HC blue no. 2
p-phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
Identification
| Name | HC blue no. 2 |
| CAS Number | 33229-34-4 |
| EINECS | 251-410-3 |
| FDA UNII | 6C0EL1931V |
| Molecular Formula | C12 H19 N3 O5 |
| Molecular Weight | 285.30043000 |
| MDL Number | MFCD00071762 |
| Nikkaji Number | J78.133I |
| Beilstein | 2148848 |
Regulatory
Physical Properties
| Appearance | dark blue to dark brown microcrystalline powder (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 93.00 °C. @ 760.00 mm Hg |
| Boiling Point | 582.70 °C. @ 760.00 mm Hg (est) |
| Flash Point | 583.00 °F. TCC ( 306.20 °C. ) (est) |
| logP (o/w) | 1.700 |
| Soluble in | water, 527.8 mg/L @ 25 °C (est) |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | hair dyeing agents |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-mouse LD > 1000 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | hair dyeing agents |
| Recommendation for HC blue no. 2 usage levels up to | not for fragrance use. |
| Recommendation for HC blue no. 2 flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)bis-
ethanol, 2,2'-((4-((2-hydroxyethyl)amino)-3-nitrophenyl)imino)di-
HC blue 2
2,2'-((4-((2-
hydroxyethyl)amino)-3-nitrophenyl)imino) bisethanol
2,2'-((4-((2-
hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)
2-[4-[bis(2-
hydroxyethyl)amino]-2-nitroanilino]ethanol
2,2'-({4-[(2-
hydroxyethyl)amino]-3-nitrophenyl}imino)diethanol
3-
nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
p-
phenylenediamine, 3-nitro-N(sup 1),N(sup 1),N(sup 4)-tris(2-hydroxyethyl)-
PubMed:
Assessing the predictiveness of the Syrian hamster embryo cell transformation assay for determining the rodent carcinogenic potential of single ring aromatic/nitroaromatic amine compounds.
PubMed:
HC Blue No. 2.
PubMed:
Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, II. Effect on the in vitro induction of unscheduled DNA synthesis in rat, mouse, rabbit, hamster, and monkey primary hepatocytes.
PubMed:
Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2, I. Effect on the induction of micronuclei in mouse bone marrow cells.
PubMed:
Mutagenicity evaluation of HC Blue No. 1 and HC Blue No. 2. III. Effects in the Salmonella typhimurium/Escherichia coli reversion assay and the mouse lymphoma L5178Y TK+/- forward mutation assay.
PubMed:
Comparative metabolism and genotoxicity of the structurally similar nitrophenylenediamine dyes, HC Blue 1 and HC Blue 2, in mouse hepatocytes.
PubMed:
Species comparisons regarding comparative metabolism of two structurally similar phenylenediamines (HC Blue 1 and HC Blue 2).
PubMed:
Comparative carcinogenicity of two structurally similar phenylenediamine dyes (HC blue no. 1 and HC blue no. 2) in F344/N rats and B6C3F1 mice.
PubMed:
NTP Toxicology and Carcinogenesis Studies of C.I. Acid Orange 3 (CAS No. 6373-74-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:
Failure of short-term in vitro mutagenicity tests to predict the animal carcinogenicity of hair dyes.
PubMed:
NTP Toxicology and Carcinogenesis Studies of HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl)imino)bis(ethanol)] (CAS No. 33229-34-4) in F344/N Rats and B6C3F 1 Mice (Feed Studies).