chloral hydrate

1,1,1-trichloro-2,2-dihydroxyethane

CAS: 302-17-0 C2 H3 Cl3 O2 MW: 165.40031000

Identification

Namechloral hydrate
CAS Number302-17-0
FDA UNII418M5916WG
Molecular FormulaC2 H3 Cl3 O2
Molecular Weight165.40031000
MDL NumberMFCD00044479
Nikkaji NumberJ1.517B
Beilstein1698497
XlogP31.00 (est)

Regulatory

FDA Mainterm (IAUFC)302-17-0 ; CHLORAL HYDRATE
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance white crystals (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 57.00 °C. @ 760.00 mm Hg
Boiling Point 98.00 °C. @ 760.00 mm Hg, 96.00 to 97.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure 15.000000 mmHg @ 25.00 °C.
Flash Point 135.00 °F. TCC ( 57.30 °C. ) (est)
logP (o/w) 0.990
Soluble in water, 3.83E+06 mg/L @ 38C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-cat LDLo 400 mg/kg
Dermal Toxicitysubcutaneous-mouse LDLo 800 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: GENERAL ANESTHETIC\nCARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)\nVASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION']

Safety in Use

Categoryindirect food additives: adhesives and components of coatings
Recommendation for chloral hydrate usage levels up tonot for fragrance use.
Recommendation for chloral hydrate flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

aquachloral chloradorm chloral monohydrate chloralhydrate ethanediol, 2,2,2-trichloro- 1,1- ethanediol, 2,2,2-trichloro- knockout drops lycoral novochlorhydrate 2,2,2- trichloro-1,1-ethanediol 1,1,1- trichloro-2,2-dihydroxyethane 1,1,1- trichloro-2,2-ethanediol trichloroacetaldehyde trichloroacetaldehyde hydrate trichloroacetaldehyde monohydrate trichloroacetaldehyde, hydrated 2,2,2- trichloroethane-1,1-diol PubMed: Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat. PubMed: Rapid and facile detection of four date rape drugs in different beverages utilizing proton transfer reaction mass spectrometry (PTR-MS). PubMed: Meal-feeding rodents and toxicology research. PubMed: Verocytotoxin-producing Escherichia coli (VTEC). PubMed: [Depressive-like state and sleep in laboratory mice]. PubMed: Use of anesthetic agents in neonates and young children. PubMed: Effect of taurine on gastric oxidative stress and hemorrhagic erosion in brain ischemic rats. PubMed: Role of gastric oxidative stress and nitric oxide in formation of hemorrhagic erosion in rats with ischemic brain. PubMed: History repeats itself: pharmacodynamic trends in the treatment of anxiety disorders. PubMed: Increased osmolality of breast milk with therapeutic additives. PubMed: Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure. PubMed: Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice. PubMed: Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays. PubMed: Lipid peroxidation and cell death mechanisms in rats and human cells induced by chloral hydrate. PubMed: Toxicology and carcinogenesis study of chloral hydrate (ad libitum and dietary controlled) (CAS no. 302-17-0) in male B6C3F1 mice (gavage study). PubMed: Subchronic toxicity of chloral hydrate on rats: a drinking water study. PubMed: NTP Technical Report on the Toxicology and Carcinogenesis Studies of Chloral Hydrate (Cas No. 302-17-0) in B6C3F1 mice (Gavage Studies). PubMed: Inhibition of purified pig and human liver retinyl ester hydrolase by pharmacologic agents. PubMed: Comparative study of a combination of isometheptene mucate, dichloralphenazone with acetaminophen and sumatriptan succinate in the treatment of migraine. PubMed: Analytical methods for water disinfection byproducts in foods and beverages. PubMed: Adverse sedation events in pediatrics: analysis of medications used for sedation. PubMed: Migraine in older patients: a case report and management strategies. PubMed: Monoamines and nitric oxide are employed by afferents engaged in midline thalamic regulation. PubMed: Tonic sympathetic nervous system inhibition of insulin secretion is diminished in obese Zucker rats. PubMed: Should chloral hydrate be banned? PubMed: Chloral hydrate side effects in young children: causes and management. PubMed: Dynamics of oral intake resumption after general anesthesia and operation in rats. PubMed: Ninety-day toxicity study of chloral hydrate in the Sprague-Dawley rat. PubMed: Myocardial mechanics predict hemodynamic performance during normal function and alcohol-induced dysfunction in rats. PubMed: Ethyl carbamate metabolism: in vivo inhibitors and in vitro enzymatic systems. PubMed: The rediscovery of infant feeding formula with magnetic resonance imaging. PubMed: Methods of euthanasia in poultry and food-producing animals. PubMed: [Inhibition of methanogenesis in the rumen of sheep. II. Methanogenesis after administration of inhibitors]. PubMed: Effect of perinatal polybrominated biphenyl exposure on acquisition and performance of an autoshaping paradigm. PubMed: Effects of some volatile sedative-hypnotics on punished behavior. PubMed: Breast-feeding and failure to thrive. PubMed: Chlorpromazine induced hyperphagia in the rat. PubMed: Radiation-induced dechlorination of chloral hydrate and 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT). PubMed: Generalization by rats of alcohol and atropine stimulus characteristics to other drugs. PubMed: Enumeration of Bacillus cereus in foods. PubMed: Effect of prolonged individual caging on toxicity parameters in rats.