quassin
picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-
Identification
| Name | quassin |
| CAS Number | 76-78-8 |
| EINECS | 200-985-9 |
| FDA UNII | QP1YAK6QGK |
| Molecular Formula | C22 H28 O6 |
| Molecular Weight | 388.46036000 |
| MDL Number | MFCD00273126 |
| Nikkaji Number | J13.927K |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 222.00 °C. @ 760.00 mm Hg |
| Boiling Point | 586.30 °C. @ 760.00 mm Hg (est) |
| Flash Point | 492.00 °F. TCC ( 255.40 °C. ) (est) |
| logP (o/w) | 2.220 (est) |
| Soluble in | water, 566.3 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | denaturants |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
| Recommendation for quassin usage levels up to | not for fragrance use. |
| Recommendation for quassin flavor usage levels up to | not for flavor use. |
BOC Sciences
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Potential Uses
Natural Occurrence
Synonyms
2,12-
dimethoxypicrasa-2,12-diene-1,11,16-trione
(3aS,6aR,7aS,8S,11aS,11bS,11cS)-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c-
dodecahydro-2,10-dimethoxy-3,8,11a,11c-tetramethyl dibenzo(de,g)chromene-1,5,11-trione
nigakilactone D
3ab,6ab,7,7aa,8,11a,11ba,11c-
octahydro-2,10-dimethoxy-3,8a,11ab,11cb-tetramethylphenanthro[10,1-bc]pyran-1,5,11(4H)-trione
picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy-
picrasmin
quassine
PubMed:
Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats.
PubMed:
Liquid chromatography electrospray ionization tandem mass spectrometric determination of quassin and neoquassin in fruits and vegetables.
PubMed:
Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara.
PubMed:
Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity.
PubMed:
[Examination of original plant of Jamaica quassia extract, a natural bittering agent, based on composition of the constituents].
PubMed:
[Analysis of constituents in Jamaica quassia extract, a natural bittering agent].
PubMed:
Quassinoids from Picrasma crenata.
PubMed:
Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica.
PubMed:
Liquid chromatography electrospray ionization tandem mass spectrometric determination of quassin and neoquassin in fruits and vegetables.
PubMed:
Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara.
PubMed:
[Examination of original plant of Jamaica quassia extract, a natural bittering agent, based on composition of the constituents].
PubMed:
Quassin alters the immunological patterns of murine macrophages through generation of nitric oxide to exert antileishmanial activity.
PubMed:
Inhibition of CYP1A1 by Quassinoids found in Picrasma excelsa.
PubMed:
[Analysis of constituents in Jamaica quassia extract, a natural bittering agent].
PubMed:
Quassinoids from Picrasma crenata.
PubMed:
Antiviral activity of simalikalactone D, a quassinoid from Quassia africana.
PubMed:
Total synthesis of (+)-quassin.
PubMed:
[Weitz' aminium salt initiated electron transfer reactions and application to the synthesis of natural products].
PubMed:
Indonesian medicinal plants. XVII. Characterization of quassinoids from the stems of Quassia indica.
PubMed:
Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro.
PubMed:
2-Methoxycanthin-6-one: A New Alkaloid from the Stem Wood of Quassia amara.
PubMed:
A microwell cytotoxicity assay using Artemia salina (brine shrimp).
PubMed:
Effect of quassin on the metabolism of catecholamines in different life cycle stages of Culex quinquefasciatus.
PubMed:
Larvicidal efficacy of Quassin against Culex quinquefasciatus.
PubMed:
Activity of quassinoids as antifeedants against aphids.
PubMed:
Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids.
PubMed:
1H- and 13C-NMR spectroscopic studies of selected quassinoids.
PubMed:
Acute insecticidal activity of quassin and its congeners against the American cockroach.
PubMed:
Production of the triterpenoid quassin in callus and cell suspension cultures of Picrasma quassioides Bennett.
PubMed:
Quassinoid bitter principles. II.
PubMed:
Antifeedant activity of quassinoids.
PubMed:
An enzyme-linked immunosorbent assay for quassin and closely related metabolites.
PubMed:
Structure-activity relationships for binding and inactivation of rabbit reticulocyte ribosomes by quassinoid antineoplastic agents.
PubMed:
[Antiamebic properties of some derivatives of ailantone and quassin].
PubMed:
A thin-layer chromatographic method for the determination of "quassin" in cosmetic preparations.
PubMed:
[Research on the constituents of the bark of the subspontaneous Ailanthus glandulosa Desf. of Liguria. I. Identification of two amaroids (quassin and neopuassin)].