piroctone olamine

2(1H)-pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1)

CAS: 68890-66-4 C16 H30 N2 O3 MW: 298.42670000

Identification

Namepiroctone olamine
CAS Number68890-66-4
EINECS272-574-2
FDA UNIIA4V5C6R9FB
Molecular FormulaC16 H30 N2 O3
Molecular Weight298.42670000
MDL NumberMFCD01690792

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 344.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure 0.000004 mmHg @ 25.00 °C. (est)
Flash Point 323.00 °F. TCC ( 161.90 °C. ) (est)
logP (o/w) 3.696 (est)
Soluble in water, 18.75 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 5000 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for piroctone olamine usage levels up tonot for fragrance use.
Recommendation for piroctone olamine flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

View All Website 86-510-86023169 info@healthwaychem.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

2- aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1) 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1) 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-aminoethanol salt 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1) 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1) 1- hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1) octopirox piroctone ethanolamine salt 2(1H)- pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1) 2(1H)- pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1) PubMed: Effect of Wnt inhibitors in pancreatic cancer. PubMed: Targeting the Wnt/beta-catenin pathway in renal cell carcinoma. PubMed: Preparation and evaluation of the effect of Fe3 O4 @piroctone olamine magnetic nanoparticles on matrix metalloproteinase-2: a preliminary in vitro study. PubMed: Targeting renal cancer with a combination of WNT inhibitors and a bi-functional peptide. PubMed: Double-blinded, placebo-controlled study to evaluate an antipruritic shampoo for dogs with allergic pruritus. PubMed: Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure. PubMed: Increased in vivo efficacy of lenalidomide by addition of piroctone olamine. PubMed: Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff. PubMed: Allergic contact dermatitis to propyl gallate and pentylene glycol in an emollient cream. PubMed: The in vitro effect of a collagenolytic enzyme inhibitor on lesion development in root dentin. PubMed: The antidandruff efficacy of a shampoo containing piroctone olamine and salicylic acid in comparison to that of a zinc pyrithione shampoo. PubMed: Nudging hair shedding by antidandruff shampoos. A comparison of 1% ketoconazole, 1% piroctone olamine and 1% zinc pyrithione formulations. PubMed: Effect of residence time on the efficacy of antidandruff shampoos. PubMed: Treatment of mild to moderate seborrhoeic dermatitis with MAS064D (Sebclair), a novel topical medical device: results of a pilot, randomized, double-blind, controlled trial. PubMed: In vitro investigations on the mode of action of the hydroxypyridone antimycotics rilopirox and piroctone on Candida albicans. PubMed: [Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography]. PubMed: In vitro antimycotic activity and nail permeation models of a piroctone olamine (octopirox) containing transungual water soluble technology. PubMed: Enhanced delivery of an anti-dandruff active in a shampoo vehicle. PubMed: Comparative anti-dandruff efficacy between a tar and a non-tar shampoo. PubMed: [Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents]. PubMed: Malassezia furfur: a fungus belonging to the physiological skin flora and its relevance in skin disorders. PubMed: In vitro susceptibility of Malassezia furfur. PubMed: Evaluation de l'activité antifongique de deux dérivés et test d'innocuitéin vivo de shampooings à visée antipelliculaire ainsi formulés. PubMed: The effect of piroctone olamine on reproduction of male and female rats. PubMed: The effects of dietary iron supplementation on the toxicity of piroctone olamine in the growing rat. PubMed: Percutaneous absorption of Octopirox. PubMed: [Anti-pityriasis activity of a line of products containing piroctone olamine].