubMed: Solubility and solution stability studies of different amino acid prodrugs of bromhexine. PubMed: Stability-indicating HPLC Method for Simultaneous Determination of Terbutaline Sulphate, Bromhexine Hydrochloride and Guaifenesin. PubMed: [Treatment of acute exacerbation of the obstructive pulmonary disease with hospitalization at an intensive care unit]. PubMed: Cyclodextrins: Efficient biocompatible solubilizing excipients for bromhexine liquid and semi-solid drug delivery systems. PubMed: Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration. PubMed: Simultaneous determination of salbutamol sulphate and bromhexine hydrochloride in tablets by reverse phase liquid chromatography. PubMed: Recent developments in the treatment of alcoholic chronic pancreatitis. PubMed: Bioequivalence study of bromhexine by liquid chromatography-electrospray ionization-mass spectrometry after oral administration of bromhexine hydrochloride tablets. PubMed: Chemiluminescence determination of bromhexine hydrochloride with morin as chemiluminescent reagent. PubMed: Design and evaluation of deformable talc agglomerates prepared by crystallo-co-agglomeration technique for generating heterogeneous matrix. PubMed: Simultaneous determination of salbutamol sulphate, bromhexine hydrochloride and etofylline in pharmaceutical formulations with the use of four rapid derivative spectrophotometric methods. PubMed: Development and validation of chemometrics-assisted spectrophotometric and liquid chromatographic methods for the simultaneous determination of two multicomponent mixtures containing bronchodilator drugs. PubMed: Effect of bromhexine hydrochloride therapy for alcoholic chronic pancreatitis. PubMed: A pilot study of aerosolized N-acetylcysteine for idiopathic pulmonary fibrosis. PubMed: Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography. PubMed: Mediastinal pancreatic pseudocyst caused by obstruction of the pancreatic duct was eliminated by bromhexine hydrochloride. PubMed: Treatment of gingival overgrowth induced by manidipine administration. A case report. PubMed: Solubilization of bromhexine hydrochloride in aqueous lecithin dispersions. Physicochemical characterization of interactions between drug and carrier. PubMed: Sjögren syndrome associated with multiple myeloma of the IgA κ-type. PubMed: Bromhexine hydrochloride eliminates protein plugs and relieves attacks of pancreatitis. PubMed: Simultaneous determination of bromhexine hydrochloride and methyl and propyl p-hydroxybenzoate and determination of dextromethorphan hydrobromide in cough-cold syrup by high-performance liquid chromatography. PubMed: Improvement of some pharmaceutical properties of drugs by cyclodextrin complexation. 3. Bromhexine hydrochloride. PubMed: [Experimental studies on the influence of selected preparations on secretion of tear fluid. II: Light and transmission electron microscopy]. PubMed: [Experimental studies on the influence of selected preparations on secretion of tear fluid. I. Schirmer test I and lysozyme test]. PubMed: Automatic determination of amylocaine and bromhexine by atomic absorption spectrometry. PubMed: Bromhexine plus oxytetracycline: the effect of combined administration upon the rheological properties of mucus from the mini-pig. PubMed: Predisposition to uterine microbial contamination in the guinea-pig following administration of mucolytic drugs and steroid hormones. PubMed: [Experimental investigations on the influence of bromhexine hydrochloride on the excretion of lacrimal fluid]. PubMed: The effect of bromhexine hydrochloride on the viscoelastic properties of mucus from the mini-pig. PubMed: [Simultaneous determination of three components in compound clorprenaline tablet by using the derivative-complementary tristimulus method]. PubMed: Lack of detectable DNA alkylation for bromhexine in man. PubMed: The effects of bromhexine hydrochloride and S-carboxymethyl-L-cysteine on guinea-pig uterine microflora. PubMed: The negative effects of mucolytics in otitis media with effusion. PubMed: Gas-liquid chromatographic and ion-pair high-performance liquid chromatographic determination of pseudoephedrine hydrochloride and bromhexine hydrochloride in pharmaceuticals. PubMed: [Application of second derivative spectrometry to the determination of bromhexine hydrochloride and spectrophotometry to the determination of dyphylline in compound preparations]. PubMed: Bromhexine in the treatment of otitis media with effusion. PubMed: Spectrophotometric determination of bromhexine hydrochloride in pharmaceutical preparations. PubMed: [Pharmacological effects of brovanexine hydrochloride (BR-222) on the respiratory tract system, particularly on the respiratory tract fluid, mucociliary transport and cough]. PubMed: Effect of expectorants on relaxation behavior of sputum viscoelasticity in vivo. PubMed: Bioavailability of bromhexine tablets and preliminary pharmacokinetics in humans. PubMed: [Incompatibility of cefotiam dihydrochloride in parenteral preparation by high-performance liquid chromatography]. PubMed: Bromhexine for otitis media with effusion. PubMed: Pharmacokinetics of bromhexine in the dog. PubMed: Bromhexine hydrochloride in chronic secretory otitis media--a clinical trial.