ferric citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)
Identification
| Name | ferric citrate |
| CAS Number | 3522-50-7 |
| FDA UNII | 63G354M39Z |
| Molecular Formula | C6 H5 Fe O7 |
| Molecular Weight | 244.94525000 |
| MDL Number | MFCD00013098 |
| Nikkaji Number | J1.249A |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents and indirect food additives: paper and paperboard components |
| Recommendation for ferric citrate usage levels up to | not for fragrance use. |
| Recommendation for ferric citrate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
citric acid, iron(3+) salt (1:1)
2-
hydroxypropane-1,2,3-tricarboxylate;iron(3+)
iron(III) citrate
1,2,3-
propanetricarboxylic acid, 2-hydroxy-, iron(3+) salt (1:1)
zerenex
PubMed:
Visual detection technique for efficient screening and isolation of Salmonella based on a novel enrichment assay using chromatography membrane.
PubMed:
Microbial Metabolism Shifts Towards an Adverse Profile with Supplementary Iron in the TIM-2 In vitro Model of the Human Colon.
PubMed:
Dose-related effects of ferric citrate supplementation on endoplasmic reticular stress responses and insulin signalling pathways in streptozotocin-nicotinamide-induced diabetes.
PubMed:
Managing hyperphosphatemia in patients with chronic kidney disease on dialysis with ferric citrate: latest evidence and clinical usefulness.
PubMed:
Novel iron-based phosphate binders in patients with chronic kidney disease.
PubMed:
Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.
PubMed:
Dietary polyunsaturated fatty acids and heme iron induce oxidative stress biomarkers and a cancer promoting environment in the colon of rats.
PubMed:
Cultivar variability of iron uptake mechanisms in rice (Oryza sativa L.).
PubMed:
Ferric citrate hydrate as a phosphate binder and risk of aluminum toxicity.
PubMed:
A 13-week subchronic toxicity study of ferric citrate in F344 rats.
PubMed:
Dietary iron supplements and Moringa oleifera leaves influence the liver hepcidin messenger RNA expression and biochemical indices of iron status in rats.
PubMed:
Enhancement of non-heme iron absorption by anchovy (Engraulis japonicus) muscle protein hydrolysate involves a nanoparticle-mediated mechanism.
PubMed:
Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
PubMed:
Role of ferric reductases in iron acquisition and virulence in the fungal pathogen Cryptococcus neoformans.
PubMed:
Dynamics in the rhizosphere and iron-uptake gene expression in peanut induced by intercropping with maize: role in improving iron nutrition in peanut.
PubMed:
Silencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1).
PubMed:
Effect of iron liposomes on anemia of inflammation.
PubMed:
Hepatocyte divalent metal-ion transporter-1 is dispensable for hepatic iron accumulation and non-transferrin-bound iron uptake in mice.
PubMed:
High bioavailability iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro (Caco-2 model) and in vivo (Gallus gallus).
PubMed:
Ferric citrate CYP2E1-independently promotes alcohol-induced apoptosis in HepG2 cells via oxidative/nitrative stress which is attenuated by pretreatment with baicalin.
PubMed:
Heme carrier protein 1 transports heme and is involved in heme-Fe metabolism.
PubMed:
Iron and zinc concentrations in grain and flour of winter wheat as affected by foliar application.
PubMed:
Accelerating glycolytic flux of Torulopsis glabrata CCTCC M202019 at high oxidoreduction potential created using potassium ferricyanide.
PubMed:
A thioredoxin reductase-like protein from the thermophile, Thermus scotoductus SA-01, displaying iron reductase activity.
PubMed:
Transport of iron bound to recombinant human lactoferrin from rice and iron citrate across Caco-2 cell monolayers.
PubMed:
Effects of glyphosate application on seed iron and root ferric (III) reductase in soybean cultivars.
PubMed:
Biodegradation of anthraquinone dyes by Shewanella sp. NTOU1 under anaerobic conditions.
PubMed:
Ascorbic acid uptake affects ferritin, Dcytb and Nramp2 expression in Caco-2 cells.
PubMed:
Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions.
PubMed:
A cyclic AMP receptor protein-regulated cell-cell communication system mediates expression of a FecA homologue in Stenotrophomonas maltophilia.
PubMed:
Isolation of a soluble and membrane-associated Fe(III) reductase from the thermophile, Thermus scotoductus (SA-01).
PubMed:
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.
PubMed:
Rates of foliar penetration of chelated Fe(III): role of light, stomata, species, and leaf age.
PubMed:
Inhibition of iron uptake from iron salts and chelates by divalent metal cations in intestinal epithelial cells.
PubMed:
Oxidative stress and antioxidant status in mouse kidney: effects of dietary lipid and vitamin E plus iron.
PubMed:
Physiological modulation of iron metabolism in rainbow trout (Oncorhynchus mykiss) fed low and high iron diets.
PubMed:
Ferric citrate is half as effective as ferrous sulfate in meeting the iron requirement of juvenile tilapia, Oreochromis niloticus x O. aureus.
PubMed:
Iron bioavailability and utilization in rats are lower from lime-treated corn flour than from wheat flour when they are fortified with different sources of iron.
PubMed:
Mutagenicity and DNA-damaging activity caused by decomposed products of potassium sorbate reacting with ascorbic acid in the presence of Fe salt.
PubMed:
Molecular cloning and identification of UTR1 of a yeast Saccharomyces cerevisiae as a gene encoding an NAD kinase.
PubMed:
Enhanced iron uptake of Saccharomyces cerevisiae by heterologous expression of a tadpole ferritin gene.
PubMed:
The importance of the proportion of heme/nonheme iron in the diet to minimize the interference with calcium, phosphorus, and magnesium metabolism on recovery from nutritional ferropenic anemia.
PubMed:
Red meat and colon cancer: the cytotoxic and hyperproliferative effects of dietary heme.
PubMed:
Oxidative stress and antioxidant status in mouse liver: effects of dietary lipid, vitamin E and iron.
PubMed:
Effects of iron replenishment on iron, calcium, phosphorus and magnesium metabolism in iron-deficient rats.
PubMed:
Iron supplementation generates hydroxyl radical in vivo. An ESR spin-trapping investigation.
PubMed:
Reduction of exogenous ferric iron by a surface-associated ferric reductase of Listeria spp.
PubMed:
Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells.
PubMed:
Tumorigenicity study of ferric citrate administered orally to mice.
PubMed:
Induction of oxidative single- and double-strand breaks in DNA by ferric citrate.
PubMed:
Heat resistance of Listeria monocytogenes by two recovery media used with and without cold preincubation.
PubMed:
Development of an improved chemically defined minimal medium for Listeria monocytogenes.
PubMed:
Effect of dietary fat on growth of MCF-7 and MDA-MB231 human breast carcinomas in athymic nude mice: relationship between carcinoma growth and lipid peroxidation product levels.
PubMed:
Development of a protein-free medium with ferric citrate substituting transferrin for the cultivation of mouse-mouse hybridomas.
PubMed:
Effect of endotoxin on colonisation of Campylobacter jejuni in infant mice.
PubMed:
Effect of excess dietary iron as ferrous sulfate and ferric citrate on tissue mineral composition of sheep.
PubMed:
[The determination of iron in ammoniacal ferric citrate and in syrups that contain it].