Identification

Namebenzophenone
IUPACdiphenylmethanone
CAS Number119-61-9
EINECS204-337-6
FDA UNII701M4TTV9O
Molecular FormulaC13 H10 O
Molecular Weight182.22190000
MDL NumberMFCD00003076
Nikkaji NumberJ2.481C
Beilstein1238185
CoE Number166
XlogP33.40 (est)

Regulatory

JECFA Food Flavoring831 benzophenone
DG SANTE Food Flavourings07.032 benzophenone
DG SANTE Food Contact Materialsbenzophenone
FEMA Number2134
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)119-61-9 ; BENZOPHENONE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance white crystalline powder (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed Yes
Melting Point 47.00 to 51.00 °C. @ 760.00 mm Hg
Boiling Point 305.00 to 307.00 °C. @ 760.00 mm Hg, 170.00 to 171.00 °C. @ 15.00 mm Hg
Congealing Point 47.20 °C.
Vapor Pressure 0.001000 mmHg @ 25.00 °C. (est)
Vapor Density 6.3 ( Air = 1 )
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 3.180
Shelf Life 36.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
Insoluble in glycerin
Stability bath foam

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength medium ,
Substantivity 394 hour(s) at 100.00 %
Odor Description
at 10.00 % in dipropylene glycol.
faint, sweet rose, light herbal nuance like geranium
fruity, citric note, sweet, geranium
sweet aromatic slightly-rose fruity-vinyl Very faint powdery-rosy geranium-like odor with a slightly metallic note
Floral-rose, powdery, geranium, metalic
Odor sample from Ungerer & Company, Inc.
Taste Description
plastic geranium herbal metallic rose phenolic
slightly citrus, somewhat fruity
citric, slightly fruity
apricot peach
apricot peach

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience6 % solution: non-sensitising.
Oral/Parenteral Toxicityoral-rat LD50 > 10000 mg/kg
Dermal Toxicityskin-rabbit LD50 3535 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryfragrance agents
Recommendation for benzophenone usage levels up to6.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)23.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)11.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)3.7 (μg/person/day)
Threshold of Concern90 (μg/person/day)
Structure ClassIII
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Augustus Oils Ltd

The Premier Supplier

Augustus Oils Ltd, in harmony with nature - to present it at its best...

View All Website +44 (0)1420 590555 essentials@augustus-oils.ltd.uk

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

View All Website 973-748-8980 tlauzurica@berjeinc.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-504-6093 account@bocsci.com

Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

Odowell Co.,ltd

Fulfilling Demand

Product quality and consistency.

View All Website +86-21-56410859 info@odowell.com

OQEMA

With a focus on providing the highest level of service

OQEMA has established itself at the forefront of the global chemical industry.

View All Website +1 973 886 3778 fandf@oqema.co.uk

Pell Wall Perfumes

Hand-made fragrances

Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.

View All Website +44 (0) 20 3745 0887 https://pellwall.com/contact-us/

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

PerfumersWorld Ltd.

feeeel... the smell!

The one-stop resource for the creative perfumer.

View All Website +66(0)2-99-800-80 pwenquiries@perfumersworld.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

Symrise AG

Always Insiring More

Symrise aroma molecules & cosmetic ingredients for unique and innovative fragrances, flavors and cosmetics.

View All Website +49 5531 90 0 scentandcare@symrise.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

The Good Scents Company

Fragrance Creators

For your fragrance creations.

View All Website 414-764-2659 goodscnt@thegoodscentscompany.com

The John D. Walsh Company, Inc

Suppliers Since 1942

Supplying the fragrance and flavor industry with high quality products.

View All Website 973-962-1400 info@johndwalsh.com

The Lermond Company

Your Sourcing Resource

The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.

View All Website 201-896-3300 info@lermond.com

R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

View All Website +1 863 668 9500 enquiries@treatt.com

Ernesto Ventós S.A.

Continued Customer Satisfaction

We employ our five senses to do our job well.

View All Website +34 934706210 info@ventos.com

Vigon International, Inc.

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

WholeChem, LLC

Connecting Innovators To the Building Blocks Of the Universe

Custom manufacturer and distributor of specialty ingredients. We make global local.

View All Website +1 (262) 995.8668 info@wholechem.com

Potential Uses

FR agate FR amber FR apricot FR baby powder FR balsam FR bayberry FR berry FR bouquet FR butterscotch FR cedar forest FR christmas clean FR fir balsam fixer FR floral FR freesia FR fruit FR geranium FR ginger white ginger FR heather FR herbal FR hollyberry FR hyacinth FR juniper berry FR lavender FR lily of the valley FR mimosa FR moss FR musk FR new car FL nut FR oriental FR patchouli FR peach FR pine FR pomegranate FR rain FR rose FR rose white rose FR sweet pea FR tea green tea tide FR vanilla FR woody

Natural Occurrence

arisaema ciliatum arisaema tortuosum

Synonyms

adjutan 6016 benzene, benzoyl- benzophenone cryst. benzophenone crystals benzophenone extra pure benzophenone FCC benzophenone flake benzophenone flakes benzoyl benzene benzoylbenzene diphenyl ketone alpha-oxo diphenyl methane diphenyl methanone diphenyl-methanone diphenylketone a-oxo diphenylmethane diphenylmethanone kayacure BP ketone, diphenyl methanone, diphenyl- a- oxoditane alpha- oxoditane phenyl ketone speedcure BP PubMed: The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients. PubMed: Toxicology and carcinogenesis studies of benzophenone (CAS No. 119-61-9) in F344/N rats and B6C3F1 mice (feed studies). PubMed: NTP technical report on the toxicity studies of benzophenone (CAS No. 119-61-9). Administered in feed to F344/N rats and B6C3F mice. PubMed: Safety evaluation of benzophenone. PubMed: Comparison between solid phase microextraction (SPME) and hollow fiber liquid phase microextraction (HFLPME) for determination of extractables from post-consumer recycled PET into food simulants. PubMed: Post-harvest UV-B irradiation induces changes of phenol contents and corresponding biosynthetic gene expression in peaches and nectarines. PubMed: Migration study of optical brighteners from polymer packing materials to jam squeeze and fruit drink by spectrofluorimetry and RP-HPLC methods. PubMed: Molecular evolution and sequence divergence of plant chalcone synthase and chalcone synthase-Like genes. PubMed: Model studies of migration from paper and board into fruit and vegetables and into Tenax™ as a food simulant. PubMed: Printing ink compounds in foods: UK survey results. PubMed: Measurement of urinary biomarkers of parabens, benzophenone-3, and phthalates in a Belgian population. PubMed: Synthesis and carbonic anhydrase isoenzymes inhibitory effects of brominated diphenylmethanone and its derivatives. PubMed: Iriflophenone-3-C-glucoside from Cyclopia genistoides: isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays. PubMed: Induction of p21(Waf1/Cip1) by garcinol via downregulation of p38-MAPK signaling in p53-independent H1299 lung cancer. PubMed: Urinary concentrations of environmental phenols in pregnant women in a pilot study of the National Children's Study. PubMed: Optimization of matrix solid-phase dispersion for the rapid determination of salicylate and benzophenone-type UV absorbing substances in marketed fish. PubMed: Evaluation of the migration of 15 photo-initiators from cardboard packaging into Tenax(®) using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). PubMed: Optimisation of an analytical method and results from the inter-laboratory comparison of the migration of regulated substances from food packaging into the new mandatory European Union simulant for dry foodstuffs. PubMed: Bio-based coatings as potential barriers to chemical contaminants from recycled paper and board for food packaging. PubMed: Childhood exposure to DEHP, DBP and BBP under existing chemical management systems: a comparative study of sources of childhood exposure in Korea and in Denmark. PubMed: Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece. PubMed: Solvent-assisted dispersive solid phase extraction. PubMed: Survey on the occurrence of photo-initiators and amine synergists in cartonboard packaging on the German market and their migration into the packaged foodstuffs. PubMed: Rapid screening method to study the reactivity of UV filter substances towards skin proteins by high-performance thin-layer chromatography. PubMed: Regulation of lipid and glucose homeostasis by mango tree leaf extract is mediated by AMPK and PI3K/AKT signaling pathways. PubMed: Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors. PubMed: [Determination of the migration of seven photoinitiators in food packaging materials into aqueous solvent]. PubMed: Synthesis and characterization of polymerizable one-component photoinitiator based on sesamol. PubMed: Targeted multidimensional gas chromatography using a heart-cutting device and cryogenic focusing for the determination of benzophenone derivatives in foodstuffs. PubMed: Isolation, structural elucidation, MS profiling, and evaluation of triglyceride accumulation inhibitory effects of benzophenone C-glucosides from leaves of Mangifera indica L. PubMed: Food ingredient extracts of Cyclopia subternata (Honeybush): variation in phenolic composition and antioxidant capacity. PubMed: Effect of relative humidity on the migration of benzophenone from paperboard into the food simulant Tenax® and modelling hereof. PubMed: An amperometric sensor for the determination of benzophenone in food packaging materials based on the electropolymerized molecularly imprinted poly-o-phenylenediamine film. PubMed: Potential role of garcinol as an anticancer agent. PubMed: Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. PubMed: Simultaneous analysis and monitoring of 16 UV filters in cosmetics by high-performance liquid chromatography. PubMed: The power of hyphenated chromatography/time-of-flight mass spectrometry in public health laboratories. PubMed: Identification and quantification of the migration of chemicals from plastic baby bottles used as substitutes for polycarbonate. PubMed: 7-epiclusianone, the natural prenylated benzophenone, inhibits superoxide anions in the neutrophil respiratory burst. PubMed: Emerging pollutants in sewage, surface and drinking water in Galicia (NW Spain). PubMed: Preventing false negatives with high-resolution mass spectrometry: the benzophenone case. PubMed: Identification of benzophenone C-glucosides from mango tree leaves and their inhibitory effect on triglyceride accumulation in 3T3-L1 adipocytes. PubMed: [Determination of photoinitiators in printing inks used in food contact materials]. PubMed: [Safety verification for reuse of PET and glass bottles]. PubMed: Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells. PubMed: Metabolism of a new herbicide, [(14)c]pyribenzoxim, in rice. PubMed: 4-Methylbenzophenone and benzophenone are inactive in the micronucleus assay. PubMed: Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. PubMed: Effect of 2,4-dihydroxybenzophenone (BP1) on early life-stage development of the marine copepod Acartia tonsa at different temperatures and salinities. PubMed: A new method for the determination of carbonyl compounds in wines by headspace solid-phase microextraction coupled to gas chromatography-ion trap mass spectrometry. PubMed: Photoinduced reduction of divalent mercury in ice by organic matter. PubMed: A rapid High Performance Liquid Chromatographic (HPLC) method for the simultaneous determination of seven UV filters found in sunscreen and cosmetics. PubMed: Rapid multi-analyte quantification of benzophenone, 4-methylbenzophenone and related derivatives from paperboard food packaging. PubMed: Analysis of benzophenone and 4-methylbenzophenone in breakfast cereals using ultrasonic extraction in combination with gas chromatography-tandem mass spectrometry (GC-MS(n)). PubMed: Evaluation of sub-critical water as an extraction fluid for model contaminants from recycled PET for reuse as food packaging material. PubMed: [Hazards for health related to migration of substances from packaging into food]. PubMed: Widespread occurrence of estrogenic UV-filters in aquatic ecosystems in Switzerland. PubMed: Importance of prey and predator feeding behaviors for trophic transfer and secondary poisoning. PubMed: Migration of photoinitiators by gas phase into dry foods. PubMed: Study of the migration of photoinitiators used in printed food-packaging materials into food simulants. PubMed: Determination of low-level ink photoinitiator residues in packaged milk by solid-phase extraction and LC-ESI/MS/MS using triple-quadrupole mass analyzer. PubMed: Photostability and phytotoxicity of selected sunscreen agents and their degradation mixtures in water. PubMed: Identification and determination butylmethoxydibenzoylmethane in the presence benzophenone-3 and ethylhexylmethoxycinnamate in suncare preparation. PubMed: Synthesis and antifungal activity of 2-azetidinonyl-5-(2-benzoylphenoxy)methyl-1,3,4-oxadiazoles against seed-borne pathogens of Eleusine coracana (L.) Gaertn. PubMed: Bioassay and ultraperformance liquid chromatography/mass spectrometry guided isolation of apoptosis-inducing benzophenones and xanthone from the pericarp of Garcinia yunnanensis Hu. PubMed: Migration measurement and modelling from poly(ethylene terephthalate) (PET) into soft drinks and fruit juices in comparison with food simulants. PubMed: Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia. PubMed: Determination of ink photoinitiators in packaged beverages by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry. PubMed: SiOx layer as functional barrier in polyethylene terephthalate (PET) bottles against potential contaminants from post-consumer recycled PET. PubMed: Development of a method to study the migration of six photoinitiators into powdered milk. PubMed: Development of a multimethod for the determination of photoinitiators in beverage packaging. PubMed: Development of an analytical method for the determination of photoinitiators used for food packaging materials with potential to migrate into milk. PubMed: In utero exposure to benzophenone-2 causes hypospadias through an estrogen receptor dependent mechanism. PubMed: Migration of organic compounds from a multilayer plastic-paper material intended for food packaging. PubMed: 1,3-diene probes for detection of triplet carbonyls in biological systems. PubMed: Soil metabolism of a new herbicide, [14C]Pyribenzoxim, under flooded conditions. PubMed: Carcinogenesis studies of benzophenone in rats and mice. PubMed: The FEMA GRAS assessment of aromatic substituted secondary alcohols, ketones, and related esters used as flavor ingredients. PubMed: [Migration of bisphenol A and benzophenones from paper and paperboard products used in contact with food]. PubMed: A two-generation reproductive toxicity study of benzophenone in rats. PubMed: Application of Finite Element Analysis (FEA) for the simulation of release of additives from multilayer polymeric packaging structures. PubMed: Migration of contaminants by gas phase transfer from carton board and corrugated board box secondary packaging into foods. PubMed: Identification of rat urinary and fecal metabolites of a new herbicide, pyribenzoxim. PubMed: [Estrogenic activity of ultraviolet absorbers and the related compounds]. PubMed: Estrogenic and antiandrogenic activities of 17 benzophenone derivatives used as UV stabilizers and sunscreens. PubMed: Determination of sixteen UV filters in suncare formulations by high-performance liquid chromatography. PubMed: Characterization of gallotannins and benzophenone derivatives from mango (Mangifera indica L. cv. 'Tommy Atkins') peels, pulp and kernels by high-performance liquid chromatography/electrospray ionization mass spectrometry. PubMed: Chemical analysis and genotoxicological safety assessment of paper and paperboard used for food packaging. PubMed: Effectiveness of polypropylene film as a barrier to migration from recycled paperboard packaging to fatty and high-moisture food. PubMed: Contaminants and levels of occurrence in washed and shredded poly(ethylene terephthalate) from curbside collection. Part 1: Extraction conditions. PubMed: Benzophenone in cartonboard packaging materials and the factors that influence its migration into food. PubMed: Migration of surrogate contaminants in paper and paperboard into water through polyethylene coating layer. PubMed: [Determination of alkylphenols, bisphenol A, benzophenone and phthalates in containers of baby food, and migration into food simulants]. PubMed: Evaluating the potential for recycling all PET bottles into new food packaging. PubMed: Induction of apoptosis by garcinol and curcumin through cytochrome c release and activation of caspases in human leukemia HL-60 cells. PubMed: Analytical procedure for quantifying five compounds suspected as possible contaminants in recycled paper/paperboard for food packaging. PubMed: Free radical scavenging activity and antiulcer activity of garcinol from Garcinia indica fruit rind. PubMed: Antioxidative and anti-glycation activity of garcinol from Garcinia indica fruit rind. PubMed: A polyisoprenylated benzophenone from Cuban propolis. PubMed: Migration studies from paper and board food packaging materials. Part 2. Survey for residues of dialkylamino benzophenone UV-cure ink photoinitiators. PubMed: Migration studies from paper and board food packaging materials. 1. Compositional analysis. PubMed: Safety evaluation of benzophenone-3 after dermal administration in rats. PubMed: Current research on food contact materials undertaken by the UK Ministry of Agriculture, Fisheries and Food. PubMed: Safety evaluation of benzophenone. PubMed: Cysteine-374 of actin resides at the gelsolin contact site in the EGTA-resistant actin-gelsolin complex. PubMed: In vivo percutaneous absorption of fragrance ingredients in rhesus monkeys and humans. PubMed: Effect of food on absorption of 450191-S, a 1H-1,2,4-triazolyl benzophenone derivative from rat small intestine. PubMed: [Pharmacological studies on drug dependence. (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats]. PubMed: U.v. absorbers in sun cosmetics 1978. PubMed: [Migration of UV stabilizers, derivatives of benzophenone].