costic acid
2-[(2R,4aR,8aS)-4a-methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
Identification
| Name | costic acid |
| IUPAC | 2-[(2R,4aR,8aS)-4a-methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid |
| CAS Number | 3650-43-9 |
| FDA UNII | 6109CN8DDD |
| Molecular Formula | C15 H22 O2 |
| Molecular Weight | 234.33874000 |
| Nikkaji Number | J22.564I |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 1.05010 @ 25.00 °C. |
| Boiling Point | 170.00 to 175.00 °C. @ 11.00 mm Hg |
| Flash Point | 507.00 °F. TCC ( 263.80 °C. ) (est) |
| logP (o/w) | 4.930 (est) |
| Soluble in | water, 2.899 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for costic acid usage levels up to | not for fragrance use. |
| Recommendation for costic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
b-
costic acid
beta-
costic acid
(2R-(2alpha,4aalpha,8abeta))-
decahydro-4a-methyl-alpha,8-bis(methylene)-2-naphthalene acetic acid
2-[(2R,4aR,8aS)-4a-
methyl-8-methylenedecahydro-2-naphthalenyl]acrylic acid
2-[(2R,4aR,8aS)-4a-
methyl-8-methylidene-1,2,3,4,5,6,7,8a-octahydronaphthalen-2-yl]prop-2-enoic acid
2-[(2R,4aR,8aS)-4a-
methyl-8-methylidenedecahydronaphthalen-2-yl]prop-2-enoic acid
2-
naphthaleneacetic acid, decahydro-4a-methyl-a,8-bis(methylene)-, (2R,4aR,8aS)-
Google Patents:
Use of costic acid or extracts of dittrichia viscosa against varroa destructor
PubMed:
[Network pharmacology study on major active compounds of siwu decoction analogous formulae for treating primary dysmenorrhea of gynecology blood stasis syndrome].
PubMed:
Inuloxins A-D, phytotoxic bi-and tri-cyclic sesquiterpene lactones produced by Inula viscosa: potential for broomrapes and field dodder management.
PubMed:
[Chemical constituents of Dolomiaea souliei].
PubMed:
[Study on chemical constituents from the roots of Saussurea lappa].
PubMed:
Chemical composition and in vitro activity of plant extracts from Ferula communis and Dittrichia viscosa against postharvest fungi.
PubMed:
Extracts of Inula viscosa Control Downy Mildew of Grapes Caused by Plasmopara viticola.
PubMed:
PTP1B inhibitors from Saussrurea lappa.
PubMed:
Antifeedant/insecticidal terpenes from asteraceae and labiatae species native to Argentinean semi-arid lands.
PubMed:
Identification and quantitative determination of eudesmane-type acids from the essential oil of Dittrichia viscosa sp. viscosa using 13C-NMR spectroscopy.
PubMed:
Cytotoxic versus anti-inflammatory effects in HeLa, Jurkat T and human peripheral blood cells caused by guaianolide-type sesquiterpene lactones.
PubMed:
Eudesmane derivatives from Laggera pterodonta.
PubMed:
Allelochemical effects of eudesmane and eremophilane sesquiterpenes on Tribolium castaneum larvae.
PubMed:
Germacrenes from fresh costus roots.
PubMed:
Mass spectral study of a sesquiterpene: gamma-costic acid.
PubMed:
Sesquiterpenlactone aus berkheya-arten.
PubMed:
Antibiotic principle of Eupatorium capillifolium.