areca caticula extract
areca faufel extract
Identification
| Name | areca caticula extract |
| IUPAC | areca caticula extract |
| CAS Number | 94349-64-1 |
| FDA UNII | Search |
Regulatory
Physical Properties
| Food Chemicals Codex Listed | No |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for areca caticula extract usage levels up to | not for fragrance use. |
| Recommendation for areca caticula extract flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
areca faufel extract
areca himalayana extract
areca hortensis extract
areca nigra extract
sublimia areca extract
PubMed:
Panax notoginseng saponins inhibit areca nut extract-induced oral submucous fibrosis in vitro.
PubMed:
Inhibitory effects of areca nut extract on expression of complement receptors and fc receptors in human neutrophils.
PubMed:
Effects of areca nut extract on lipopolysaccharides-enhanced adhesion and migration of human mononuclear leukocytes.
PubMed:
STRESS-responsive deacetylase SIRT3 is up-regulated by areca nut extract-induced oxidative stress in human oral keratinocytes.
PubMed:
Impairment of thymocyte function via induction of apoptosis by areca nut extract.
PubMed:
Usefulness of pumpkin seeds combined with areca nut extract in community-based treatment of human taeniasis in northwest Sichuan Province, China.
PubMed:
Toxicity of areca nut ingredients: activation of CHK1/CHK2, induction of cell cycle arrest, and regulation of MMP-9 and TIMPs production in SAS epithelial cells.
PubMed:
Areca nut extracts increased the expression of cyclooxygenase-2, prostaglandin E2 and interleukin-1α in human immune cells via oxidative stress.
PubMed:
Anti-migraine effect of Areca Catechu L. nut extract in bradykinin-induced plasma protein extravasation and vocalization in rats.
PubMed:
Protective Effect of Areca catechu Leaf Ethanol Extract Against Ethanol-Induced Gastric Ulcers in ICR Mice.
PubMed:
Areca nut extract induces pyknotic necrosis in serum-starved oral cells via increasing reactive oxygen species and inhibiting GSK3β: an implication for cytopathic effects in betel quid chewers.
PubMed:
Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity.
PubMed:
Potential antidepressant activity of Areca catechu nut via elevation of serotonin and noradrenaline in the hippocampus of rats.
PubMed:
Areca nut contributes to oral malignancy through facilitating the conversion of cancer stem cells.
PubMed:
The anti-inflammatory effect of Indonesian Areca catechu leaf extract in vitro and in vivo.
PubMed:
Induction of chromosome instability and stomach cancer by altering the expression pattern of mitotic checkpoint genes in mice exposed to areca-nut.
PubMed:
Direct-acting DNA alkylating agents present in aqueous extracts of areca nut and its products.
PubMed:
Separation of polyphenols and arecoline from areca nut (Areca catechu L.) by solvent extraction, its antioxidant activity, and identification of polyphenols.
PubMed:
Inhibition of Tanshinone IIA, salvianolic acid A and salvianolic acid B on Areca nut extract-induced oral submucous fibrosis in vitro.
PubMed:
The Protective Effects of Areca catechu Extract on Cognition and Social Interaction Deficits in a Cuprizone-Induced Demyelination Model.
PubMed:
Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition.
PubMed:
Epithelial atrophy in oral submucous fibrosis is mediated by copper (II) and arecoline of areca nut.
PubMed:
Effects of Areca Nut Extracts on Phagocytosis of Actinobacillus actinomycete mcomitans ATCC 33384 by Neutrophils in Patients with Chronic Periondontitis.
PubMed:
Activation of TGF-β pathway by areca nut constituents: a possible cause of oral submucous fibrosis.
PubMed:
Downregulation of Ches1 and other novel genes in oral cancer cells chronically exposed to areca nut extract.
PubMed:
Areca nut procyanidins ameliorate streptozocin-induced hyperglycemia by regulating gluconeogenesis.
PubMed:
Association between areca-stimulated vimentin expression and the progression of head and neck cancers.
PubMed:
Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice.
PubMed:
Antibacterial, mechanical, and barrier properties of sago starch film incorporated with Betel leaves extract.
PubMed:
Precocious anaphase and expression of Securin and p53 genes as candidate biomarkers for the early detection in areca nut-induced carcinogenesis.
PubMed:
Areca nut extract upregulates vimentin by activating PI3K/AKT signaling in oral carcinoma.
PubMed:
Potential analgesic, anti-inflammatory and antioxidant activities of hydroalcoholic extract of Areca catechu L. nut.
PubMed:
Cytotoxicity and transformation of C3H10T1/2 cells induced by areca nut components.
PubMed:
[Chemical constituents from the fruits of Areca catechu].
PubMed:
The inhibiting activity of areca inflorescence extracts on human low density lipoprotein oxidation induced by cupric ion.
PubMed:
Effects of areca nut extract on the apoptosis pathways in human neutrophils.
PubMed:
Peroxidase as the major protein constituent in areca nut and identification of its natural substrates.
PubMed:
Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells.
PubMed:
Impacts of autophagy-inducing ingredient of areca nut on tumor cells.
PubMed:
Evaluation of anti-migraine potential of Areca catechu to prevent nitroglycerin-induced delayed inflammation in rat meninges: possible involvement of NOS inhibition.
PubMed:
Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling.
PubMed:
Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling.
PubMed:
Betel nut extract and arecoline block insulin signaling and lipid storage in 3T3-L1 adipocytes.
PubMed:
Autophagy induction by the 30-100kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species.
PubMed:
Stimulatory effects of areca nut extracts on prostaglandin E2 production by human polymorphonuclear leukocytes.
PubMed:
Involvement of the mitochondrion-dependent pathway and oxidative stress in the apoptosis of murine splenocytes induced by areca nut extract.
PubMed:
Areca nut extract represses migration and differentiation while activating matrix metalloproteinase-9 of normal gingival epithelial cells.
PubMed:
Absorption of intestinal free cholesterol is lowered by supplementation of Areca catechu L. extract in rats.
PubMed:
Highly oligomeric procyanidins from areca nut induce lymphocyte apoptosis via the depletion of intracellular thiols.
PubMed:
Effects of Areca catechu L. containing procyanidins on cyclooxygenase-2 expression in vitro and in vivo.
PubMed:
Supplementation of Areca catechu L. extract alters triglyceride absorption and cholesterol metabolism in rats.
PubMed:
Studies on anti-inflammatory and analgesic activities of betel nut in rodents.
PubMed:
Lower absorption of cholesteryl oleate in rats supplemented with Areca catechu L. extract.
PubMed:
Areca nut extract lowers the permeability of vaginal mucosa to reduced arecoline and arecaidine.
PubMed:
A preliminary study of arecoline and guvacoline presence in the saliva of a "betel-quid" chewer using liquid-chromatography ion trap mass spectrometry.
PubMed:
Editorial. Oral submucous fibrosis: revised hypotheses as to its cause.
PubMed:
Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential.
PubMed:
In vitro genotoxic effects of areca nut extract and arecoline.
PubMed:
Ripe areca nut extract induces G1 phase arrests and senescence-associated phenotypes in normal human oral keratinocyte.
PubMed:
Areca nut extract-treated gingival fibroblasts modulate the invasiveness of polymorphonuclear leukocytes via the production of MMP-2.
PubMed:
Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells.
PubMed:
The effect of baked areca nut extract on the growth of buccal mucosa fibroblasts from healthy non-areca nut chewers.
PubMed:
[Research on inhibition of areca nut extract on human buccal keratinocytes].
PubMed:
Areca (betel) nut extract activates mitogen-activated protein kinases and NF-kappaB in oral keratinocytes.
PubMed:
Establishment of OC3 oral carcinoma cell line and identification of NF-kappa B activation responses to areca nut extract.
PubMed:
Areca nut extract inhibits the growth, attachment, and matrix protein synthesis of cultured human gingival fibroblasts.
PubMed:
Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes.
PubMed:
Areca nut extract up-regulates prostaglandin production, cyclooxygenase-2 mRNA and protein expression of human oral keratinocytes.
PubMed:
Fibrotic Effects of Arecoline N-Oxide in Oral Potentially Malignant Disorders.
PubMed:
Clinico-immunochemical studies on airborne Areca catechu L. Pollen, a probable risk factor in emergency asthma hospitalization from Eastern India.
PubMed:
Oxidative damage to DNA induced by areca nut extract.
PubMed:
Areca nut extract treatment down-regulates involucrin in normal human oral keratinocyte through P13K/AKT activation.
PubMed:
Modulation of KGF-1 gene expression in oral fibroblasts by ripe areca nut extract.
PubMed:
Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E2, interleukin-6 and TNF-alpha production of oral epithelial cells by areca nut extract and arecoline.
PubMed:
Prevention of the areca nut extract-induced unscheduled DNA synthesis of gingival keratinocytes by vitamin C and thiol compounds.
PubMed:
Mini review on chemotherapy of taeniasis and cysticercosis due to Taenia solium in Asia, and a case report with 20 tapeworms in China.
PubMed:
[Study on the cytotoxic and DNA damaging effects in oral mucosal fibroblasts by areca nut extract].
PubMed:
Antiovulatory and abortifacient effects of Areca catechu (betel nut) in female rats.
PubMed:
In vitro cytotoxicity study of agave americana, strychnos nuxvomica and areca catechu extracts using mcf-7 cell line.
PubMed:
Effect of lime composition on the formation of reactive oxygen species from areca nut extract in vitro.
PubMed:
Areca nut extract treatment elicits the fibroblastoid morphological changes, actin re-organization and signaling activation in oral keratinocytes.
PubMed:
Altered BRCA1 and BRCA2 responses and mutation of BRCA1 gene in mice exposed chronically and transgenerationally to aqueous extract of betel nut (AEBN).
PubMed:
Induction of the c-jun protooncogene expression by areca nut extract and arecoline on oral mucosal fibroblasts.
PubMed:
Areca nut extract suppresses T-cell activation and interferon-gamma production via the induction of oxidative stress.
PubMed:
Arecoline and the 30-100 kDa fraction of areca nut extract differentially regulate mTOR and respectively induce apoptosis and autophagy: a pilot study.
PubMed:
Up-regulation of inflammatory signalings by areca nut extract and role of cyclooxygenase-2 -1195G>a polymorphism reveal risk of oral cancer.
PubMed:
Possible mechanism of betel-quid-extract-induced expression of matrix metalloproteinase-2.
PubMed:
Areca nut: a review.
PubMed:
Effect of betel/areca nut (Areca catechu) extracts on intestinal epithelial cell lining.
PubMed:
Areca-treated fibroblasts enhance tumorigenesis of oral epithelial cells.
PubMed:
Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells.
PubMed:
Areca nut-induced micronuclei and cytokinesis failure in Chinese hamster ovary cells is related to reactive oxygen species production and actin filament deregulation.
PubMed:
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives.
PubMed:
Association of expression aberrances and genetic polymorphisms of lysyl oxidase with areca-associated oral tumorigenesis.
PubMed:
Effects of areca nut, inflorescence piper betle extracts and arecoline on cytotoxicity, total and unscheduled DNA synthesis in cultured gingival keratinocytes.
PubMed:
Contractile effect of radish and betel nut extracts on rabbit gallbladder.
PubMed:
Monoamine oxidase A variants are associated with heavy betel quid use.
PubMed:
Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu).
PubMed:
Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression.
PubMed:
Therapeutic interventions in oral submucous fibrosis: an experimental and clinical study.
PubMed:
Areca-nut toxicity in cultured human buccal epithelial cells.
PubMed:
Ultrastructural alterations in liver of mice exposed chronically and transgenerationally to aqueous extract of betel nut: Implications in betel nut-induced carcinogenesis.
PubMed:
Treatment of experimental heterophyiasis with two plant extracts, areca nut and pumpkin seed.
PubMed:
Chemical and analytical aspects of areca nut.
PubMed:
Ingredients contribute to variation in production of reactive oxygen species by areca quid.
PubMed:
Observations on the effect of areca nut extracts on oral fibroblast proliferation.
PubMed:
Modulation of platelet aggregation by areca nut and betel leaf ingredients: roles of reactive oxygen species and cyclooxygenase.
PubMed:
Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut.
PubMed:
Autophagy induction by a natural ingredient of areca nut.
PubMed:
The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation.
PubMed:
Molluscicidal activity of Carica papaya and Areca catechu against the freshwater snail Lymnaea acuminata.
PubMed:
Dose-dependent genotoxic effect of pan masala and areca nut in the Salmonella typhimurium assay.
PubMed:
Increased expression of matrix metalloproteinase-2 in oral cells after short-term stimulation and long-term usage of areca quid.
PubMed:
Prognostic role of c-Jun activation in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan.
PubMed:
Is the blood donated by habitual nut quid chewers suitable for use in transfusion?
PubMed:
[Preparation and pharmacodynamics studies on anti-inflammatory effect of catechu gel].
PubMed:
Purification of Cu/Zn superoxide dismutase from Piper betle leaf and its characterization in the oral cavity.
PubMed:
Anti-depressant activities of Areca catechu fruit extract.
PubMed:
Oral microflora in betel-chewing adults of the Karen tribe in Thailand.
PubMed:
Chemical composition and toxicity of Taiwanese betel quid extract.
PubMed:
The effects of areca catechu L extract on anti-inflammation and anti-melanogenesis.
PubMed:
The effects of areca catechu L extract on anti-aging.
PubMed:
Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells.
PubMed:
Inhibitory effect of betel quid on the volatility of methyl mercaptan.
PubMed:
Cardio-selective inhibitory effect of the betel nut extract: possible explanation.
PubMed:
Antimutagenic and anticarcinogenic effects of betel leaf extract against the tobacco-specific nitrosamine 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (NNK).
PubMed:
Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nut.
PubMed:
Study of the genotoxicity of the total aqueous extract of betel nut and its tannin.
PubMed:
Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility.
PubMed:
Striatal dopamine release regulation by the cholinergic properties of the smokeless tobacco, gutkha.
PubMed:
Aqueous extract of betel-nut of north-east India induces DNA-strand breaks and enhances rate of cell proliferation in vitro. Effects of betel-nut extract in vitro.
PubMed:
The mutagenicity of nitrite-treated aqueous extract of Piper betle L.
PubMed:
Establishment and characterization of a cell line (HCDB-1) derived from a hamster buccal pouch carcinoma induced by DMBA and Taiwanese betel quid extract.
PubMed:
Dual role of betel leaf extract on thyroid function in male mice.
PubMed:
Specific induction of the high-molecular-weight microtubule-associated protein 2 (hmw-MAP2) by betel quid extract in cultured oral keratinocytes: clinical implications in betel quid-associated oral squamous cell carcinoma (OSCC).
PubMed:
Antimutagenic effects of betel leaf extract against the mutagenicity of two tobacco-specific N-nitrosamines.
PubMed:
Genotoxic effect of raw betel-nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells.
PubMed:
Chemopreventive efficacy of a betel leaf extract against benzo[a]pyrene-induced forestomach tumors in mice.
PubMed:
Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin.
PubMed:
Anticarcinogenic effect of betel leaf extract against tobacco carcinogens.
PubMed:
The effect of betel nut extract on cell growth and prostaglandin endoperoxide synthase in human epidermoid carcinoma cells.
PubMed:
Availability and characteristics of betel products in the U.S.
PubMed:
Carcinogenic effect of a dimethyl sulphoxide extract of betel nut on the mucosa of the hamster buccal pouch.
PubMed:
Screening for hemostatic activities of popular Chinese medicinal herbs in vitro.
PubMed:
Thai herbal formulas used for wound treatment: a study of their antibacterial potency, anti-inflammatory, antioxidant, and cytotoxicity effects.
PubMed:
Signaling pathways for induction of platelet aggregation by SAS tongue cancer cells--a mechanism of hematogenous metastasis.
PubMed:
Formation of reactive oxygen species and of 8-hydroxydeoxyguanosine in DNA in vitro with betel quid ingredients.
PubMed:
Presence of cholinomimetic and acetylcholinesterase inhibitory constituents in betel nut.
PubMed:
Inhibitory effect of betel nut extracts on endogenous nitrosation in humans.
PubMed:
Consumption of guava (Psidium guajava L) and noni (Morinda citrifolia L) may protect betel quid-chewing Papua New Guineans against diabetes.
PubMed:
Promoting activity of betel quid ingredients and their inhibition by retinol.
PubMed:
Development of photochemoprotective herbs containing cosmetic formulations for improving skin properties.
PubMed:
Oral submucous fibrosis in a 12-year-old girl: case report.
PubMed:
Protection from pan masala induced genomic damage by beta-carotene and retinoic acid--an in vitro experience.
PubMed:
Formation of reactive oxygen species and of 8-hydroxy-2'-deoxyguanosine in DNA in vitro with betel-quid ingredients.
PubMed:
Src family kinases mediate betel quid-induced oral cancer cell motility and could be a biomarker for early invasion in oral squamous cell carcinoma.
PubMed:
Experimental studies on betel nut and tobacco carcinogenicity.
PubMed:
Influence of alpha-tocopherol and ascorbic acid on pan masala induced genomic damage. An in vitro experiment.
PubMed:
Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro.
PubMed:
O6-methylguanine-DNA methyltransferase activity in human buccal mucosal tissue and cell cultures. Complex mixtures related to habitual use of tobacco and betel quid inhibit the activity in vitro.
PubMed:
Studies on promoting activity of Taiwan betel quid ingredients in hamster buccal pouch carcinogenesis.
PubMed:
Inhibitory action of Piper betle on the initiation of 7,12-dimethylbenz[a]anthracene-induced mammary carcinogenesis in rats.
PubMed:
Ethanol potentiates the clastogenicity of pan masala--an in vitro experience.
PubMed:
Evaluation of carcinogenic/co-carcinogenic activity of a common chewing product, pan masala, in mouse skin, stomach and esophagus.
PubMed:
Stabilisation of collagen by betel nut polyphenols as a mechanism in oral submucous fibrosis.
PubMed:
The influence of pH on the convertogenic activity of plant phenolics.
PubMed:
Nonmutagenicity of betel leaf and its antimutagenic action against environmental mutagens.
PubMed:
Evaluation of chemopreventive effects of betel leaf on the genotoxicity of pan masala.
PubMed:
Morphological transformation, sister chromatid exchange and mutagenesis assay of betel constituents.
PubMed:
Protective single/combined treatment with betel leaf and turmeric against methyl (acetoxymethyl) nitrosamine-induced hamster oral carcinogenesis.
PubMed:
An in vitro assessment of the genotoxic potential of pan masalas.
PubMed:
Effect of Piper betle L. and its extracts on the growth and aflatoxin production by Aspergillus parasiticus.
PubMed:
The presence of cholinomimetic and calcium channel antagonist constituents in Piper betle Linn.
PubMed:
Modifying influences of betel quid ingredients on B(a)P-induced carcinogenesis in the buccal pouch of hamster.
PubMed:
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products.
PubMed:
Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress.
PubMed:
Role of mouse spleen cell HMG proteins and their poly-ADP-ribosylation in betelnut induced carcinogenesis.
PubMed:
Acute toxicities of betel nut: rare but probably overlooked events.
PubMed:
Cancer-promoting effect of Taiwan betel quid in hamster buccal pouch carcinogenesis.
PubMed:
Mutual interactions among ingredients of betel quid in inducing genotoxicity on Chinese hamster ovary cells.
PubMed:
Pan masala--a genotoxic menace.
PubMed:
Embryotoxicity of betel nuts in mice.
PubMed:
Upregulation of matrix metalloproteinase-1 (MMP-1) expression in oral carcinomas of betel quid (BQ) users: roles of BQ ingredients in the acceleration of tumour cell motility through MMP-1.
PubMed:
Effect of glutathione on arecanut treated normal human buccal fibroblast culture.
PubMed:
The tumor promoting effect of lime-piper betel quid in JB6 cells.
PubMed:
Betel quid chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan.
PubMed:
Evaluation of the mutagenicity of 'pan masala', a chewing substitute widely used in India.
PubMed:
Correlation of mutagenicity and tumorigenicity of betel quid and its ingredients.
PubMed:
Inhibition of DNA synthesis in cultured lymphocytes and tumor cells by extracts of betel nut, tobacco, and miang leaf, plant substances associated with cancer of the ororespiratory epithelium.
PubMed:
Chromosome-damaging effect of betel leaf.
PubMed:
Role of lime in the generation of reactive oxygen species from betel-quid ingredients.
PubMed:
Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra.
PubMed:
Relationship between cellular levels of beta-carotene and sensitivity to genotoxic agents.
PubMed:
Allergenic relationship among four common and dominant airborne palm pollen grains from Eastern India.
PubMed:
Anthiovulatory activity of five indigenous plants in rabbits.
PubMed:
Effects of aqueous extracts of "Betel quid" and its constituents on testosterone production by dispersed mouse interstitial cells.
PubMed:
Hypoglycemic effects of Potentilla fulgens L in normal and alloxan-induced diabetic mice.
PubMed:
Inhibitory effect of bupleuri radix saponins on adhesion of some solid tumor cells and relation to hemolytic action: screening of 232 herbal drugs for anti-cell adhesion.
PubMed:
Carotenoids suppress proliferating cell nuclear antigen and cyclin D1 expression in oral carcinogenic models.
PubMed:
Human vaginal mucosa as a model of buccal mucosa for in vitro permeability studies: an overview.