sclareol

alpha- ethenyl decahydro-2-hydroxy-a,2,5,5,8a-pentamethyl(1R-(1alpha(R*),2beta,4abeta,8H (1theta- (1alpha (theta),2beta, 4abeta,8aalpha))-alpha- ethenyl decahydro-2-hydroxy-alpha,2,5,5,8a-pentamethyl-1-naphthalene propanol (1r,2r,8as)-1-[(3R)-3- hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol (1R,2R,8aS)-1-[(3R)-3- hydroxy-3-methylpent-4-enyl]-2,5,5,8a-tetramethyl-3,4,4a,6,7,8-hexahydro-1H-naphthalen-2-ol (1R-(1alpha(R*), 2beta,4abeta, 8aalpha))-2- hydroxy-alpha,2,5,5,8a-pentamethyl-alpha-vinyl decahydronaphthalene-1-propan-1-ol (13R)- labd-14-ene-8,13-diol labd-14-ene-8,13-diol, (13R)- 1- naphthalenepropanol, a-ethenyldecahydro-2-hydroxy-a,2,5,5,8a-pentamethyl-, (aR,1R,2R,4aS,8aS)- (-)- sclareol sclareol natural PubMed: Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes. PubMed: [Engineering Saccharomyces cerevisiae for sclareol production]. PubMed: [Preface for special issue on synthetic biology (2013)]. PubMed: Sclareol reduces CD4+ CD25+ FoxP3+ Treg cells in a breast cancer model in vivo. PubMed: Hh signaling inhibitors from Vitex negundo; naturally occurring inhibitors of the GLI1-DNA complex. PubMed: Chemical composition and anticancer activity of essential oils of Mediterranean sage (Salvia officinalis L.) grown in different environmental conditions. PubMed: Extracellular localization of the diterpene sclareol in clary sage (Salvia sclarea L., Lamiaceae). PubMed: Bioactive constituents of Salvia chrysophylla Stapf. PubMed: Toward a biosynthetic route to sclareol and amber odorants. PubMed: Enzymatic biotransformation of terpenes as bioactive agents. PubMed: A diterpene synthase from the clary sage Salvia sclarea catalyzes the cyclization of geranylgeranyl diphosphate to (8R)-hydroxy-copalyl diphosphate. PubMed: Cancer cell spheroids as a model to evaluate chemotherapy protocols. PubMed: Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea (L.) and their relevance for perfume manufacture. PubMed: Identification of natural diterpenes that inhibit bacterial wilt disease in tobacco, tomato and Arabidopsis. PubMed: Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model. PubMed: Antimicrobial evaluation of diterpenes from Copaifera langsdorffii oleoresin against periodontal anaerobic bacteria. PubMed: First enantiospecific synthesis of marine sesquiterpene quinol akaol A. PubMed: Four potato (Solanum tuberosum) ABCG transporters and their expression in response to abiotic factors and Phytophthora infestans infection. PubMed: Synthesis of the scalarane sesterterpenoid 16-deacetoxy-12-epi-scalarafuranacetate. PubMed: The labdane diterpene sclareol (labd-14-ene-8, 13-diol) induces apoptosis in human tumor cell lines and suppression of tumor growth in vivo via a p53-independent mechanism of action. PubMed: Isolation, chemical, and biotransformation routes of labdane-type diterpenes. PubMed: Chemical composition and antimicrobial activity of the essential oils from Cleome spinosa. PubMed: Sclareol modulates the Treg intra-tumoral infiltrated cell and inhibits tumor growth in vivo. PubMed: Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol. PubMed: Hemisynthesis of two marine cheilanthane sesterterpenes from (-)-sclareol: first enantioselective synthesis of petrosaspongiolide R. PubMed: Fragrance material review on sclareol. PubMed: Diversity of essential oil glands of clary sage (Salvia sclarea L., Lamiaceae). PubMed: Microbial hydroxylation of sclareol by Rhizopus stolonifer. PubMed: Cell growth inhibitory action of an unusual labdane diterpene, 13-epi-sclareol in breast and uterine cancers in vitro. PubMed: Antibacterial and cytotoxic activity of the acetone extract of the flowers of Salvia sclarea and some natural products. PubMed: Diels-Alder cycloaddition approach to puupehenone-related metabolites: synthesis of the potent angiogenesis inhibitor 8-epipuupehedione. PubMed: Liposomes modify the subcellular distribution of sclareol uptake by HCT-116 cancer cell lines. PubMed: Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice. PubMed: Structure elucidation and antibacterial activity of new fungal metabolites of sclareol. PubMed: Calorimetric study on the induction of interdigitated phase in hydrated DPPC bilayers by bioactive labdanes and correlation to their liposome stability: The role of chemical structure. PubMed: Hemisynthesis of new labdane derivatives from (-)-sclareol. PubMed: Synthesis of ent-thallusin. PubMed: A new route toward 7-Oxo-13-hydroxy-8,11,13-podocarpatrienes from labdane diterpenes. PubMed: Labd-14-ene-8,13-diol (sclareol) induces cell cycle arrest and apoptosis in human breast cancer cells and enhances the activity of anticancer drugs. PubMed: Cytotoxic and antitumor activity of liposome-incorporated sclareol against cancer cell lines and human colon cancer xenografts. PubMed: NpPDR1, a pleiotropic drug resistance-type ATP-binding cassette transporter from Nicotiana plumbaginifolia, plays a major role in plant pathogen defense. PubMed: First enantiospecific synthesis of the antitumor marine sponge metabolite (-)-15-oxopuupehenol from (-)-sclareol. PubMed: A comparative study of the effects of cholesterol and sclareol, a bioactive labdane type diterpene, on phospholipid bilayers. PubMed: Effect of 13-epi-sclareol on the bacterial respiratory chain. PubMed: Pathogen-responsive expression of a putative ATP-binding cassette transporter gene conferring resistance to the diterpenoid sclareol is regulated by multiple defense signaling pathways in Arabidopsis. PubMed: Identification of regulatory sequence elements within the transcription promoter region of NpABC1, a gene encoding a plant ABC transporter induced by diterpenes. PubMed: Antibacterial diterpenoids from Astragalus brachystachys. PubMed: The plant PDR family of ABC transporters. PubMed: Molecular basis of pimarane compounds as novel activators of large-conductance Ca(2+)-activated K(+) channel alpha-subunit. PubMed: The ABC transporter SpTUR2 confers resistance to the antifungal diterpene sclareol. PubMed: Chromatographic (GC-MS, HPLC) and virological evaluations of Salvia sclarea infected by BBWV-I. PubMed: A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion. PubMed: Labdane type diterpenes down-regulate the expression of c-Myc protein, but not of Bcl-2, in human leukemia T-cells undergoing apoptosis. PubMed: Biotransformation of two cytotoxic terpenes, alpha-santonin and sclareol by Botrytis cinerea. PubMed: Potential nitrite scavengers as inhibitors of the formation of N-nitrosamines in solution and tobacco matrix systems. PubMed: Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol. PubMed: Synthesis and antitumoral activities of marine ent-chromazonarol and related compounds. PubMed: Chemical analysis and antimicrobial activity of the resin Ladano, of its essential oil and of the isolated compounds. PubMed: The effect of sclareol on growth and cell cycle progression of human leukemic cell lines. PubMed: A concise synthesis and in vitro cytotoxicity of new labdane diterpenes. PubMed: A concise conversion of (-)-sclareol into (+)-coronarin E and (-)-7-epi-coronarin A PubMed: [Plant anatomical and phytochemical evaluation of Salvia species]. PubMed: Biorationals fromNicotiana protect cucumbers againstColletotrichum lagenarium (Pass.) ell. & halst disease development. PubMed: Terpenoids from Salvia sclarea. PubMed: Synthesis of manool-related labdane diterpenes as platelet aggregation inhibitors. PubMed: Identification of four biliary metabolites of the diterpene sclareol in the laboratory rat. PubMed: Leaf surface chemicals fromNicotiana affecting germination ofPeronospora tabacina (adam) sporangia. PubMed: Hydroxylation and glucoside conjugation in the microbial metabolism of the diterpene sclareol. PubMed: Microbial models of mammalian metabolism: fungal metabolism of the diterpene sclareol by Cunninghamella species. PubMed: Influences of diterpene sclareol glycol on some dopamine related behavior. PubMed: The effects of the diterpene sclareol glycol on seizures do not depend on central benzodiazepine receptors. PubMed: The response of diterpene sclareol glycol to acute hypoxia in mice. PubMed: [The effect of sclareol lactone and sclareol glycol on artificially induced lung metastases of Lewis lung carcinoma (a preliminary report)]. PubMed: Measures of anxiety, retention and stress in the rat following treatment with the diterpene sclareol glycol. PubMed: Diterpene sclareol glycol inhibits clonidine-induced aggressive responses in mice. PubMed: Effects of the diterpene sclareol glycol on convulsive seizures. PubMed: Effects of the diterpene sclareol glycol on body temperature in rats. PubMed: [Study of the effect of sclareol glycol diterpene on the release of adenohypophysial hormones prolactin, somatotropin and adenocorticotrophic hormone]. PubMed: [Study of the effect of sclareol glycol diterpene on the 3',5'-AMP level]. PubMed: Experimental study of essential oils from two varieties of cultivated thyme, sesquiterpene Germacron and diterpene Sclareol for cholagogic and choleretic activity. PubMed: [Effect of diterpene sklareol glycol on the conflict test and its correlation with diazepam]. PubMed: [Effects of sklareol-glycol on pentylenetetrazole-induced convulsions and its interaction with diazepam]. PubMed: BIOSYNTHESIS AND METABOLISM OF (14C)SCLAREOL. PubMed: Biosynthesis of sclareol, beta-sitosterol, and oleanolic acid from mevalonic acid-2-C-14. PubMed: Biosynthesis of 14C-sclareol and beta-sitosterol from 2-14C-mevalonic acid. PubMed: [Sclareol, its chemical constitution and use in the synthesis of aromatic principles of amber; a review]. PubMed: [Not Available].