1H-isoindole-1,3(2H)-dione, 2-[(trichloromethyl)thio]-

CAS: 133-07-3 C9 H4 Cl3 N O2 S MW: 296.55728000

Identification

Namefolpet
IUPAC2-(trichloromethylsulfanyl)isoindole-1,3-dione
CAS Number133-07-3
EINECS205-088-6
FDA UNIIX5NFK36917
Molecular FormulaC9 H4 Cl3 N O2 S
Molecular Weight296.55728000
MDL NumberMFCD00047303
Nikkaji NumberJ2.948C
Beilstein0193373
XlogP32.80 (est)

Regulatory

Physical Properties

Appearance white crystals (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 177.00 °C. @ 760.00 mm Hg
Boiling Point 333.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure 2.100000 mmHg @ 25.00 °C. (est)
Flash Point 312.00 °F. TCC ( 155.70 °C. ) (est)
logP (o/w) 2.850
Soluble in water, 0.8 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LD50 80 mg/kg
Dermal Toxicityskin-mouse LDLo 5000 mg/kg
Inhalation Toxicityinhalation-mouse LC50 > 6000 mg/m3/2H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for folpet usage levels up tonot for fragrance use.
Recommendation for folpet flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

faltex folnit folpan folpel fungitrol 1H-iso indole-1,3(2H)-dione, 2-((trichloromethyl)thio)- 1H-iso indole-1,3(2H)-dione, 2-[(trichloromethyl)thio]- intercide TMP murphy's rose fungicide ortho phaltan 50W orthophaltan phaltan phthalimide, N-((trichloromethyl)thio)- phthalimide, N-[(trichloromethyl)thio]- spolacid thiophal 2-[( trichlormethyl)sulfanyl]-1H-isoindol-1,3(2H)-dion N-( trichlormethylthio)phthalimide N-( trichloromethanesulphenyl)phthalimide 2-[( trichloromethyl)sulfanyl]-1H-isoindole-1,3(2H)-dione 2-(( trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione 2-(( trichloromethyl)thio)isoindoline-1,3-dione 2-[( trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione N-( trichloromethylmercapto)phthalimide 2-( trichloromethylsulfanyl)isoindole-1,3-dione N-( trichloromethylthio)phthalimide N- trichloromethylthiophthalimide troysan anti-mildew O vinicoll PubMed: Levels and determinants of pesticide exposure in re-entry workers in vineyards: Results of the PESTEXPO study. PubMed: Aldehyde dehydrogenase variation enhances effect of pesticides associated with Parkinson disease. PubMed: Implementing the contamination prevention programs in the pesticide industry by infrared spectroscopy. PubMed: A new alternative method for testing skin irritation using a human skin model: a pilot study. PubMed: Pesticide residues in berries harvested from South-Eastern Poland (2009-2011). PubMed: Development and validation of a method for the determination of 159 pesticide residues in tobacco by gas chromatography-tandem mass spectrometry. PubMed: Heterogeneous ozonolysis of folpet and dimethomorph: a kinetic and mechanistic study. PubMed: Extraction of imide fungicides in water and juice samples using magnetic graphene nanoparticles as adsorbent followed by their determination with gas chromatography and electron capture detection. PubMed: Degradation of metalaxyl and folpet by filamentous fungi isolated from Portuguese (Alentejo) vineyard soils. PubMed: Effects of temperature and purity of magnesium sulfate during extraction of pesticide residues using the QuEChERS method. PubMed: Levels and determinants of pesticide exposure in operators involved in treatment of vineyards: results of the PESTEXPO Study. PubMed: A multi-residue method for pesticides analysis in green coffee beans using gas chromatography-negative chemical ionization mass spectrometry in selective ion monitoring mode. PubMed: Exploiting the lithiation-directing ability of oxetane for the regioselective preparation of functionalized 2-aryloxetane scaffolds under mild conditions. PubMed: A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies. PubMed: [Pesticides]. PubMed: Toxicokinetic modeling of folpet fungicide and its ring-biomarkers of exposure in humans. PubMed: Folpet-induced short term cytotoxic and proliferative changes in the mouse duodenum. PubMed: Multipesticide residue analysis in maize combining acetonitrile-based extraction with dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. PubMed: Multiresidue determination of 160 pesticides in wines employing mixed-mode dispersive-solid phase extraction and gas chromatography-tandem mass spectrometry. PubMed: Snails as indicators of pesticide drift, deposit, transfer and effects in the vineyard. PubMed: Groundwater from infiltration galleries used for small public water supply systems: contamination with pesticides and endocrine disruptors. PubMed: Determination of 40 currently used pesticides in airborne particulate matter (PM 10) by microwave-assisted extraction and gas chromatography coupled to triple quadrupole mass spectrometry. PubMed: Qualitative aspects in the analysis of pesticide residues in fruits and vegetables using fast, low-pressure gas chromatography-time-of-flight mass spectrometry. PubMed: Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers. PubMed: Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers. PubMed: Gas-chromatography mass-spectrometry determination of phthalic acid in human urine as a biomarker of folpet exposure. PubMed: Chiral separation of metalaxyl and benalaxyl fungicides by electrokinetic chromatography and determination of enantiomeric impurities. PubMed: Liquid chromatography-tandem mass spectrometry (LC/APCI-MS/MS) methods for the quantification of captan and folpet phthalimide metabolites in human plasma and urine. PubMed: Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions. PubMed: Genetic toxicology of folpet and captan. PubMed: Carcinogenic mode of action of folpet in mice and evaluation of its relevance to humans. PubMed: The effects of fungicides on non-target mites can be mediated by plant pathogens. PubMed: Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables. PubMed: Multiresidue analysis of 50 pesticides in grape, pomegranate, and mango by gas chromatography-ion trap mass spectrometry. PubMed: Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of selected fungicides in wine. PubMed: A survey of antifoulants in sediments from Ports and Marinas along the French Mediterranean coast. PubMed: Analysis of captan, folpet, and captafol in apples by dispersive liquid-liquid microextraction combined with gas chromatography. PubMed: Cytotoxicity of folpet fungicide on human bronchial epithelial cells. PubMed: Pesticide residues in grapes from vineyards included in integrated pest management in Slovenia. PubMed: Quantification methods of folpet degradation products in plasma with HPLC-UV/DAD: application to an in vivo toxicokinetic study in rats. PubMed: Suitability of two laboratory testing methods to evaluate the side effects of pesticides on Typhlodromus pyri Scheuten (Acari: Phytoseiidae). PubMed: Physicochemical characteristics and bronchial epithelial cell cytotoxicity of Folpan 80 WG(R) and Myco 500(R), two commercial forms of folpet. PubMed: Seasonal distributions of fungicides in soils and sediments of a small river basin partially devoted to vineyards. PubMed: [Simultaneous determination of captan and folpet pesticide residues in apples by solid-phase extraction and high performance liquid chromatography]. PubMed: Multiresidue pesticide analysis of the medicinal plant Origanum syriacum. PubMed: [Susceptibility of Trichogramma pretiosum Riley (Hymenoptera: Trichogrammatidae) adults to fungicides used to control apple diseases]. PubMed: Large volume cold on-column injection for gas chromatography-negative chemical ionization-mass spectrometry analysis of selected pesticides in air samples. PubMed: Assessment of QoI resistance in Plasmopara viticola oospores. PubMed: Residue determination of captan and folpet in vegetable samples by gas chromatography/negative chemical ionization-mass spectrometry. PubMed: Residue levels of captan and trichlorfon in field-treated kaki fruits, individual versus composite samples, and after household processing. PubMed: Effect of dose rate and mixtures of fungicides on selection for QoI resistance in populations of Plasmopara viticola. PubMed: Quality and safety assessment of ginseng extracts by determination of the contents of pesticides and metals. PubMed: Use of buffering and other means to improve results of problematic pesticides in a fast and easy method for residue analysis of fruits and vegetables. PubMed: Side effects of mancozeb on Typhlodromus pyri (Acari: Phytoseiidae) in vineyards: results of multi-year field trials and a laboratory study. PubMed: Evaluation of common organic solvents for gas chromatographic analysis and stability of multiclass pesticide residues. PubMed: Activity of some chemicals in the control of Botrytis cinerea on roses. PubMed: Phytotoxicity of diuron alone and in combination with copper or folpet on duckweed (Lemna minor). PubMed: Multiresidue method using SPME for the determination of various pesticides with different volatility in confined atmospheres. PubMed: Multiresidue method for the determination of pesticides in Korean domestic crops by gas chromatography/mass selective detection. PubMed: Folpet permeation through nitrile gloves. PubMed: Cell-cycle deregulation in BALB/c 3T3 cells transformed by 1,2-dibromoethane and folpet pesticides. PubMed: Coupling solid-phase microextraction and high-performance liquid chromatography for direct and sensitive determination of halogenated fungicides in wine. PubMed: Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns. PubMed: Induction of hsp70 in transgenic Drosophila: biomarker of exposure against phthalimide group of chemicals. PubMed: A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry. PubMed: The effect of simulated rain on folpet and mancozeb residues on grapes and on vine leaves. PubMed: Resolution by polarographic techniques of the ternary mixture of captan, captafol and folpet by using PLS calibration and artificial neuronal networks. PubMed: Development of a SPME-GC-ECD methodology for selected pesticides in must and wine samples. PubMed: Monitoring of antifouling agents in water samples by on-line solid-phase extraction-liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. PubMed: Rapid determination of fungicides in fruit juices by micellar electrokinetic chromatography: use of organic modifiers to enhance selectivity and on-column high-salt stacking to improve sensitivity. PubMed: Determination of fungicides in natural waters using solid-phase microextraction and gas chromatography coupled with electron-capture and mass spectrometric detection. PubMed: Making best use of available residue data for acute intake assessment. PubMed: Distribution of folpet on the grape surface after treatment. PubMed: Analysis of pesticide residues in matrices with high lipid contents by membrane separation coupled on-line to a high-performance liquid chromatography system. PubMed: 2-trichloromethylthio-1H-isoindole-1,3(2H)-dione (Folpet). PubMed: Concentrations of phthalate esters and identification of other additives in PVC children's toys. PubMed: Ascorbate and glutathione contents in duckweed, Lemna minor, as biomarkers of the stress generated by copper, folpet and diuron. PubMed: Cancer risk assessment of direct acting carcinogens. PubMed: Chloropicrin dechlorination in relation to toxic action. PubMed: Multiresidue determination of 19 fungicides in processed fruits and vegetables by capillary gas chromatography after gel permeation chromatography. PubMed: Solid phase microextraction of pesticide residues from strawberries. PubMed: Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, gallic acid and caffeine. PubMed: Allergic contact and photoallergic contact dermatitis to plant and pesticide allergens. PubMed: Toxic responses and catalase activity of Lemna minor L. Exposed to folpet, copper, and their combination. PubMed: Comparative investigation on the mutagenicities of organophosphate, phthalimide, pyrethroid and carbamate insecticides by the Ames and lactam tests. PubMed: Evaluation of multiwavelength chromatograms for the quantification of mixtures of pesticides by high-performance liquid chromatography-diode array detection with multivariate calibration. PubMed: Prevalence of dermatoses and skin sensitisation associated with use of pesticides in fruit farmers of southern Taiwan. PubMed: Transgenic strains of the nematode C. elegans in biomonitoring and toxicology: effects of captan and related compounds on the stress response. PubMed: Matrix solid-phase dispersion extraction procedure for multiresidue pesticide analysis in oranges. PubMed: Transformation of BALB/c 3T3 cells in vitro by the fungicides captan, captafol and folpet. PubMed: [Twenty-eight days repeated dose toxicity test of N-(fluorodichloromethylthio)phthalimide in rats]. PubMed: Application of solid-phase partition cartridges in the determination of fungicide residues in vegetable samples. PubMed: Carcinogenic potential of some pesticides in a medium-term multi-organ bioassay in rats. PubMed: Evaluation of the carcinogenic potential of pesticides. 4. Chloroalkylthiodicarboximide compounds with fungicidal activity. PubMed: Safety/risk assessment of pesticides: principles, procedures and examples. PubMed: The Ca(2+)-transport-ATPase of human erythrocytes as an in vitro toxicity test system--acute effects of some chlorinated compounds. PubMed: Gas chromatographic determination of captan, folpet, and captafol residues in tomatoes, cucumbers, and apples using a wide-bore capillary column: interlaboratory study. PubMed: A rapid in vivo bioassay for the carcinogenicity of pesticides. PubMed: Induction of gastrointestinal tumors in mice fed the fungicide folpet: possible mechanisms. PubMed: Comparative studies of the effects on liver and liver microsomal drug-metabolizing enzyme system by the fungicides captan, captafol and folpet in rats. PubMed: Influence of bacterial growth of the overnight culture on the captan- and folpet-induced reversion in the Ames test. PubMed: Mutagenic evaluation of the pesticides captan, folpet, captafol, dichlofluanid and related compounds with the mutants TA102 and TA104 of Salmonella typhimurium. PubMed: Degradation behavior of captan and folpet on greenhouse tomatoes. PubMed: Residues of captan and folpet on greenhouse tomatoes with emphasis on the effect of storing, washing, and cooking on their removal. PubMed: Irritation and sensitization potential of pesticides. PubMed: Rapid titrimetric method for the determination of captan and folpet in fungicide formulations. PubMed: Comparison of the penetration of 14 pesticides through the skin of young and adult rats. PubMed: Evaluation of the genetic activity profiles of 65 pesticides. PubMed: A test series for pesticide dermatitis. PubMed: Residues of captan and folpet in strawberries and grapes. PubMed: Determination of captan, folpet, and captafol in fruits and vegetables, using two multiresidue methods. PubMed: Clastogenic and physiological response of chromosomes to nine pesticides in the Vicia faba in vivo root tip assay system. PubMed: [Late sequelae of prolonged phthalan exposure]. PubMed: Hepatotoxicity of orally and intraperitoneally administered folpet in male rats. PubMed: High-pressure liquid chromatographic determination of captan, captafol, and folpet residues in plant material. PubMed: Cytotoxicity and mutagenicity of the fungicides captan and folpet in cultured mammalian cells CHO/HGPRT system). PubMed: Effect of human gastric juice on the mutagenicity of chemicals. PubMed: Metabolic activation and deactivation of mutagens and carcinogens. PubMed: [Use of fungi as a biological test for determination of fungicide residues in plant material. II. Determination of benomyl, dichlofluanide, folpet, captane, carbendazyme, methyl thiophanate and thiram in fruit, vegetables and champignons]. PubMed: Teratogenicity of the fungicides captan and folpet in the chick embryo. PubMed: Effect of fungicide Folpet on growth and chromosomes of human lymphoid cell lines. PubMed: Mutagenicity screening of pesticides in the microbial system. PubMed: Mutagenicity studies with captan, captofol, folpet and thalidomide. PubMed: Mutagenicity tests with captan and folpet in Drosophila melanogaster. PubMed: Fungicide residues. II. The simultaneous determination of residues of folpet, captan and captafol in selected fruits by gas chromatography. PubMed: Dominant lethal assay. II. Folpet and Difolatan. PubMed: Action of the fungicides captan and folpet on rat liver mitochondria. PubMed: An investigation into the teratogenic potential of captan, folpet, and Difolatan in nonhuman primates. PubMed: An investigation of the teratogenic potential of captan, folpet, and difolatan. PubMed: Reactions of captan and folpet with thiols.