sodium feredetate

acetic acid, (ethylenedinitrilo)tetra-, sodium salt, iron complex

CAS: 15708-41-5 C10 H12 Fe N2 Na O8 MW: 367.04800928

Identification

Namesodium feredetate
CAS Number15708-41-5
EINECS239-802-2
FDA UNII403J23EMFA
Molecular FormulaC10 H12 Fe N2 Na O8
Molecular Weight367.04800928
MDL NumberMFCD00078215
Nikkaji NumberJ2.239.441J

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices1980
JECFA Food AdditiveSodium Iron (III) Ethylenediaminetetraacetate, Trihydrate
FDA Mainterm (IAUFC)15708-41-5 ; EDTA, IRON (III) SODIUM

Physical Properties

Appearance pale yellow powder (est)
Assay 80.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 614.20 °C. @ 760.00 mm Hg (est)
Flash Point 617.00 °F. TCC ( 325.20 °C. ) (est)
logP (o/w) -0.434 (est)
Soluble in water

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 5000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient supplements
Recommendation for sodium feredetate usage levels up tonot for fragrance use.
Recommendation for sodium feredetate flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

acetic acid, (ethylenedinitrilo)tetra-, sodium salt, iron complex EDTA ferric sodium salt EDTA iron(III) sodium salt [[N,N'- ethanediylbis[N-(carboxymethyl)glycinato]](4-)]-N,N',O,O',ON,ON'-ferrate(1-) Sodium ethylenediaminetetraacetic acid ferric sodium salt ethylenediaminetetraacetic acid,monosodium ferric salt ethylenedinitrilo)tetraacetic acid, monosodium iron salt ferrate(1-), ((ethylenedinitrilo)tetraacetato)-, sodium (8CI) ferrazone ferric sodium edetate ferric sodium EDTA ferric sodium ethylenediaminetetraacetate iron chelate of the monosodium salt of (ethylenedinitrilo) tetraacetic acid iron chelate of the monosodium salt of (ethylenedinitrilo)tetraacetic acid iron sodium ethylenediaminetetraacetate (1:1:1) iron(3+) sodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate iron(3+) sodium 2,2',2'',2'''-(1,2-ethanediyldinitrilo)tetraacetate (1:1:1) iron(3+) sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate iron(3+) sodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate (1:1:1) iron(III)-sodium ethylenediaminetetraacetate hydrate sodium ((ethylenedinitrilo)tetraacetato)ferrate(1-) sodium (N,N,N',N'-ethylenediaminetetraacetato)ferrate(1-) sodium [(ethylenedinitrilo)tetraacetato]ferrate(1-) sodium ferric EDTA sodium ferric ethylenediaminetetraacetate sodium iron edetate sodium iron EDTA sodium Iron(III) ethylene diamine tetraacetate trihydrate sodium iron(III) ethylenediaminetetraacetate sodium ironedetate sodium; 2-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl-(2-oxido-2-oxoethyl)amino] acetate; iron(3+) PubMed: [Meta analysis of condiments fortified with sodium iron ethylenediaminetetraacetate on the prevention and treatment of anemia]. PubMed: Reasons for raising the maximum acceptable daily intake of EDTA and the benefits for iron fortification of foods for children 6-24 months of age. PubMed: Impact of activation methods on persulfate oxidation of methyl tert-butyl ether. PubMed: Rapid quantification of iron content in fish sauce and soy sauce: a promising tool for monitoring fortification programs. PubMed: Fish sauce, soy sauce, and vegetable oil fortification in Cambodia: where do we stand to date? PubMed: Differences in circulating non-transferrin-bound iron after oral administration of ferrous sulfate, sodium iron EDTA, or iron polymaltose in women with marginal iron stores. PubMed: Sodium iron EDTA and ascorbic acid, but not polyphenol oxidase treatment, counteract the strong inhibitory effect of polyphenols from brown sorghum on the absorption of fortification iron in young women. PubMed: Iron bioavailability from a lipid-based complementary food fortificant mixed with millet porridge can be optimized by adding phytase and ascorbic acid but not by using a mixture of ferrous sulfate and sodium iron EDTA. PubMed: Fortification of wheat flour and maize meal with different iron compounds: results of a series of baking trials. PubMed: Fortification of staple cereal flours with iron and other micronutrients: cost implications of following World Health Organization-endorsed recommendations. PubMed: Effect of wheat flour fortified with sodium iron EDTA on urinary zinc excretion in school-aged children. PubMed: Oral administration of ferrous sulfate, but not of iron polymaltose or sodium iron ethylenediaminetetraacetic acid (NaFeEDTA), results in a substantial increase of non-transferrin-bound iron in healthy iron-adequate men. PubMed: Mixture of ferric sodium ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate: an effective iron fortificant for complementary foods for young Chinese children. PubMed: Effect of iron-fortified foods on hematologic and biological outcomes: systematic review of randomized controlled trials. PubMed: [Iron and zinc in vitro potential availability in an infant diet with fortified bread with different iron sources or with the addition of different iron absorption promoters]. PubMed: Equivalent effects on fecal reactive oxygen species generation with oral supplementation of three iron compounds: ferrous sulfate, sodium iron EDTA and iron polymaltose. PubMed: Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women. PubMed: Fortifying complementary foods with NaFeEDTA--considerations for developing countries. PubMed: Development of fortified biscuit using NaFeEDTA. PubMed: Fortification iron as ferrous sulfate plus ascorbic acid is more rapidly absorbed than as sodium iron EDTA but neither increases serum nontransferrin-bound iron in women. PubMed: Random serial sampling to evaluate efficacy of iron fortification: a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate. PubMed: Comparative study of efficacy, tolerability and compliance of oral iron preparations (iron edetae, iron polymatose complex) and intramuscular iron sorbitol in iron deficiency anaemia in children. PubMed: Oral supplementation with NaFeEDTA reduces blood lead in postmenopausal but not premenopausal Korean women with anemia. PubMed: Effect of sodium iron ethylenediaminetetra-acetate (NaFeEDTA) on haemoglobin and serum ferritin in iron-deficient populations: a systematic review and meta-analysis of randomised and quasi-randomised controlled trials. PubMed: Fortifying brown bread with sodium iron EDTA, ferrous fumarate, or electrolytic iron does not affect iron status in South African schoolchildren. PubMed: A randomised double-blind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy. PubMed: Tissue iron distribution and urinary mineral excretion vary depending on the form of iron (FeSO4 or NaFeEDTA) and the route of administration (oral or subcutaneous) in rats given high doses of iron. PubMed: Effects of various iron fortificants on sensory acceptability and shelf-life stability of instant noodles. PubMed: Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: a randomised controlled trial. PubMed: Iron dissociates from the NaFeEDTA complex prior to or during intestinal absorption in rats. PubMed: Iron uptake by Caco-2 cells from NaFeEDTA and FeSO4: Effects of ascorbic acid, pH, and a Fe(II) chelating agent. PubMed: Sodium iron (III) ethylenediaminetetraacetic acid synthesis to reduce iron deficiency globally. PubMed: [Determination of sodium iron (III) ethylenediaminetetraacetate in iron-fortified soy sauce by reversed-phase ion-pair high performance liquid chromatography]. PubMed: [Capillary zone electrophoretic determination of NaFeEDTA in iron fortified soy sauce]. PubMed: Studies on the effectiveness of NaFeEDTA-fortified soy sauce in controlling iron deficiency: a population-based intervention trial. PubMed: Increased osmolality of breast milk with therapeutic additives. PubMed: Alkaline anaerobic respiration: isolation and characterization of a novel alkaliphilic and metal-reducing bacterium. PubMed: [Study on the effect of NaFeEDTA on preventing lead poisoning in rats and its impact on zinc, copper]. PubMed: Iron absorption from fish sauce and soy sauce fortified with sodium iron EDTA. PubMed: Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. PubMed: The effect of different iron fortificants on iron absorption from iron-fortified rice. PubMed: Photodegradation of ethylenediaminetetraacetic acid (EDTA) and ethylenediamine disuccinic acid (EDDS) within natural UV radiation range. PubMed: The effect of change in pH on the solubility of iron bis-glycinate chelate and other iron compounds. PubMed: Overexpression of EC-SOD suppresses endothelial-cell-mediated LDL oxidation. PubMed: Disposition, accumulation and toxicity of iron fed as iron (II) sulfate or as sodium iron EDTA in rats. PubMed: Absorption of iron from unmodified maize and genetically altered, low-phytate maize fortified with ferrous sulfate or sodium iron EDTA. PubMed: Safety assessment of iron EDTA [sodium iron (Fe(3+)) ethylenediaminetetraacetic acid]: summary of toxicological, fortification and exposure data. PubMed: Genotoxicity of iron compounds in Salmonella typhimurium and L5178Y mouse lymphoma cells. PubMed: Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant does not influence absorption and urinary excretion of manganese in healthy adults. PubMed: Short communication: the use of sodium ironedetate (Sytron) as an MRI rectal contrast agent. PubMed: Fortification of sugar with iron sodium ethylenediaminotetraacetate (FeNaEDTA) improves iron status in semirural Guatemalan populations. PubMed: Iron from complex salts and its bioavailability to rats. PubMed: Fractionation of liver microsomes with polyethylene glycol and purification of NADH-cytochrome b5 oxidoreductase and cytochrome b5. PubMed: Synthesis and iron(III) binding properties of 3-hydroxypyrid-4-ones derived from kojic acid. PubMed: Sodium iron EDTA [NaFe(III)EDTA] as a food fortificant: the effect on the absorption and retention of zinc and calcium in women. PubMed: Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells. PubMed: Toxicological profile, current use, and regulatory issues on EDTA compounds for assessing use of sodium iron EDTA for food fortification. PubMed: Degradation of the Ferric Chelate of EDTA by a Pure Culture of an Agrobacterium sp. PubMed: Application of a long-term enhanced xanthine oxidase-induced luminescence in solid-phase immunoassays. PubMed: Kinetics and mechanism of electron transfer between meso-tetra sulphonated phenyl porphyrin iron(III)-apomyoglobin and Fe(EDTA)2- complexes. PubMed: Iron stimulation of free radical-mediated porphyrinogen oxidation by hepatic and renal mitochondria. PubMed: Photosensitization by antitumor agents, 4. Anthrapyrazole-photosensitized formation of single strand-breaks in DNA. PubMed: Hydroxyl radicals are not involved in NADPH dependent microsomal lipid peroxidation. PubMed: Iron deficiency in the tropics. PubMed: Ironstrene (ferric sodium edetate) treatment of anaemic infants. PubMed: Aerobic photodegradation of X(N) chelates of (ethylenedinitrilo)tetraacetic acid (EDTA): implications for natural waters. PubMed: A comparative study of iron absorption and utilization following ferrous sulphate and sodium ironedetate ("Sytron"). PubMed: Ferric sodium EDTA; clinical experience with infants and young children suffering from anaemia; preliminary report.