carmustine

BCNU

CAS: 154-93-8 C5 H9 Cl2 N3 O2 MW: 214.05013000

Identification

Namecarmustine
IUPAC1,3-bis(2-chloroethyl)-1-nitrosourea
CAS Number154-93-8
EINECS205-838-2
FDA UNIIU68WG3173Y
Molecular FormulaC5 H9 Cl2 N3 O2
Molecular Weight214.05013000
MDL NumberMFCD00057706
Nikkaji NumberJ2.968H
Beilstein2049744
XlogP31.50 (est)

Regulatory

Physical Properties

Appearance orange-yellow solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 4000 mg/L @ 25 °C (exp)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-child LDLo 78 mg/kg/52W-I
Dermal Toxicitysubcutaneous-mouse LD50 24 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for carmustine usage levels up tonot for fragrance use.
Recommendation for carmustine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

clam PMC

Synonyms

BCNU carmubris bis chloroethyl nitrosourea 1,3-bis(2- chloroethyl)-1-nitrosourea N,N'-bis(2- chloroethyl)-N-nitrosourea bis-N,N'-( chloroethyl)nitrosourea PubMed: Developing Therapies for Brain Tumors: The Impact of the Johns Hopkins Hunterian Neurosurgical Research Laboratory. PubMed: Gliadel wafer implantation combined with standard radiotherapy and concurrent followed by adjuvant temozolomide for treatment of newly diagnosed high-grade glioma: a systematic literature review. PubMed: Mechlorethamine gel for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma. PubMed: Modeling mass transfer from carmustine-loaded polymeric implants for malignant gliomas. PubMed: Impact of United States Food and Drug Administration's boxed warnings on adverse drug reactions reporting rates and risk mitigation for multiple myeloma drugs. PubMed: Growth pattern of tumor recurrence following bis-chloroethylnitrosourea (BCNU) wafer implantation in malignant glioma. PubMed: Establishing the standard of care for patients with newly diagnosed and recurrent glioblastoma. PubMed: The chemopreventive effect of dimethylthiourea against carmustine-induced myelotoxicity in rats. PubMed: Controversies in the adjuvant therapy of high-grade gliomas. PubMed: Space-occupying cyst development in the resection cavity of malignant gliomas following Gliadel® implantation--incidence, therapeutic strategies, and outcome. PubMed: Protective effect of N-acetylcysteine against carmustine-induced myelotoxicity in rats. PubMed: Extended O6-methylguanine methyltransferase promoter hypermethylation following n-butylidenephthalide combined with 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) on inhibition of human hepatocellular carcinoma cell growth. PubMed: Protective mechanism of quercetin and rutin using glutathione metabolism on HO-induced oxidative stress in HepG2 cells. PubMed: Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. PubMed: Myeloid clonogenic assays for comparison of the in vitro toxicity of alkylating agents. PubMed: Recurrent malignant glioma in adults. PubMed: Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. PubMed: Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. PubMed: In vivo enhanced antitumor activity of carmustine [N,N'-bis(2-chloroethyl)-N-nitrosourea] by simvastatin. PubMed: Comparative study on the influence of two 2-chloroethylnitrosoureas with different carbamoylating potential towards glutathione and glutathione-related enzymes in different organs of the rat. PubMed: Influence of glutathione on the mutagenicity of 2-chloroethylnitrosoureas. Mutagenic potential of glutathione derivatives formed from 2-chloroethylnitrosoureas and glutathione. PubMed: A method to determine the carbamoylating potential of 1-(2-chloroethyl)-1-nitrosoureas. PubMed: Carcinogenic N-nitroso compounds and their environmental significance. PubMed: Solid tumor chemotherapy: new drugs and horizons.