chlorphenesin

p-chlorophenyl a-glyceryl ether

CAS: 104-29-0 C9 H11 Cl O3 MW: 202.63627000

Identification

Namechlorphenesin
CAS Number104-29-0
EINECS203-192-6
FDA UNIII670DAL4SZ
Molecular FormulaC9 H11 Cl O3
Molecular Weight202.63627000
Nikkaji NumberJ5.029F
Beilstein2210845

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 78.00 °C. @ 760.00 mm Hg
Boiling Point 369.45 °C. @ 760.00 mm Hg (est)
Flash Point 351.00 °F. TCC ( 177.20 °C. ) (est)
logP (o/w) 1.713 (est)
Soluble in water, 2204 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal Toxicitysubcutaneous-mouse LD50 911 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial preservatives
Recommendation for chlorphenesin usage levels up tonot for fragrance use.
Recommendation for chlorphenesin flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

View All Website (800) 238-0001 info@aicma.com

BOC Sciences

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Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

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ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

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Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

adermykon chlorophenesin 3-(4- chlorophenoxy)-1,2-propanediol 3-(p- chlorophenoxy)-1,2-propanediol 3-(4- chlorophenoxy)propane-1,2-diol 3-(p- chlorophenoxy)propane-1,2-diol p- chlorophenyl a-glyceryl ether p- chlorophenyl-a-glyceryl ether 2- chlorphenesin chlorphenesine chlorphenesinum demykon gechophen gecophen mycil 1,2- propanediol, 3- (p-chlorophenoxy)- 1,2- propanediol, 3-(4-chlorophenoxy)- 1,2- propanediol, 3-(p-chlorophenoxy)- PubMed: [Analysis of the preservative chlorphenesin in cosmetics by high performance liquid chromatography]. PubMed: Contact allergy to chlorphenesin. PubMed: Occurrence of preservatives and antimicrobials in Japanese rivers. PubMed: Production of chlorphenesin galactoside by whole cells of β-galactosidase-containing Escherichia coli. PubMed: β-galactosidase-catalyzed synthesis of galactosyl chlorphenesin and its characterization. PubMed: Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea. PubMed: High-throughput and simultaneous analysis of eight central-acting muscle relaxants in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry in the positive and negative ionization modes. PubMed: Relative bioavailability of generic and branded 250-mg and 500-mg oral chlorphenesin carbamate tablets in healthy Korean volunteers: a single-dose, randomized-sequence, open-label, two-period crossover trial. PubMed: [Detection of the preservative chlorphenesin in cosmetics by high-performance liquid chromatography]. PubMed: Comparison of objective and sensory skin irritations of several cosmetic preservatives. PubMed: The synthesis of amphipathic prodrugs of 1,2-diol drugs with saccharide conjugates by high regioselective enzymatic protocol. PubMed: HPLC determination of tolperisone in human plasma. PubMed: Beta-galactosidase catalyzed selective galactosylation of aromatic compounds. PubMed: Optimization of chlorphenesin emulgel formulation. PubMed: Two cases of facial dermatitis due to chlorphenesin in cosmetics. PubMed: Stimulatory effects of chlorzoxazone, a centrally acting muscle relaxant, on large conductance calcium-activated potassium channels in pituitary GH3 cells. PubMed: [Photocontact dermatitis due to ketoprofen and photosensitization to tetrachlorosalicylanide and to Fenticlor(R)]. PubMed: Dermatitis from chlorphenesin in a facial cosmetic. PubMed: [The photostability of antimycotics. 3. Photostability of locally acting antimycotics]. PubMed: Indirect spectrophotometric methods for the determination of chlorphenesin. PubMed: Review of oral skeletal muscle relaxants for the craniomandibular disorder (CMD) practitioner. PubMed: Trigeminal neuralgia. PubMed: Medical treatment of the major neuralgias. PubMed: Simultaneous evaluation of drug effects on both the spinal cord and the descending pathways in rats. PubMed: Dermatitis from chlorphenesin in a deodorant. PubMed: Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats. PubMed: Studies on the kinetics and mechanism of drug degradation. I. Kinetics and mechanism of degradation of chlorphenesin carbamate in strongly alkaline aqueous solutions. PubMed: Allergic contact sensitivity to chlorphenesin. PubMed: [Treatment of typical trigeminus neuralgias. Overview of the current state of drug and surgical therapy]. PubMed: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. PubMed: Cluster headache with trigeminal neuralgia. An uncommon association that may be more than coincidental. PubMed: [Vaginal mycosis. Therapy with chlorphenesin]. PubMed: An experimental study of the F-wave in the dog: effects of spasticity and central muscle relaxant. PubMed: Trigeminal neuralgia. A practical approach to treatment. PubMed: Fixed drug eruption from chlorphenesin carbamate. PubMed: Chlorphenesin sensitivity. PubMed: Tic douloureux. PubMed: Centrally acting oral skeletal muscle relaxants. PubMed: The action of chlorphenesin carbamate on the frog spinal cord. PubMed: Suppressive effects of chlorphenesin on lymphocyte function in mice and humans. PubMed: [Mycological and clinical studies on a new local antimycotic drug]. PubMed: [Influence of the enterohepatic circulation on the metabolism of chlorphenesin carbamate (CPC). II. Metabolic fate of biliary CPC-glucuronide (author's transl)]. PubMed: [Influence of the enterohepatic circulation on the metabolism of chlorphenesin carbamate (CPC). I. Comparison between guinea pigs and bile duct-ligated rats (author's transl)]. PubMed: [Electroencephalographic effects of chlorphenesin carbamate, a new central muscle relaxant, in rabbits (author's transl)]. PubMed: [Studies on the physical dependence liability of chlorphenesin carbamate (author's transl)]. PubMed: The management of tic douloureux. PubMed: [A pharmacological study of chlorphenesin carbamate. Tolerance to chlorphenesin carbamate (author's transl)]. PubMed: Complement-induced histamine release from human basophils. III. Effect of pharmacologic agents. PubMed: Medical treatment of trigeminal neuralgia. PubMed: High-pressure liquid chromatographic determination of chlorphenesin carbamate and the beta-isomeric carbamate. PubMed: Interactions of chlorphenesin and divalent metal ions with phosphodiesterase. PubMed: New non-steroid non-antibiotic skin medicaments. PubMed: Initiation-promotion skin carcinogenesis and immunological competence. PubMed: [Muscle relaxants in the treatment of idiopathic trigeminal neuralgia (author's transl)]. PubMed: Modulation of the formation and release of bovine SRS-A in vitro by several anti-anaphylactic drugs. PubMed: Chlorphenesin carbamate serum levels during subchronic administration to human (normal) volunteers. PubMed: Field desorption mass spectrometry of ten medicinal carbamates. PubMed: GLC determination of chlorphenesin carbamate in serum. PubMed: Basophil activation by concanavalin A: characteristics of the reaction. PubMed: [Pharmacologial studies on a centrally acting muscle relaxant, chlorphenesin carbamate, with special reference to the effect on the motor system]. PubMed: Soluble lymphocytic mediators. I. Inhibition of macrophage migration inhibitory factor production by drugs. PubMed: Chlorphenesin for trigeminal neuralgia. PubMed: Influence of genotype of host on regression of solid and ascitic forms of sarcoma 180 and effect of chemotherapy on the solid form. PubMed: [Progress in the treatment of bronchial asthma]. PubMed: The immunologic effect of chlorphenesin on skin grafts in normal and thymectomized mice. PubMed: Synthesis and pharmacological activity of some chlorphenesin phenoxyalkanoates. PubMed: Attenuation of certain neoplasias by chlorphenesin. 1. PubMed: Cyclic AMP affects macrophage migration. PubMed: Normal neonatal mandibular growth not affected by muscular inactivity. PubMed: Comparative pharmacokinetics of chlorphenesin carbamate and methocarbamol in man. PubMed: The immediate allergic response: in vitro separation of antigen activation, decay and histamine release. PubMed: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. PubMed: Drug-induced modulation of the immunologic release of histamine and slow reacting substance of anaphylaxis. PubMed: Chlorphenesin: an antigen-associated immunosuppressant. PubMed: Interaction between "sensitized lymphocytes" and antigen in vitro. II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors. PubMed: Therapeutics X. Topical antifungal agents. PubMed: Gas chromatographic determination of chlorphenesin in plasma. PubMed: Shear cell measurements of powders: proposed procedures for elucidating the mechanistic behavior of powder beds in shear. PubMed: A comparative trial of chlorphenesin and pecilocin in a prison community. PubMed: Chlorphenesin metabolism in the rat and dog. PubMed: Chlorphenesin: a new inhibitor IgE-mediated histamine release. PubMed: Chlorphenesin: a new inhibitor of IgE-mediated histamine release. PubMed: The influence of chlorphenesin carbamate and carisoprodol on psychological test scores. PubMed: Renal distrubution of sulfisoxazole in canine kidney. PubMed: A comparison between propoxyphene hydrochloride (Darvon) and chlorphenesin carbamate (Maolate) in musculoskeletal disorders. A controlled study in 92 patients. PubMed: The effect of chlorphenesin on the immune response. PubMed: [Treatment of trigeminal neuralgia with muscle relaxants]. PubMed: Effect of chlorphenesin on localized hemolysis in gel assay. PubMed: Still more corticosteroid preparations for the skin. Synalar Forte, Fluoderm, Ultralanum Cream. PubMed: The analgesic properties of chlorphenesin carbamate in the treatment of osteoarthrosis. Report of a trial. PubMed: [Hydrocortisone therapy in outpatient care]. PubMed: Comparative analgesic efficacy of chlorphenesin carbamate and acetylsalicylic acid after episiotomy. PubMed: Maolate (chlorphenesin carbamate) a new myanalgic drug in industrial medicine. PubMed: Chlorphenesin carbamate (Maolate). PubMed: Metabolism of 3-(p-chlorophenoxy)-2-methoxypropyl carbamate in the rat. PubMed: Qualitative and quantitative tests for chlorphenesin carbamate. PubMed: Chlorphenesin carbamate in the treatment of muscle spasm and musculoskeletal disorders. PubMed: Chlorphenesin carbamate (maolate) in the relief of muscle pain. PubMed: Preparation of tritium-labeled compounds. II. Chlorphenesin carbamate by exposure to tritium gas and determination of intramolecular distribution of tritium. PubMed: Selective suppression of penicillin hypersensitivity by certain phenoxy propanediols. PubMed: The absorption, excretion, and metabolism of chlorphenesin carbamate in the dog. PubMed: Clinical evaluation of chlorphenesin carbamate (maolate) in spasticity, rigidity and pain associated with neurologic and arthritic diseases. PubMed: CHARACTERIZATION OF THE GLUCURONIDE CONJUGATE OF CHLORPHENESIN CARBAMATE FROM THE RAT AND FROM MAN. PubMed: DETERMINATION OF RESIDUAL CHLORPHENESIN IN CHLORPHENESIN-1-CARBAMATE. PubMed: THE METABOLISM OF CHLORPHENESIN CARBAMATE. PubMed: A CONTROLLED EVALUATION OF CHLORPHENESIN CARBAMATE IN PAINFUL MUSCULOSKELETAL SYNDROMES. PubMed: EFFECT OF CHLORPHENESIN CARBAMATE (MAOLATE) ON A CASE OF ACUTE ARACHNIDISM. PubMed: CLINICAL TRIAL OF CHLORPHENESIN CARBAMATE IN PATIENTS WITH MUSCLE SPASM. PubMed: Controlled clinical evaluation of a new muscle relaxant--chlorphenesin carbamate. PubMed: Controlled clinical evaluation of a new muscle relaxant-chlorphenesin carbamate. PubMed: The pharmacology of chlorphenesin carbamate, a centrally active muscle relaxant. PubMed: Clinical evaluation of the analgesic activity of chlorphenesin carbamate.