Identification

Namediallyl trisulfide
IUPAC3-prop-2-enylsulfanyldisulfanylprop-1-ene
CAS Number2050-87-5
EINECS218-107-8
FDA UNII0ZO1U5A3XX
Molecular FormulaC6 H10 S3
Molecular Weight178.34070000
MDL NumberMFCD00040025
Nikkaji NumberJ86.684I
Beilstein1745734
CoE Number486

Regulatory

JECFA Food Flavoring587 diallyl trisulfide
DG SANTE Food Flavourings12.009 diallyl trisulfide
FEMA Number3265
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)2050-87-5 ; DIALLYL TRISULFIDE

Physical Properties

Appearance yellow clear liquid (est)
Assay 65.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 1.13500 to 1.17000 @ 25.00 °C.
Pounds per Gallon - (est). 9.444 to 9.736
Refractive Index 1.60000 to 1.62000 @ 20.00 °C.
Boiling Point 112.00 to 120.00 °C. @ 16.00 mm Hg, 95.00 to 97.00 °C. @ 5.00 mm Hg
Vapor Pressure 0.105000 mmHg @ 25.00 °C. (est)
Vapor Density 6.1 ( Air = 1 )
Flash Point 145.00 °F. TCC ( 62.78 °C. )
logP (o/w) 3.367 (est)
Soluble in ether
Insoluble in alcohol

Organoleptic Properties

Odor Description
at 0.10 % in propylene glycol.
sweet/herbaceous, onion
Alliaceous, Green, Onion
Taste Description
sulfurous green onion garlic metallic
onion

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-mouse LD50 [sex: M,F] 100 - 400 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
IFRA Purity Specification< 0.1% free allyl alcohol
Recommendation for diallyl trisulfide usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.05 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.02 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)348 (μg/person/day)
NOEL (No Observed Effect Level)4.6 (mg/kg bw per day)
Threshold of Concern540 (μg/person/day)
Structure ClassII
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)0.60000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.04000
Edible ices, including sherbet and sorbet (03.0)0.50000
Processed fruit (04.1)-
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)0.20000
Confectionery (05.0)0.75000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.62000
Bakery wares (07.0)0.80000
Meat and meat products, including poultry and game (08.0)0.73000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)0.10000
Eggs and egg products (10.0)0.08000
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)0.45000
Foodstuffs intended for particular nutritional uses (13.0)-
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)0.50000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)0.10000
Ready-to-eat savouries (15.0)1.10000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)-

Beijing Lys Chemicals Co, LTD.

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FRUTAROM USA INC,

Flavor & Specialty Ingredients

Your preferred partner for flavour and fragrance success.

View All Website +44 (0) 1429 863 222 Sales.IFFIngredients@iff.com

Jiangyin Healthway International Trade Co., Ltd

Independent Ingredients Supplier

We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.

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Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

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M&U International LLC

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Penta International Corporation

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Tianjin Danjun International Trade Co., LTD.

Quality Products

We know the Chinese chemical market well.

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R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

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Qingdao Free Trade Zone United International Co Ltd

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WholeChem, LLC

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Potential Uses

FL garlic FL meat FL onion FL vegetable

Natural Occurrence

garlic bud garlic bulb garlic oil onion oil

Synonyms

allitridin allitridum allyl trisulfide dasuansu di-2-propenyl trisulfide diallyl trisulphide diallyltrisulfane diallyltrisulfide diprop-2-en-1-yltrisulfane prop-2-enyl prop-2-enylthio disulfide 3- prop-2-enylsulfanyldisulfanylprop-1-ene trisulfane, 1,3-di-2-propen-1-yl- trisulfide, di-2-propenyl trisulfide, diallyl PubMed: Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells. PubMed: Anticancer effects of diallyl trisulfide derived from garlic. PubMed: Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of beta-tubulin. PubMed: Solid-phase microextraction-gas chromatographic-mass spectrometric analysis of garlic oil obtained by hydrodistillation. PubMed: Comparative study of extraction techniques for determination of garlic flavor components by gas chromatography-mass spectrometry. PubMed: Modulation of cytochrome P4501-mediated bioactivation of benzo[a]pyrene by volatile allyl sulfides in human hepatoma cells. PubMed: Postharvest control of gray mold in table grapes using volatile sulfur compounds from Allium sativum. PubMed: Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation. PubMed: A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment. PubMed: Diallyl trisulfide-induced apoptosis of bladder cancer cells is caspase-dependent and regulated by PI3K/Akt and JNK pathways. PubMed: Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators. PubMed: Organosulfur garlic compounds induce neovasculogenesis in human endothelial progenitor cells through a modulation of MicroRNA 221 and the PI3-K/Akt signaling pathways. PubMed: Molecular mechanisms for the anti-cancer effects of diallyl disulfide. PubMed: Garlic as an anti-diabetic agent: recent progress and patent reviews. PubMed: Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. PubMed: Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1. PubMed: Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. PubMed: Diallyl trisulfide as an inhibitor of benzo(a)pyrene-induced precancerous carcinogenesis in MCF-10A cells. PubMed: Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. PubMed: Effects of onion (Allium cepa L.) and garlic (Allium sativum L.) essential oils on the Aspergillus versicolor growth and sterigmatocystin production. PubMed: Studies on purification of allicin by molecular distillation. PubMed: Effect of garlic sulfur compounds on neutrophil infiltration and damage to the intestinal mucosa by endotoxin in rats. PubMed: Diallyl trisulfide suppresses the adipogenesis of 3T3-L1 preadipocytes through ERK activation. PubMed: Investigating antibacterial effects of garlic (Allium sativum) concentrate and garlic-derived organosulfur compounds on Campylobacter jejuni by using Fourier transform infrared spectroscopy, Raman spectroscopy, and electron microscopy. PubMed: Potential beneficial effects of garlic in oncohematology. PubMed: Effect of diallyl trisulfide on the pharmacokinetics of nifedipine in rats. PubMed: Consumption of S-allylcysteine inhibits the growth of human non-small-cell lung carcinoma in a mouse xenograft model. PubMed: Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. PubMed: Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. PubMed: The antidiabetic effect of onion and garlic in experimental diabetic rats: meta-analysis. PubMed: Antimicrobial activity of elephant garlic oil against Vibrio cholerae in vitro and in a food model. PubMed: Diallyl sulfide content and antimicrobial activity against food-borne pathogenic bacteria of chives (Allium schoenoprasum). PubMed: Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents. PubMed: Inhibition of acrylamide toxicity in mice by three dietary constituents. PubMed: Identification of characteristic aroma components of Thai fried chili paste. PubMed: Bioactive food components and cancer risk reduction. PubMed: Synergistic antiyeast activity of garlic oil and allyl alcohol derived from alliin in garlic. PubMed: Diallyl disulfide and diallyl trisulfide up-regulate the expression of the pi class of glutathione S-transferase via an AP-1-dependent pathway. PubMed: Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats. PubMed: Structure-activity relationship of neuroprotective and reactive oxygen species scavenging activities for allium organosulfur compounds. PubMed: Antithrombotic and anticancer effects of garlic-derived sulfur compounds: a review. PubMed: Garlic allyl sulfides display differential modulation of rat cytochrome P450 2B1 and the placental form glutathione S-transferase in various organs. PubMed: DATS reduces LPS-induced iNOS expression, NO production, oxidative stress, and NF-kappaB activation in RAW 264.7 macrophages. PubMed: The effects of allitridin on the expression of transcription factors T-bet and GATA-3 in mice infected by murine cytomegalovirus. PubMed: Fumigant activity of plant essential oils and components from garlic (Allium sativum) and clove bud (Eugenia caryophyllata) oils against the Japanese termite (Reticulitermes speratus Kolbe). PubMed: Allicin and allicin-derived garlic compounds increase breath acetone through allyl methyl sulfide: use in measuring allicin bioavailability. PubMed: Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. PubMed: Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. PubMed: The effects of allyl sulfides on the induction of phase II detoxification enzymes and liver injury by carbon tetrachloride. PubMed: Inhibitory activity of essential oils of garlic and onion against bacteria and yeasts. PubMed: Protective effect of three diallyl sulphides against glucose-induced erythrocyte and platelet oxidation, and ADP-induced platelet aggregation. PubMed: Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats. PubMed: Modulation of cytochrome P4501-mediated bioactivation of benzo[a]pyrene by volatile allyl sulfides in human hepatoma cells. PubMed: Effects of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells. PubMed: Thermal Degradation of Allyl Isothiocyanate in Aqueous Solution. PubMed: Bioactivities of methyl allyl disulfide and diallyl trisulfide from essential oil of garlic to two species of stored-product pests, Sitophilus zeamais (Coleoptera: Curculionidae) and Tribolium castaneum (Coleoptera: Tenebrionidae).