carbofuran

2,2-dimethyl-7-coumaranyl N-methylcarbamate

CAS: 1563-66-2 C12 H15 N O3 MW: 221.25615000

Identification

Namecarbofuran
IUPAC(2,2-dimethyl-3H-1-benzofuran-7-yl) N-methylcarbamate
CAS Number1563-66-2
EINECS216-353-0
FDA UNIISKF77S6Y67
Molecular FormulaC12 H15 N O3
Molecular Weight221.25615000
MDL NumberMFCD00041819
Nikkaji NumberJ3.369C
Beilstein1428746
XlogP32.30 (est)

Regulatory

Physical Properties

Appearance white crystalline solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 151.00 °C. @ 760.00 mm Hg
Boiling Point 313.30 °C. @ 760.00 mm Hg (est)
Flash Point 290.00 °F. TCC ( 143.30 °C. ) (est)
logP (o/w) 2.320
Soluble in water, 320 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-bird - wild LD50 420 ug/kg
Dermal Toxicityskin-bird - wild LD50 100 mg/kg
Inhalation Toxicityinhalation-dog LC50 52 mg/m3

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ATAXIA\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE', 'U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#11280']

Safety in Use

Categoryherbicides / pesticides
Recommendation for carbofuran usage levels up tonot for fragrance use.
Recommendation for carbofuran flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

bayer 70143 benzofuran-7-ol, 2,3-dihydro, 2,2-dimethyl, N-methylcarbamate 7- benzofurano, 2,3-dihydro-2,2-dimethyl, methylcarbamate 7- benzofuranol, 2,3-dihydro-2,2-dimethyl-, 7-(N-methylcarbamate) 7- benzofuranol, 2,3-dihydro-2,2-dimethyl-, methylcarbamate brifur carbamic acid, methyl-, 2, 3-dihydro-2,2-dimethyl-7-benzofuranyl ester carbamic acid, methyl-, 2,2-dimethyl-2, 3-dihydrobenzofuran-7-yl ester carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydro-7-benzofuranyl ester carbamic acid, methyl-, 2,2-dimethyl-2,3-dihydrobenzofuran-7-yl ester carbamic acid, methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester carbodan carbofurane chinufur crisfuran curaterr 2,3- dihydro-2,2-dimethyl-7-benzofuranol methylcarbamate 2,3- dihydro-2,2-dimethyl-7-benzofuranol N-methylcarbamate 2,3- dihydro-2,2-dimethyl-7-benzofuranyl methylcarbamate 2,3- dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate 2,3- dihydro-2,2-dimethylbenzofuranyl-7-N-methylcarbamate 2,2- dimethyl-2,2-dihydrobenzofuranyl-7 N-methylcarbamate 2,2- dimethyl-2,3-dihydro-1-benzofuran-7-yl hydrogen methylcarbonimidate 2,2- dimethyl-2,3-dihydro-1-benzofuran-7-yl methylcarbamate 2,2- dimethyl-2,3-dihydro-1-benzofuran-7-yl N-methylcarbamate 2,2- dimethyl-2,3-dihydro-7-benzofuranyl N-methylcarbamate 2,2- dimethyl-2,3-dihydro-7-benzofuranyl-N-methylcarbamate 2,2- dimethyl-2,3-dihydrobenzoduranyl-7-N-methylcarbamate 2,2- dimethyl-2,3-dihydrobenzofuran-7-yl methylcarbamate (2,2- dimethyl-3H-1-benzofuran-7-yl) N-methylcarbamate 2,2- dimethyl-7-coumaranyl N-methylcarbamate (2,2- dimethyl(2,3-dihydrobenzo[2,3-b]furan-7-yloxy))-N-methylcarboxamide furacarb furadan 3G furadan G furadane furodan karbofuranu kenofuran methanol, 1-[(2,3-dihydro-2,2-dimethyl-7-benzofuranyl)oxy]-1-(methylimino)-, (E)- methyl carbamic acid 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester niagara 10242 pillarfuran yaltox PubMed: Determination of carbamate and organophosphorus pesticides in vegetable samples and the efficiency of gamma-radiation in their removal. PubMed: Protective effect of secondary plant metabolites from Ipomoea aquatica Forsk. against carbofuran induced damages. PubMed: Electrochemical nonenzymatic sensor based on CoO decorated reduced graphene oxide for the simultaneous determination of carbofuran and carbaryl in fruits and vegetables. PubMed: Evaluation of hepatotoxicity and clastogenicity of carbofuran in male Wistar rats. PubMed: High-Throughput Screening and Confirmation of 22 Banned Veterinary Drugs in Feedstuffs Using LC-MS/MS and High-Resolution Orbitrap Mass Spectrometry. PubMed: Survey of pesticide application on vegetables in the Littoral area of Togo. PubMed: Amperometric immunosensor for carbofuran detection based on MWCNTs/GS-PEI-Au and AuNPs-antibody conjugate. PubMed: Laccase-Prussian blue film-graphene doped carbon paste modified electrode for carbamate pesticides quantification. PubMed: Bacterial sensors based on biosilica immobilization for label-free OWLS detection. PubMed: Organophosphorus and carbamate pesticide residues detected in water samples collected from paddy and vegetable fields of the Savar and Dhamrai Upazilas in Bangladesh. PubMed: Acetylcholinesterase biosensor based on chitosan/prussian blue/multiwall carbon nanotubes/hollow gold nanospheres nanocomposite film by one-step electrodeposition. PubMed: Comparative effect of pesticides on brain acetylcholinesterase in tropical fish. PubMed: Interactions with DOM and biofilms affect the fate and bioavailability of insecticides to invertebrate grazers. PubMed: A novel and highly sensitive acetyl-cholinesterase biosensor modified with hollow gold nanospheres. PubMed: Total diet study on pesticide residues in France: levels in food as consumed and chronic dietary risk to consumers. PubMed: Occurrence of organophosphorus and carbamate pesticide residues in surface water samples from the Rangpur district of Bangladesh. PubMed: Chromogenic platform based on recombinant Drosophila melanogaster acetylcholinesterase for visible unidirectional assay of organophosphate and carbamate insecticide residues. PubMed: Amperometric immunosensor based on a protein A/deposited gold nanocrystals modified electrode for carbofuran detection. PubMed: A label-free electrochemical immunosensor for carbofuran detection based on a sol-gel entrapped antibody. PubMed: Sequential injection-bead injection-lab-on-valve coupled to high-performance liquid chromatography for online renewable micro-solid-phase extraction of carbamate residues in food and environmental samples. PubMed: Disposable screen-printed electrode coupled with recombinant Drosophila melanogaster acetylcholinesterase and multiwalled carbon nanotubes for rapid detection of pesticides. PubMed: Dispersive liquid-liquid microextraction coupled with high-performance liquid chromatography-diode array detection for the determination of N-methyl carbamate pesticides in vegetables. PubMed: Enhanced pesticide sensitivity of novel housefly acetylcholinesterases: a new tool for the detection of residual pesticide contamination. PubMed: Survey of pesticide residues in maize, cowpea and millet from northern Cameroon: part I. PubMed: Monitoring of pesticide residues in vegetables marketed in Al-Qassim region, Saudi Arabia. PubMed: Organ-specific ATPase and phosphorylase enzyme activities in a food fish exposed to a carbamate insecticide and recovery response. PubMed: Development, validation and application of a methodology based on solid-phase micro extraction followed by gas chromatography coupled to mass spectrometry (SPME/GC-MS) for the determination of pesticide residues in mangoes. PubMed: Determination of four carbamate pesticides in corn by cloud point extraction and high-performance liquid chromatography in the visible region based on their derivatization reaction. PubMed: Pesticide extraction from table grapes and plums using ionic liquid based dispersive liquid-liquid microextraction. PubMed: Ionic liquid based dispersive liquid-liquid microextraction for the extraction of pesticides from bananas. PubMed: Cloning, expression, and identification of anti-carbofuran single chain Fv gene. PubMed: Effects of exposure to oxamyl, carbofuran, dichlorvos, and lindane on acetylcholinesterase activity in the gills of the Pacific oyster Crassostrea gigas. PubMed: Gold immunochromatographic assay for simultaneous detection of carbofuran and triazophos in water samples. PubMed: [Determination of carbofuran residue in aquatic products by gas chromatography]. PubMed: Development of a bispecific monoclonal antibody to pesticide carbofuran and triazophos using hybrid hybridomas. PubMed: Tumor promoting and co-carcinogenic effects in medium-term rat hepatocarcinogenesis are not modified by co-administration of 12 pesticides in mixture at acceptable daily intake. PubMed: Determination of carbamates in nature water based on the enhancement of electrochemiluminescent of Ru(bpy)(3)(2+) at the multi-wall carbon nanotube-modified electrode. PubMed: Rapid hydrolysis and electrochemical detection of trace carbofuran at a disposable heated screen-printed carbon electrode. PubMed: Atmospheric pressure glow discharge desorption mass spectrometry for rapid screening of pesticides in food. PubMed: Development of an enzyme-linked immuno-sorbent assay (ELISA) method for carbofuran residues. PubMed: Determination of 23 pesticide residues in leafy vegetables using gas chromatography-ion trap mass spectrometry and analyte protectants. PubMed: [Study on usage of pesticides in various countries]. PubMed: [Behavior of N-methylcarbamate pesticides during refinement processing of edible oils]. PubMed: Dissipation of carbofuran and carbaryl on Oolong tea during tea bushes, manufacturing and roasting processes. PubMed: Multi-residue determination of pesticides in water using multi-walled carbon nanotubes solid-phase extraction and gas chromatography-mass spectrometry. PubMed: Comparative evaluation of acetylcholinesterase status and genome damage in blood cells of industrial workers exposed to carbofuran. PubMed: Quantitative determination of diuron in ground and surface water by time-resolved fluoroimmunoassay: seasonal variations of diuron, carbofuran, and paraquat in an agricultural area. PubMed: Liquid chromatography quadrupole time-of-flight mass spectrometry analysis of carbosulfan, carbofuran, 3-hydroxycarbofuran, and other metabolites in food. PubMed: The delayed genotoxic effect of N-nitroso N-propoxur insecticide in mammalian cells. PubMed: Effects of combined and sequential addition of dual oxidants (H2O2/S2O8(2-)) on the aqueous carbofuran photodegradation. PubMed: Survey of carbamate and organophosphorous pesticide export from a south Florida (U.S.A.) agricultural watershed: implications of sampling frequency on ecological risk estimation. PubMed: Carbofuran sorption kinetics by corn crop soils. PubMed: High-sensitivity detection for model organophosphorus and carbamate pesticide with quartz crystal microbalance-precipitation sensor. PubMed: Development of controlled release formulations of carbofuran and evaluation of their efficacy against Meloidogyne incognita. PubMed: N-methyl carbamate pesticide residues in conventional and organic infant foods available on the Canadian retail market, 2001-03. PubMed: Determination of pesticides in soy-based infant formula using liquid chromatography with electrospray ionization tandem mass spectrometry. PubMed: Sorption of carbofuran and diuron pesticides in 43 tropical soils of Sri Lanka. PubMed: Influence of micelles on the basic degradation of carbofuran. PubMed: Use of bentonite and activated carbon in controlled release formulations of carbofuran. PubMed: Determination of carbofuran by flow-injection with chemiluminescent detection. PubMed: Occupational exposure to carbofuran and the incidence of cancer in the Agricultural Health Study. PubMed: Determination of pesticides in apple-based infant foods using liquid chromatography electrospray ionization tandem mass spectrometry. PubMed: High-performance liquid chromatography multiresidue method for the determination of N-methyl carbamates in fruit and vegetable juices. PubMed: Nanocolloidal gold-based immunoassay for the detection of the N-methylcarbamate pesticide carbofuran. PubMed: Soil photolysis in a moisture- and temperature-controlled environment. 2. Insecticides. PubMed: Sphingomonas sp. strain SB5 degrades carbofuran to a new metabolite by hydrolysis at the furanyl ring. PubMed: Assessment of pesticide residues in honey samples from portugal and Spain. PubMed: Multiresidue screening methods for the determination of pesticides in tomatoes. PubMed: Competitive degradation and detoxification of carbamate insecticides by membrane anodic Fenton treatment. PubMed: Continuous ultrasound-assisted extraction coupled to on line filtration-solid-phase extraction-column liquid chromatography--post column derivatisation-fluorescence detection for the determination of N-methylcarbamates in soil and food. PubMed: Influence of suspended solids on acute toxicity of carbofuran to Daphnia magna: II. An evaluation of potential interactive mechanisms. PubMed: Carbofuran residue in water chestnut. PubMed: Chemiluminescence determination of carbofuran and promecarb by flow injection analysis using two photochemical reactions. PubMed: Determination of pesticide residues in nonfatty foods by supercritical fluid extraction and gas chromatography/mass spectrometry: collaborative study. PubMed: Comparison of solid-phase extraction and solid-phase microextraction for carbofuran in water analyzed by high-performance liquid chromatography-photodiode-array detection. PubMed: Monitoring of pesticide residues on cucumber, tomatoes and strawberries in Gaza Governorates, Palestine. PubMed: Effect of insecticides used in corn, sorghum, and alfalfa on the predator Orius insidiosus (Hemiptera: Anthocoridae). PubMed: N-nitrosocarbofuran, but not carbofuran, induces apoptosis and cell cycle arrest in CHL cells. PubMed: Determination of organophosphate and carbamate pesticides in spiked samples of tap water and fruit juices by a biosensor with photothermal detection. PubMed: Validation of a monoclonal enzyme immunoassay for the determination of carbofuran in fruits and vegetables. PubMed: Influence of insecticides on microbial transformation of nitrogen and phosphorus in Typic Orchragualf soil. PubMed: Development of monoclonal antibody-based immunoassays to the N-methylcarbamate pesticide carbofuran. PubMed: Controlled release of carbofuran from an alginate-bentonite formulation: water release kinetics and soil mobility. PubMed: Enzyme inhibition and enzyme-linked immunosorbent assay methods for carbamate pesticide residue analysis in fresh produce. PubMed: Kuwait's total diet study: dietary intake of organochlorine, carbamate, benzimidazole and phenylurea pesticide residues. PubMed: Chemical models of cytochrome P450 catalyzed insecticide metabolism. Application to the oxidative metabolism of carbamate insecticides. PubMed: Solid phase microextraction of pesticide residues from strawberries. PubMed: The impact of rice pesticides on the aquatic ecosystems of the Sacramento River and Delta (California). PubMed: Supercritical fluid extraction of pesticides from meat: a systematic approach for optimisation. PubMed: Reproductive efficiency in mink (Mustela vison) treated with the pesticides lindane, carbofuran and pentachlorophenol. PubMed: [Study on the determination of N-methylcarbamate insecticides in milk by HPLC]. PubMed: Behavioral effects of waterborne carbofuran in goldfish. PubMed: Characterization of the expression of the thcB gene, coding for a pesticide-degrading cytochrome P-450 in Rhodococcus strains. PubMed: CO2 production in three earthworm species exposed to terbuthylazine and carbofuran in food. PubMed: Environmental pollutants alter taste responses in the gerbil. PubMed: Fate of carbofuran and its effects on aquatic macroinvertebrates in Canadian prairie parkland ponds. PubMed: Carbofuran poisoning in herons: diagnosis using cholinesterase reactivation techniques. PubMed: Effects of fenamiphos, carbofuran, and aldicarb on zearalenone production by toxigenic Fusarium spp. contaminating roots and fruits of tomato. PubMed: Use of a Gammarus pulex bioassay to measure the effects of transient carbofuran runoff from farmland. PubMed: Carbofuran toxicity. PubMed: Bioavailability to rats and toxicity in mice of carbofuran residues bound to faba beans. PubMed: Atrazine, alachlor, and carbofuran contamination of well water in central Maine. PubMed: Simulated field ingestion of carbofuran-contaminated feedstuffs by pheasants. PubMed: A review of insecticide poisonings among domestic livestock in southern Ontario, Canada, 1982-1989. PubMed: Determination of carbofuran by GLC/NPD and HPLC in tomato fruits. PubMed: Factors influencing discrimination between insecticide-treated and untreated foods by northern bobwhite. PubMed: High-performance liquid chromatographic determination of aryl N-methylcarbamate residues using post-column hydrolysis electrochemical detection. PubMed: Bacterial metabolism of carbofuran. PubMed: Two methods for evaluating avian food avoidance data. PubMed: [Complex hygienic standardization of furadan in reservoir water and in food products]. PubMed: Insecticide residues in commercially-grown quick-maturing carrots. PubMed: Liquid chromatographic determination of N-methylcarbamate insecticides and metabolites in crops. II. Analytical characteristics and residue findings. PubMed: Worker reentry research for carbosulfan applied to California citrus trees. PubMed: Determination of carbosulfan and carbofuran residues in plants, soil, and water by gas chromatography. PubMed: Residues of carbofuran and its two carbamate metabolites in field-treated rutabaga. PubMed: Extraction of biologically incorporated [14C]Carbofuran residues from root crops. PubMed: Direct analysis of carbofuran and its carbamate metabolites in rapeseed plants by nitrogen-phosphorus detector gas chromatography. PubMed: Effects of carbamates on bobwhite food intake, body weight, and locomotor activity. PubMed: Isolation and identification of a new conjugated carbofuran metabolite in carrots: angelic acid ester of 3-hydroxycarbofuran. PubMed: Direct analysis of carbofuran and 3-hydroxycarbofuran in rape plants by reverse-phase high-pressure liquid chromatography. PubMed: Determination of carbofuran and 3-hydroxycarbofuran residues in plant tissue by nitrogen selective gas chromatography. PubMed: Direct analysis of carbofuran and two nonconjugated metabolites in crops by high-pressure liquid chromatography with UV absorption detection. PubMed: Formation of the N-trifluoroacetate of carbofuran. PubMed: Determination of the phenolic metabolites of carbofuran in plant and animal matrices by gas chromatography of their 2,4-dinitrophenyl ether derivatives. PubMed: Bioavailability in rats of bound and conjugated plant carbamate insecticide residues. PubMed: Fate of carbofuran and its metabolites on strawberries in the environment. PubMed: Persistence and biodegradation of carbofuran in flooded soils. PubMed: Persistence of some insecticides in subtropical soil. PubMed: Effects of light on the fate of carbofuran during the drying of alfalfa. PubMed: Distribution of insecticide residues in carrots at harvest. PubMed: Esters of sulfonic acids as derivatives for the gas chromatographic analysis of carbamate pesticides. PubMed: Determination of carbofuran and its toxic metabolites in animal tissue by gas chromatography of their N-trifluoroacetyl derivatives. PubMed: Persistence in soil and losses in runoff of soil-incorporated carbaryl in a small watershed. PubMed: Carbofuran. Comparative toxicity and metabolism in the worms Lumbricus terrestris L. and Eisenia foetida S. PubMed: Metabolism of carbofuran in mugho pine. PubMed: Fate of carbofuran in a model ecosystem. PubMed: Dissipation of soil-incorporated carbofuran in the field. PubMed: Selective toxicity of N-sulfenylated derivatives of insecticidal methylcarbamate esters. PubMed: Determination of carbofuran and 3-hydroxycarbofuran residues in small fruits. PubMed: Carbofuran: its toxicity to and metabolism by earthworm (Lumbricus terrestris). PubMed: Evaluation of extraction procedures for the removal of 14 C-carbofuran and its toxic metabolites from cabbage leaves. PubMed: Inhibition of acetylcholinesterase from mammals and insects by carbofuran and its related compounds and their toxicities toward these animals. PubMed: Insecticide inhibition of herbicide metabolism in leaf tissues. PubMed: Metabolism of carbofuran alfalfa residues in the dairy cow.