disodium citrate
1,2,3-propanetricarboxylate, 2-hydroxy-, hydrogen sodium salt (1:1:2)
Identification
| Name | disodium citrate |
| IUPAC | disodium 3-carboxy-3-hydroxypentanedioate |
| CAS Number | 144-33-2 |
| EINECS | 205-623-3 |
| FDA UNII | 6FO62KCQ7A |
| Molecular Formula | C6 H6 Na2 O7 |
| Molecular Weight | 236.08775856 |
| MDL Number | MFCD00036367 |
| Nikkaji Number | J2.344.233G |
Regulatory
| FDA Mainterm (SATF) | 144-33-2 ; DISODIUM CITRATE |
| FDA Regulation | FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS |
Physical Properties
| Assay | 97.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 309.60 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 0.000057 mmHg @ 25.00 °C. (est) |
| Flash Point | 311.00 °F. TCC ( 155.20 °C. ) (est) |
| logP (o/w) | -1.721 (est) |
| Soluble in | water, 333000 mg/L @ 25 °C (exp) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-rat LD50 1724 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LD50 2580 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | stabilizing agents |
| Recommendation for disodium citrate usage levels up to | not for fragrance use. |
| Recommendation for disodium citrate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
alkacitron
citralka
citric acid disodium salt
citric acid, disodium salt
disodium 2-(carboxymethyl)-2-hydroxysuccinate
disodium 2-hydroxy-1,2,3-propane tricarboxylate
disodium 2-hydroxy-1,2,3-propanetricarboxylate
disodium 3-carboxy-3-hydroxypentanedioate
disodium hydrogen citrate
disodium monohydrogen citrate
hydrogen sodium 2-hydroxypropane-1,2,3-tricarboxylate (1:2:1)
2-
hydroxy-1,2,3-propanetricarboxylic acid disodium salt
1,2,3-
propanetricarboxylate, 2-hydroxy-, hydrogen sodium salt (1:1:2)
1,2,3-
propanetricarboxylic acid, 2-hydroxy-, disodium salt
1,2,3-
propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:2)
PubMed:
Multiple long-term, experimentally-evolved populations of Escherichia coli acquire dependence upon citrate as an iron chelator for optimal growth on glucose.
PubMed:
Chiroptical spectroscopy of natural products: avoiding the aggregation effects of chiral carboxylic acids.
PubMed:
Production of microbial cellulose by a bacterium isolated from fruit.
PubMed:
Influence of mixtures of calcium-chelating salts on the physicochemical properties of casein micelles.
PubMed:
Analysis of pesticides residues in fresh produce using buffered acetonitrile extraction and aminopropyl cleanup with gas chromatography/triple quadrupole mass spectrometry, liquid chromatography/triple quadrupole mass spectrometry, gas chromatography/ion trap detector mass spectrometry, and GC with a halogen-specific detector.
PubMed:
Extraction, partial characterization, and storage stability of β-glucosidase from propolis.
PubMed:
Toward an understanding of the salting-out effects in aqueous ionic liquid solutions: vapor-liquid equilibria, liquid-liquid equilibria, volumetric, compressibility, and conductivity behavior.
PubMed:
Microfluidic formation of ionically cross-linked polyamine gels.
PubMed:
Preparation of icariside II from icariin by enzymatic hydrolysis method.
PubMed:
Effects of pH on the textural properties and meltability of pasteurized process cheese made with different types of emulsifying salts.
PubMed:
Extractive spectrophotometric determination of TRODAT-1 hydrochloride in lyophilized kit.
PubMed:
Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria.
PubMed:
Effects of phosphates and citrates on sediment formation in UHT goats' milk.
PubMed:
Synthesis of tetracalcium phosphate from mechanochemically activated reactants and assessment as a component of bone cements.
PubMed:
An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies.
PubMed:
Desorption of copper and cadmium from soils enhanced by organic acids.
PubMed:
Effects of additives on the rheological properties and injectability of a calcium phosphate bone substitute material.
PubMed:
Effects of emulsifying salts on the turbidity and calcium-phosphate-protein interactions in casein micelles.
PubMed:
[Determination of trace cobalt in water samples by graphite furnace atomic absorption spectrometry after cloud point].
PubMed:
Extraction behavior of metallic contaminants and soil constituents from contaminated soils.
PubMed:
Identification of factors involved in recovery of heat-injured Salmonella Enteritidis.
PubMed:
Influences of osmotic agents in diffusion layer on drug release from multilayer coated pellets.
PubMed:
Regional citrate anticoagulation in continuous venovenous haemodiafiltration using commercial solutions.
PubMed:
Influence of EDTA and citrate on physicochemical properties of whey protein-stabilized oil-in-water emulsions containing CaCl2.
PubMed:
Alkaline CPD and the preservation of RBC 2,3-DPG.
PubMed:
Intravenous tolerability of an acid vehicle in Sprague Dawley rats and beagle dogs after daily slow bolus injection and infusion for one hour during 14 days.
PubMed:
Effect of salt form on chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms.
PubMed:
Heat resistance of Bacillus cereus spores: effects of milk constituents and stabilizing additives.
PubMed:
Chemical stability of an ester prodrug of a glycoprotein IIb/IIIa receptor antagonist in solid dosage forms.
PubMed:
Determination of heterocyclic amines in flame-grilled fish patty by capillary electrophoresis.
PubMed:
In vivo viability studies of two additive solutions in the postthaw preservation of red cells held for 3 weeks at 4 degrees C.
PubMed:
Quantification of human amniotic fluid constituents by high resolution proton nuclear magnetic resonance (NMR) spectroscopy.
PubMed:
Importance of extracellular divalent cations to polarisation of polymorphonuclear leukocytes induced by plasma.
PubMed:
Residues in fish exposed to sublethal doses of endosulfan and fish collected from cotton growing area.
PubMed:
One-step extraction and cleanup procedure for determination of p,p'-DDT, p,p'-DDD, and p,p'-DDE in fish.
PubMed:
Effects of different anticoagulants on human platelet size distribution and serotonin (5-HT) induced shape change and uptake kinetics.
PubMed:
High-performance liquid chromatography with amperometric detection of plasma L-3,4-dihydroxyphenylalanine in Parkinsonian patients.
PubMed:
In vivo study of the influence of adenine and guanosine on the erythrocytes of ACD (pH 5.0 and 5.6) preserved blood.
PubMed:
Effects of sodium picosulfate and other laxatives in cultured Chang cells.
PubMed:
Zinc-iodide-osmium procedures as markers of subcellular structures. I. Standardization of staining of transmitter containing vesicles.
PubMed:
Aggregation of calcium oxalate crystals: effect of urine and various inhibitors.
PubMed:
Some properties of p-coumarate decarboxylase from Cladosporium phlei.
PubMed:
The effect of citric acid and its sodium salts in test meals on the gastric outputs of acid and of chloride.
PubMed:
Inhibition of Rh agglutination by disodium hydrogen citrate.
PubMed:
Disodium-Citrate-Glucose Mixture as a Blood Preservative.