tefluthrin

cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester, (1-alpha,3-alpha(Z))-(+-)-

CAS: 79538-32-2 C17 H14 Cl F7 O2 MW: 418.73780240

Identification

Nametefluthrin
CAS Number79538-32-2
FDA UNII2HE8P42H2J
Molecular FormulaC17 H14 Cl F7 O2
Molecular Weight418.73780240
MDL NumberMFCD00274607
Nikkaji NumberJ547.675E
Beilstein8398039

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 44.60 °C. @ 760.00 mm Hg
Boiling Point 156.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 6.000000 mmHg @ 20.00 °C. (est)
logP (o/w) 6.500
Soluble in water, 0.02 mg/L @ 20 °C (exp)

No sensory data available

Safety Information

Oral/Parenteral Toxicityoral-duck LD50 4190 mg/kg
Dermal Toxicityskin-rat LD50 148 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for tefluthrin usage levels up tonot for fragrance use.
Recommendation for tefluthrin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

cyclopropanecarboxylic acid, 3-((1Z)-2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester, (1R,3R)-rel- cyclopropanecarboxylic acid, 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl-, (2,3,5,6-tetrafluoro-4-methylphenyl)methyl ester, (1-alpha,3-alpha(Z))-(+-)- forza tefluthrine 2,3,5,6- tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate (2,3,5,6- tetrafluoro-4-methylphenyl)methyl (1S,3S)-3-[(Z)-2-chloro-3,3,3-trifluoroprop-1-enyl]-2,2-dimethylcyclopropane-1-carboxylate PubMed: A site-specific ecological risk assessment for corn-associated insecticides. PubMed: A multi-year field study to evaluate the environmental fate and agronomic effects of insecticide mixtures. PubMed: Modeling of action potential generation in NG108-15 cells. PubMed: Soil application of an encapsulated CO2 source and its potential for management of western corn rootworm larvae. PubMed: The role of carbon dioxide as an orientation cue for western corn rootworm larvae within the maize root system: implications for an attract-and-kill approach. PubMed: Use of solid phase microextraction to estimate toxicity: relating fiber concentrations to toxicity--part I. PubMed: Parameters for pyrethroid insecticide QSAR and PBPK/PD models for human risk assessment. PubMed: Coexpression with Auxiliary β Subunits Modulates the Action of Tefluthrin on Rat Na(v)1.6 and Na(v)1.3 Sodium Channels. PubMed: Electrophysiological characterization of sodium-activated potassium channels in NG108-15 and NSC-34 motor neuron-like cells. PubMed: Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin. PubMed: Characterizing the effects of Eugenol on neuronal ionic currents and hyperexcitability. PubMed: Differential state-dependent modification of rat Na(v)1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin. PubMed: Actions of Tefluthrin on Rat Na(v)1.7 Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes. PubMed: Multipesticide residue analysis in maize combining acetonitrile-based extraction with dispersive liquid-liquid microextraction followed by gas chromatography-mass spectrometry. PubMed: Toxicity of pesticide and fertilizer mixtures simulating corn production to eggs of snapping turtles (Chelydra serpentina). PubMed: Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture. PubMed: Decomposition rates and residue-colonizing microbial communities of Bacillus thuringiensis insecticidal protein Cry3Bb-expressing (Bt) and non-Bt corn hybrids in the field. PubMed: Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons. PubMed: Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Na(v)1.6 sodium channels. PubMed: Wireworm management I: stand protection versus wireworm mortality with wheat seed treatments. PubMed: Human embryonic kidney (HEK293) cells express endogenous voltage-gated sodium currents and Na v 1.7 sodium channels. PubMed: Development of a rapid determination of pesticides in coated seeds using a high-performance liquid chromatography-UV detection system. PubMed: Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. PubMed: Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure. PubMed: The mechanism of the actions of oxaliplatin on ion currents and action potentials in differentiated NG108-15 neuronal cells. PubMed: Underlying mechanism of actions of tefluthrin, a pyrethroid insecticide, on voltage-gated ion currents and on action currents in pituitary tumor (GH3) cells and GnRH-secreting (GT1-7) neurons. PubMed: Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. PubMed: Actions of ATX-II and other gating-modifiers on Na(+) currents in HEK-293 cells expressing WT and DeltaKPQ hNa(V) 1.5 Na(+) channels. PubMed: Modeling of action potential generation in NG108-15 cells. PubMed: Mortality of a wireworm, Agriotes obscurus (Coleoptera: Elateridae), after topical application of various insecticides. PubMed: Repellency of a wireworm, Agriotes obscurus (Coleoptera: Elateridae), on exposure to synthetic insecticides in a soil-less bioassay. PubMed: Soil bioassay for studying behavioral responses of wireworms (Coleoptera: Elateridae) to insecticide-treated wheat seed. PubMed: Effects of insecticide exposure on movement and population size estimates of predatory ground beetles (Coleoptera: Carabidae). PubMed: Efficacy of various pyrethroid structures against a highly metabolically resistant isogenic strain of Helicoverpa armigera (Lepidoptera: Noctuidae) from China. PubMed: Differential pharmacology of the cardiac anionic background current I(AB). PubMed: An outwardly rectifying anionic background current in atrial myocytes from the human heart. PubMed: Interactions of alternate hosts, postemergence grass control, and rootworm-resistant transgenic corn on western corn rootworm (Coleoptera: Chrysomelidae) damage and adult emergence. PubMed: Abundance of Coleomegilla maculata (Coleoptera: Coccinellidae) in corn rootworm-resistant Cry3Bb1 maize. PubMed: Toxin detection based on action potential shape analysis using a realistic mathematical model of differentiated NG108-15 cells. PubMed: Relative potencies for acute effects of pyrethroids on motor function in rats. PubMed: Microelectrode array recordings of cardiac action potentials as a high throughput method to evaluate pesticide toxicity. PubMed: Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes. PubMed: Mechanisms underlying the effects of the pyrethroid tefluthrin on action potential duration in isolated rat ventricular myocytes. PubMed: Effect of Cry3Bb transgenic corn and tefluthrin on the soil microbial community: biomass, activity, and diversity. PubMed: Differential effects of extracellular cesium on early afterdepolarizations in ventricular myocytes and arrhythmogenesis in isolated hearts of rats and guinea pigs. PubMed: Differential effects of pyrethroids on volume-sensitive anion and organic osmolyte pathways. PubMed: Larval susceptibility of an insecticide-resistant western corn rootworm (Coleoptera: Chrysomelidae) population to soil insecticides: laboratory bioassays, assays of detoxification enzymes, and field performance. PubMed: Structure-activity and interaction effects of 14 different pyrethroids on voltage-gated chloride ion channels. PubMed: Emergence of adult northern and western corn rootworms (Coleoptera: Chrysomelidae) following reduced soil insecticide applications. PubMed: Determination of pyrethroid pesticide residues in processed fruits and vegetables by gas chromatography with electron capture and mass spectrometric detection. PubMed: Cleanup of gloves contaminated with granular terbufos and tefluthrin. PubMed: Tefluthrin modulates a novel anionic background conductance (I(AB)) in guinea-pig ventricular myocytes. PubMed: Management of early-instar Japanese beetle (Coleoptera: Searabaeidae) in field-grown nursery crops. PubMed: Effects of exposure time, material type, and granular pesticide on glove contamination. PubMed: Actions of pyrethroid insecticides on sodium currents, action potentials, and contractile rhythm in isolated mammalian ventricular myocytes and perfused hearts. PubMed: Interaction of insecticides, entomopathogenic nematodes, and larvae of the western corn rootworm (Coleoptera: Chrysomelidae). PubMed: Selective extraction of pyrethroid pesticide residues from milk by solid-matrix dispersion. PubMed: Clean-up of aqueous acetone vegetable extracts by solid-matrix partition for pyrethroid residue determination by gas chromatography-electron-capture detection. PubMed: Factors Influencing Pyrethroid Resistance in a Permethrin-Selected Strain of the Soybean Looper, Pseudoplusia includens (Walker)