fibronectin
Identification
| Name | fibronectin |
| CAS Number | 86088-83-7 |
| FDA UNII | Search |
| MDL Number | MFCD00131062 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | cosmetic agents |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
fibronectins
PubMed:
Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-β1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats.
PubMed:
Infrared LED light therapy influences the expression of fibronectin and tenascin in skin wounds of malnourished rats-A preliminary study.
PubMed:
PEG-PLA nanoparticles modified with APTEDB peptide for enhanced anti-angiogenic and anti-glioma therapy.
PubMed:
Specific capture and detection of Staphylococcus aureus with high-affinity modified aptamers to cell surface components.
PubMed:
Leonurus cardiaca L. herb--a derived extract and an ursolic acid as the factors affecting the adhesion capacity of Staphylococcus aureus in the context of infective endocarditis.
PubMed:
Metyrapone Alleviates Deleterious Effects of Maternal Food Restriction on Lung Development and Growth of Rat Offspring.
PubMed:
Preclinical evaluation of IL2-based immunocytokines supports their use in combination with dacarbazine, paclitaxel and TNF-based immunotherapy.
PubMed:
Virgin olive oil phenolics extract inhibit invasion of HT115 human colon cancer cells in vitro and in vivo.
PubMed:
Whole-genome based validation of the adaptive properties of Indian origin probiotic Lactobacillus helveticus MTCC 5463.
PubMed:
Antitumor activity of the dietary diterpene carnosol against a panel of human cancer cell lines.
PubMed:
Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat.
PubMed:
Optimal conditions of LDR to protect the kidney from diabetes: exposure to 12.5 mGy X-rays for 8 weeks efficiently protects the kidney from diabetes.
PubMed:
The effects of diosgenin in the regulation of renal proximal tubular fibrosis.
PubMed:
Potential Urinary Protein Biomarker Candidates for the Accurate Detection of Prostate Cancer among Benign Prostatic Hyperplasia Patients.
PubMed:
Feeding of banana flower and pseudostem to diabetic rats results in modulation of renal GLUTs, TGFβ, PKC and extracellular matrix components.
PubMed:
Antiadhesive properties of Abelmoschus esculentus (Okra) immature fruit extract against Helicobacter pylori adhesion.
PubMed:
Grape seed extract attenuates arsenic-induced nephrotoxicity in rats.
PubMed:
A celiac cellular phenotype, with altered LPP sub-cellular distribution, is inducible in controls by the toxic gliadin peptide P31-43.
PubMed:
Rubus idaeus L. reverses epithelial-to-mesenchymal transition and suppresses cell invasion and protease activities by targeting ERK1/2 and FAK pathways in human lung cancer cells.
PubMed:
Renoprotective effect of Coccinia indica fruits and leaves in experimentally induced diabetic rats.
PubMed:
An Aqueous-Ethanol Extract of Liriope spicata var. prolifera Ameliorates Diabetic Nephropathy through Suppression of Renal Inflammation.
PubMed:
Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells.
PubMed:
Polyphenols of Hibiscus sabdariffa improved diabetic nephropathy via attenuating renal epithelial mesenchymal transition.
PubMed:
Supplementation of cyanidin-3-O-β-glucoside promotes endothelial repair and prevents enhanced atherogenesis in diabetic apolipoprotein E-deficient mice.
PubMed:
A recombinant matriptase causes an increase in caspase-3 activity in a small-intestinal epithelial IEC-6 line cultured on fibronectin-coated plates.
PubMed:
Effect of pH, salt and chemical rinses on bacterial attachment to extracellular matrix proteins.
PubMed:
In vitro colonization of the muscle extracellular matrix components by Escherichia coli O157:H7: the influence of growth medium, temperature and pH on initial adhesion and induction of biofilm formation by collagens I and III.
PubMed:
Identification of Salmonella enterica genes with a role in persistence on lettuce leaves during cold storage by recombinase-based in vivo expression technology.
PubMed:
Iron chelator alleviates tubulointerstitial fibrosis in diabetic nephropathy rats by inhibiting the expression of tenascinC and other correlation factors.
PubMed:
Riboflavin at high doses enhances lung cancer cell proliferation, invasion, and migration.
PubMed:
In vitro and in vivo characterization of DNA delivery using recombinant Lactococcus lactis expressing a mutated form of L. monocytogenes Internalin A.
PubMed:
Association between the plasma proteome and plasma α-tocopherol concentrations in humans.
PubMed:
Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.
PubMed:
Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus.
PubMed:
Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus.
PubMed:
Isolation of potential probiotic Lactobacillus rhamnosus strains from traditional fermented mare milk produced in Sumbawa Island of Indonesia.
PubMed:
Zinc inhibits magnesium-dependent migration of human breast cancer MDA-MB-231 cells on fibronectin.
PubMed:
Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.
PubMed:
Organochlorine pesticides induce epithelial to mesenchymal transition of human primary cultured hepatocytes.
PubMed:
GEF-H1 over-expression in hepatocellular carcinoma promotes cell motility via activation of RhoA signalling.
PubMed:
Effects of yeast cell wall-derived mannan-oligosaccharides on jejunal gene expression in young broiler chickens.
PubMed:
Naringenin inhibits extracellular matrix production via extracellular signal-regulated kinase pathways in nasal polyp-derived fibroblasts.
PubMed:
Bacterial attachment to immobilized extracellular matrix proteins in vitro.
PubMed:
Renal histopathology of a baboon model with type 2 diabetes.
PubMed:
Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin.
PubMed:
Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment.
PubMed:
Erythrocytes express chondroitin sulphate/dermatan sulphate, which undergoes quantitative changes during diabetes and mediate erythrocyte adhesion to extracellular matrix components.
PubMed:
Angelica acutiloba root alleviates advanced glycation end-product-mediated renal injury in streptozotocin-diabetic rats.
PubMed:
Protective effect of yacon leaves decoction against early nephropathy in experimental diabetic rats.
PubMed:
Anti-inflammatory and antifibrotic effects of naringenin in diabetic mice.
PubMed:
Curcumin attenuates diabetic nephropathy by inhibiting PKC-α and PKC-β1 activity in streptozotocin-induced type I diabetic rats.
PubMed:
Curcumin suppresses Streptococcus mutans adherence to human tooth surfaces and extracellular matrix proteins.
PubMed:
Tissue engineering a fetal membrane.
PubMed:
Selection of non-competitive leptin antagonists using a random nanobody-based approach.
PubMed:
Virulence factors and genetic characteristics of methicillin-resistant and -susceptible Staphylococcus aureus isolates in Myanmar.
PubMed:
The genome sequence of the lactic acid bacterium, Carnobacterium maltaromaticum ATCC 35586 encodes potential virulence factors.
PubMed:
Copper ability to induce premature senescence in human fibroblasts.
PubMed:
Antiglycative effects of protocatechuic acid in the kidneys of diabetic mice.
PubMed:
Diabetes results in structural alteration of chondroitin sulfate/dermatan sulfate in the rat kidney: effects on the binding to extracellular matrix components.
PubMed:
Binding to extracellular matrix proteins and formation of biogenic amines by food-associated coagulase-negative staphylococci.
PubMed:
DNA microarray based detection of genes involved in safety and technologically relevant properties of food associated coagulase-negative staphylococci.
PubMed:
Major host factors involved in epithelial cell invasion of Campylobacter jejuni: role of fibronectin, integrin beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase Rac1.
PubMed:
Luteolin ameliorates experimental lung fibrosis both in vivo and in vitro: implications for therapy of lung fibrosis.
PubMed:
Parenteral and enteral feeding in preterm piglets differently affects extracellular matrix proteins, enterocyte proliferation and apoptosis in the small intestine.
PubMed:
A recombinant catalytic domain of matriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin-coated surface.
PubMed:
Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines.
PubMed:
Relationships between pregnancy outcomes, biochemical markers and pre-pregnancy body mass index.
PubMed:
Binding of Host Factors Influences Internalization and Intracellular Trafficking of Streptococcus uberis in Bovine Mammary Epithelial Cells.
PubMed:
Functional roles of aggregation-promoting-like factor in stress tolerance and adherence of Lactobacillus acidophilus NCFM.
PubMed:
Peptides from Pisum sativum L. enzymatic protein digest with anti-adhesive activity against Helicobacter pylori: structure-activity and inhibitory activity against BabA, SabA, HpaA and a fibronectin-binding adhesin.
PubMed:
The activities of MMP-9 and total gelatinase respond differently to substrate coating and cyclic mechanical stretching in fibroblasts and myoblasts.
PubMed:
Interaction between myostatin and extracellular matrix components.
PubMed:
Functional and probiotic attributes of an indigenous isolate of Lactobacillus plantarum.
PubMed:
Campylobacter jejuni FlpA binds fibronectin and is required for maximal host cell adherence.
PubMed:
Chemical characterization, antiproliferative and antiadhesive properties of polysaccharides extracted from Pleurotus pulmonarius mycelium and fruiting bodies.
PubMed:
Staphylococcus aureus: the toxic presence of a pathogen extraordinaire.
PubMed:
Supplemental calcium attenuates the colitis-related increase in diarrhea, intestinal permeability, and extracellular matrix breakdown in HLA-B27 transgenic rats.
PubMed:
Cellular receptors of extracellular matrix molecules.
PubMed:
Characterization of two putative fibronectin-binding proteins of Clostridium perfringens.
PubMed:
Inhibitory effects of gamma-tocotrienol on invasion and metastasis of human gastric adenocarcinoma SGC-7901 cells.
PubMed:
Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture.
PubMed:
Adhesion properties of Lactobacillus casei strains to resected intestinal fragments and components of the extracellular matrix.
PubMed:
The type 4 pili of enterohemorrhagic Escherichia coli O157:H7 are multipurpose structures with pathogenic attributes.
PubMed:
A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6).
PubMed:
[Inhibitory effects of BIO-1211 on bronchoconstriction and neutrophil adhesion in rats].
PubMed:
Endostar suppresses invasion through downregulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells.
PubMed:
Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts.
PubMed:
Three-dimensional observation of connective tissue of bovine masseter muscle under concentrate- and roughage-fed conditions by using immunohistochemical/confocal laser-scanning microscopic methods.
PubMed:
Functional and structural properties of CbpA, a collagen-binding protein from Arcanobacterium pyogenes.
PubMed:
Cathepsin L activity controls adipogenesis and glucose tolerance.
PubMed:
Protective effect of Hachimi-jio-gan against the development of pancreatic fibrosis and oxidative damage in Otsuka Long-Evans Tokushima Fatty rats.
PubMed:
Mechanical stimulation increases proliferation, differentiation and protein expression in culture: stimulation effects are substrate dependent.
PubMed:
Expression patterns and role of the CadF protein in Campylobacter jejuni and Campylobacter coli.
PubMed:
Isolation of surface (S) layer protein carrying Lactobacillus species from porcine intestine and faeces and characterization of their adhesion properties to different host tissues.
PubMed:
Role of the small Rho GTPases Rac1 and Cdc42 in host cell invasion of Campylobacter jejuni.
PubMed:
Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture.
PubMed:
Inflammatory gene expression patterns revealed by DNA microarray analysis in TNF-alpha-treated SGBS human adipocytes.
PubMed:
Leptin and renal fibrosis.
PubMed:
Inhibition of tumor invasion and metastasis by aqueous extract of the radix of Platycodon grandiflorum.
PubMed:
Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFM.
PubMed:
Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin.
PubMed:
Remodeling of actin cytoskeleton in lupeol-induced B16 2F2 cell differentiation.
PubMed:
Micromechanical cantilever array sensors for selective fungal immobilization and fast growth detection.
PubMed:
Expression pattern of matrix metalloproteinases in alcohol- and thermally oxidized sunflower oil-induced toxicity: protective role of an aminothiazole derivative.
PubMed:
Effects of intrauterine food restriction and long-term dietary supplementation with L-arginine on age-related changes in renal function and structure of rats.
PubMed:
Complete genome sequence of the probiotic lactic acid bacterium Lactobacillus acidophilus NCFM.
PubMed:
Crystal structure and binding properties of the Serratia marcescens chitin-binding protein CBP21.
PubMed:
Binding interaction studies of the immobilized Salmonella typhimurium with extracellular matrix and muscle proteins, and polysaccharides.
PubMed:
Effects of c9,t11-conjugated linoleic acid on adhesion of human gastric carcinoma cell line SGC-7901.
PubMed:
Possible role of amyloid beta-(1-40)-BSA conjugates in transdifferentiation of lens epithelial cells.
PubMed:
The ShdA adhesin binds to the cationic cradle of the fibronectin 13FnIII repeat module: evidence for molecular mimicry of heparin binding.
PubMed:
Effect of food on pharmacokinetics of an inhaled drug: a case study with a VLA-4 antagonist, HMR1031.
PubMed:
Inhibitory effects of c9, t11-conjugated linoleic acid on invasion of human gastric carcinoma cell line SGC-7901.
PubMed:
Binding of extracellular matrix molecules by probiotic bacteria.
PubMed:
The Arcanobacterium pyogenes collagen-binding protein, CbpA, promotes adhesion to host cells.
PubMed:
Retinoids as a potential treatment for experimental puromycin-induced nephrosis.
PubMed:
[Renal effects of low doses of mercury].
PubMed:
T lymphocytes in food allergy: overview of an intricate network of circulating and organ-resident cells.
PubMed:
Bovine somatotropin administration to dairy goats in late lactation: effects on mammary gland function, composition and morphology.
PubMed:
Basement membrane and connective tissue proteins in intestinal mucosa of patients with coeliac disease.
PubMed:
A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover.
PubMed:
A fibronectin-binding protein from rice bran with cell adhesion activity for animal tumor cells.
PubMed:
Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats.
PubMed:
Radiolabeled peptides in the detection of deep venous thrombosis.
PubMed:
Identification of differentially expressed genes following treatment of monkey kidney cells with the mycotoxin fumonisin B(1).
PubMed:
Intrauterine food restriction as a determinant of nephrosclerosis.
PubMed:
Reduction in left ventricular messenger RNA for transforming growth factor beta(1) attenuates left ventricular fibrosis and improves survival without lowering blood pressure in the hypertensive TGR(mRen2)27 Rat.
PubMed:
Cloning, sequencing and characterisation of a Listeria monocytogenes gene encoding a fibronectin-binding protein.
PubMed:
Nutritional follow-up of critically ill infants receiving short term parenteral nutrition.
PubMed:
Listeria monocytogenes possesses adhesins for fibronectin.
PubMed:
The absence of cecal colonization of chicks by a mutant of Campylobacter jejuni not expressing bacterial fibronectin-binding protein.
PubMed:
Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration.
PubMed:
Reversal of cardiac fibrosis in deoxycorticosterone acetate-salt hypertensive rats by inhibition of the renin-angiotensin system.
PubMed:
The contribution of nitric oxide to renal vascular wall thickening in rats with L-NAME-induced hypertension.
PubMed:
Co-ligation of alpha4beta1 integrin and TCR rescues human thymocytes from steroid-induced apoptosis.
PubMed:
Influence of food consistency and dental extractions on the rat mandibular condyle: a morphological, histological and immunohistochemical study.
PubMed:
Interaction between the carboxyl-terminal heparin-binding domain of fibronectin and (-)-epigallocatechin gallate.
PubMed:
Anorexigen (TNF-alpha, cholecystokinin) and orexigen (neuropeptide Y) plasma levels in peritoneal dialysis (PD) patients: their relationship with nutritional parameters.
PubMed:
Properties of human milk and their relationship with maternal nutrition.
PubMed:
Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy.
PubMed:
Effects of small-peptide and whole-protein enteral feedings on serum proteins and diarrhea in critically ill patients: a randomized trial.
PubMed:
In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution.
PubMed:
Evidence for the interaction between (-)-epigallocatechin gallate and human plasma proteins fibronectin, fibrinogen, and histidine-rich glycoprotein.
PubMed:
V+ fibronectin mRNA is increased in the brains of aged rats: effect of food restriction.
PubMed:
[The effect of fibronectin on generation of superoxide anion by neutrophils during food poisoning and experimental salmonella endotoxemia].
PubMed:
Regulation of leukocyte adhesion and signaling in inflammation and disease.
PubMed:
[Genetic diagnosis of colorectal cancer].
PubMed:
Cardiac levels of fibronectin, laminin, isomyosins, and cytochrome c oxidase of weanling rats are more vulnerable to copper deficiency than those of postweanling rats.
PubMed:
Fibronectin mRNA (FN-V95+) is increased in the liver of old Sprague-Dawley rats: effect of food restriction.
PubMed:
Dietary omega-3 lipids delay the onset and progression of autoimmune lupus nephritis by inhibiting transforming growth factor beta mRNA and protein expression.
PubMed:
Hormonal and extracellular matrix regulation of plasminogen activator in a bovine mammary epithelial cell line.
PubMed:
Copper deficiency alters isomyosin types and levels of laminin, fibronectin and cytochrome c oxidase subunits from rat hearts.
PubMed:
Isolation of a novel collagen-binding protein from the mushroom, Hypsizigus marmoreus, which inhibits the Lewis lung carcinoma cell adhesion to type IV collagen.
PubMed:
Pathogenic potential of lactobacilli.
PubMed:
Effect of abrasion of teat orifice epithelium on development of bovine staphylococcal mastitis.
PubMed:
Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes.
PubMed:
Immunochemical localization of integrin subunits in the human placenta.
PubMed:
Perinatal food restriction in rats reduces the content but not concentration of liver extracellular matrix proteins.
PubMed:
Cholesterol, macrophages, and gene expression of TGF-beta 1 and fibronectin during nephrosis.
PubMed:
Electro-magnetic fields in the home environment (color TV, computer monitor, microwave oven, cellular phone, etc) as potential contributing factors for the induction of oncogen C-fos Ab1, oncogen C-fos Ab2, integrin alpha 5 beta 1 and development of cancer, as well as effects of microwave on amino acid composition of food and living human brain.
PubMed:
Alterations in bronchoalveolar lavage fluid but not in lung function and bronchial responsiveness in swine confinement workers.
PubMed:
Myosin light chain kinase inhibitors ML-7 and ML-9 inhibit mouse lung carcinoma cell attachment to the fibronectin substratum.
PubMed:
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.
PubMed:
Characterization of lipoprotein secreted by cultured eel hepatocytes and its comparison with serum lipoproteins.
PubMed:
Establishment of a macrophagelike cell line derived from U-937, human histiocytic lymphoma, grown serum-free.
PubMed:
A novel human hepatoblastoma cell line (HuH-6KK) with rapid growth in serum-free medium without extracellular matrix.
PubMed:
[In vitro use of a model for studying the effects of tumor promoters in food].
PubMed:
[The plasma fibronectin level in food poisoning].
PubMed:
Plasma fibronectin concentrations in breast fed and formula fed neonates.
PubMed:
[Dynamics of the plasma fibronectin level in patients with food poisoning].
PubMed:
Comparison of serum fibronectin, prealbumin, and albumin concentrations during nutritional repletion in protein-calorie malnourished infants.
PubMed:
Changes in nutritional assessment variables caused by total parenteral nutrition in anorexia nervosa.
PubMed:
Immediate postoperative feeding in urological surgery.