polyquaternium-1
poly[(dimethylimino)-2-butene-1,4-diyl chloride], .alpha.-[4-[tris(2-hydroxyethyl)ammonium]-2-butenyl]-.omega.-[tris(2-hydroxyethyl)ammonium]-, dichloride
Identification
| Name | polyquaternium-1 |
| CAS Number | 75345-27-6 |
| FDA UNII | 6716Z5YR3G |
| Molecular Formula | C22 H48 Cl3 N3 O6 |
| Molecular Weight | 556.99676000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| logP (o/w) | -9.896 (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | film formers |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | film forming agents |
| Recommendation for polyquaternium-1 usage levels up to | not for fragrance use. |
| Recommendation for polyquaternium-1 flavor usage levels up to | not for flavor use. |
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Potential Uses
Natural Occurrence
Synonyms
dimethyl-bis[(E)-4-[tris(2-hydroxyethyl)azaniumyl]but-2-enyl]azanium;trichloride
a-((E)-4-(tris(2-
hydroxyethyl)ammonio)-2-butenyl-omega-(tris(2-hydroxyethyl)ammonio)poly((dimethyliminio)((E)-2-butenylene)chloride)dichloride
onamer M
polidronium chloride
poly[(dimethylimino)-2-butene-1,4-diyl chloride], .alpha.-[4-[tris(2-hydroxyethyl)ammonium]-2-butenyl]-.omega.-[tris(2-hydroxyethyl)ammonium]-, dichloride
polyquaternium 1
PubMed:
Confocal microscopy of epithelial and langerhans cells of the cornea in patients using travoprost drops containing two different preservatives.
PubMed:
Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures.
PubMed:
Short-term clinical comparison of two dual-disinfection multipurpose disinfecting solutions.
PubMed:
Meta-analysis of the ocular biocompatibility of a new multipurpose lens care system.
PubMed:
Relative efficacy and safety of preservative-free latanoprost (T2345) for the treatment of open-angle glaucoma and ocular hypertension: an adjusted Indirect comparison meta-analysis of randomized clinical trials.
PubMed:
Effect of lens and solution choice on the comfort of contact lens wearers.
PubMed:
Quantification of individual proteins in silicone hydrogel contact lens deposits.
PubMed:
[Preservatives in ophthalmology].
PubMed:
The effect of contact lens materials on disinfection activity of polyquaternium-1 and myristamidopropyl dimethylamine multipurpose solution against Staphylococcus aureus.
PubMed:
Corneal epithelial cell viability following exposure to ophthalmic solutions containing preservatives and/or antihypertensive agents.
PubMed:
Toxicity evaluation of antiglaucoma drugs using stratified human cultivated corneal epithelial sheets.
PubMed:
The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells.
PubMed:
Dendritic immune cell densities in the central cornea associated with soft contact lens types and lens care solution types: a pilot study.
PubMed:
Reduced in vivo ocular surface toxicity with polyquad-preserved travoprost versus benzalkonium-preserved travoprost or latanoprost ophthalmic solutions.
PubMed:
A preservative-and-fluorescein interaction model for benign multipurpose solution-associated transient corneal hyperfluorescence.
PubMed:
Cytotoxicity and effects on metabolism of contact lens care solutions on human corneal epithelium cells.
PubMed:
Comparison of a travoprost BAK-free formulation preserved with polyquaternium-1 with BAK-preserved travoprost in ocular hypertension or open-angle glaucoma.
PubMed:
Comparative in vitro toxicology study of travoprost polyquad-preserved, travoprost BAK-preserved, and latanoprost BAK-preserved ophthalmic solutions on human conjunctival epithelial cells.
PubMed:
Ophthalmic preservatives: focus on polyquaternium-1.
PubMed:
Assessment of effects of multipurpose contact lens care solutions on human corneal epithelial cells.
PubMed:
Effects of benzalkonium chloride- or polyquad-preserved fixed combination glaucoma medications on human trabecular meshwork cells.
PubMed:
Travoprost 0.004%/timolol 0.5%-fixed combination with and without benzalkonium chloride: a prospective, randomized, doubled-masked comparison of safety and efficacy.
PubMed:
[In vitro evaluation for corneal damages by anti-glaucoma combination eye drops using human corneal epithelial cell (HCE-T)].
PubMed:
Effects of benzalkonium chloride- and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells.
PubMed:
Effects of glaucoma medications and preservatives on cultured human trabecular meshwork and non-pigmented ciliary epithelial cell lines.
PubMed:
A preliminary study of silicone hydrogel lens material and care solution bioincompatibilities.
PubMed:
Polyquad-preserved travoprost/timolol, benzalkonium chloride (BAK)-preserved travoprost/timolol, and latanoprost/timolol in fixed combinations: a rabbit ocular surface study.
PubMed:
In vitro comparative toxicology of polyquad-preserved and benzalkonium chloride-preserved travoprost/timolol fixed combination and latanoprost/timolol fixed combination.
PubMed:
Effects of benzalkonium chloride-preserved, polyquad-preserved, and sofZia-preserved topical glaucoma medications on human ocular epithelial cells.
PubMed:
Stability of fortified cefazolin ophthalmic solutions prepared in artificial tears containing surfactant-based versus oxidant-based preservatives.
PubMed:
Interactions of lens care with silicone hydrogel lenses and effect on comfort.
PubMed:
Antimicrobial efficacy assessment of multi-use solution to disinfect hydrophilic contact lens, in vitro.
PubMed:
Detection of virulence factors in Serratia strains isolated from contact lens-associated corneal ulcers.
PubMed:
A randomized clinical comparison of OPTI-FREE EXPRESS and ReNu MultiPLUS multipurpose lens care solutions.
PubMed:
Do multipurpose solutions damage porcine corneal epithelial cells?
PubMed:
Clinical evaluation of long-term users of two contact lens care preservative systems.
PubMed:
[Toxicity of a new moistening agent and preservative in vitro].
PubMed:
Broad spectrum of antibacterial activity of a new multipurpose disinfecting solution.
PubMed:
Trabeculectomy trapdoor separation with allergic periorbital dermatitis: an unusual late-onset complication of guarded filtration surgery.
PubMed:
Superficial corneal "staining"-clinical observation and risk assessment.
PubMed:
Efficacy of contact lens multipurpose solutions against serratia marcescens.
PubMed:
The comparative clinical performance of a new polyhexamethylene biguanide- vs a polyquad-based contact lens care regime with two silicone hydrogel contact lenses.
PubMed:
Biocide uptake in contact lenses and loss of fungicidal activity during storage of contact lenses.
PubMed:
Comparison of toxicological profiles of benzalkonium chloride and polyquaternium-1: an experimental study.
PubMed:
The safety and intraocular pressure-lowering efficacy of brimonidine tartrate 0.15% preserved with polyquaternium-1.
PubMed:
Resistance to a polyquaternium-1 lens care solution and isoelectric points of Pseudomonas aeruginosa strains.
PubMed:
An investigation into the antimicrobial mechanisms of action of two contact lens biocides using electron microscopy.
PubMed:
Subjective and objective measures of corneal staining related to multipurpose care systems.
PubMed:
Disinfecting action of a new multi-purpose disinfection solution for contact lenses.
PubMed:
Amoebicidal activity of a preserved contact lens multipurpose disinfecting solution compared to a disinfection/neutralisation peroxide system.
PubMed:
Amoebicidal activity of multipurpose contact lens solutions.
PubMed:
Identification of genes involved in the susceptibility of Serratia marcescens to polyquaternium-1.
PubMed:
Quantitative and conformational characterization of lysozyme deposited on balafilcon and etafilcon contact lens materials.
PubMed:
Aspects of the antimicrobial mechanisms of action of a polyquaternium and an amidoamine.
PubMed:
Asymptomatic corneal staining associated with the use of balafilcon silicone-hydrogel contact lenses disinfected with a polyaminopropyl biguanide-preserved care regimen.
PubMed:
Rheological evaluation of the interactions between cationic celluloses and Carbopol 974P in water.
PubMed:
Bacillus cereus keratitis associated with contact lens wear.
PubMed:
Broad spectrum antimicrobial activity of a new multi-purpose disinfecting solution.
PubMed:
Antimicrobial comparison of a new multi-purpose disinfecting solution to a 3% hydrogen peroxide system.
PubMed:
Loss of bactericidal activity from contact lens storage solutions.
PubMed:
Evaluating the preservative effectiveness of RGP lens care solutions.
PubMed:
Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions.
PubMed:
A comparative study of the microbiologic effectiveness of chemical disinfectants and peroxide-neutralizer systems.
PubMed:
Artificial tear composition and promotion of recovery of the damaged corneal epithelium.
PubMed:
Comparative efficacies of soft contact lens disinfectant solutions against microbial films in lens cases.
PubMed:
Quantitative evaluation of the corneal epithelial barrier: effect of artificial tears and preservatives.
PubMed:
Disinfecting activities of non-peroxide soft contact lens cold disinfection solutions.
PubMed:
D-value determinations are an inappropriate measure of disinfecting activity of common contact lens disinfecting solutions.
PubMed:
Effect of contact lens preservatives on Acanthamoeba.
PubMed:
The effect of currently available contact lens disinfection systems on Acanthamoeba castellanii and Acanthamoeba polyphaga.
PubMed:
Opti-Free chemical disinfectant: a safety study with various soft contact lenses.
PubMed:
The margin of safety of polyquaternium-1 preserved lens care solutions: a phase I clinical study.