sodium deoxycholate

deoxycholic acid, sodium salt

CAS: 302-95-4 C24 H39 Na O4 MW: 414.56139928

Identification

Namesodium deoxycholate
CAS Number302-95-4
EINECS206-132-7
FDA UNII436LS6U35Y
Molecular FormulaC24 H39 Na O4
Molecular Weight414.56139928
MDL NumberMFCD00064139
Nikkaji NumberJ21.480I
Beilstein3643164

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in water, 215.2 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LD50 36 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 815 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nBEHAVIORAL: ATAXIA\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: ATAXIA', 'BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nBEHAVIORAL: ATAXIA\nLUNGS, THORAX, OR RESPIRATION: OTHER CHANGES', 'LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES\nBEHAVIORAL: ATAXIA\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for sodium deoxycholate usage levels up tonot for fragrance use.
Recommendation for sodium deoxycholate flavor usage levels up tonot for flavor use.

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We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

deoxycholate sodium deoxycholic acid, sodium salt desoxycholate sodium desoxycholic acid sodium salt (4R)-4-((1S,2S,11S,16S,5R,7R,10R,14R,15R)-5,16- dihydroxy-2,15-dimethyltetracyc lo[8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoic acid, sodium salt (4R)-4-((1S,2S,11S,16S,5R,7R,10R,14R,15R)-5,16- dihydroxy-2,15-dimethyltetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-14-yl)pentanoic acid, sodium salt sodium (4R)-4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate sodium 7-deoxycholate sodium deoxycholic acid sodium desoxycholate sodiumdeoxycholate PubMed: Efficient transformation of Rhizopus delemar by electroporation of germinated spores. PubMed: Use of sodium lauroyl sarcosinate (sarkosyl) in viable real-time PCR for enumeration of Escherichia coli. PubMed: Toxicokinetic and mechanistic basis for the safety and tolerability of liposomal amphotericin B. PubMed: A novel immunoproteomics method for identifying in vivo-induced Campylobacter jejuni antigens using pre-adsorbed sera from infected patients. PubMed: Effects of microwave (2.45 GHz) irradiation on some biological characters of Salmonella typhimurium. PubMed: Global transcriptional and phenotypic analyses of Escherichia coli O157:H7 strain Xuzhou21 and its pO157_Sal cured mutant. PubMed: Study on interaction of bile salts with curcumin and curcumin embedded in dipalmitoyl-sn-glycero-3-phosphocholine liposome. PubMed: Enzymatic synthesis of phosphatidylserine using bile salt mixed micelles. PubMed: Resistance to bile salts and sodium deoxycholate in macrolide- and fluoroquinolone-susceptible and resistant Campylobacter jejuni and Campylobacter coli strains. PubMed: Effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeB in biocide resistance of Campylobacter jejuni and Campylobacter coli. PubMed: Role of anionic charges of periplasmic glucans of Shigella flexneri in overcoming detergent stress. PubMed: Cj1136 is required for lipooligosaccharide biosynthesis, hyperinvasion, and chick colonization by Campylobacter jejuni. PubMed: Role of anionic charges of osmoregulated periplasmic glucans of Salmonella enterica serovar Typhimurium SL1344 in mice virulence. PubMed: In vitro binding capacity of bile acids by defatted corn protein hydrolysate. PubMed: Evaluation of a new enrichment broth for detection of Cronobacter spp. in powdered infant formula. PubMed: Separation of dipeptides with two chiral centers using 2-hydroxypropyl-beta-CD-modified MEKC. PubMed: Arcobacter trophiarum sp. nov., isolated from fattening pigs. PubMed: Evaluation of Mycoplasma inactivation during production of biologics: egg-based viral vaccines as a model. PubMed: Probiotic properties of yeasts isolated from chicken feces and kefirs. PubMed: Discrimination of viable and dead Vibrio vulnificus after refrigerated and frozen storage using EMA, sodium deoxycholate and real-time PCR. PubMed: Crab digestive phospholipase: a new invertebrate member. PubMed: Improving the enrichment procedure for Enterobacteriaceae detection. PubMed: Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli. PubMed: Transport of Val-Leu-Pro-Val-Pro in human intestinal epithelial (Caco-2) cell monolayers. PubMed: Culture of Campylobacter jejuni with sodium deoxycholate induces virulence gene expression. PubMed: Virulence properties of Campylobacter jejuni isolates of poultry and human origin. PubMed: Direct and rapid discrimination of aflatoxigenic strains based on fibre-optic room temperature phosphorescence detection. PubMed: Modification of milk and whey surface properties by enzymatic hydrolysis of milk phospholipids. PubMed: Study of a room temperature phosphorescence phenomenon to allow the detection of aflatoxigenic strains in culture media. PubMed: In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. PubMed: Purification and characterization of a fructosyltransferase from onion bulbs and its key role in the synthesis of fructo-oligosaccharides in vivo. PubMed: A new micellar electrokinetic capillary chromatography method for separation of the components of the aminoglycoside antibiotics. PubMed: Growth of autobioluminescent Campylobacter jejuni in response to various environmental conditions. PubMed: Development of a method for direct visual determination of aflatoxin production by colonies of the Aspergillus flavus group. PubMed: Comparison of recovery of airborne microorganisms in a dairy cattle facility using selective agar and thin agar layer resuscitation media. PubMed: Improvements in the measurement of stool decay-accelerating factor in the detection of colorectal cancer. PubMed: Biosynthetic requirements for the repair of membrane damage in pressure-treated Escherichia coli. PubMed: Survival of Campylobacter jejuni during stationary phase: evidence for the absence of a phenotypic stationary-phase response. PubMed: Cholesterol solubilization in aqueous micellar solutions of quillaja saponin, bile salts, or nonionic surfactants. PubMed: Determination of biogenic amines in fish implicated in food poisoning by micellar electrokinetic capillary chromatography. PubMed: Simultaneous determination of sweeteners and preservatives in preserved fruits by micellar electrokinetic capillary chromatography. PubMed: Antitumorigenic effects of several food proteins in a rat model with colon cancer and their reverse correlation with plasma bile acid concentration. PubMed: Simultaneous determination of antioxidants, preservatives and sweeteners permitted as additives in food by mixed micellar electrokinetic chromatography. PubMed: A food-grade process for isolation and partial purification of bacteriocins of lactic acid bacteria that uses diatomite calcium silicate. PubMed: Isolation of Campylobacter spp. from slaughtered cattle and swine on blood-free selective medium. PubMed: Evaluation of cell death in EBV-transformed lymphocytes using agarose gel electrophoresis, light microscopy and electron microscopy. I. Induction of classic apoptosis by the bile salt, sodium deoxycholate. PubMed: Micellar electrokinetic capillary chromatographic determination of artificial sweeteners in low-Joule soft drinks and other foods. PubMed: Effects of rat bile-pancreatic juice on Fe2+ induced peroxidation of phospholipids. PubMed: Use of inexpensive O antisera as the detecting antibodies for Salmonella antigens in the polymyxin-cloth enzyme immunoassay. PubMed: [Features of Vibrio cholerae 0:1 El Tor, Inaba serotype, isolated during the cholera epidemic in Cartagena (Colombia)]. PubMed: Evaluation of Chemicals for Restricting Colony Spreading by a Xerophilic Mold, Eurotium amstelodami, on Dichloran-18% Glycerol Agar. PubMed: Distribution of 5'-nucleotidase in muscle of some marine fishes. PubMed: Different forms of alkaline phosphatase in adult rat femur. Effect of a vitamin D3-deficient diet and of a sorbitol-enriched diet. PubMed: Cytochrome b5/cytochrome b5 reductase complex in rat liver microsomes has NADH-linked aquacobalamin reductase activity. PubMed: Purification of rough-type lipopolysaccharides of Neisseria meningitidis from cells and outer membrane vesicles in spent media. PubMed: Pathogenic Escherichia coli O157:H7 and their detection. PubMed: A p-nitrophenyl phosphorylcholine phosphodiesterase from mouse brain. PubMed: The action of sodium deoxycholate on Escherichia coli. PubMed: Ornithine decarboxylase induction in rat colon: synergistic effects of intrarectal instillation of sodium deoxycholate and starvation-refeeding. PubMed: Immobilization of fumarase by entrapment of rat liver mitochondria in polyacrylamide gel using gamma rays. PubMed: Fermentation by the human large intestine microbial community in an in vitro semicontinuous culture system.