Identification

Nameethyl salicylate
IUPACethyl 2-hydroxybenzoate
CAS Number118-61-6
EINECS204-265-5
FDA UNII555U6TZ2MV
Molecular FormulaC9 H10 O3
Molecular Weight166.17630000
MDL NumberMFCD00002215
Nikkaji NumberJ5.527A
Beilstein0907659
CoE Number432
XlogP33.00 (est)

Regulatory

JECFA Food Flavoring900 ethyl salicylate
DG SANTE Food Flavourings09.748 ethyl salicylate
FEMA Number2458
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)118-61-6 ; ETHYL SALICYLATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless clear liquid (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed Yes
Specific Gravity 1.12700 to 1.13000 @ 25.00 °C.
Pounds per Gallon - (est). 9.378 to 9.403
Refractive Index 1.52100 to 1.52300 @ 20.00 °C.
Melting Point 1.00 to 3.00 °C. @ 760.00 mm Hg
Boiling Point 233.00 to 235.00 °C. @ 760.00 mm Hg, 107.00 to 108.00 °C. @ 12.00 mm Hg
Acid Value 1.00 max. KOH/g
Vapor Pressure 0.035000 mmHg @ 25.00 °C. (est)
Flash Point 225.00 °F. TCC ( 107.22 °C. )
logP (o/w) 2.950
Soluble in alcohol
Stability non-discoloring in most media
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength medium
Substantivity 4 hour(s) at 100.00 %
Odor Description
at 100.00 %.
Sweet, wintergreen, tutti frutti, cooling, spicy and balsamic
mild, sweet, reminiscent of wintergreen oil
aromatic, sweet, curative, phenolic
Sweet minty, floral, fruity, health balsamic
Odor sample from Givaudan Corporation
Taste Description
at 10.00 ppm.
sweet-phenolic, herbal-medicinal
sweet, wintergreen

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience12 % solution: no irritation or sensitization.
Oral/Parenteral Toxicityoral-rat LD50 1320 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
maximum skin levels for fine fragrances0.1400 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2002)
Recommendation for ethyl salicylate usage levels up to6.0000 % in the fragrance concentrate.
use level in formulae for use in cosmetics0.0064 %
Dermal Systemic Exposure in Cosmetic Products0.0002 mg/kg/day (IFRA, 2002)
Maximised Survey-derived Daily Intakes (MSDI-EU)27.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)1700.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

FR acacia FR apricot FR berry FR blackberry FR cranberry FR floral FR fruit FL grenadine FR lily FR meadowsweet FR melon FR papaya FR raspberry FR root beer spirea FR strawberry FR wintergreen FR ylang ylang

Natural Occurrence

capsicum frutescens cassie absolute @ 0.18% Data elder black elder leaf elder black elder leaf oil feijoa fruit grape mangrove bark red oil cuba @ 0.10% Data osmanthus absolute @ trace% Data papaya fruit plumcot fruit PMC raspberry red raspberry fruit rum PMC tomato whiskey scotch whiskey wine red wine

Synonyms

benzoic acid, 2-hydroxy-, ethyl ester o-( ethoxycarbonyl) phenol ortho-( ethoxycarbonyl) phenol o-( ethoxycarbonyl)phenol ortho-( ethoxycarbonyl)phenol ethyl 2-hydroxybenzoate ethyl o-hydroxybenzoate ethyl ortho-hydroxybenzoate ethyl salicylate FCC ethylsalicylate 2- hydroxybenzoic acid ethyl ester mesotol sal ether sal ethyl salicilato de etila salicylic acid ethyl ester salicylic acid ethylester salicylic ether salicylic ethyl ester PubMed: Plasticized branched aliphatic oligoesters as potential mucoadhesive drug carriers. PubMed: Preparation of Aryl-Susbstituted 2-Oxyindoles by Superelectrophilic Chemistry. PubMed: Evaluation of the new anti-inflammatory compound ethyl salicylate 2-O-β-D-glucoside and its possible mechanism of action. PubMed: The estrogenic potential of salicylate esters and their possible risks in foods and cosmetics. PubMed: Optimization and validation of liquid chromatography and headspace-gas chromatography based methods for the quantitative determination of capsaicinoids, salicylic acid, glycol monosalicylate, methyl salicylate, ethyl salicylate, camphor and l-menthol in a topical formulation. PubMed: On-line reaction monitoring by extractive electrospray ionisation. PubMed: Levels of mint and wintergreen flavorants: smokeless tobacco products vs. confectionery products. PubMed: Encapsulation of methyl and ethyl salicylates by beta-cyclodextrin HPLC, UV-vis and molecular modeling studies. PubMed: Fragrance material review on ethyl salicylate. PubMed: DFT and ab initio study of structure of dyes derived from 2-hydroxy and 2,4-dihydroxy benzoic acids. PubMed: N'-Ferrocenyl-2-hydroxy-benzohydrazide. PubMed: Salicylate activity. 2. Potentiation of atrazine. PubMed: [Study on the phosphorylaions reaction between ethyl salicylate and DEPH]. PubMed: Percutaneous penetration and skin metabolism of ethylsalicylate-containing agent, TU-2100: in-vitro and in-vivo evaluation in guinea pigs. PubMed: Phase transfer and characterization of poly(epsilon-caprolactone) and poly(L-lactide) microspheres. PubMed: sal genes determining the catabolism of salicylate esters are part of a supraoperonic cluster of catabolic genes in Acinetobacter sp. strain ADP1. PubMed: Sensitive and selective gas chromatographic methods for the quantitation of camphor, menthol and methyl salicylate from human plasma. PubMed: The Effect of Slight Deformation on Thermocapillary-Driven Droplet Coalescence and Growth. PubMed: Simultaneous quantitative analysis of methyl salicylate, ethyl salicylate and salicylic acid from biological fluids using gas chromatography-mass spectrometry. PubMed: Chemical release from topical formulations across synthetic membranes: infinite dose. PubMed: [Stability of phenyl salicylate in alcoholic-aqueous solution]. PubMed: A four-component attractant for the mexican fruit fly,Anastrepha ludens (Diptera: Tephritidae), from host fruit. PubMed: Identification of a cocaine esterase in a strain of Pseudomonas maltophilia. PubMed: Evaluation of antifungal volatile compounds on the basis of the elongation rate of a single hypha. PubMed: Some observations on the pharmacology of 'deep-heat', a topical rubifacient. PubMed: Inhibition of Aspergillus growth and aflatoxin release by derivatives of benzoic acid. PubMed: Simultaneous GLC determination of methyl salicylate and menthol in a topical analgesic formulation.