clotrimazole
diphenyl-(2-chlorophenyl)-1-imidazolylmethane
Identification
| Name | clotrimazole |
| IUPAC | 1-[(2-chlorophenyl)-diphenylmethyl]imidazole |
| CAS Number | 23593-75-1 |
| FDA UNII | G07GZ97H65 |
| Molecular Formula | C22 H17 Cl N2 |
| Molecular Weight | 344.84349000 |
| MDL Number | MFCD00057220 |
| Nikkaji Number | J3.156I |
| Beilstein | 0622318 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 148.00 °C. @ 760.00 mm Hg |
| Soluble in | water, 0.02984 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | antidandruff agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-cat LD50 > 1000 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LDLo 10000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antidandruff, antimicrobial agents |
| Recommendation for clotrimazole usage levels up to | not for fragrance use. |
| Recommendation for clotrimazole flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
bay 5097
bay-B 5097
canesten
canestene
canifug
1-(o-
chloro-alpha,alpha-diphenylbenzyl)imidazole
1-((o-
chloro-phenyl)diphenylmethyl)imidazole
1-[(2-
chlorophenyl)-diphenylmethyl]imidazole
1-(alpha-(2-
chlorophenyl)benzhydryl)imidazole
(2-
chlorophenyl)diphenyl-1-imidazolylmethane
1-((2-
chlorophenyl)diphenylmethyl)-1H-imidazole
1-((2-
chlorophenyl)diphenylmethyl)-1H-imidazole (9CI)
1-(o-
chlorophenyldiphenylmethyl)imidazole
chlorotrityl)imidazole
1-(o-
chlorotrityl)imidazole
clomatin
clotrimazolum
cutistad
desamix F
diphenyl-(2-chlorophenyl)-1-imidazolylmethane
diphenyl(2-chlorophenyl)(1-imidazolyl)methane
empecid
bis-
fenil-(2-clorofenil)-1-imidazolil-metano
gino-lotremine
gyne lotrimin
gyne-lotrimin
gyne-lotrimin 3
gyne-lotrimin 3 combination pack
gyne-lotrimin combination pack
gynix
1H-
imidazole, 1-((2-chlorophenyl)diphenylmethyl)-
imidazole, 1-(o-chloro-alpha,alpha-diphenylbenzyl)-
jidesheng
lotrimax
lotrimin AF
lotrisone
methane, bis-phenyl-(2-chlorophenyl)-1-imidazolyl-
mono-baycuten
monobaycuten
mycelex 7
mycelex G
mycelex OTC
mycelex troches
mycelex-7
mycelex-7 combination pack
mycelex-G
mycofug
mycosporin
mykosporin
nalbix
pan-fungex
pedisafe
bis-
phenyl-(2-chlorophenyl)(1-imidazoyl)methane
bis
phenyl-(2-chlorphenyl)-1-imidazolyl-methan
bis
phenyl-(2-chlorphenyl)-1-imidazolyl-methan [German]
rimazole
stiemazol
tibatin
trimysten
trivagizole 3
veltrim
PubMed:
Lauric acid in crown daisy root exudate potently regulates root-knot nematode chemotaxis and disrupts Mi-flp-18 expression to block infection.
J-Stage:
A Correlation between Antioxidant Activity and Metabolite Release during the Blanching of Chrysanthemum coronarium L.
PubMed:
Disarming the jasmonate-dependent plant defense makes nonhost Arabidopsis plants accessible to the American serpentine leafminer.
PubMed:
Preference of a polyphagous mirid bug, Apolygus lucorum (Meyer-Dür) for flowering host plants.
PubMed:
Xanthine oxidase inhibitory activity of the methanolic extracts of selected Jordanian medicinal plants.
PubMed:
Mediterranean wild plants reduce postprandial platelet aggregation in patients with metabolic syndrome.
PubMed:
Characterization and risk assessment of polychlorinated biphenyls in soils and vegetations near an electronic waste recycling site, South China.
PubMed:
A correlation between antioxidant activity and metabolite release during the blanching of Chrysanthemum coronarium L.
PubMed:
Toll-like receptor-dependent IL-12 production by dendritic cells is required for activation of natural killer cell-mediated Type-1 immunity induced by Chrysanthemum coronarium L.
PubMed:
Larvicidal activity of selected plant hydrodistillate extracts against the house mosquito, Culex pipiens, a West Nile virus vector.
PubMed:
Volatile oil profiles of the aerial parts of Jordanian garland, Chrysanthemum coronarium.
PubMed:
Isolation of a gibberellin-producing fungus (Penicillium sp. MH7) and growth promotion of Crown daisy (Chrysanthemum coronarium).
PubMed:
Reducing plant uptake of PAHs by cationic surfactant-enhanced soil retention.
PubMed:
Chemical and biological comparisons on supercritical extracts of Tanacetum cinerariifolium (Trevir) Sch. Bip. with three related species of chrysanthemums of Sardinia (Italy).
PubMed:
In planta dynamic analysis of onion yellows phytoplasma using localized inoculation by insect transmission.
PubMed:
Isolation and Characterization of Derivative Lines of the Onion Yellows Phytoplasma that Do Not Cause Stunting or Phloem Hyperplasia.
PubMed:
Heterocyclic compounds from Chrysanthemum coronarium L. and their inhibitory activity on hACAT-1, hACAT-2, and LDL-oxidation.
PubMed:
Metabolic fate of nicotinamide in higher plants.
PubMed:
Copper accumulation and tolerance in Chrysanthemum coronarium L. and Sorghum sudanense L.
PubMed:
Identification of campesterol from Chrysanthemum coronarium L. and its antiangiogenic activities.
PubMed:
[Relationships between host preference of Liriomyza huidobrensis (Blanchard) and nutrient and chlorophyll contents in host foliage].
PubMed:
Biodegradable chelating agent ethylenediaminedisuccinic acid reduces uptake of copper through alleviation of copper toxicity in hydroponically grown Chrysanthemum coronarium L.
PubMed:
Identification and characterization of major flavonoids and caffeoylquinic acids in three Compositae plants by LC/DAD-APCI/MS.
PubMed:
EDDS and EDTA-enhanced phytoextraction of metals from artificially contaminated soil and residual effects of chelant compounds.
PubMed:
Milk and cheese fatty acid composition in sheep fed Mediterranean forages with reference to conjugated linoleic acid cis-9,trans-11.
PubMed:
Anti-inflammatory effects of extracts from some traditional Mediterranean diet plants.
PubMed:
Germination requirements and dispersal timing in two heterocarpic weedy asteraceae.
PubMed:
Accumulation of pathogenesis-related type-5 like proteins in phytoplasma-infected garland chrysanthemum Chrysanthemum coronarium.
PubMed:
Multiresidue method for the determination of pesticides in Korean domestic crops by gas chromatography/mass selective detection.
PubMed:
Purification and characterization of polyphenol oxidase from garland chrysanthemum (Chrysanthemum coronarium L.).
PubMed:
Differences in the fragrances of pollen, leaves, and floral parts of garland (Chrysanthemum coronarium) and composition of the essential oils from flowerheads and leaves.
PubMed:
Isolation and identification of dihydrochrysanolide and its 1-epimer from Chrysanthemum coronarium L.
PubMed:
Purification of chrysancorin, a novel antifungal protein with mitogenic activity from garland chrysanthemum seeds.
PubMed:
Antifungal activity of the essential oil of flowerheads of garland chrysanthemum (Chrysanthemum coronarium) against agricultural pathogens.
PubMed:
Stability and bioavailability of antioxidants in garland (Chrysanthemum coronarium L.).
PubMed:
Chromatographic separation of a small subunit (PsbW/PsaY) and its assignment to Photosystem I reaction center.
PubMed:
[Oxyanthraquinones and flavonoids from garland chrysanthenum].
PubMed:
Pattern of cross-sensitivity between 4 Compositae plants, Parthenium hysterophorus, Xanthium strumarium, Helianthus annuus and Chrysanthemum coronarium, in Indian patients.
PubMed:
Rhizosphere fungi of five plants in Egypt.
PubMed:
Fluorescent petal constituents of Chrysanthemum coronarium L.
PubMed:
Influence of moisture on the availability and persistence of clotrimazole and fluconazole in sludge-amended soil.
PubMed:
Fate of the antifungal drug clotrimazole in agricultural soil.
PubMed:
Effects of food limitation and pharmaceutical compounds on the larval development and morphology of Palaemon serratus.
PubMed:
Typical azole biocides in biosolid-amended soils and plants following biosolid applications.
PubMed:
Determination of clotrimazole in mice plasma by capillary electrophoresis.
PubMed:
Clotrimazole/betamethasone diproprionate: a review of costs and complications in the treatment of common cutaneous fungal infections.
PubMed:
Influence of gender, feeding regimen, and exposure duration on gene expression associated with xenobiotic metabolism in fathead minnows (Pimephales promelas).
PubMed:
Presence of pharmaceuticals in benthic fauna living in a small stream affected by effluent from a municipal sewage treatment plant.
PubMed:
QSAR model for human pregnane X receptor (PXR) binding: screening of environmental chemicals and correlations with genotoxicity, endocrine disruption and teratogenicity.
PubMed:
Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections.
PubMed:
From the Food and Drug Administration.
PubMed:
Topical antifungal drug products for over-the-counter human use; amendment of final monograph. Final rule.
PubMed:
Candidiasis (oropharyngeal).
PubMed:
Arachidonic acid increases antifungal susceptibility of Candida albicans and Candida dubliniensis.
PubMed:
Comparative efficacy of two regimens in syndromic management of lower genital infections.
PubMed:
Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends.
PubMed:
Candidiasis (oropharyngeal).
PubMed:
Development of stably transfected human and rat hepatoma cell lines for the species-specific assessment of xenobiotic response enhancer module (XREM)-dependent induction of drug metabolism.
PubMed:
Solid-state stability and characterization of hot-melt extruded poly(ethylene oxide) films.
PubMed:
Management of oropharyngeal candidiasis with localized oral miconazole therapy: efficacy, safety, and patient acceptability.
PubMed:
Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression.
PubMed:
Athlete's foot.
PubMed:
Is there a role for fluconazole in the treatment of vulvovaginal candidiasis?
PubMed:
Safety assessment of dairy microorganisms: Geotrichum candidum.
PubMed:
Antimycotic activity of 5'-prenylisoflavanones of the plant Geoffroea decorticans, against Aspergillus species.
PubMed:
Comparative ability of various prescription and over-the-counter topical antifungal drug products to inhibit the growth of C. albicans.
PubMed:
Targeting of cancer energy metabolism.