Identification

Namecyclohexanol
IUPACcyclohexanol
CAS Number108-93-0
EINECS203-630-6
FDA UNII8E7S519M3P
Molecular FormulaC6 H12 O
Molecular Weight100.16084000
MDL NumberMFCD00003855
Nikkaji NumberJ2.871A
Beilstein0906744
CoE Number2138

Regulatory

DG SANTE Food Flavourings02.070 cyclohexanol
FDA Mainterm (IAUFC)108-93-0 ; CYCLOHEXANOL
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance colorless liquid to crystalline needles (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.94200 to 0.94800 @ 25.00 °C.
Pounds per Gallon - (est). 7.838 to 7.888
Refractive Index 1.46200 to 1.46800 @ 20.00 °C.
Melting Point 25.50 °C. @ 760.00 mm Hg
Boiling Point 158.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.975000 mmHg @ 20.00 °C.
Vapor Density 3.5 ( Air = 1 )
Flash Point 145.00 °F. TCC ( 62.78 °C. )
logP (o/w) 1.230
Soluble in water, 42000 mg/L @ 10 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Description at 10.00 % in dipropylene glycol.

Safety Information

European informationMost important hazard(s):
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M] 1750 mg/kg
Dermal Toxicityskin-rabbit LDLo 794 mg/kg
Inhalation Toxicityinhalation-human TCLo 75 ppm

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents and cosmetic fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Maximised Survey-derived Daily Intakes (MSDI-EU)3.70 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)1600 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
Dairy products, excluding products of category 02.0 (01.0)3.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)2.00000
Edible ices, including sherbet and sorbet (03.0)3.00000
Processed fruit (04.1)2.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)4.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)2.00000
Bakery wares (07.0)5.00000
Meat and meat products, including poultry and game (08.0)1.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)1.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)2.00000
Foodstuffs intended for particular nutritional uses (13.0)3.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)2.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)4.00000
Ready-to-eat savouries (15.0)5.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)2.00000

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Potential Uses

FL buchu leaf FL/FR cajeput FL/FR camphor tree bark FR cardamom oil replacer FR hinoki oil replacer FL/FR hyssop FR lavandin FR myrtle oil replacer FR niaouli FR oregano FR thyme oil white replacer

Natural Occurrence

basil oil okra fruit passion fruit - up to 0.1 mg/kg sauromatum guttatum tomato fruit wine white wine - 0.006 mg/kg

Synonyms

adronal adronol 1- cyclohexanol cyclohexanol w/methanol cyclohexyl alcohol hexahydrophenol hexalin hydralin hydrophenol hydroxycyclohexane naxol PubMed: Migration of odorous compounds from adhesives used in market samples of food packaging materials by chromatography olfactometry and mass spectrometry (GC-O-MS). PubMed: Isolation, purification and identification of nine chemical compounds from Flammulina velutipes fruiting bodies. PubMed: Identification of raloxifene as a novel CB2 inverse agonist. PubMed: Opioids in the perifornical lateral hypothalamus suppress ethanol drinking. PubMed: Preparation and evaluation of poly(4-vinylphenylboronic acid-co-pentaerythritol triacrylate) monolithic column for capillary liquid chromatography of small molecules and proteins. PubMed: Chronic cannabinoid treatment during young adulthood induces sex-specific behavioural deficits in maternally separated rats. 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PubMed: Preparation of a neutral porous monolith and its evaluation in pressurized capillary electrochromatography with neutral and charged solutes. PubMed: Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake. PubMed: Preparation and evaluation of the highly cross-linked poly(1-hexadecane-co-trimethylolpropane trimethacrylate) monolithic column for capillary electrochromatography. PubMed: Opioids in the nucleus accumbens stimulate ethanol intake. PubMed: Central cannabinoid signaling mediating food intake: a pharmacological-challenge magnetic resonance imaging and functional histology study in rat. PubMed: Determination of tetracyclines in food samples by molecularly imprinted monolithic column coupling with high performance liquid chromatography. PubMed: Fragrance material review on 1-methyl-4-(1-methylvinyl)cyclohexyl acetate. PubMed: Fragrance material review on cyclohexyl acetate. 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PubMed: Interactions between endocannabinoids and stress-induced decreased sensitivity to natural reward. PubMed: Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21. PubMed: Novel approach to the detection and quantification of phenolic compounds in olive oil based on 31P nuclear magnetic resonance spectroscopy. PubMed: Analyses of phenolic compounds by microemulsion electrokinetic chromatography. PubMed: Cannabinoids augment the release of neuropeptide Y in the rat hypothalamus. PubMed: Structure-function analysis of the vanillin molecule and its antifungal properties. PubMed: Discriminative stimulus effects of the structurally novel cannabinoid CB1/CB2 receptor partial agonist BAY 59-3074 in the rat. PubMed: Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys. PubMed: Partial agonist-like profile of the cannabinoid receptor antagonist SR141716A in a food-reinforced operant paradigm. PubMed: Behavioral effects of cannabinoids show differential sensitivity to cannabinoid receptor blockade and tolerance development. PubMed: Cannabinoid agonist, CP 55,940, facilitates intake of palatable foods when injected into the hindbrain. PubMed: In vivo studies on the metabolism of the monoterpene pulegone in humans using the metabolism of ingestion-correlated amounts (MICA) approach: explanation for the toxicity differences between (S)-(-)- and (R)-(+)-pulegone. PubMed: Intrinsic activity estimation of cannabinoid CB1 receptor ligands in a drug discrimination paradigm. PubMed: Chronic treatment with CP 55,940 during the peri-adolescent period differentially affects the behavioural responses of male and female rats in adulthood. PubMed: Discriminative stimulus effects of BAY 38-7271, a novel cannabinoid receptor agonist. 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