ribavirin

virazide

CAS: 36791-04-5 C8 H12 N4 O5 MW: 244.20764000

Identification

Nameribavirin
IUPAC1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide
CAS Number36791-04-5
FDA UNII49717AWG6K
Molecular FormulaC8 H12 N4 O5
Molecular Weight244.20764000
MDL NumberMFCD00058564
Nikkaji NumberJ17.798I
Beilstein0892462
XlogP3-1.80 (est)

Regulatory

Physical Properties

Appearance white powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 166.00 °C. @ 760.00 mm Hg (est)
Boiling Point 639.80 °C. @ 760.00 mm Hg (est)
Vapor Pressure 5.100000 mmHg @ 25.00 °C. (est)
Flash Point 645.00 °F. TCC ( 340.70 °C. ) (est)
logP (o/w) -2.260 (est)
Soluble in water, 4.74e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityunreported-dog LDLo 1500 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypharmaceuticals / chemical synthisis
Recommendation for ribavirin usage levels up tonot for fragrance use.
Recommendation for ribavirin flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1-[(4S,2R,3R,5R)-3,4- dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3- carboxamide 1-[(2R,3R,4S,5R)-3,4- dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide 1-((2R,3R,4S,5R)-3,4- dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxamide 1-[(2R,3R,4S,5R)-3,4- dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-1,2,4-triazol-3-carboxamid 1-[(2R,3R,4S,5R)-3,4- dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-1,2,4-triazole-3-carboxamide 1-((2R,3R,4S,5R)-3,4- dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-[1,2,4]triazole-3-carboxylic acid amide 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-( hydroxymethyl)oxolan-2-yl]-1,2,4-triazole-3-carboxamide ribavirina ribavirine ribavirinum 1-b-D- ribofuranosyl-1H-1,2,4-triazole-3-carboxamide 1-(b-D- ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide 1H-1,2,4- triazole-3-carboxamide, 1-b-D-ribofuranosyl- 1H-1,2,4- triazole-3-carboxamide, 1-β-D-ribofuranosyl- virazide PubMed: Hepatitis C virus: Virology, diagnosis and treatment. PubMed: Ribavirin Reduces Absolute Lymphocyte Counts in Hepatitis C Virus-Infected Patients Treated With Interferon-Free, Direct-Acting Antiviral Regimens. PubMed: Direct-acting antiviral drug approvals for treatment of chronic hepatitis C virus infection: Scientific and regulatory approaches to clinical trial designs. PubMed: Faldaprevir for the treatment of hepatitis C. PubMed: Preparation of monoPEGylated Cyanovirin-N's derivative and its anti-influenza A virus bioactivity in vitro and in vivo. PubMed: Ribavirin stimulates the immune response of Atlantic salmon. PubMed: Application of "hydrogen bonding interaction" in new drug development: design, synthesis, antiviral activity, and SARs of thiourea derivatives. PubMed: Development of live-attenuated arenavirus vaccines based on codon deoptimization. PubMed: FDA perspective on sofosbuvir therapy for patients with chronic hepatitis C virus genotype 1 infection who did not respond to treatment with pegylated interferon and ribavirin. 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PubMed: New genetic discoveries and treatment for hepatitis C. PubMed: Response-guided telaprevir therapy in prior relapsers? The role of bridging data from treatment-naïve and experienced subjects. PubMed: Advances in the treatment of hepatitis C virus infection. PubMed: Boceprevir: a novel NS3/4 protease inhibitor for the treatment of hepatitis C. PubMed: [Hepatitis E: molecular virology, epidemiology and pathogenesis]. PubMed: A pharmacological profile of ribavirin and monitoring of its plasma concentration in chronic hepatitis C infection. PubMed: The Role of IL28B Genotype Testing in the Era of Direct Acting Antiviral Agents. PubMed: The era of direct-acting antivirals has begun: the beginning of the end for HCV? PubMed: Telaprevir: an oral protease inhibitor for hepatitis C virus infection. PubMed: Quantitative trace analysis of a broad range of antiviral drugs in poultry muscle using column-switch liquid chromatography coupled to tandem mass spectrometry. 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PubMed: Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting System. PubMed: Chronic hepatitis C virus infection in children and adolescents: Epidemiology, natural history, and assessment of the safety and efficacy of combination therapy. PubMed: Taste disturbances during therapy with pegylated interferon-alpha 2b and ribavirin in patients with chronic hepatitis C. PubMed: [Effects of Tankejing dry powder inhaler on the inflammatory damage in the lungs of mice infected by FM1]. PubMed: [Anti-viral effects of Tankejing preparations against influenza virus A]. PubMed: Evidence-based antimicrobial therapy in pregnancy: long overdue. PubMed: Original research: Intravenous ribavirin--review of the FDA's Emergency Investigational New Drug Database (1997-2008) and literature review. PubMed: Effect of dietary purines on the pharmacokinetics of orally administered ribavirin. PubMed: Acrolein, a ubiquitous pollutant and lipid hydroperoxide product, inhibits antiviral activity of interferon-alpha: relevance to hepatitis C. PubMed: Treatment for chronic hepatitis C in children: a review. PubMed: Severe hepatocellular injury with apoptosis induced by a hepatitis C polymerase inhibitor. PubMed: Neuraminidase activity provides a practical read-out for a high throughput influenza antiviral screening assay. PubMed: Hepatitis C: current and future therapies. PubMed: The impact of combination therapy with peginterferon alpha-2a and ribavirin on the energy intake and body weight of adult hepatitis C patients. PubMed: Overcoming hurdles in hepatitis C virus research: efficient production of infectious virus in cell culture. PubMed: Oral lesions in HIV and HCV co-infected individuals in HAART era. PubMed: Stability-indicating thin-layer chromatographic method for quantitative determination of ribavirin. PubMed: Design of the PEDS-C trial: pegylated interferon +/- ribavirin for children with chronic hepatitis C viral infection. PubMed: Gastrointestinal medications in pregnancy. PubMed: Strategies for managing anemia in hepatitis C patients undergoing antiviral therapy. PubMed: Bronchiolitis. PubMed: Hepatitis C (chronic). PubMed: Development of a tomato-based food for special medical purposes as therapy adjuvant for patients with HCV infection. PubMed: Pharmacokinetics of ribavirin in patients with hepatitis C virus. PubMed: Bupleurum kaoi inhibits Coxsackie B virus type 1 infection of CCFS-1 cells by induction of type I interferons expression. PubMed: [Inhibitory effect of new antimicrobial substance by Bacillus subtilis fmbJ on Newcastle disease virus and infectious Bursal disease virus in vitro]. PubMed: FDA approves Pegasys and Copegus for hepatitis C in patients with HIV co-infection. PubMed: Cost-efficacy analysis of peginterferon alfa-2b plus ribavirin compared with peginterferon alfa-2a plus ribavirin for the treatment of chronic hepatitis C. PubMed: Clinical experience with nonstandard doses ofinterferon alfa-2b and ribavirin in the treatment of chronic hepatitis C infection: A retrospective analysis. PubMed: Hepatitis drug gets approval for coinfection treatment. PubMed: The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin. PubMed: Oxidative stress in chronic hepatitis C: a preliminary study on the protective effects of antioxidant flavonoids. PubMed: Maintenance therapy for chronic hepatitis C. PubMed: Crimean-Congo hemorrhagic fever. PubMed: Evolution of the HALT-C Trial: pegylated interferon as maintenance therapy for chronic hepatitis C in previous interferon nonresponders. PubMed: Oxidative status in chronic hepatitis C: the influence of antiviral therapy and prognostic value of serum hydroperoxide assay. PubMed: Treatment Options for Hepatitis C Infection in Children. PubMed: Peginterferon alfa-2a: a review of approved and investigational uses. PubMed: FDA approves Hep C drugs. PubMed: Tomato-based functional food as interferon adjuvant in HCV eradication therapy. PubMed: Anti-HCV activities of selective polyunsaturated fatty acids. PubMed: Nucleoside analogues and mitochondrial toxicity. PubMed: Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers. PubMed: Hantavirus infection in children. PubMed: Pediatric drug labeling: improving the safety and efficacy of pediatric therapies. PubMed: Pediatric issues in new therapies for hepatitis B and C. PubMed: Hepatitis C: FDA public meeting on peginterferon plus ribavirin, Nov. 14. PubMed: Hepatitis C virus infection. PubMed: Ribavirin and chronic hepatitis C infection. PubMed: Ribavirin for hepatitis C: 80% price reduction available July 9? PubMed: Ribavirin approved with a big fat price. PubMed: Hepatitis C: new treatment overview. PubMed: Treating hepatitis C: a clinician's perspective. Interview by Bob Roehr. PubMed: Can science meet the challenges of the HCV pandemic: new treatment options for chronic hepatitis C. PubMed: Ribavirin approved for hepatitis C combination treatment. PubMed: FDA approves new combination treatment for hepatitis C. Food and Drug Administration. PubMed: Hepatitis C and HIV: ribavirin plus interferon study recruiting. PubMed: Hepatitis C important treatment advance: interview with Douglas Dieterich, M.D. Interview by John S. James. PubMed: Pediatric drug trials: women and children last? PubMed: The clinical pharmacology of ribavirin. PubMed: Underused options for preventing and treating influenza. PubMed: Hepatitis C not incurable. PubMed: From the Food and Drug Administration. PubMed: Evaluation of a rapid diagnostic test for respiratory syncytial virus (RSV): potential for bedside diagnosis. PubMed: Molecular mechanisms of action of ribavirin. PubMed: AIDS drug gets green light. PubMed: Ribavirin aerosol approved for severe cases of RSV in infants and young children.