beta-santalol
12-beta-santalen-14-ol
Identification
| Name | beta-santalol |
| IUPAC | (Z)-2-methyl-5-(6-methyl-5-methylidene-6-bicyclo[2.2.1]heptanyl)pent-2-en-1-ol |
| CAS Number | 77-42-9 |
| EINECS | 201-027-2 |
| FDA UNII | 1JL7K2LW6L |
| Molecular Formula | C15 H24 O |
| Molecular Weight | 220.35548000 |
| Nikkaji Number | J2.946.646G |
| CoE Number | 74 |
Regulatory
| DG SANTE Food Flavourings | 02.216 12-beta-santalen-14-ol |
| FEMA Number | 3006 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 77-42-9 ; SANTALOL, BETA |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Specific Gravity | 0.96500 to 0.97500 @ 25.00 °C. |
| Pounds per Gallon - (est). | 8.030 to 8.113 |
| Refractive Index | 1.49800 to 1.50900 @ 20.00 °C. |
| Boiling Point | 311.00 to 313.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.000048 mmHg @ 25.00 °C. (est) |
| Flash Point | 241.00 °F. TCC ( 116.11 °C. ) |
| logP (o/w) | 4.446 (est) |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | perfuming agents |
Organoleptic Properties
| Odor Description | at 100.00 %. |
Safety Information
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for beta-santalol usage levels up to | 3.0000 % in the fragrance concentrate. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 0.085 (μg/capita/day) |
| Modified Theoretical Added Maximum Daily Intake (mTAMDI) | 3900 (μg/person/day) |
| Threshold of Concern | 1800 (μg/person/day) |
| Structure Class | I |
| baked goods | 1.00000 |
| beverages(nonalcoholic) | 0.06000 |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | 0.35000 |
| fruit ices | 0.35000 |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | 1.00000 |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
| Dairy products, excluding products of category 02.0 (01.0) | 7.00000 |
| Fats and oils, and fat emulsions (type water-in-oil) (02.0) | 5.00000 |
| Edible ices, including sherbet and sorbet (03.0) | 10.00000 |
| Processed fruit (04.1) | 7.00000 |
| Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2) | - |
| Confectionery (05.0) | 10.00000 |
| Chewing gum (05.3) | - |
| Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0) | 5.00000 |
| Bakery wares (07.0) | 10.00000 |
| Meat and meat products, including poultry and game (08.0) | 2.00000 |
| Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0) | 2.00000 |
| Eggs and egg products (10.0) | 2.00000 |
| Sweeteners, including honey (11.0) | 2.00000 |
| Salts, spices, soups, sauces, salads, protein products, etc. (12.0) | 5.00000 |
| Foodstuffs intended for particular nutritional uses (13.0) | 10.00000 |
| Non-alcoholic ("soft") beverages, excl. dairy products (14.1) | 5.00000 |
| Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2) | 10.00000 |
| Ready-to-eat savouries (15.0) | 20.00000 |
| Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0) | 5.00000 |
Chemical sources Association Inc
Exchange of knowledge
Need This Item for Flavor? You can contact the Chemical Sources Association.
Potential Uses
Natural Occurrence
Synonyms
(1S-(1alpha,2alpha(Z),4alpha))-2-
methyl-5-(2-methyl-3-methylene bicyclo(2.2.1)hept-2-yl)-2-penten-1-ol
2-
methyl-5-(2-methyl-3-methylene-2-norbornyl)-2-penten-1-ol
(1S-(1a,2a(Z),4a))-2-
methyl-5-(2-methyl-3-methylenebicyclo(2.2.1)hept-2-yl)-2-penten-1-ol
2-
methyl-5-(2-methyl-3-methylenebicyclo(2.2.1)hept-2-yl)-2-penten-1-ol, (1S-(1a,2a(Z(,4a))-
(2Z)-2-
methyl-5-(2-methyl-3-methylenebicyclo[2.2.1]hept-2-yl)-2-penten-1-ol
(Z)-2-
methyl-5-(6-methyl-5-methylidene-6-bicyclo[2.2.1]heptanyl)pent-2-en-1-ol
2-
penten-1-ol, 2-methyl-5-(2-methyl-3-methylenebicyclo(2.2.1)hept-2-yl)-, (1S-(1a,2a(Z),4a))-
12-beta-
santalen-14-ol
beta-
santalenol
(Z)-b-
santalol
PubMed:
Structure-odor relationships of semisynthetic β-santalol analogs.
PubMed:
endo/exo stereoselectivity in Diels-Alder reactions of α,β-dialkylated conjugated enals to cyclic 1,3-dienes: intermediates in the synthesis of (-)-β-santalol and its analogs.
PubMed:
Suppression of lipopolysaccharide-stimulated cytokine/chemokine production in skin cells by sandalwood oils and purified α-santalol and β-santalol.
PubMed:
A rare type of sesquiterpene and β-santalol derivatives from Santalum album and their cytotoxic activities.
PubMed:
The transcriptome of sesquiterpenoid biosynthesis in heartwood xylem of Western Australian sandalwood (Santalum spicatum).
PubMed:
In vitro anti-viral effect of β-santalol against influenza viral replication.
PubMed:
The synthesis of (Z)-trisubstituted allylic alcohols by the selective 1,4-hydrogenation of dienol esters: improved synthesis of (-)-β-santalol.
PubMed:
Acaricidal and oviposition deterring effects of santalol identified in sandalwood oil against two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae).
PubMed:
Chemopreventive effects of alpha-santalol on ultraviolet B radiation-induced skin tumor development in SKH-1 hairless mice.
PubMed:
Anticancer Effects of Sandalwood (Santalum album).
PubMed:
Structure-activity relationships of sandalwood odorants: total synthesis and fragrance properties of cyclopropano-beta-santalol.
PubMed:
Syntheses and odor of "bulky group"-modified sandalwood odorants: isophorono-beta-santalol analogues.
PubMed:
Structure-activity relationships of sandalwood odorants: synthesis and odor of tricyclo beta-santalol.
PubMed:
Structure-activity relationships of sandalwood odorants: synthesis and odour of methyl-beta-santalol.
PubMed:
Synthesis and olfactoric activity of side-chain modified beta-santalol analogues.
PubMed:
Repellent effect of santalol from sandalwood oil against Tetranychus urticae (Acari: Tetranychidae).
PubMed:
Geographic and phenotypic variation in heartwood and essential-oil characters in natural populations of Santalum austrocaledonicum in Vanuatu.
PubMed:
α- and β-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.
PubMed:
Enantioselective synthesis of (-)-beta-santalol by a copper-catalyzed enynol cyclization-fragmentation reaction.
PubMed:
Hawaiian sandalwood: oil composition of Santalum paniculatum and comparison with other sandal species.
PubMed:
Effect of α-santalol and β-santalol from sandalwood on the central nervous system in mice.
PubMed:
Biosynthesis of Sandalwood Oil: Santalum album CYP76F cytochromes P450 produce santalols and bergamotol.
PubMed:
Preparative separation of α- and β-santalenes and (Z)-α- and (Z)-β-santalols using silver nitrate-impregnated silica gel medium pressure liquid chromatography and analysis of sandalwood oil.
PubMed:
Chemical composition of volatile oils from the pericarps of Indian sandalwood (Santalum album) by different extraction methods.
PubMed:
Chemical composition of the essential oils of Clausena lansium from Hainan Island, China.
PubMed:
Structure-activity relationships of sandalwood odorants: synthesis of a new campholene derivative.
PubMed:
Synthesis of new exo- and endo-3,8-dihydro-beta-santalols and other norbornyl-derived alcohols.
PubMed:
Anti-Helicobacter pylori compounds from Santalum album.
PubMed:
Comprehensive two-dimensional gas chromatography with flame ionization and time-of-flight mass spectrometry detection: qualitative and quantitative analysis of West Australian sandalwood oil.
PubMed:
Comparative molecular and phytochemical study of the tree species Santalum austrocaledonicum (Santalaceae) distributed in the New-Caledonian archipelago.
PubMed:
Composition, antimicrobial activity and cytotoxicity of essential oils from Aristolochia mollissima.
PubMed:
Evaluation of the quality of sandalwood essential oils by gas chromatography-mass spectrometry.
PubMed:
Analysis of fragrance compounds in blood samples of mice by gas chromatography, mass spectrometry, GC/FTIR and GC/AES after inhalation of sandalwood oil.