glyceryl arachidonate
2,3-dihydroxypropyl 5,8,11,14-eicosatetraenoate
Identification
| Name | glyceryl arachidonate |
| CAS Number | 35474-99-8 |
| FDA UNII | 6UXX4LRJ92 |
| Molecular Formula | C23 H38 O4 |
| Molecular Weight | 378.55266000 |
| Nikkaji Number | J145.189H |
| XlogP3 | 5.50 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 508.65 °C. @ 760.00 mm Hg (est) |
| Flash Point | 325.00 °F. TCC ( 163.00 °C. ) (est) |
| logP (o/w) | 6.286 (est) |
| Soluble in | water, 0.007305 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning - emollient |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | emollients, emulsifiers |
| Recommendation for glyceryl arachidonate usage levels up to | not for fragrance use. |
| Recommendation for glyceryl arachidonate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
arachidonic acid, monoester with 1,2,3-propanetriol
mono
arachidonin
1-
arachidonoyl glycerol
1-
arachidonoyl-sn-glycerol
1-
arachidonoylglycerol
1-
arachidonyl monoglyceride
2,3-
dihydroxypropyl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
2,3-
dihydroxypropyl 5,8,11,14-eicosatetraenoate
5,8,11,14-
eicosatetraenoic acid, 2,3-dihydroxypropyl ester-
5,8,11,14-
eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (5Z,8Z,11Z,14Z)-
5,8,11,14-
eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (all-Z)-
glyceryl monoarachidonate
(5Z,8Z,11Z,14Z)-
icosa-5,8,11,14-tetraenoic acid 2,3-dihydroxy-propyl ester
PubMed:
Assessment of skin absorption and irritation potential of arachidonic acid and glyceryl arachidonate using in vitro diffusion cell techniques.
PubMed:
Final report of the amended safety assessment of Glyceryl Laurate, Glyceryl Laurate SE, Glyceryl Laurate/Oleate, Glyceryl Adipate, Glyceryl Alginate, Glyceryl Arachidate, Glyceryl Arachidonate, Glyceryl Behenate, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Caprylate/Caprate, Glyceryl Citrate/Lactate/Linoleate/Oleate, Glyceryl Cocoate, Glyceryl Collagenate, Glyceryl Erucate, Glyceryl Hydrogenated Rosinate, Glyceryl Hydrogenated Soyate, Glyceryl Hydroxystearate, Glyceryl Isopalmitate, Glyceryl Isostearate, Glyceryl Isostearate/Myristate, Glyceryl Isostearates, Glyceryl Lanolate, Glyceryl Linoleate, Glyceryl Linolenate, Glyceryl Montanate, Glyceryl Myristate, Glyceryl Isotridecanoate/Stearate/Adipate, Glyceryl Oleate SE, Glyceryl Oleate/Elaidate, Glyceryl Palmitate, Glyceryl Palmitate/Stearate, Glyceryl Palmitoleate, Glyceryl Pentadecanoate, Glyceryl Polyacrylate, Glyceryl Rosinate, Glyceryl Sesquioleate, Glyceryl/Sorbitol Oleate/Hydroxystearate, Glyceryl Stearate/Acetate, Glyceryl Stearate/Maleate, Glyceryl Tallowate, Glyceryl Thiopropionate, and Glyceryl Undecylenate.
PubMed:
Lipoxygenase and cyclo-oxygenase products in the control of regional kidney blood flow in rabbits.
PubMed:
15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
PubMed:
Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase.
PubMed:
Oxygenation of the endocannabinoid, 2-arachidonylglycerol, to glyceryl prostaglandins by cyclooxygenase-2.
PubMed:
Effect of octadecylmethylglycerophosphocholine and hexadecylmethylglycerol on arachidonic acylation or release in macrophages.
PubMed:
v-Src activates a unique phospholipase D activity that can be distinguished from the phospholipase D activity activated by phorbol esters.
PubMed:
Phospholipid metabolism in bradykinin-stimulated human fibroblasts. I. Biphasic formation of diacylglycerol from phosphatidylinositol and phosphatidylcholine, controlled by protein kinase C.
PubMed:
A glycerol ether induces mobilization and 12-lipoxygenation of arachidonic acid in macrophages. Synergistic effect on mobilization and induction of leukotriene C formation by activators of protein kinase C.
PubMed:
Endothelium-dependent vasodilatation in bovine coronary arteries: calcium dependence and inhibition by proadifen.
PubMed:
Acetyl glycerylphosphorylcholine aggregates human platelets through two distinct pathways, both dependent on arachidonic acid metabolism.
PubMed:
Acetyl glyceryl ether phosphorylcholine (PAF-acether) and leukotriene B4-mediated neutrophil chemotaxis through an intact endothelial cell monolayer.
PubMed:
Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility.
PubMed:
Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes.
PubMed:
Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release.
PubMed:
Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro.