picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-

CAS: 76-78-8 C22 H28 O6 MW: 388.46036000

Identification

Namequassin
CAS Number76-78-8
EINECS200-985-9
FDA UNIIQP1YAK6QGK
Molecular FormulaC22 H28 O6
Molecular Weight388.46036000
MDL NumberMFCD00273126
Nikkaji NumberJ13.927K

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 222.00 °C. @ 760.00 mm Hg
Boiling Point 586.30 °C. @ 760.00 mm Hg (est)
Flash Point 492.00 °F. TCC ( 255.40 °C. ) (est)
logP (o/w) 2.220 (est)
Soluble in water, 566.3 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesdenaturants

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for quassin usage levels up tonot for fragrance use.
Recommendation for quassin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

quassia amara

Synonyms

2,12- dimethoxypicrasa-2,12-diene-1,11,16-trione (3aS,6aR,7aS,8S,11aS,11bS,11cS)-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c- dodecahydro-2,10-dimethoxy-3,8,11a,11c-tetramethyl dibenzo(de,g)chromene-1,5,11-trione nigakilactone D 3ab,6ab,7,7aa,8,11a,11ba,11c- octahydro-2,10-dimethoxy-3,8a,11ab,11cb-tetramethylphenanthro[10,1-bc]pyran-1,5,11(4H)-trione picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy- picrasmin quassine PubMed: Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats. PubMed: Liquid chromatography electrospray ionization tandem mass spectrometric determination of quassin and neoquassin in fruits and vegetables. PubMed: Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara. PubMed: Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity. PubMed: [Examination of original plant of Jamaica quassia extract, a natural bittering agent, based on composition of the constituents]. PubMed: [Analysis of constituents in Jamaica quassia extract, a natural bittering agent]. PubMed: Quassinoids from Picrasma crenata. PubMed: Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica. PubMed: Liquid chromatography electrospray ionization tandem mass spectrometric determination of quassin and neoquassin in fruits and vegetables. PubMed: Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara. PubMed: [Examination of original plant of Jamaica quassia extract, a natural bittering agent, based on composition of the constituents]. PubMed: Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity. PubMed: Inhibition of CYP1A1 by Quassinoids found in Picrasma excelsa. PubMed: [Analysis of constituents in Jamaica quassia extract, a natural bittering agent]. PubMed: Quassinoids from Picrasma crenata. PubMed: Antiviral activity of simalikalactone D, a quassinoid from Quassia africana. PubMed: Total synthesis of (+)-quassin. PubMed: [Weitz' aminium salt initiated electron transfer reactions and application to the synthesis of natural products]. PubMed: Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica. PubMed: Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. PubMed: 2-Methoxycanthin-6-one: A New Alkaloid from the Stem Wood of Quassia amara. PubMed: A microwell cytotoxicity assay using Artemia salina (brine shrimp). PubMed: Effect of quassin on the metabolism of catecholamines in different life cycle stages of Culex quinquefasciatus. PubMed: Larvicidal efficacy of Quassin against Culex quinquefasciatus. PubMed: Activity of quassinoids as antifeedants against aphids. PubMed: Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. PubMed: 1H- and 13C-NMR spectroscopic studies of selected quassinoids. PubMed: Acute insecticidal activity of quassin and its congeners against the American cockroach. PubMed: Production of the triterpenoid quassin in callus and cell suspension cultures of Picrasma quassioides Bennett. PubMed: Quassinoid bitter principles. II. PubMed: Antifeedant activity of quassinoids. PubMed: An enzyme-linked immunosorbent assay for quassin and closely related metabolites. PubMed: Structure-activity relationships for binding and inactivation of rabbit reticulocyte ribosomes by quassinoid antineoplastic agents. PubMed: [Antiamebic properties of some derivatives of ailantone and quassin]. PubMed: A thin-layer chromatographic method for the determination of "quassin" in cosmetic preparations. PubMed: [Research on the constituents of the bark of the subspontaneous Ailanthus glandulosa Desf. of Liguria. I. Identification of two amaroids (quassin and neopuassin)].