carmustine
BCNU
Identification
| Name | carmustine |
| IUPAC | 1,3-bis(2-chloroethyl)-1-nitrosourea |
| CAS Number | 154-93-8 |
| EINECS | 205-838-2 |
| FDA UNII | U68WG3173Y |
| Molecular Formula | C5 H9 Cl2 N3 O2 |
| Molecular Weight | 214.05013000 |
| MDL Number | MFCD00057706 |
| Nikkaji Number | J2.968H |
| Beilstein | 2049744 |
| XlogP3 | 1.50 (est) |
Regulatory
Physical Properties
| Appearance | orange-yellow solid (est) |
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 4000 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-child LDLo 78 mg/kg/52W-I |
| Dermal Toxicity | subcutaneous-mouse LD50 24 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for carmustine usage levels up to | not for fragrance use. |
| Recommendation for carmustine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
BCNU
carmubris
bis
chloroethyl nitrosourea
1,3-bis(2-
chloroethyl)-1-nitrosourea
N,N'-bis(2-
chloroethyl)-N-nitrosourea
bis-N,N'-(
chloroethyl)nitrosourea
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Modeling mass transfer from carmustine-loaded polymeric implants for malignant gliomas.
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Impact of United States Food and Drug Administration's boxed warnings on adverse drug reactions reporting rates and risk mitigation for multiple myeloma drugs.
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Growth pattern of tumor recurrence following bis-chloroethylnitrosourea (BCNU) wafer implantation in malignant glioma.
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Establishing the standard of care for patients with newly diagnosed and recurrent glioblastoma.
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The chemopreventive effect of dimethylthiourea against carmustine-induced myelotoxicity in rats.
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Controversies in the adjuvant therapy of high-grade gliomas.
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Space-occupying cyst development in the resection cavity of malignant gliomas following Gliadel® implantation--incidence, therapeutic strategies, and outcome.
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Protective effect of N-acetylcysteine against carmustine-induced myelotoxicity in rats.
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Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth.
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Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells.
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Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas.
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Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents.
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Recurrent malignant glioma in adults.
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Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview.
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Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention.
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In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin.
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Comparative study on the influence of two 2-chloroethylnitrosoureas with different carbamoylating potential towards glutathione and glutathione-related enzymes in different organs of the rat.
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Influence of glutathione on the mutagenicity of 2-chloroethylnitrosoureas. Mutagenic potential of glutathione derivatives formed from 2-chloroethylnitrosoureas and glutathione.
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A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas.
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Carcinogenic N-nitroso compounds and their environmental significance.
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Solid tumor chemotherapy: new drugs and horizons.