diisononyl phthalate
phthalic acid, diisononyl ester
Identification
| Name | diisononyl phthalate |
| CAS Number | 28553-12-0 |
| EINECS | 249-079-5 |
| FDA UNII | 4010KIX4CK |
| Molecular Formula | C26 H42 O4 |
| Molecular Weight | 418.61754000 |
| Nikkaji Number | J216.866I |
| Beilstein | 3217775 |
| XlogP3 | 9.10 (est) |
Regulatory
| FDA Mainterm (IAUFC) | 28553-12-0 ; DIISONONYL PHTHALATE |
Physical Properties
| Appearance | colorless to pale yellow clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | -48.00 °C. @ 760.00 mm Hg (est) |
| Boiling Point | 463.35 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 5.400000 mmHg @ 25.00 °C. (est) |
| Flash Point | 419.00 °F. TCC ( 214.90 °C. ) (est) |
| logP (o/w) | 9.026 (est) |
| Soluble in | water, 0.2 mg/L @ 20 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for diisononyl phthalate usage levels up to | not for fragrance use. |
| Recommendation for diisononyl phthalate flavor usage levels up to | not for flavor use. |
Penta International Corporation
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At Penta, our products and services help businesses do business better.
Potential Uses
Natural Occurrence
Synonyms
baylectrol 4200
1,2-
benzene dicarboxylic acid diisononyl ester
1,2-
benzenedicarboxylic acid bis(3,5,5-trimethylhexyl) ester
1,2-
benzenedicarboxylic acid, bis(3,5,5-trimethylhexyl) ester
1,2-
benzenedicarboxylic acid, diisononyl ester
di-''isononyl'' phthalate
diisononylphthalate
DINP2
DINP3
JAY-DINP
jayflex DINP
palatinol DN
palatinol N
phthalic acid, diisononyl ester
phthalisocizer DINP
plasthall DINP
sansocizer DINP
bis(3,5,5-
trimethylhexyl) phthalate
vestinol 9
vestinol NN
vinylcizer 90
witamol 150
PubMed:
Generation of hazard indices for cumulative exposure to phthalates for use in cumulative risk assessment.
PubMed:
Oral exposure of Kunming mice to diisononyl phthalate induces hepatic and renal tissue injury through the accumulation of ROS. Protective effect of melatonin.
PubMed:
Toxicity and estrogenic endocrine disrupting activity of phthalates and their mixtures.
PubMed:
Dispersive solid-phase extraction based on magnetic dummy molecularly imprinted microspheres for selective screening of phthalates in plastic bottled beverages.
PubMed:
Semivolatile organic compounds in indoor air and settled dust in 30 French dwellings.
PubMed:
Associations between serum phthalates and biomarkers of reproductive function in 589 adult men.
PubMed:
Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice.
PubMed:
Ecological risk assessment of chemicals migrated from a recycled plastic product.
PubMed:
Emissions of two phthalate esters and BDE 209 to indoor air and their impact on urban air quality.
PubMed:
[The occurrence of plasticisers (phthalates) in communal facilities under special consideration of results from LUPE 3].
PubMed:
Skin permeation and metabolism of di(2-ethylhexyl) phthalate (DEHP).
PubMed:
Adverse effects of diisooctyl phthalate on the male rat reproductive development following prenatal exposure.
PubMed:
[Hazardous endocrine disruptors. Phthalates in our hospital].
PubMed:
Environmental exposure to the plasticizer 1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH) in U.S. adults (2000-2012).
PubMed:
Analysis of selected phthalates in Canadian indoor dust collected using household vacuum and standardized sampling techniques.
PubMed:
Determination of phthalate diesters in foods.
PubMed:
[Toxicity effects of phthalate substitute plasticizers used in toys].
PubMed:
[Determination of phthalic acid esters in imitation jewellery and investigation of their migration risk].
PubMed:
Urinary biomarkers for phthalates associated with asthma in Norwegian children.
PubMed:
A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.
PubMed:
Plasticizer incident and its health effects in Taiwan.
PubMed:
Phthalate excretion pattern and testicular function: a study of 881 healthy Danish men.
PubMed:
Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats.
PubMed:
Effects of 4-nonylphenol and/or diisononylphthalate on THP-1 cells: impact of endocrine disruptors on human immune system parameters.
PubMed:
[Determination of 23 phthalate esters in food by solid-phase extraction coupled with gas chromatography-mass spectrometry].
PubMed:
Dummy molecularly imprinted solid-phase extraction for selective determination of five phthalate esters in plastic bottled functional beverages.
PubMed:
Human biological monitoring of diisononyl phthalate and diisodecyl phthalate: a review.
PubMed:
[Survey of plasticizers in polyvinyl chloride toys].
PubMed:
High urinary phthalate concentration associated with delayed pubarche in girls.
PubMed:
Phthalates and perfluorooctanesulfonic acid in human amniotic fluid: temporal trends and timing of amniocentesis in pregnancy.
PubMed:
Endocrine disruptors and asthma-associated chemicals in consumer products.
PubMed:
A comprehensive review of intake estimates of di-isononyl phthalate (DINP) based on indirect exposure models and urinary biomonitoring data.
PubMed:
[Test method for 6 phthalates in polyvinyl chloride].
PubMed:
Identification of di-isononyl phthalate metabolites for exposure marker discovery using in vitro/in vivo metabolism and signal mining strategy with LC-MS data.
PubMed:
Beyond phthalates: gas phase concentrations and modeled gas/particle distribution of modern plasticizers.
PubMed:
Analysis of phthalic acid diesters, monoester, and other plasticizers in polyvinyl chloride household products in Japan.
PubMed:
Phthalate exposure during cold plastisol application--a human biomonitoring study.
PubMed:
Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations.
PubMed:
Dose-response assessment of fetal testosterone production and gene expression levels in rat testes following in utero exposure to diethylhexyl phthalate, diisobutyl phthalate, diisoheptyl phthalate, and diisononyl phthalate.
PubMed:
Biomonitoring equivalents for di-isononyl phthalate (DINP).
PubMed:
Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats.
PubMed:
Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey.
PubMed:
Childhood exposure to phthalates: associations with thyroid function, insulin-like growth factor I, and growth.
PubMed:
Determination of five phthalate monoesters in human urine using gas chromatography-mass spectrometry.
PubMed:
Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro.
PubMed:
Determination of phthalates in diet and bedding for experimental animals using gas chromatography-mass spectrometry.
PubMed:
Rapid and nondestructive analysis of phthalic acid esters in toys made of poly(vinyl chloride) by direct analysis in real time single-quadrupole mass spectrometry.
PubMed:
Effects of maternal exposure to di-isononylphthalate (DINP) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) on steroidogenesis in the fetal rat testis and adrenal gland.
PubMed:
Effects of plasticizers and their mixtures on estrogen receptor and thyroid hormone functions.
PubMed:
Phthalates and nonylphenols in urban runoff: Occurrence, distribution and area emission factors.
PubMed:
P450(BM-3)-catalyzed whole-cell biotransformation of alpha-pinene with recombinant Escherichia coli in an aqueous-organic two-phase system.
PubMed:
Hazard to the developing male reproductive system from cumulative exposure to phthalate esters--dibutyl phthalate, diisobutyl phthalate, butylbenzyl phthalate, diethylhexyl phthalate, dipentyl phthalate, and diisononyl phthalate.
PubMed:
Biodegradation of a phthalate plasticizer, di-isononyl phthalate (DINP), by Sphingobium chungbukense.
PubMed:
Phthalates: metabolism and exposure.
PubMed:
Metabolism of phthalates in humans.
PubMed:
Urinary metabolites of diisodecyl phthalate in rats.
PubMed:
Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP.
PubMed:
[Determination of phthalic acid esters in textiles by solid phase extraction-gas chromatography].
PubMed:
[Survey of epoxidized soybean oil in cap sealing for bottled foods].
PubMed:
Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment.
PubMed:
Urinary biomarkers of di-isononyl phthalate in rats.
PubMed:
Effects of perinatal exposure to phthalate/adipate esters on hypothalamic gene expression and sexual behavior in rats.
PubMed:
Consumer product in vitro digestion model: Bioaccessibility of contaminants and its application in risk assessment.
PubMed:
Modulation of iodide uptake by dialkyl phthalate plasticisers in FRTL-5 rat thyroid follicular cells.
PubMed:
Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring.
PubMed:
Hazard evaluation of diisononyl phthalate and diisodecyl phthalate in a Japanese medaka multigenerational assay.
PubMed:
Risk assessment of oral exposure to diisononyl phthalate from children's products.
PubMed:
Enhancement of interleukin-4 production in activated CD4+ T cells by diphthalate plasticizers via increased NF-AT binding activity.
PubMed:
Steroidogenesis in fetal male rats is reduced by DEHP and DINP, but endocrine effects of DEHP are not modulated by DEHA in fetal, prepubertal and adult male rats.
PubMed:
Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals.
PubMed:
Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life.
PubMed:
[Material labeling of soft plastic toys and plasticizers in polyvinyl chloride products].
PubMed:
Role of the peroxisome proliferator-activated receptor alpha in responses to diisononyl phthalate.
PubMed:
[Estimation of daily oral exposure to phthalates derived from soft polyvinyl chloride baby toys].
PubMed:
Determination of phthalate ester congeners and mixtures by LC/ESI-MS in sediments and biota of an urbanized marine inlet.
PubMed:
Pediatric exposure and potential toxicity of phthalate plasticizers.
PubMed:
Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of DEHP-containing PVC gloves in Japan.
PubMed:
A simple and reproducible testing method for dialkyl phthalate migration from polyvinyl chloride products into saliva simulant.
PubMed:
[Contents of plasticizers in cap-sealing for bottled food and their migration into food].
PubMed:
Adjuvant effect of di-n-butyl-, di-n-octyl-, di-iso-nonyl- and di-iso-decyl phthalate in a subcutaneous injection model using BALB/c mice.
PubMed:
Gas chromatography-mass spectrometry determination of the migration of phthalate plasticisers from polyvinyl chloride toys and childcare articles.
PubMed:
Comments on Foster, P., and McIntyre, B. (2002). Endocrine active agents: implications of adverse and non-adverse changes. Toxicol Pathol 30(1): 59-65.
PubMed:
Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation.
PubMed:
NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-isononyl phthalate.
PubMed:
Absorption, disposition and metabolism of di-isononyl phthalate (DINP) in F-344 rats.
PubMed:
Species differences in response to the phthalate plasticizer monoisononylphthalate (MINP) in vitro: a comparison of rat and human hepatocytes.
PubMed:
Migration of phthalates from PVC toys into saliva simulant by dynamic extraction.
PubMed:
An assessment of the toxicity of phthalate esters to freshwater benthos. 2. Sediment exposures.
PubMed:
[Contents of eleven phthalates and di(2-ethylhexyl) adipate in retail packed lunches after prohibition of DEHP-containing PVC gloves for cooking purposes].
PubMed:
[Contents of phthalate in polyvinyl chloride toys].
PubMed:
Analysis of plasticizers in cap-sealing resins for bottled foods.
PubMed:
Di(isononyl) phthalate (DINP) and di(isodecyl) phthalate (DIDP) are not mutagenic.
PubMed:
Response letter from ACSH phthalate panel.
PubMed:
Letter in response to ACSH report on plasticizers.
PubMed:
Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat.
PubMed:
The role of inhibition of gap junctional intercellular communication in rodent liver tumor induction by phthalates: review of data on selected phthalates and the potential relevance to man.
PubMed:
Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys.
PubMed:
Comparative in vivo hepatic effects of Di-isononyl phthalate (DINP) and related C7-C11 dialkyl phthalates on gap junctional intercellular communication (GJIC), peroxisomal beta-oxidation (PBOX), and DNA synthesis in rat and mouse liver.
PubMed:
Concentrations of phthalate esters and identification of other additives in PVC children's toys.
PubMed:
Two-generation reproduction study in rats given di-isononyl phthalate in the diet.
PubMed:
Suppression of apoptosis and induction of DNA synthesis in vitro by the phthalate plasticizers monoethylhexylphthalate (MEHP) and diisononylphthalate (DINP): a comparison of rat and human hepatocytes in vitro.
PubMed:
The potential health effects of phthalate esters in children's toys: a review and risk assessment.
PubMed:
Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate.
PubMed:
Effects of di-isononyl phthalate (DINP) on peroxisomal markers in the marmoset-DINP is not a peroxisome proliferator.
PubMed:
Developmental toxicity of di-isodecyl and di-isononyl phthalates in rats.
PubMed:
Analysis of potentially toxic phthalate plasticizers used in toy manufacturing.
PubMed:
Differential prenatal toxicity of branched phthalate esters in rats.
PubMed:
Biodegradation of DEHP, DBP, and DINP: poorly water soluble and widely used phthalate plasticizers.
PubMed:
Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats.
PubMed:
Sqwish Ball dermatitis.