methoxyacetaldehyde
acetaldehyde, methoxy- (8CI,9CI)
Identification
| Name | methoxyacetaldehyde |
| IUPAC | 2-methoxyacetaldehyde |
| CAS Number | 10312-83-1 |
| EINECS | 233-693-5 |
| FDA UNII | 5G4O7K64WA |
| Molecular Formula | C3 H6 O2 |
| Molecular Weight | 74.07922000 |
| MDL Number | MFCD00059176 |
| Nikkaji Number | J54.041B |
| Beilstein | 1738030 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 92.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 406.300000 mmHg @ 25.00 °C. (est) |
| Flash Point | -38.00 °F. TCC ( -38.90 °C. ) (est) |
| logP (o/w) | -0.640 (est) |
| Soluble in | water, 9.39e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 2330 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 1170 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for methoxyacetaldehyde usage levels up to | not for fragrance use. |
| Recommendation for methoxyacetaldehyde flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acetaldehyde, 2-methoxy-
acetaldehyde, methoxy- (8CI,9CI)
2-
methoxyacetaldehyde
methoxyethanal
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Efficient enzymatic synthesis of phosphoroselenoate RNA by using adenosine 5'-(alpha-P-seleno)triphosphate.
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2-Methoxyethanol metabolism, embryonic distribution, and macromolecular adduct formation in the rat: the effect of radiofrequency radiation-induced hyperthermia.
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Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse.
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A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels.
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Concurrent teratogenic and mutagenic action of 2-methoxyethanol in Drosophila melanogaster larvae resulted in similar phenotypes: close resemblance to directed mutations.
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Apoptosis inhibition and ornithine decarboxylase superinduction as early epigenetic events in morphological transformation of Syrian hamster embryo cells exposed to 2-methoxyacetaldehyde, a metabolite of 2-methoxyethanol.
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Oligosaccharides of recombinant mouse gelatinase B variants.
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The role of metabolism in 2-methoxyethanol-induced suppression of in vitro polyclonal antibody responses by rat and mouse lymphocytes.
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Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5.
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Effects of reactive oxygen species (ROS) modulators, TEMPOL and catalase, on methoxyacetaldehyde (MALD) -induced chromosome aberrations in Chinese hamster ovary (CHO)-AS52 cells.
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Induction of deletion mutations by methoxyacetaldehyde in Chinese hamster ovary (CHO)-AS52 cells.
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Mutagenicity and cytotoxicity of 2-butoxyethanol and its metabolite, 2-butoxyacetaldehyde, in Chinese hamster ovary (CHO-AS52) cells.
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Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-.
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Cytogenetic effects of 2-methoxyethanol and its metabolite, methoxyacetaldehyde, in mammalian cells in vitro.
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Evaluation of the clastogenic effects of 2-methoxyethanol in mice.
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Methoxyacetaldehyde, an intermediate metabolite of 2-methoxyethanol, is immunosuppressive in the rat.
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Fluorometric determination of L-tryptophan with methoxyacetaldehyde.
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Mutagenicity and cytotoxicity of 2-methoxyethanol and its metabolites in Chinese hamster cells (the CHO/HPRT and AS52/GPT assays).
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Antimicrobial effects of some mono- and bishydrazones.
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N-(cyanomethyl)- and N-(2-methoxy-1-cyanoethyl)anthracyclines and related carboxyl derivatives.
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Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat.
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Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat.