nopol
10-hydroxymethylene-2-pinene
Identification
| Name | nopol |
| IUPAC | 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol |
| CAS Number | 128-50-7 |
| EINECS | 204-890-3 |
| FDA UNII | XK8HU7WJQC |
| Molecular Formula | C11 H18 O |
| Molecular Weight | 166.26366000 |
| Nikkaji Number | J21.520A |
Regulatory
| JECFA Food Flavoring | 986 10-hydroxymethylene-2-pinene |
| DG SANTE Food Flavourings | 02.141 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethan-1-ol |
| FEMA Number | 3938 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 128-50-7 ; 10-HYDROXYMETHYLENE-2-PINENE |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.96500 to 0.97300 @ 25.00 °C. |
| Pounds per Gallon - (est). | 8.030 to 8.096 |
| Refractive Index | 1.49000 to 1.50000 @ 20.00 °C. |
| Boiling Point | 110.50 °C. @ 10.00 mm Hg, 230.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.009000 mmHg @ 25.00 °C. (est) |
| Flash Point | 210.00 °F. TCC ( 98.89 °C. ) |
| logP (o/w) | 3.152 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | perfuming agents |
Organoleptic Properties
| Odor Strength | medium |
| Substantivity | 32 hour(s) at 100.00 % |
| Odor Description |
at 100.00 %. Very mild, woody-camphoraceous characteristic, soft woody (pine note)
|
| Odor sample from | Ungerer & Company, Inc. |
Safety Information
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | oral-rat LD50 890 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 5000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for nopol usage levels up to | 8.0000 % in the fragrance concentrate. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 33.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA) | 0.01 (μg/capita/day) |
| Threshold of Concern | 1800 (μg/person/day) |
| Structure Class | I |
| baked goods | 2.00000 |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | 2.00000 |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | 1.00000 |
| fruit ices | - |
| gelatins / puddings | 2.00000 |
| granulated sugar | - |
| gravies | - |
| hard candy | 4.00000 |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | 1.50000 |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
Berje Inc.
Where the world comes to its senses
Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
BOC Sciences
Best of Chemicals Supplier
Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...
Lluch Essence S.L.
A family company dedicated to sales and distribution
Flexibility, availability, price and quality.
Penta International Corporation
Chemistry innovation
At Penta, our products and services help businesses do business better.
Vigon International
Passion for Simplicity
Manufacturer and supplier of high quality flavor and fragrance ingredients.
Potential Uses
Natural Occurrence
Synonyms
bicyclo(3.1.1)hept-2-ene-2-ethanol, 6,6-dimethyl-
bicyclo[3.1.1]hept-2-ene-2-ethanol, 6,6-dimethyl-
2-(6,6-
dimethyl bicyclo(3.1.1)hept-2-en-2-yl) ethan-1-ol
6,6-
dimethyl-2-hydroxyethyl-6,6-dimethyl bicyclo(3,1,1)hept-2-ene bicyclo(3.1.1)hept-2-ene-2-ethanol
6,6-
dimethyl-2-norpinene-2-ethanol
6,6-
dimethylbicyclo-(3.1.1)-2-heptene-2-ethanol
2-(6,6-
dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethan-1-ol
2-(6,6-
dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethanol
6,6-
dimethylbicyclo[3.1.1]hept-2-ene-2-ethanol
2-
hydroxyethyl-6,6-dimethyl-bicyclo[3,1,1]-hept-2-ene
10-
hydroxymethylene-2-pinene
homo
myrtenol
2-nor
pinene-2-ethanol, 6,6-dimethyl-
PubMed:
Superior performance of metal-organic frameworks over zeolites as solid acid catalysts in the Prins reaction: green synthesis of nopol.
PubMed:
On the synergistic catalytic properties of bimetallic mesoporous materials containing aluminum and zirconium: the Prins cyclisation of citronellal.
PubMed:
Microbial transformation of (-)-nopol benzyl ether: direct dihydroxylation of benzene ring.
PubMed:
Transition metal-substituted Dawson anions as chemo- and regio-selective oxygen transfer catalysts for H2O2 in the epoxidation of allylic alcohols.
PubMed:
Antioxidant responses and reactive oxygen species generation in different body regions of the estuarine polychaeta Laeonereis acuta (Nereididae).
PubMed:
Analysis of the essential oil composition of eight Anthemis species from Greece.
PubMed:
Mesoporous iron phosphate as an active, selective and recyclable catalyst for the synthesis of nopol by Prins condensation.
PubMed:
Synthesis of nopol over MCM-41 catalysts.
PubMed:
Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.
PubMed:
Enzymatic synthesis of structural analogs of PAF-acether by phospholipase D-catalysed transphosphatidylation.
PubMed:
Glucuronidation of 2-arylpropionic acids pirprofen, flurbiprofen, and ibuprofen by liver microsomes.
PubMed:
Differential action of thyroid hormones and chemically related compounds on the activity of UDP-glucuronosyltransferases and cytochrome P-450 isozymes in rat liver.
PubMed:
Effect of 1-benzylimidazole on cytochromes P-450 induction and on the activities of epoxide hydrolases and UDP-glucuronosyltransferases in rat liver.
PubMed:
Properties of human hepatic UDP-glucuronosyltransferases. Relationship to other inducible enzymes in patients with cholestasis.
PubMed:
[On a new local anesthetic. Homomyrtenol and diethylaminoethanol ether].