alpha-tocopheryl succinate

butanedioic acid (2R-(2R*(4R*,8R*)))-mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester butanedioic acid mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester butanedioic acid, mono((2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))- butanedioic acid, mono[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester covitol 1210 mono((2R)-3,4- dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate (2R-(2R*(4R*,8R*)))-mono(3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyl tridecyl)-2H-1-benzopyran-6-yl) butane dioate [2R-[2R*(4R*,8R*)]]-3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol succinate mono(3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) butanedioate, (2R-(2R*(4R*,8R*)))- (3,4- dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl) hydrogen succinate succinic acid mono-[(R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyl-tridecyl)-chroman-6-yl] ester succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester, (+)- (8CI) (±)-2,5,7,8- tetramethyl-2-(4,8,12-trimethyl tridecyl)-6-chromanyl hydrogen succinate (+)-2,5,7,8- tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl hydrogen succinate mono(2,5,7,8- tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) succinate, (+)- 4-oxo-4-({(2R)-2,5,7,8- tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl}oxy)butanoic acid 4-oxo-4-[[(2R)-2,5,7,8- tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl]oxy]butanoic acid a- tocopherol acid succinate a- tocopherol acid succinate, D- a- tocopherol hemisuccinate a- tocopherol succinate a- tocopherol, succinate (6CI) a- tocopheryl acid succinate D-a- tocopheryl acid succinate a- tocopheryl hydrogen succinate alpha- tocopheryl hydrogen succinate (+)-a- tocopheryl succinate a- tocopheryl succinate D-a- tocopheryl succinate D-alpha- tocopheryl succinate dextro-alpha- tocopheryl succinate 3-{[(2R)-2-((4R,8R)-4,8,12- trimethyltridecyl)-2,5,7,8-tetramethylchroman-6-yl]oxycarbonyl}propanoic acid vitamin E acid succinate vitamin E hemisuccinate vitamin E succinate vitamine E succinate PubMed: RRR-α-tocopheryl succinate induces apoptosis in human gastric cancer cells via the NF-κB signaling pathway. PubMed: Inhibition of mitochondrial glycerol-3-phosphate dehydrogenase by α-tocopheryl succinate. PubMed: Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles. PubMed: α-Tocopheryl succinate pre-treatment attenuates quinone toxicity in prostate cancer PC3 cells. PubMed: Nanoparticles consisting of tocopheryl succinate are a novel drug-delivery system with multifaceted antitumor activity. PubMed: The role of alpha tocopheryl succinate (α-TOS) as a potential anticancer agent. PubMed: Mitochondrial targeting of α-tocopheryl succinate enhances its anti-mesothelioma efficacy. PubMed: Indoleamine-2,3-dioxygenase elevated in tumor-initiating cells is suppressed by mitocans. PubMed: Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment. PubMed: Influence of critical parameters of nanosuspension formulation on the permeability of a poorly soluble drug through the skin--a case study. PubMed: Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development. PubMed: Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate. PubMed: Alpha-tocopheryl succinate inhibits autophagic survival of prostate cancer cells induced by vitamin K3 and ascorbate to trigger cell death. PubMed: Mitochondrial Pathway of α-Tocopheryl Succinate-Induced Apoptosis in Human Epidermoid Carcinoma A431 Cells. PubMed: α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption. PubMed: Cyclooxygenase-2/prostaglandin E₂ inducing effects of α-tocopheryl polyethylene glycol succinate in lung epithelial cells. PubMed: Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeutics. PubMed: Contrasting effects of α-tocopheryl succinate on cisplatin- and etoposide-induced apoptosis. PubMed: Efficacy and biodistribution of tocopheryl polyethylene glycol succinate noncovalent functionalized single walled nanotubes loading doxorubicin in sarcoma bearing mouse model. PubMed: Crosstalk between endoplasmic reticulum stress and oxidative stress in apoptosis induced by α-tocopheryl succinate in human gastric carcinoma cells. PubMed: Development of a novel drug delivery system consisting of an antitumor agent tocopheryl succinate. PubMed: Molecular mechanism for the selective impairment of cancer mitochondrial function by a mitochondrially targeted vitamin E analogue. PubMed: Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity. PubMed: Comparison of three tocopherol analogs as an inhibitor of production of proinflammatory mediators in macrophages. PubMed: Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression. PubMed: α-Tocopheryloxyacetic acid is superior to α-tocopheryl succinate in suppressing HER2-high breast carcinomas due to its higher stability. PubMed: Mitochondrially targeted α-tocopheryl succinate is antiangiogenic: potential benefit against tumor angiogenesis but caution against wound healing. PubMed: (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo. PubMed: Formulation and in vitro evaluation of quercetin loaded polymeric micelles composed of pluronic P123 and D-a-tocopheryl polyethylene glycol succinate. PubMed: Purification of d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS) by a temperature-modulated silica gel column chromatography: use of Taguchi method to optimize purification conditions. PubMed: Affinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells. PubMed: Alpha-tocopheryl succinate enhances doxorubicin-induced apoptosis in human gastric cancer cells via promotion of doxorubicin influx and suppression of doxorubicin efflux. PubMed: Nano self-assembly of recombinant human gelatin conjugated with α-tocopheryl succinate for Hsp90 inhibitor, 17-AAG, delivery. PubMed: Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: a new paradigm for effective cancer therapy. PubMed: Investigating the stability of the nonionic surfactants tocopheryl polyethylene glycol succinate and sucrose laurate by HPLC-MS, DAD, and CAD. PubMed: Hippo/Mst1 stimulates transcription of the proapoptotic mediator NOXA in a FoxO1-dependent manner. PubMed: α-Tocopheryl succinate induces apoptosis in erbB2-expressing breast cancer cell via NF-κB pathway. PubMed: Redox-silent tocotrienol esters as breast cancer proliferation and migration inhibitors. PubMed: Nanoparticles of Poly(Lactide-Co-Glycolide)-d-a-Tocopheryl Polyethylene Glycol 1000 Succinate Random Copolymer for Cancer Treatment. PubMed: Analogs of vitamin E epitomized by alpha-tocopheryl succinate for pancreatic cancer treatment: in vitro results induce caution for in vivo applications. PubMed: Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. PubMed: alpha-Tocopheryl succinate promotes selective cell death induced by vitamin K3 in combination with ascorbate. PubMed: alpha-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels. PubMed: Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression. PubMed: Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization. PubMed: Lyophilised liposome-based formulations of alpha-tocopheryl succinate: preparation and physico-chemical characterisation. PubMed: Tocopheryl succinate-based lipid nanospheres for paclitaxel delivery: preparation, characters, and in vitro release kinetics. PubMed: [Anticancer mechanisms of vitamin E succinate]. PubMed: alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion. PubMed: Bid integrates intrinsic and extrinsic signaling in apoptosis induced by alpha-tocopheryl succinate in human gastric carcinoma cells. PubMed: Alpha-tocopheryl succinate induces rapid and reversible phosphatidylserine externalization in histiocytic lymphoma through the caspase-independent pathway. PubMed: Alpha-tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells. PubMed: Liposomal formulation of alpha-tocopheryl maleamide: in vitro and in vivo toxicological profile and anticancer effect against spontaneous breast carcinomas in mice. PubMed: alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis. PubMed: Suppression of tumor growth in vivo by the mitocan alpha-tocopheryl succinate requires respiratory complex II. PubMed: Targeting of cancer energy metabolism. PubMed: Vitamin E analogues as mitochondria-targeting compounds: from the bench to the bedside? PubMed: Apoptosis induction by (+)alpha-tocopheryl succinate in the absence or presence of all-trans retinoic acid and arsenic trioxide in NB4, NB4-R2 and primary APL cells. PubMed: Combination of vitamin E and selenium causes an induction of apoptosis of human prostate cancer cells by enhancing Bax/Bcl-2 ratio. PubMed: Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II. PubMed: Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress. PubMed: Alpha-Tocopheryl succinate: toxicity and lack of anti-tumour activity in immuno-competent mice. PubMed: alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling. PubMed: Vitamin E analogues and immune response in cancer treatment. PubMed: Stabilization of cranberry anthocyanins in nutraceutical capsules. PubMed: Solubility of α-Tocopheryl Succinate in Supercritical Carbon Dioxide Using Offline HPLC-MS/MS Analysis. PubMed: A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. PubMed: Mitocans as anti-cancer agents targeting mitochondria: lessons from studies with vitamin E analogues, inhibitors of complex II. PubMed: [Proapoptotic action of alpha-tocopheryl succinate in rat thymocytes is conditioned by the inhibition of mitochondrial succinate dehydrogenase]. PubMed: Vitamin E analogs, a novel group of "mitocans," as anticancer agents: the importance of being redox-silent. PubMed: Alpha-tocopheryl succinate sensitizes human colon cancer cells to exisulind-induced apoptosis. PubMed: Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells. PubMed: Alpha-tocopheryl succinate (alpha-TOS) modulates human prostate LNCaP xenograft growth and gene expression in BALB/c nude mice fed two levels of dietary soybean oil. PubMed: Alpha-tocopheryl phosphate is a novel apoptotic agent. PubMed: Augmented suppression of androgen receptor signaling by a combination of alpha-tocopheryl succinate and methylseleninic acid. PubMed: Dietary administration of the proapoptotic vitamin E analogue alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer. PubMed: Molecular mechanism of 'mitocan'-induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl-2 family proteins. PubMed: Novel antioxidant technology for prostate cancer chemoprevention and treatment. PubMed: alpha-Tocopheryl succinate-induced apoptosis in human gastric cancer cells is modulated by ERK1/2 and c-Jun N-terminal kinase in a biphasic manner. PubMed: Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate. PubMed: Beneficial effect of alpha-tocopheryl succinate in rat cardiac transplants. PubMed: Alpha-tocopheryl succinate, in contrast to alpha-tocopherol and alpha-tocopheryl acetate, inhibits prostaglandin E2 production in human lung epithelial cells. PubMed: Flavonoids and vitamin E reduce the release of the angiogenic peptide vascular endothelial growth factor from human tumor cells. PubMed: Role of thioredoxin-1 in apoptosis induction by alpha-tocopheryl succinate and TNF-related apoptosis-inducing ligand in mesothelioma cells. PubMed: Tocopherol-associated protein-1 accelerates apoptosis induced by alpha-tocopheryl succinate in mesothelioma cells. PubMed: Chemo-immunotherapy of breast cancer using vesiculated alpha-tocopheryl succinate in combination with dendritic cell vaccination. PubMed: Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis. PubMed: Cytotoxicity of alpha-tocopheryl succinate, malonate and oxalate in normal and cancer cells in vitro and their anti-cancer effects on mouse melanoma in vivo. PubMed: alpha-Tocopheryl succinate induces apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 function. PubMed: Low and high levels of alpha-tocopherol exert opposite effects on IL-2 possibly through the modulation of PPAR-gamma, IkappaBalpha, and apoptotic pathway in activated splenocytes. PubMed: Alpha-tocopheryl succinate alters cell cycle distribution sensitising human osteosarcoma cells to methotrexate-induced apoptosis. PubMed: Synthesis and study of the cancer cell growth inhibitory properties of alpha-, gamma-tocopheryl and gamma-tocotrienyl 2-phenylselenyl succinates. PubMed: 5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole acts in a reactive oxygen species-dependent manner to suppress human lung cancer growth. PubMed: Cytotoxicity of liposomal alpha-tocopheryl succinate towards hamster cheek pouch carcinoma (HCPC-1) cells in culture. PubMed: Enhanced anticancer efficacy of alpha-tocopheryl succinate by conjugation with polyethylene glycol. PubMed: Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic cell vaccines. PubMed: Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? PubMed: [Effective molecular form of alpha-tocopheryl succinate in inducing apoptosis of SGC-7901 cells]. PubMed: Angiotensin II protects cultured midbrain dopaminergic neurons against rotenone-induced cell death. PubMed: Tocotrienol inhibits proliferation of human Tenon's fibroblasts in vitro: a comparative study with vitamin E forms and mitomycin C. PubMed: Pharmacokinetics and tissue distribution of d-alpha-tocopheryl succinate formulations following intravenous administration in the rat. PubMed: Vitamin E amides, a new class of vitamin E analogues with enhanced proapoptotic activity. PubMed: Alpha-tocopheryl succinate induces cytostasis and apoptosis in osteosarcoma cells: the role of E2F1. PubMed: Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. PubMed: Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol. PubMed: Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer prevention. PubMed: Up-regulation of c-Jun-NH2-kinase pathway contributes to the induction of mitochondria-mediated apoptosis by alpha-tocopheryl succinate in human prostate cancer cells. PubMed: Hepatic processing determines dual activity of alpha-tocopheryl succinate: a novel paradigm for a shift in biological activity due to pro-vitamin-to-vitamin conversion. PubMed: Potentiation by alpha-tocopheryl succinate of the etoposide response in multidrug resistance protein 1-expressing glioblastoma cells. PubMed: Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. PubMed: Vitamin E and breast cancer. PubMed: Multiple dietary antioxidants enhance the efficacy of standard and experimental cancer therapies and decrease their toxicity. PubMed: Chemopreventive effect of dietary d-alpha-tocopheryl succinate supplementation on precancer colon aberrant crypt formation and vitamin E analogue levels in young and old rats. PubMed: Comparison of vitamin E derivatives alpha-TEA and VES in reduction of mouse mammary tumor burden and metastasis. PubMed: Role of reactive oxygen species in the induction of apoptosis by alpha-tocopheryl succinate. PubMed: Differential response of human ovarian cancer cells to induction of apoptosis by vitamin E Succinate and vitamin E analogue, alpha-TEA. PubMed: Pro-apoptotic mechanisms of action of a novel vitamin E analog (alpha-TEA) and a naturally occurring form of vitamin E (delta-tocotrienol) in MDA-MB-435 human breast cancer cells. PubMed: Inhibition of lung carcinoma cell growth by high density lipoprotein-associated alpha-tocopheryl-succinate. PubMed: Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. PubMed: alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. PubMed: Structural characteristic of terminal dicarboxylic moiety required for apoptogenic activity of alpha-tocopheryl esters. PubMed: Alpha-tocopheryl succinate and TRAIL selectively synergise in induction of apoptosis in human malignant mesothelioma cells. PubMed: RRR-alpha-tocopheryl succinate inhibits human prostate cancer cell invasiveness. PubMed: A vitamin E analogue suppresses malignant mesothelioma in a preclinical model: a future drug against a fatal neoplastic disease? PubMed: alpha-Tocopheryl succinate sensitizes established tumors to vaccination with nonmatured dendritic cells. PubMed: Enhancement of nitric oxide and superoxide generations by alpha-tocopheryl succinate and its apoptotic and anticancer effects. PubMed: Antioxidant supplementation preserves antioxidant response in physical training and low antioxidant intake. PubMed: alpha-Tocopheryl succinate activates protein kinase C in cellular and cell-free systems. PubMed: Vitamin E succinate and cancer treatment: a vitamin E prototype for selective antitumour activity. PubMed: Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. PubMed: Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation. PubMed: Inhibition of tumour necrosis factor-alpha and interleukin 6 production by mononuclear cells following dietary fish-oil supplementation in healthy men and response to antioxidant co-supplementation. PubMed: Vitamin E analogues as inducers of apoptosis: structure-function relation. PubMed: RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells involves Bax translocation to mitochondria. PubMed: Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. PubMed: Alpha-tocopheryl succinate, the most effective form of vitamin E for adjuvant cancer treatment: a review. PubMed: An in vitro examination of the impact of polyethylene glycol 400, Pluronic P85, and vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate on P-glycoprotein efflux and enterocyte-based metabolism in excised rat intestine. PubMed: RRR-alpha-tocopheryl succinate induction of DNA synthesis arrest of human MDA-MB-435 cells involves TGF-beta-independent activation of p21Waf1/Cip1. PubMed: The effect of various vitamin E derivatives on the urokinase-plasminogen activator system of ovine macrophages and neutrophils. PubMed: Alpha-tocopheryl succinate sensitises a T lymphoma cell line to TRAIL-induced apoptosis by suppressing NF-kappaB activation. PubMed: Cholesteryl-hemisuccinate-induced apoptosis of promyelocytic leukemia HL-60 cells through a cyclosporin A-insensitive mechanism. PubMed: Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. PubMed: Free radical scavenging and skin penetration of troxerutin and vitamin derivatives. PubMed: D-alpha-tocopheryl succinate (vitamin E) enhances radiation-induced chromosomal damage levels in human cancer cells, but reduces it in normal cells. PubMed: Prostaglandin E2 is involved in the increase of cytochrome P-450 2B1 expression by alpha-tocopheryl succinate in primary rat hepatocytes in the presence of phenobarbital. PubMed: Alpha-tocopheryl succinate epitomizes a compound with a shift in biological activity due to pro-vitamin-to-vitamin conversion. PubMed: Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. PubMed: Role of extracellular signal-regulated kinase pathway in RRR-alpha-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells. PubMed: Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. PubMed: Alpha-tocopheryl succinate, an agent with in vivo anti-tumour activity, induces apoptosis by causing lysosomal instability. PubMed: RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest. PubMed: Inhibitory effects of RRR-alpha-tocopheryl succinate on benzo(a)pyrene (B(a)P)-induced forestomach carcinogenesis in female mice. PubMed: Alpha tocopheryl succinate, retinoic acid and polar carotenoids enhanced the growth-inhibitory effect of a cholesterol-lowering drug on immortalized and transformed nerve cells in culture. PubMed: Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes. PubMed: Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents. PubMed: RRR-alpha-tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation. PubMed: Vitamin E analogues as inducers of apoptosis: implications for their potential antineoplastic role. PubMed: Activation of extracellular signal-regulated kinase and c-Jun-NH(2)-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-alpha-tocopheryl succinate-induced apoptosis of human breast cancer cells. PubMed: Mitochondrial electron transport inhibitors cause lipid peroxidation-dependent and -independent cell death: protective role of antioxidants. PubMed: Coenzyme Q blocks biochemical but not receptor-mediated apoptosis by increasing mitochondrial antioxidant protection. PubMed: Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice. PubMed: Vitamin E reduces lipid peroxidation in experimental hepatotoxicity in rats. PubMed: Inhibition of inflammatory endothelial responses by a pathway involving caspase activation and p65 cleavage. PubMed: Hydrolysis of tocopheryl and retinyl esters by porcine carboxyl ester hydrolase is affected by their carboxylate moiety and bile acids. PubMed: Interfacial properties of phosphatidylcholine bilayers containing vitamin E derivatives. PubMed: Inhibition of heart mitochondrial lipid peroxidation by non-toxic concentrations of carvedilol and its analog BM-910228. PubMed: Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements. PubMed: Selective cancer cell killing by alpha-tocopheryl succinate. PubMed: Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione. PubMed: Mechanism of alpha-tocopheryl succinate-induced apoptosis of promyelocytic leukemia cells. PubMed: Lipoprotein-associated alpha-tocopheryl-succinate inhibits cell growth and induces apoptosis in human MCF-7 and HBL-100 breast cancer cells. PubMed: Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis. PubMed: Vitamin E (d-alpha-tocopheryl succinate) decreases mitotic accumulation in gamma-irradiated human tumor, but not in normal, cells. PubMed: Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. PubMed: alpha-tocopheryl succinate-induced apoptosis in Jurkat T cells involves caspase-3 activation, and both lysosomal and mitochondrial destabilisation. PubMed: High doses of multiple antioxidant vitamins: essential ingredients in improving the efficacy of standard cancer therapy. PubMed: Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. PubMed: RRR-alpha-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells. PubMed: Inhibition of NF-kappa B transcriptional activity by alpha-tocopheryl succinate. PubMed: alpha-Tocopheryl succinate inhibits monocytic cell adhesion to endothelial cells by suppressing NF-kappa B mobilization. PubMed: c-Jun involvement in vitamin E succinate induced apoptosis of reticuloendotheliosis virus transformed avian lymphoid cells. PubMed: Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells. PubMed: Evidence for role of transforming growth factor-beta in RRR-alpha-tocopheryl succinate-induced apoptosis of human MDA-MB-435 breast cancer cells. PubMed: RRR-alpha-tocopheryl succinate inhibits EL4 thymic lymphoma cell growth by inducing apoptosis and DNA synthesis arrest. PubMed: alpha-tocopherol ameliorates oxidant injury in isolated copper-overloaded rat hepatocytes. PubMed: RRR-alpha-tocopheryl succinate enhances TGF-beta 1, -beta 2, and -beta 3 and TGF-beta R-II expression by human MDA-MB-435 breast cancer cells. PubMed: Importance of the form of topical vitamin E for prevention of photocarcinogenesis. PubMed: Effect of individual and multiple antioxidant vitamins on growth and morphology of human nontumorigenic and tumorigenic parotid acinar cells in culture. PubMed: RRR-alpha-tocopheryl succinate induces apoptosis in avian retrovirus-transformed lymphoid cells. PubMed: Modulation of murine EL-4 thymic lymphoma cell proliferation and cytokine production by vitamin E succinate. PubMed: Biokinetics in humans of RRR-alpha-tocopherol: the free phenol, acetate ester, and succinate ester forms of vitamin E. PubMed: Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids. PubMed: alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells. PubMed: RRR-alpha-tocopheryl succinate inhibits DNA synthesis and enhances the production and secretion of biologically active transforming growth factor-beta by avian retrovirus-transformed lymphoid cells. PubMed: RRR-alpha-tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways. PubMed: Vitamin E succinate induction of HL-60 cell adhesion: a role for fibronectin and a 72-kDa fibronectin-binding molecule. PubMed: Metabolism of tritiated D-alpha-tocopherol and D-alpha-tocopheryl succinate in intraruminally dosed sheep. PubMed: The selective antiproliferative effects of alpha-tocopheryl hemisuccinate and cholesteryl hemisuccinate on murine leukemia cells result from the action of the intact compounds. PubMed: Modification of the expression of adenosine 3',5'-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate. PubMed: The protective but nonsynergistic effect of dietary beta-carotene and vitamin E on skin tumorigenesis in Skh mice. PubMed: Tissue alpha-tocopherol concentrations following supplementation with various forms of vitamin E in sheep. PubMed: Modification of the effect of tamoxifen, cis-platin, DTIC, and interferon-alpha 2b on human melanoma cells in culture by a mixture of vitamins. PubMed: Inhibition of NF-kappa B DNA binding activity by alpha-tocopheryl succinate. PubMed: Vitamins regulate gene expression and induce differentiation and growth inhibition in cancer cells. Their relevance in cancer prevention. PubMed: Inhibition of NF-kappa B activation by vitamin E derivatives. PubMed: Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. PubMed: RRR-alpha-tocopheryl succinate induced interleukin-2 production by avian splenic T lymphocytes and murine EL-4 thymic lymphoma cells. PubMed: RRR-alpha-tocopheryl succinate inhibition of lectin-induced T cell proliferation. PubMed: RRR-alpha-tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor-beta (TGF-beta) by human breast cancer cells. PubMed: Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol. PubMed: Effects of RRR-alpha-tocopheryl succinate on IL-1 and PGE2 production by macrophages. PubMed: Vitamin E and cancer prevention: recent advances and future potentials. PubMed: Bioavailability of vitamin E compounds in lambs. PubMed: RRR-alpha-tocopheryl succinate modulation of human promyelocytic leukemia (HL-60) cell proliferation and differentiation. PubMed: Plasma alpha-tocopherol profiles in sheep after oral administration of dl-alpha-tocopheryl acetate and d-alpha-tocopheryl succinate. PubMed: Cadmium toxicity: unique cytoprotective properties of alpha tocopheryl succinate in hepatocytes. PubMed: RRR-alpha-tocopheryl succinate enhances T cell mitogen-induced proliferation and reduces suppressor activity in spleen cells derived from AEV-infected chickens. PubMed: New opportunities with neuronal cultures to study the mechanisms of neurotoxic injuries. PubMed: Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells. PubMed: Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture. PubMed: Beta-carotene induces morphological differentiation and decreases adenylate cyclase activity in melanoma cells in culture. PubMed: Lipid peroxidation in rat tissue slices: effect of dietary vitamin E, corn oil-lard and menhaden oil. PubMed: Effect of dietary lipids and vitamin E on in vitro lipid peroxidation in rat liver and kidney homogenates. PubMed: Alpha-tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. PubMed: Effect of D, alpha-tocopheryl succinate and polyethylene glycol on performance tests after fluid percussion brain injury. PubMed: Induction of differentiated phenotypes in melanoma cells by a combination of an adenosine 3',5'-cyclic monophosphate stimulating agent and D-alpha tocopheryl succinate. PubMed: Uptake of intact TPGS (d-alpha-tocopheryl polyethylene glycol 1000 succinate) a water-miscible form of vitamin E by human cells in vitro. PubMed: Combined effect of adenosine 3',5'-cyclic monophosphate stimulating agents, vitamin E succinate, and heat on the survival of murine B-16 melanoma cells in culture. PubMed: Effect of alpha tocopheryl succinate on adenylate cyclase activity in murine neuroblastoma cells in culture. PubMed: Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture. PubMed: Alpha tocopheryl succinate inhibits melanocyte-stimulating hormone (MSH)-sensitive adenylate cyclase activity in melanoma cells. PubMed: Vitamin E protection against chemical-induced cell injury. II. Evidence for a threshold effect of cellular alpha-tocopherol in prevention of adriamycin toxicity. PubMed: Vitamin E protection against chemical-induced cell injury. I. Maintenance of cellular protein thiols as a cytoprotective mechanism. PubMed: A role of vitamin E in protection against cell injury. Maintenance of intracellular glutathione precursors and biosynthesis. PubMed: Relationship between cellular calcium and vitamin E metabolism during protection against cell injury. PubMed: Effects of dl-alpha-tocopheryl succinate in combination with sodium butyrate and cAMP stimulating agent on neuroblastoma cells in culture. PubMed: Serum concentrations of alpha-tocopherol after ingestion of various vitamin E preparations. PubMed: dl-alpha-Tocopheryl succinate enhances the effect of gamma-irradiation on neuroblastoma cells in culture. PubMed: Study on the specificity of alpha-tocopheryl (vitamin E) acid succinate effects on melanoma, glioma and neuroblastoma cells in culture. PubMed: Biological activity of all-rac-a-tocopherol and RRR-a-tocopherol determined by three different rat bioassays. PubMed: Induction of macrostome formation in Blepharisma americanum (Suzuki, 1954) by alpha-tocopheryl succinate.