cycasin

beta-D- glucopyranoside, (methyl-ONN-azoxy)methyl- beta-D- glucosyloxyazoxymethane methyl-ONN-azoxy)-methyl-beta-D-glucopyranoside (Z)- methyl-oxido-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethylimino]azanium methylazoxymethanolbeta-D-glucoside PubMed: Toxic phytochemicals and their potential risks for human cancer. PubMed: Relative seed and fruit toxicity of the Australian cycads Macrozamia miquelii and Cycas ophiolitica: further evidence for a megafaunal seed dispersal syndrome in cycads, and its possible antiquity. PubMed: Effect of methanolic extract of Vernonia amygdalina (common bitter leaf) on lipid peroxidation and antioxidant enzymes in rats exposed to cycasin. PubMed: Animal models of brain maldevelopment induced by cycad plant genotoxins. PubMed: Cycads and their association with certain neurodegenerative diseases. PubMed: Unraveling 50-Year-Old Clues Linking Neurodegeneration and Cancer to Cycad Toxins: Are microRNAs Common Mediators? PubMed: Does the cycad genotoxin MAM implicated in Guam ALS-PDC induce disease-relevant changes in mouse brain that includes olfaction? PubMed: Is neurodegenerative disease a long-latency response to early-life genotoxin exposure? PubMed: Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants. PubMed: The cycad genotoxin MAM modulates brain cellular pathways involved in neurodegenerative disease and cancer in a DNA damage-linked manner. PubMed: Two genera of Aulacoscelinae beetles reflexively bleed azoxyglycosides found in their host cycads. PubMed: A survey of phytotoxic microbial and plant metabolites as potential natural products for pest management. PubMed: [Studies on the chemical constituents of the roots of Anemone altaica]. PubMed: Return of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? PubMed: Molecular networks perturbed in a developmental animal model of brain injury. PubMed: Azoxyglycoside content and beta-glycosidase activities in leaves of various cycads. PubMed: Acute Cycas seed poisoning in Taiwan. PubMed: Western Pacific ALS/PDC and flying foxes: What's next? PubMed: Cycads: their evolution, toxins, herbivores and insect pollinators. PubMed: Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour. PubMed: Toxicology. Fruit bats linked to mystery disease. PubMed: Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam. PubMed: Effects of single injection of methylazoxymethanol at postnatal day one on cell proliferation in different brain regions of male rats. PubMed: SOS induction of selected naturally occurring substances in Escherichia coli (SOS chromotest). PubMed: Damage and repair of nerve cell DNA in toxic stress. PubMed: The Guam cycad toxin methylazoxymethanol damages neuronal DNA and modulates tau mRNA expression and excitotoxicity. PubMed: Cycad poisoning in cattle in Japan--studies on spontaneous and experimental cases. PubMed: Are age-related neurodegenerative diseases linked with various types of magnesium depletion? PubMed: Na+-dependent and phlorizin-inhibitable transport of glucose and cycasin in brain endothelial cells. PubMed: ApoE and CYP2D6 polymorphism with and without parkinsonism-dementia complex in the people of Chamorro, guam. PubMed: Neuroepidemiology of amyotrophic lateral sclerosis: clues to aetiology and pathogenesis. PubMed: Motor neuron disease on Guam: geographic and familial occurrence, 1956-85. PubMed: Potential role of environmental genotoxic agents in diabetes mellitus and neurodegenerative diseases. PubMed: Substrate specificity and transglucosylation catalyzed by cycad beta-glucosidase. PubMed: A partially purified beta-glucosidase from Bifidobacterium adolescentis converts cycasin to a mutagenic compound. PubMed: Cycad toxin-induced damage of rodent and human pancreatic beta-cells. PubMed: Genotoxic activity in vivo of the naturally occurring glucoside, cycasin, in the Drosophila wing spot test. PubMed: Early biochemical events in mice exposed to cycas and fed a Nigerian-like diet. PubMed: Transport of cycasin by the intestinal Na+/glucose cotransporter. PubMed: The magical and medicinal usage of Stangeria eriopus in South Africa. PubMed: Tumor incidence in a chemical carcinogenesis study of nonhuman primates. PubMed: Seeds of discovery: a new look at one environmental factor in Alzheimer's disease. PubMed: Guam ALS-PDC: possible causes. PubMed: Content of the neurotoxins cycasin (methylazoxymethanol beta-D-glucoside) and BMAA (beta-N-methylamino-L-alanine) in cycad flour prepared by Guam Chamorros. PubMed: Long-latency neurodegenerative disease in the western Pacific. PubMed: Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region. PubMed: Dietary protein and chronic toxicity of 1,2-dimethylhydrazine fed to mice. PubMed: Mutagenicity of methylazoxymethanol acetate in the presence of alcohol dehydrogenase, aldehyde dehydrogenase, and rat liver microsomes in Salmonella typhimurium His G46. PubMed: Intestinal microflora: metabolism of drugs and carcinogens. PubMed: Etiology of Alzheimer's disease: a western pacific view. PubMed: Acquired chemical defense in the lycaenid butterfly,Eumaeus atala. PubMed: Mutagenic activity of promutagens in plants: indirect evidence of their activation. PubMed: A poison tree. PubMed: Statistical analysis of a carcinogen mixture experiment. I. Liver carcinogens. PubMed: Hepatic and spinal lesions in goats chronically intoxicated with cycasin. PubMed: On the distribution of genotoxic factors in various organs of mice treated with cycasin. PubMed: Induction of tumors with cycasin in newborn and preweanling rats. PubMed: Animal model for colorectal cancer. PubMed: Diet and nutrition as risk factors for cancer. PubMed: [Experimental multiple primary malignant tumors induced by chemical carcinogen]. PubMed: Review: putative mutagens and carcinogens in foods. V. Cycad azoxyglycosides. PubMed: Potentiation of large intestinal tumorigenicity of cycasin derivative by high-fat diet and Lactobacillus in germfree mice. PubMed: Activation of cycasin to a mutagen for Saccharomyces cerevisiae by rat intestinal flora. PubMed: Bacterial mutagenicity of natural materials, pyrolysis products and additives in foodstuffs and their association with genotoxic effects in mammals. PubMed: Cycasin and its mutagenic metabolites. PubMed: Genetic damage caused by methylazoxymethanol acetate, the aglycone of cycasin. Analysis of sister-chromatid exchange frequency under in vivo conditions and in cell cultures. PubMed: Comparison of the carcinogenicity of methylazoxymethanol-beta-D-glucosiduronic acid in conventional and germfree Sprague-Dawley rats. PubMed: Determination of the carcinogen methylazoxymethyl-beta-D-glucosiduronic acid in rat bile and urine. PubMed: Natural carcinogenic products of plant origin. PubMed: [Occurrence of neoplasms in the large intestine and role of intestinal bacteria]. PubMed: Genotoxicity of cycasin in the hepatocyte primary culture/DNA repair test supplemented with beta-glucosidase. PubMed: Rapid hepatoma induction in rats by dipentylnitrosamine and its modification by other carcinogens. PubMed: Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats. PubMed: [Classification, histochemistry and ultrastructure of experimental renal tumors (author's transl)]. PubMed: Carcinogenicity and hepatotoxicity of cycasin and its aglycone methylazoxymethanol acetate in nonhuman primates. PubMed: Role of bacteria in human carcinogenesis. PubMed: Mutagenicity of the naturally occurring carcinogen cycasin and synthetic methylazoxymethanol conjugates in Salmonella typhimurium. PubMed: Synthesis of the glucuronic acid conjugate of methylazoxymethanol. PubMed: DNA fragmentation in some organs of rats and mice treated with cycasin. PubMed: Mutagenicity of alkaloids in the Salmonella/microsome system. PubMed: Contributions of gnotobiology to nutrition science. PubMed: Toxins and carcinogens in the environment: an observation in the tropics. PubMed: A practical procedure for testing DNA damage in vivo, proposed for a pre-screening of chemical carcinogens. PubMed: [Histology, fine structure and differentiation of experimental Wilms tumors (author's transl)]. PubMed: Naturally occurring compounds Containing a nitrogen-nitrogen bond. PubMed: Cancer and the environment. PubMed: Effect of coffee on carcinogenicity of cycasin. PubMed: PHA response and methylazoxymethanol acetate. PubMed: Pathogenesis of methylazoxymethanol-induced lesions in the postnatal mouse cerebellum. PubMed: Carcinogens occurring naturally in foods. PubMed: Leiomyomas and leiomyosarcomas of the kidney in 4-day-old BUF rats given methylazoxymethanol acetate intraperitoneally. PubMed: Naturally occuring mutagens. PubMed: Cycasin. PubMed: Experimental carcinogenesis in small aquarium fishes. PubMed: [Microorganisms as indicators of the mutagenic activity of chemical compounds and their metabolites]. PubMed: Intestinal tumors of rats by gastric or intestinal administration of cycad extract and cycasin. PubMed: Hepatic tumors of rabbits induced by cycad extract. PubMed: Dendritic growth in vitro. PubMed: [Ultrastructure of cycasin-induced adenomas of kidney (author's transl)]. PubMed: Renal carcinogenesis. PubMed: The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine. PubMed: Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice. PubMed: [Cycasin carcinogenesis. (5). Carcinogenic properties of cycasin, methylazoxymethanol and methylazoxymethyl benzoate]. PubMed: Acute hepatic lesions induced by cycasin. PubMed: Induction of a retinal disorder with cycasin in newborn mice and rats. PubMed: Relations between postnatal days of mice and carcinogenic effect of cycasin. PubMed: High yield of hepatic tumors in rats by cycasin. PubMed: Cycasin-induced central nervous system lesions in postnatal mice. PubMed: Fine structure of cycasin-induced cerebellar alterations. PubMed: Cycasin in cycad materials used in Japan. PubMed: Lipid composition of the cerebellum and spinal cord in postnatal cycasin-treated Swiss albino mice: preliminary observations. PubMed: Carcinogenicity and neurotoxicity of cycasin with sepcial reference to species differences. PubMed: -Glucosidase modulation in preweanling rats and its association with tumor induction by cycasin. PubMed: [Natural carcinogens: target organs and species specificity in induction of cancer by single administration of cycasin]. PubMed: [Natural carcinogens: aglycon-methylazoxymethanol in cycasin]. PubMed: [Natural carcinogens: isolation of cycasin]. PubMed: [Natural carcinogens: toxicity and carcinogenicity of cyasin: induction of tumors by cycasin in the seeds of Cycas revoluta]. PubMed: [Natural carcinogens: hepatic disorders in the rat caused by cycasin, with special reference to the induction of hepatic tumors]. PubMed: Decomposition of methylazoxymethanol, the aglycone of cycasin, in D 2 O. PubMed: An electron microscopic study of cycasin-induced cerebellar alterations. PubMed: Shift of target organs in cycasin carcinogenesis. PubMed: Dose related effects of cycasin induced renal and hepatic tumors. PubMed: Carcinogenic effects of cycasin in Syrian golden hamsters and the transplantability of induced tumors. PubMed: High incidence of pulmonary tumors in dd mice by a single injection of cycasin. PubMed: [Carcinogenesis by cycasin, with special reference to the target organs]. PubMed: Tumor induction in C57BL-6 mice by a single administration of cycasin. PubMed: Induction of a cerebellar disorder with cycasin in newborn mice and hamsters. PubMed: Cycling of cycasin from newborn rats to their mother and back to the newborn. PubMed: Cycasin: detection of associated mutagenic activity in vivo. PubMed: [Cycasin-induced renal tumors in the Wistar rat with special consideration of the adenoma]. PubMed: Toxicology of cycasin. PubMed: Toxicology of cycasin. PubMed: Effect of cycasin on protein synthesis. PubMed: Induction of mammary cancer in rats with cycasin: a preliminary report. PubMed: Tumor induction in Fischer and Osborne-Mendel rats by a single administration of cycasin. PubMed: Transplantability of cycasin-induced tumors in rats, with emphasis on nephroblastomas. PubMed: Evidence for transplacental passage of the natural carcinogen cycasin and its aglycone. PubMed: Induction of a neurological disorder by cycasin in mice. PubMed: Similarities between the biochemical actions of cycasin and dimethylnitrosamine. PubMed: Tumor induction in germfree rats with methylazoxymethanol (MAM) and synthetic MAM acetate. PubMed: Mutation in Drosophila by methylazoxymethanol, the aglycone of cycasin. PubMed: Cycasin synthesis in Seirarctia echo (Lepidoptera) larvae fed methylazoxymethanol. PubMed: Role of intestinal microorganisms in determining cycasin toxicity. PubMed: [Histological-histochemical studies on the "interstitial cycasin tumor" of rat kidneys]. PubMed: Mutagenicity of cycasin aglycone (methylazoxymethanol), a naturally occurring carcinogen. PubMed: Effect of boiling and storing on cycasin content of Cycas circinalis L. PubMed: Studies on methylazoxymethanol, the aglycone of cycasin: methylation of nucleic acids in vitro. PubMed: Cycasin excretion in conventional and germfree rats. PubMed: Naturally occurring toxicants in foods. PubMed: The induction of intestinal neoplasms in rats with the glycoside cycasin and its aglycone. PubMed: CYCASIN: RADIOMIMETIC EFFECT. PubMed: Cycasin content of Cycas circinalis. PubMed: STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN. ISOLATION, BIOLOGICAL, AND CHEMICAL PROPERTIES. PubMed: STUDIES ON METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN: A SYNTHESIS OF METHYLAZOXYMETHYL ACETATE. PubMed: RESPONSE OF LIVER NUCLEIC ACIDS AND LIPIDS IN RATS FED CYCAS CIRCINALIS L. ENDOSPERM OR CYCASIN. PubMed: EFFECT OF INGESTED CYCASIN ON RAT BLOOD PLASMA CHOLINESTERASE. PubMed: CARCINOGENIC EFFECTS OF CYCAD MEAL AND CYCASIN, METHYLAZOXYMETHANOL GLYCOSIDE, IN RATS AND EFFECTS OF CYCASIN IN GERMFREE RATS. PubMed: EFFECTS OF CYCAD MEAL AND CYCASIN ON HISTOCHEMICALLY DEMONSTRABLE LIVER PHOSPHATASES AND NON SPECIFIC ESTERASES. PubMed: RATES AND KINETICS OF CATALASE SYNTHESIS AND DESTRUCTION IN RATS FED CYCAD AND CYCASIN IN VIVO. PubMed: EFFECT OF CYCAD AND CYCASIN FEEDING ON LIVER RNA, DNA, SUCCINIC OXIDASE, AND LIPIDS IN THE RAT. PubMed: EFFECTS OF CYCASIN AND CYCAD MEAL. PubMed: METHYLAZOXYMETHANOL, THE AGLYCONE OF CYCASIN.