areca caticula extract

areca faufel extract

CAS: 94349-64-1

Identification

Nameareca caticula extract
IUPACareca caticula extract
CAS Number94349-64-1
FDA UNIISearch

Regulatory

Physical Properties

Food Chemicals Codex Listed No

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for areca caticula extract usage levels up tonot for fragrance use.
Recommendation for areca caticula extract flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

areca caticula

Synonyms

areca faufel extract areca himalayana extract areca hortensis extract areca nigra extract sublimia areca extract PubMed: Panax notoginseng saponins inhibit areca nut extract-induced oral submucous fibrosis in vitro. PubMed: Inhibitory effects of areca nut extract on expression of complement receptors and fc receptors in human neutrophils. PubMed: Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leukocytes. PubMed: STRESS-responsive deacetylase SIRT3 is up-regulated by areca nut extract-induced oxidative stress in human oral keratinocytes. PubMed: Impairment of thymocyte function via induction of apoptosis by areca nut extract. PubMed: Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China. PubMed: Toxicity of areca nut ingredients: activation of CHK1/CHK2, induction of cell cycle arrest, and regulation of MMP-9 and TIMPs production in SAS epithelial cells. PubMed: Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress. PubMed: Anti-migraine effect of Areca Catechu L. nut extract in bradykinin-induced plasma protein extravasation and vocalization in rats. PubMed: Protective Effect of Areca catechu Leaf Ethanol Extract Against Ethanol-Induced Gastric Ulcers in ICR Mice. PubMed: Areca nut extract induces pyknotic necrosis in serum-starved oral cells via increasing reactive oxygen species and inhibiting GSK3β: an implication for cytopathic effects in betel quid chewers. PubMed: Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity. PubMed: Potential antidepressant activity of Areca catechu nut via elevation of serotonin and noradrenaline in the hippocampus of rats. PubMed: Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells. PubMed: The anti-inflammatory effect of Indonesian Areca catechu leaf extract in vitro and in vivo. PubMed: Induction of chromosome instability and stomach cancer by altering the expression pattern of mitotic checkpoint genes in mice exposed to areca-nut. PubMed: Direct-acting DNA alkylating agents present in aqueous extracts of areca nut and its products. PubMed: Separation of polyphenols and arecoline from areca nut (Areca catechu L.) by solvent extraction, its antioxidant activity, and identification of polyphenols. PubMed: Inhibition of Tanshinone IIA, salvianolic acid A and salvianolic acid B on Areca nut extract-induced oral submucous fibrosis in vitro. PubMed: The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model. PubMed: Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. PubMed: Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut. PubMed: Effects of Areca Nut Extracts on Phagocytosis of Actinobacillus actinomycete mcomitans ATCC 33384 by Neutrophils in Patients with Chronic Periondontitis. PubMed: Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis. PubMed: Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract. PubMed: Areca nut procyanidins ameliorate streptozocin-induced hyperglycemia by regulating gluconeogenesis. PubMed: Association between areca-stimulated vimentin expression and the progression of head and neck cancers. PubMed: Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice. PubMed: Antibacterial, mechanical, and barrier properties of sago starch film incorporated with Betel leaves extract. PubMed: Precocious anaphase and expression of Securin and p53 genes as candidate biomarkers for the early detection in areca nut-induced carcinogenesis. PubMed: Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma. PubMed: Potential analgesic, anti-inflammatory and antioxidant activities of hydroalcoholic extract of Areca catechu L. nut. PubMed: Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components. PubMed: [Chemical constituents from the fruits of Areca catechu]. PubMed: The inhibiting activity of areca inflorescence extracts on human low density lipoprotein oxidation induced by cupric ion. PubMed: Effects of areca nut extract on the apoptosis pathways in human neutrophils. PubMed: Peroxidase as the major protein constituent in areca nut and identification of its natural substrates. PubMed: Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells. PubMed: Impacts of autophagy-inducing ingredient of areca nut on tumor cells. PubMed: Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition. PubMed: Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling. PubMed: Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling. PubMed: Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes. PubMed: Autophagy induction by the 30-100kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species. PubMed: Stimulatory effects of areca nut extracts on prostaglandin E2 production by human polymorphonuclear leukocytes. PubMed: Involvement of the mitochondrion-dependent pathway and oxidative stress in the apoptosis of murine splenocytes induced by areca nut extract. PubMed: Areca nut extract represses migration and differentiation while activating matrix metalloproteinase-9 of normal gingival epithelial cells. PubMed: Absorption of intestinal free cholesterol is lowered by supplementation of Areca catechu L. extract in rats. PubMed: Highly oligomeric procyanidins from areca nut induce lymphocyte apoptosis via the depletion of intracellular thiols. PubMed: Effects of Areca catechu L. containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo. PubMed: Supplementation of Areca catechu L. extract alters triglyceride absorption and cholesterol metabolism in rats. PubMed: Studies on anti-inflammatory and analgesic activities of betel nut in rodents. PubMed: Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract. PubMed: Areca nut extract lowers the permeability of vaginal mucosa to reduced arecoline and arecaidine. PubMed: A preliminary study of arecoline and guvacoline presence in the saliva of a "betel-quid" chewer using liquid-chromatography ion trap mass spectrometry. PubMed: Editorial. Oral submucous fibrosis: revised hypotheses as to its cause. PubMed: Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential. PubMed: In vitro genotoxic effects of areca nut extract and arecoline. PubMed: Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte. PubMed: Areca nut extract-treated gingival fibroblasts modulate the invasiveness of polymorphonuclear leukocytes via the production of MMP-2. PubMed: Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. PubMed: The effect of baked areca nut extract on the growth of buccal mucosa fibroblasts from healthy non-areca nut chewers. PubMed: [Research on inhibition of areca nut extract on human buccal keratinocytes]. PubMed: Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes. PubMed: Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract. PubMed: Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts. PubMed: Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. PubMed: Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes. PubMed: Fibrotic Effects of Arecoline N-Oxide in Oral Potentially Malignant Disorders. PubMed: Clinico-immunochemical studies on airborne Areca catechu L. Pollen, a probable risk factor in emergency asthma hospitalization from Eastern India. PubMed: Oxidative damage to DNA induced by areca nut extract. PubMed: Areca nut extract treatment down-regulates involucrin in normal human oral keratinocyte through P13K/AKT activation. PubMed: Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract. PubMed: Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline. PubMed: Prevention of the areca nut extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol compounds. PubMed: Mini review on chemotherapy of taeniasis and cysticercosis due to Taenia solium in Asia, and a case report with 20 tapeworms in China. PubMed: [Study on the cytotoxic and DNA damaging effects in oral mucosal fibroblasts by areca nut extract]. PubMed: Antiovulatory and abortifacient effects of Areca catechu (betel nut) in female rats. PubMed: In vitro cytotoxicity study of agave americana, strychnos nuxvomica and areca catechu extracts using mcf-7 cell line. PubMed: Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro. PubMed: Areca nut extract treatment elicits the fibroblastoid morphological changes, actin re-organization and signaling activation in oral keratinocytes. PubMed: Altered BRCA1 and BRCA2 responses and mutation of BRCA1 gene in mice exposed chronically and transgenerationally to aqueous extract of betel nut (AEBN). PubMed: Induction of the c-jun protooncogene expression by areca nut extract and arecoline on oral mucosal fibroblasts. PubMed: Areca nut extract suppresses T-cell activation and interferon-gamma production via the induction of oxidative stress. PubMed: Arecoline and the 30-100 kDa fraction of areca nut extract differentially regulate mTOR and respectively induce apoptosis and autophagy: a pilot study. PubMed: Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer. PubMed: Possible mechanism of betel-quid-extract-induced expression of matrix metalloproteinase-2. PubMed: Areca nut: a review. PubMed: Effect of betel/areca nut (Areca catechu) extracts on intestinal epithelial cell lining. PubMed: Areca-treated fibroblasts enhance tumorigenesis of oral epithelial cells. PubMed: Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells. PubMed: Areca nut-induced micronuclei and cytokinesis failure in Chinese hamster ovary cells is related to reactive oxygen species production and actin filament deregulation. PubMed: Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives. PubMed: Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis. PubMed: Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes. PubMed: Contractile effect of radish and betel nut extracts on rabbit gallbladder. PubMed: Monoamine oxidase A variants are associated with heavy betel quid use. PubMed: Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). PubMed: Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression. PubMed: Therapeutic interventions in oral submucous fibrosis: an experimental and clinical study. PubMed: Areca-nut toxicity in cultured human buccal epithelial cells. PubMed: Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut-induced carcinogenesis. PubMed: Treatment of experimental heterophyiasis with two plant extracts, areca nut and pumpkin seed. PubMed: Chemical and analytical aspects of areca nut. PubMed: Ingredients contribute to variation in production of reactive oxygen species by areca quid. PubMed: Observations on the effect of areca nut extracts on oral fibroblast proliferation. PubMed: Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase. PubMed: Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut. PubMed: Autophagy induction by a natural ingredient of areca nut. PubMed: The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation. PubMed: Molluscicidal activity of Carica papaya and Areca catechu against the freshwater snail Lymnaea acuminata. PubMed: Dose-dependent genotoxic effect of pan masala and areca nut in the Salmonella typhimurium assay. PubMed: Increased expression of matrix metalloproteinase-2 in oral cells after short-term stimulation and long-term usage of areca quid. PubMed: Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan. PubMed: Is the blood donated by habitual nut quid chewers suitable for use in transfusion? PubMed: [Preparation and pharmacodynamics studies on anti-inflammatory effect of catechu gel]. PubMed: Purification of Cu/Zn superoxide dismutase from Piper betle leaf and its characterization in the oral cavity. PubMed: Anti-depressant activities of Areca catechu fruit extract. PubMed: Oral microflora in betel-chewing adults of the Karen tribe in Thailand. PubMed: Chemical composition and toxicity of Taiwanese betel quid extract. PubMed: The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis. PubMed: The effects of areca catechu L extract on anti-aging. PubMed: Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. PubMed: Inhibitory effect of betel quid on the volatility of methyl mercaptan. PubMed: Cardio-selective inhibitory effect of the betel nut extract: possible explanation. PubMed: Antimutagenic and anticarcinogenic effects of betel leaf extract against the tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK). PubMed: Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nut. PubMed: Study of the genotoxicity of the total aqueous extract of betel nut and its tannin. PubMed: Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility. PubMed: Striatal dopamine release regulation by the cholinergic properties of the smokeless tobacco, gutkha. PubMed: Aqueous extract of betel-nut of north-east India induces DNA-strand breaks and enhances rate of cell proliferation in vitro. Effects of betel-nut extract in vitro. PubMed: The mutagenicity of nitrite-treated aqueous extract of Piper betle L. PubMed: Establishment and characterization of a cell line (HCDB-1) derived from a hamster buccal pouch carcinoma induced by DMBA and Taiwanese betel quid extract. PubMed: Dual role of betel leaf extract on thyroid function in male mice. PubMed: Specific induction of the high-molecular-weight microtubule-associated protein 2 (hmw-MAP2) by betel quid extract in cultured oral keratinocytes: clinical implications in betel quid-associated oral squamous cell carcinoma (OSCC). PubMed: Antimutagenic effects of betel leaf extract against the mutagenicity of two tobacco-specific N-nitrosamines. PubMed: Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. PubMed: Chemopreventive efficacy of a betel leaf extract against benzo[a]pyrene-induced forestomach tumors in mice. PubMed: Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin. PubMed: Anticarcinogenic effect of betel leaf extract against tobacco carcinogens. PubMed: The effect of betel nut extract on cell growth and prostaglandin endoperoxide synthase in human epidermoid carcinoma cells. PubMed: Availability and characteristics of betel products in the U.S. PubMed: Carcinogenic effect of a dimethyl sulphoxide extract of betel nut on the mucosa of the hamster buccal pouch. PubMed: Screening for hemostatic activities of popular Chinese medicinal herbs in vitro. PubMed: Thai herbal formulas used for wound treatment: a study of their antibacterial potency, anti-inflammatory, antioxidant, and cytotoxicity effects. PubMed: Signaling pathways for induction of platelet aggregation by SAS tongue cancer cells--a mechanism of hematogenous metastasis. PubMed: Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients. PubMed: Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut. PubMed: Inhibitory effect of betel nut extracts on endogenous nitrosation in humans. PubMed: Consumption of guava (Psidium guajava L) and noni (Morinda citrifolia L) may protect betel quid-chewing Papua New Guineans against diabetes. PubMed: Promoting activity of betel quid ingredients and their inhibition by retinol. PubMed: Development of photochemoprotective herbs containing cosmetic formulations for improving skin properties. PubMed: Oral submucous fibrosis in a 12-year-old girl: case report. PubMed: Protection from pan masala induced genomic damage by beta-carotene and retinoic acid--an in vitro experience. PubMed: Formation of reactive oxygen species and of 8-hydroxy-2'-deoxyguanosine in DNA in vitro with betel-quid ingredients. PubMed: Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma. PubMed: Experimental studies on betel nut and tobacco carcinogenicity. PubMed: Influence of alpha-tocopherol and ascorbic acid on pan masala induced genomic damage. An in vitro experiment. PubMed: Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro. PubMed: O6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro. PubMed: Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis. PubMed: Inhibitory action of Piper betle on the initiation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rats. PubMed: Ethanol potentiates the clastogenicity of pan masala--an in vitro experience. PubMed: Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus. PubMed: Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis. PubMed: The influence of pH on the convertogenic activity of plant phenolics. PubMed: Nonmutagenicity of betel leaf and its antimutagenic action against environmental mutagens. PubMed: Evaluation of chemopreventive effects of betel leaf on the genotoxicity of pan masala. PubMed: Morphological transformation, sister chromatid exchange and mutagenesis assay of betel constituents. PubMed: Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine-induced hamster oral carcinogenesis. PubMed: An in vitro assessment of the genotoxic potential of pan masalas. PubMed: Effect of Piper betle L. and its extracts on the growth and aflatoxin production by Aspergillus parasiticus. PubMed: The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle Linn. PubMed: Modifying influences of betel quid ingredients on B(a)P-induced carcinogenesis in the buccal pouch of hamster. PubMed: Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products. PubMed: Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress. PubMed: Role of mouse spleen cell HMG proteins and their poly-ADP-ribosylation in betelnut induced carcinogenesis. PubMed: Acute toxicities of betel nut: rare but probably overlooked events. PubMed: Cancer-promoting effect of Taiwan betel quid in hamster buccal pouch carcinogenesis. PubMed: Mutual interactions among ingredients of betel quid in inducing genotoxicity on Chinese hamster ovary cells. PubMed: Pan masala--a genotoxic menace. PubMed: Embryotoxicity of betel nuts in mice. PubMed: Upregulation of matrix metalloproteinase-1 (MMP-1) expression in oral carcinomas of betel quid (BQ) users: roles of BQ ingredients in the acceleration of tumour cell motility through MMP-1. PubMed: Effect of glutathione on arecanut treated normal human buccal fibroblast culture. PubMed: The tumor promoting effect of lime-piper betel quid in JB6 cells. PubMed: Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. PubMed: Evaluation of the mutagenicity of 'pan masala', a chewing substitute widely used in India. PubMed: Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients. PubMed: Inhibition of DNA synthesis in cultured lymphocytes and tumor cells by extracts of betel nut, tobacco, and miang leaf, plant substances associated with cancer of the ororespiratory epithelium. PubMed: Chromosome-damaging effect of betel leaf. PubMed: Role of lime in the generation of reactive oxygen species from betel-quid ingredients. PubMed: Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. PubMed: Relationship between cellular levels of beta-carotene and sensitivity to genotoxic agents. PubMed: Allergenic relationship among four common and dominant airborne palm pollen grains from Eastern India. PubMed: Anthiovulatory activity of five indigenous plants in rabbits. PubMed: Effects of aqueous extracts of "Betel quid" and its constituents on testosterone production by dispersed mouse interstitial cells. PubMed: Hypoglycemic effects of Potentilla fulgens L in normal and alloxan-induced diabetic mice. PubMed: Inhibitory effect of bupleuri radix saponins on adhesion of some solid tumor cells and relation to hemolytic action: screening of 232 herbal drugs for anti-cell adhesion. PubMed: Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models. PubMed: Human vaginal mucosa as a model of buccal mucosa for in vitro permeability studies: an overview.