glyceryl arachidonate

2,3-dihydroxypropyl 5,8,11,14-eicosatetraenoate

CAS: 35474-99-8 C23 H38 O4 MW: 378.55266000

Identification

Nameglyceryl arachidonate
CAS Number35474-99-8
FDA UNII6UXX4LRJ92
Molecular FormulaC23 H38 O4
Molecular Weight378.55266000
Nikkaji NumberJ145.189H
XlogP35.50 (est)

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 508.65 °C. @ 760.00 mm Hg (est)
Flash Point 325.00 °F. TCC ( 163.00 °C. ) (est)
logP (o/w) 6.286 (est)
Soluble in water, 0.007305 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning - emollient

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryemollients, emulsifiers
Recommendation for glyceryl arachidonate usage levels up tonot for fragrance use.
Recommendation for glyceryl arachidonate flavor usage levels up tonot for flavor use.

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Potential Uses

emollients emulsifying agents

Natural Occurrence

not found in nature

Synonyms

arachidonic acid, monoester with 1,2,3-propanetriol mono arachidonin 1- arachidonoyl glycerol 1- arachidonoyl-sn-glycerol 1- arachidonoylglycerol 1- arachidonyl monoglyceride 2,3- dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate 2,3- dihydroxypropyl 5,8,11,14-eicosatetraenoate 5,8,11,14- eicosatetraenoic acid, 2,3-dihydroxypropyl ester- 5,8,11,14- eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (5Z,8Z,11Z,14Z)- 5,8,11,14- eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (all-Z)- glyceryl monoarachidonate (5Z,8Z,11Z,14Z)- icosa-5,8,11,14-tetraenoic acid 2,3-dihydroxy-propyl ester PubMed: Assessment of skin absorption and irritation potential of arachidonic acid and glyceryl arachidonate using in vitro diffusion cell techniques. PubMed: Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate. PubMed: Lipoxygenase and cyclo-oxygenase products in the control of regional kidney blood flow in rabbits. PubMed: 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. PubMed: Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase. PubMed: Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2. PubMed: Effect of octadecylmethylglycerophosphocholine and hexadecylmethylglycerol on arachidonic acylation or release in macrophages. PubMed: v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters. PubMed: Phospholipid metabolism in bradykinin-stimulated human fibroblasts. I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C. PubMed: A glycerol ether induces mobilization and 12-lipoxygenation of arachidonic acid in macrophages. Synergistic effect on mobilization and induction of leukotriene C formation by activators of protein kinase C. PubMed: Endothelium-dependent vasodilatation in bovine coronary arteries: calcium dependence and inhibition by proadifen. PubMed: Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism. PubMed: Acetyl glyceryl ether phosphorylcholine (PAF-acether) and leukotriene B4-mediated neutrophil chemotaxis through an intact endothelial cell monolayer. PubMed: Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility. PubMed: Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. PubMed: Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release. PubMed: Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro.