methoxyacetaldehyde

acetaldehyde, methoxy- (8CI,9CI)

CAS: 10312-83-1 C3 H6 O2 MW: 74.07922000

Identification

Namemethoxyacetaldehyde
IUPAC2-methoxyacetaldehyde
CAS Number10312-83-1
EINECS233-693-5
FDA UNII5G4O7K64WA
Molecular FormulaC3 H6 O2
Molecular Weight74.07922000
MDL NumberMFCD00059176
Nikkaji NumberJ54.041B
Beilstein1738030

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 92.00 °C. @ 760.00 mm Hg
Vapor Pressure 406.300000 mmHg @ 25.00 °C. (est)
Flash Point -38.00 °F. TCC ( -38.90 °C. ) (est)
logP (o/w) -0.640 (est)
Soluble in water, 9.39e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 2330 mg/kg
Dermal Toxicityskin-rabbit LD50 1170 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for methoxyacetaldehyde usage levels up tonot for fragrance use.
Recommendation for methoxyacetaldehyde flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

acetaldehyde, 2-methoxy- acetaldehyde, methoxy- (8CI,9CI) 2- methoxyacetaldehyde methoxyethanal PubMed: Azithromycin-sulfonamide conjugates as inhibitors of resistant Streptococcus pyogenes strains. PubMed: Efficient enzymatic synthesis of phosphoroselenoate RNA by using adenosine 5'-(alpha-P-seleno)triphosphate. PubMed: Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. PubMed: Biotic and abiotic degradation behaviour of ethylene glycol monomethyl ether (EGME). PubMed: Gas chromatography-mass spectrometry of carbonyl compounds in cigarette mainstream smoke after derivatization with 2,4-dinitrophenylhydrazine. PubMed: Oxidative generation of guanine radicals by carbonate radicals and their reactions with nitrogen dioxide to form site specific 5-guanidino-4-nitroimidazole lesions in oligodeoxynucleotides. PubMed: Involvement of caspase 3 mediated apoptosis in hematopoietic cytotoxicity of metabolites of ethylene glycol monomethyl ether. PubMed: High-throughput analysis of hemoglobin from neonates using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. PubMed: Immunochemical assay of hemoglobin with N(epsilon)-(carboxymethyl)lysine at lysine 66 of the beta chain. PubMed: 2-Methoxyethanol metabolism, embryonic distribution, and macromolecular adduct formation in the rat: the effect of radiofrequency radiation-induced hyperthermia. PubMed: Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. PubMed: A novel compound heterozygote (FAP ATTR Arg104His/ATTR Val30Met) with high serum transthyretin (TTR) and retinol binding protein (RBP) levels. PubMed: Concurrent teratogenic and mutagenic action of 2-methoxyethanol in Drosophila melanogaster larvae resulted in similar phenotypes: close resemblance to directed mutations. PubMed: Apoptosis inhibition and ornithine decarboxylase superinduction as early epigenetic events in morphological transformation of Syrian hamster embryo cells exposed to 2-methoxyacetaldehyde, a metabolite of 2-methoxyethanol. PubMed: Oligosaccharides of recombinant mouse gelatinase B variants. PubMed: The role of metabolism in 2-methoxyethanol-induced suppression of in vitro polyclonal antibody responses by rat and mouse lymphocytes. PubMed: Interaction of human CYP17 (P-450(17alpha), 17alpha-hydroxylase-17,20-lyase) with cytochrome b5: importance of the orientation of the hydrophobic domain of cytochrome b5. PubMed: Effects of reactive oxygen species (ROS) modulators, TEMPOL and catalase, on methoxyacetaldehyde (MALD) -induced chromosome aberrations in Chinese hamster ovary (CHO)-AS52 cells. PubMed: Induction of deletion mutations by methoxyacetaldehyde in Chinese hamster ovary (CHO)-AS52 cells. PubMed: Mutagenicity and cytotoxicity of 2-butoxyethanol and its metabolite, 2-butoxyacetaldehyde, in Chinese hamster ovary (CHO-AS52) cells. PubMed: Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-. PubMed: Cytogenetic effects of 2-methoxyethanol and its metabolite, methoxyacetaldehyde, in mammalian cells in vitro. PubMed: Evaluation of the clastogenic effects of 2-methoxyethanol in mice. PubMed: Methoxyacetaldehyde, an intermediate metabolite of 2-methoxyethanol, is immunosuppressive in the rat. PubMed: Fluorometric determination of L-tryptophan with methoxyacetaldehyde. PubMed: Mutagenicity and cytotoxicity of 2-methoxyethanol and its metabolites in Chinese hamster cells (the CHO/HPRT and AS52/GPT assays). PubMed: Antimicrobial effects of some mono- and bishydrazones. PubMed: N-(cyanomethyl)- and N-(2-methoxy-1-cyanoethyl)anthracyclines and related carboxyl derivatives. PubMed: Testicular toxicity of 2-methoxyacetaldehyde, a possible metabolite of ethylene glycol monomethyl ether, in the rat. PubMed: Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat.