cyclohexasiloxane
dodecamethylcyclohexasiloxane
Identification
| Name | cyclohexasiloxane |
| CAS Number | 540-97-6 |
| EINECS | 208-762-8 |
| FDA UNII | XHK3U310BA |
| Molecular Formula | C12 H36 O6 Si6 |
| Molecular Weight | 444.92592000 |
| MDL Number | MFCD00144215 |
| Nikkaji Number | J120.965E |
Regulatory
Physical Properties
| Appearance | colorless clear oily liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.96720 @ 25.00 °C. |
| Refractive Index | 1.40150 @ 20.00 °C. |
| Melting Point | -3.00 °C. @ 760.00 mm Hg |
| Boiling Point | 245.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.022500 mmHg @ 25.00 °C. (est) |
| Flash Point | 256.00 °F. TCC ( 124.40 °C. ) (est) |
| Soluble in | water, 0.005007 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair conditioning |
Organoleptic Properties
| Odor Strength | none |
| Odor Description | at 100.00 %. |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 > 50000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for cyclohexasiloxane usage levels up to | not for fragrance use. |
| Recommendation for cyclohexasiloxane flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
cyclohexasiloxane, 2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-
cyclohexasiloxane, dodecamethyl-
dodecamethyl cyclohexasiloxane
2,2,4,4,6,6,8,8,10,10,12,12-
dodecamethyl-1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane
dodecamethylcyclohexasiloxan
dodecamethylcyclohexasiloxane
PubMed:
Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada.
PubMed:
Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout.
PubMed:
Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment.
PubMed:
Water-in-oil emulsions prepared by peptide-silicone hybrid polymers as active interfacial modifier: effects of silicone oil species on dispersion stability of emulsions.
PubMed:
Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation.
PubMed:
Concentrations in ambient air and emissions of cyclic volatile methylsiloxanes in Zurich, Switzerland.
PubMed:
Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model.
PubMed:
Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry.
PubMed:
Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment.
PubMed:
Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs).
PubMed:
Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air.
PubMed:
Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China.
PubMed:
Cyclic volatile methylsiloxanes in fish from the Baltic Sea.
PubMed:
Junge relationships in measurement data for cyclic siloxanes in air.
PubMed:
Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada.
PubMed:
Chemical fate, latitudinal distribution and long-range transport of cyclic volatile methylsiloxanes in the global environment: a modeling assessment.
PubMed:
Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants.
PubMed:
Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol.
PubMed:
Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane.
PubMed:
Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program.
PubMed:
Measuring chemical emissions from wet products--development of a new measurement technique.
PubMed:
Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary.
PubMed:
Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China.
PubMed:
Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method.
PubMed:
Determination of cyclic and linear siloxanes in soil samples by ultrasonic-assisted extraction and gas chromatography-mass spectrometry.
PubMed:
Volatile siloxanes in the European arctic: assessment of sources and spatial distribution.
PubMed:
Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures.
PubMed:
Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure.
PubMed:
Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products.
PubMed:
Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants.
PubMed:
[Residual chemicals in silicone rubber products for food contact use].
PubMed:
Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS.
PubMed:
Cyclosiloxanes produce fatal liver and lung damage in mice.
PubMed:
Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice.