hydrofluorocarbon 227EA
propane, 1,1,1,2,3,3,3-heptafluoro-
Identification
| Name | hydrofluorocarbon 227EA |
| IUPAC | 1,1,1,2,3,3,3-heptafluoropropane |
| CAS Number | 431-89-0 |
| EINECS | 207-079-2 |
| FDA UNII | R40P36GDK6 |
| Molecular Formula | C3 H F7 |
| Molecular Weight | 170.02979240 |
| Nikkaji Number | J28.278B |
Regulatory
Physical Properties
| Appearance | colorless gas (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | -131.00 °C. @ 760.00 mm Hg (est) |
| Boiling Point | -19.00 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 3402.334000 mmHg @ 25.00 °C. (est) |
| Vapor Density | 4.2 at ( Air = 1 ) |
| Flash Point | -58.00 °F. TCC ( -50.10 °C. ) (est) |
| logP (o/w) | 1.610 (est) |
| Soluble in | water, 79.5 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | propellants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | inhalation-mouse LC > 7200000 mg/m3/4H |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | propellants, aerating agents, and gas |
| Recommendation for hydrofluorocarbon 227EA usage levels up to | not for fragrance use. |
| Recommendation for hydrofluorocarbon 227EA flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
apaflurane
FM 200
1,1,1,2,3,3,3-
heptafluoropropane
2H-
heptafluoropropane
HFA-227
HFC 227
HFC-227EA
2-
hydroheptafluoropropane
2-
hydroperfluoropropane
khladon 227
propane, 1,1,1,2,3,3,3-heptafluoro-
solkane 227
PubMed:
Influence of Suspension Stabilisers on the Delivery of Protein-Loaded Porous Poly (DL-Lactide-co-Glycolide) (PLGA) Microparticles via Pressurised Metered Dose Inhaler (pMDI).
PubMed:
Reverse aqueous emulsions and microemulsions in HFA227 propellant stabilized by non-ionic ethoxylated amphiphiles.
PubMed:
Solvent-solute interactions in hydrofluoroalkane propellants.
PubMed:
Biocompatible and biodegradable copolymer stabilizers for hydrofluoroalkane dispersions: a colloidal probe microscopy investigation.
PubMed:
Characterization of fine particle and gaseous emissions during school bus idling.
PubMed:
Determination of 1,1,1,2,3,3,3-heptafluoropropane (HFP) in blood by headspace gas chromatography-mass spectrometry.
PubMed:
Influence of the size of micronized active pharmaceutical ingredient on the aerodynamic particle size and stability of a metered dose inhaler.
PubMed:
Novel nanoparticles for pulmonary drug administration.
PubMed:
Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3, 3-heptafluoropropane) following whole-body exposure.
PubMed:
Setting safe acute exposure limits for halon replacement chemicals using physiologically based pharmacokinetic modeling.
PubMed:
Surfactant dissolution and water solubilization in chlorine-free liquified gas propellants.
PubMed:
Tolerability and in vivo performance of a novel freon-free metered dose inhaler for a fixed combinational product of reproterol and disodium cromoglycate.
PubMed:
Biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227): lack of protein binding of the metabolite hexafluoroacetone.